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The influence of excessive daytime sleepiness and sleep quality on anxiety and depression in patients with obstructive sleep apnea hypopnea syndrome



The influence of excessive daytime sleepiness and sleep quality on anxiety and depression in patients with obstructive sleep apnea hypopnea syndrome



Zhonghua Nei Ke Za Zhi 58(2): 119-124



目的: 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者焦虑和抑郁状态的影响因素。 方法: 选2013年5月至2015年11月于中国医科大学附属第一医院呼吸科睡眠中心经多导睡眠监测诊断为OSAHS的患者196例,其中重度OSAHS患者103例,轻中度OSAHS患者93例。根据Epworth嗜睡量表(ESS)评分和嗜睡症状将患者分为OSAHS合并白日嗜睡(EDS)者和未合并EDS者,收集患者的一般资料、症状,采用焦虑自评量表(SAS)和抑郁自评量表(SDS)评价患者情绪状况,采用匹兹堡睡眠质量指数(PSQI)评价患者的主观睡眠质量。比较合并EDS与未合并EDS的OSAHS患者焦虑和抑郁评分,并进行相关因素分析。 结果: (1)重度OSAHS患者中,合并EDS者较未合并EDS者PSQI评分[(6.22±2.57)分比(4.05±3.72)分,P<0.01]、氧减指数[(57.70±17.53)次/h比(48.23±22.01)次/h,P<0.05]明显增高;(2)无论是重度还是轻中度OSAHS患者,合并EDS时均具有较高的SAS评分[重度:(33.86±7.60)分比(28.95±4.71)分,轻中度:(37.46±10.68)分比(33.40±11.07)分,P<0.05]、SDS评分[重度:(32.81±8.36)分比(28.90±4.53)分,轻中度:(36.98±12.77)分比(31.70±10.94)分,P<0.05];(3)多因素线性回归分析显示,SAS评分与ESS评分、PSQI、失眠程度、鼻塞程度相关(R(2)=0.356,P<0.05);SDS评分与ESS评分、PSQI、失眠程度相关(R(2)=0.344,P<0.05)。 结论: OSAHS患者的焦虑和抑郁状态与白日嗜睡程度和睡眠质量密切相关,无论是重度还是轻中度OSAHS患者,合并EDS时焦虑和抑郁评分明显增高。.

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