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The usage of comprehensive geriatric assessment in elderly patients with acute myeloid leukemia: a multicenter, prospective study



The usage of comprehensive geriatric assessment in elderly patients with acute myeloid leukemia: a multicenter, prospective study



Zhonghua Xue Ye Xue Za Zhi 40(1): 35-39



目的: 探讨综合老年学评估(CGA)在中国初治老年急性髓系白血病(AML)患者中应用的可行性及评估结果。 方法: 前瞻性分析83例于2016年3月至2017年12月在京津地区16家医院住院治疗的非急性早幼粒细胞白血病的老年(年龄≥60岁)初治AML患者的临床资料、CGA结果、治疗和生存数据。 结果: 83例患者中,81例(97.6%)完成了所有的CGA评价。中位CGA量表异常个数为2(0~6)个,16例(19.3%)患者无任何CGA量表异常。46例(55.4%)患者存在日常活动量表(ADL)异常,35例(42.2%)患者存在工具性日常生活活动量表(IADL)异常,40例(48.2%)患者存在简易营养评估量表(MNA-SF)异常,13例(15.7%)患者存在认知异常,26例(31.7%)患者存在老年抑郁量表(GDS)异常,16例(19.5%)患者存在造血干细胞移植共病指数(HCT-CI)异常。在46例(55.4%)美国东部肿瘤协作组(ECOG)体能评估正常的患者中,CGA量表的异常比例为6.5%~37.0%,其中32例患者存在≥1个CGA量表异常。生存分析发现CGA异常数目与患者的中位总生存相关(P=0.050)。 结论: 在中国老年AML住院患者中行CGA具有临床可行性。.

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Accession: 066446344

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PMID: 30704226


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