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Correlations between gastric Helicobacter pylori infection and colorectal polyps or cancer



Correlations between gastric Helicobacter pylori infection and colorectal polyps or cancer



Zhonghua Nei Ke Za Zhi 58(2): 139-142



目的: 幽门螺杆菌(Hp)感染与结直肠息肉及结直肠癌发生是否相关尚存争议。本研究拟探讨Hp感染与结直肠息肉及结直肠癌发病风险的相关性。 方法: 纳入2012年5月—2017年5月于北京协和医院行结肠镜检查并经病理确诊的结直肠息肉患者3 483例及初发结直肠癌患者135例,并纳入同期完成全结肠镜检查的健康对照1 925例。所有研究对象同期完成胃黏膜活检快速尿素酶检测。收集息肉数量及大小、结直肠癌部位及Hp感染情况。采用logistic回归分析Hp感染与结直肠息肉、结直肠癌发生的关系。 结果: 结直肠息肉患者Hp感染发生率为31.5%,高于健康对照(29.5%)。校正年龄及性别后,logistic回归分析显示,结直肠息肉患者相对正常对照的Hp感染发生率的OR=1.17(95%CI 1.04~1.32)。息肉直径≥1.0 cm者的Hp感染发生率为33.4%,高于息肉直径<1.0 cm者(31.0%),P=0.03;息肉数量≥2个的患者Hp感染发生率为32.5%,高于单发息肉患者(30.4%),P=0.05。结直肠癌患者Hp感染发生率为36.3%,校正性别及年龄因素后,结直肠癌患者相对正常对照的Hp感染发生率的校正OR=1.56(95%CI 1.06~2.30),P=0.03;结直肠癌的发生部位(左半结肠+直肠癌、右半结肠癌)与Hp感染无关联。 结论: 结直肠息肉、结直肠癌患者Hp感染发生率高于健康对照组,其中结直肠息肉患者息肉体积大、数量多者Hp感染发生率更高;Hp感染与结直肠癌的分布位置无相关性。.

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Accession: 066446321

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PMID: 30704201


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