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Clinical significance of recombinant virus-specific detection for viable circulating tumor cells in lung cancer patients



Clinical significance of recombinant virus-specific detection for viable circulating tumor cells in lung cancer patients



Zhonghua Jie He He Hu Xi Za Zhi 42(2): 101-105



目的: 初步探讨重组病毒特异性检测肺癌患者外周血活性循环肿瘤细胞(CTC)的临床意义。 方法: 纳入首都医科大学附属北京安贞医院呼吸与危重症医学科2017年6月至2018年8月住院且经影像及病理学检查确诊的肺癌患者63例(肺癌组),其中腺癌38例,鳞癌13例,小细胞癌12例;男36例,女27例,平均年龄(65±11)岁;纳入同期本科室住院的21例良性肺疾病患者(良性肺疾病组),男11例,女10例,平均年龄(57±13)岁;本院健康体检者18名(健康对照组),男10名,女8名,平均年龄(32±10)岁。应用含重组病毒的CTC体外检测试剂盒检测肺癌组外周血中活性CTC数,并与另外2组进行比较。采用Fisher精确检验比较CTC阳性检出率的组间差异。 结果: 肺癌组56例活性CTC阳性;良性肺疾病组4例活性CTC阳性,健康组未检出;该检测方法的敏感度为89%(56/63),特异度为90%(35/39)。肺癌组腺癌患者中CTC阳性率为84%(32/38),鳞癌为92%(12/13),小细胞癌12例均阳性;肺腺癌和鳞癌患者活性CTC阳性分布:Ⅰ期2例均阳性,Ⅱ期8例中6例阳性,Ⅲ期8例中7例阳性,Ⅳ期33例中29例阳性。肺癌组不同病理分型、不同临床分期患者CTC阳性率比较差异无统计学意义(χ(2)=1.881和3.419,均P>0.05)。 结论: 重组病毒特异性检测肺癌患者外周血中活性CTC的方法简便、无创,且敏感度和特异度较高。.

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Accession: 066446302

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PMID: 30704181


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