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Programmed death-1/programmed death-ligand 1 pathway and T cell exhaustion in sepsis



Programmed death-1/programmed death-ligand 1 pathway and T cell exhaustion in sepsis



Zhonghua Nei Ke Za Zhi 58(2): 158-160



脓毒症是导致ICU患者死亡的主要原因之一,免疫抑制是脓毒症主要病理生理学过程之一,T细胞耗竭是导致脓毒症免疫抑制的重要机制。脓毒症T细胞耗竭是以程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡蛋白配体-1(PD-L1)通路活化导致T细胞效应及增殖功能受损的免疫应答障碍,阻断PD-1/PD-L1通路来逆转T细胞耗竭可能成为脓毒症的免疫治疗方法之一。.

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Accession: 066446326

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PMID: 30704206


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