+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Correlation between myeloperoxidase expression and gene alterations and prognosis in acute myeloid leukemia



Correlation between myeloperoxidase expression and gene alterations and prognosis in acute myeloid leukemia



Zhonghua Xue Ye Xue Za Zhi 40(1): 40-45



目的: 观察髓过氧化物酶(MPO)在急性髓系白血病(AML)中的表达,探讨其与AML临床特征、基因突变、疗效和预后的关系。 方法: 回顾性分析233例初诊AML患者骨髓中原始细胞MPO表达的阳性率,根据MPO表达率不同将其分为MPO低表达组(MPO≤70%)与MPO高表达组(MPO>70%),并对两组患者的临床特征、基因突变、疗效和预后进行比较。 结果: ①233例AML患者中MPO低表达组121例(51.9%),MPO高表达组112例(48.1%)。NCCN预后良好组患者多为MPO高表达(χ(2)=32.773,P<0.001),而MPO低表达与预后不良核型相关(χ(2)=7.078,P=0.008)。②MPO低表达组DNMT3A基因(χ(2)=6.905,P=0.009)、RNA剪接复合物相关基因(SF3B1/SRSF2/U2AF1)(χ(2)=5.246,P=0.022)、RUNX1基因(χ(2)=4.577,P=0.032)、ASXL1基因(χ(2)=7.951,P=0.005)及TP53基因(P=0.004)突变发生率明显高于MPO高表达组,而C-KIT基因(χ(2)=8.936,P=0.003)及CEBPA基因(χ(2)=12.340,P<0.001)突变更多见于MPO高表达组,尤其CEBPA双位点突变。③MPO低表达组首次诱导治疗缓解(CR(1))率为38.8%,MPO高表达组为68.1%,差异有统计学意义(χ(2)=15.197,P<0.001)。多因素分析显示MPO低表达是影响患者CR(1)的独立危险因素。④MPO低表达组患者的2年总生存(OS)率及无进展生存(PFS)率均明显低于高表达组(18.0%对89.4%和11.5%对56.7%),差异有统计学意义(χ(2)分别为15.212和17.016,P值均<0.001)。Cox模型多因素分析显示MPO低表达是影响患者OS及PFS的独立预后不良指标。⑤正常核型AML中,MPO低表达组患者OS和PFS差于MPO高表达组(2年OS率:31.1%对83.7%,χ(2)=2.895,P=0.089;2年PFS率:18.8%对45.8%,χ(2)=5.068,P=0.024)。 结论: 不同MPO表达的AML具有独特的基因突变谱;MPO低表达是影响AML患者CR(1)、OS和PFS的独立危险因素,细胞化学染色检测MPO表达可能为评估AML疗效和预后提供一种简单而有效的手段。.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 066446345

Download citation: RISBibTeXText

PMID: 30704227


Related references

Expression of the myeloperoxidase gene in AC133 positive leukemia cells relates to the prognosis of acute myeloid leukemia. Leukemia Research 30(9): 1105-1112, 2006

Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia. Leukemia Research 65: 34-41, 2018

Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia. Leukemia Research 65: 34-41, 2018

Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia: over-expression of PDCD7, FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia. Plos one 9(1): E84150, 2014

ASXL1 mutations define a subgroup of patients with acute myeloid leukemia with distinct gene expression profile and poor prognosis: a meta-analysis of 3311 adult patients with acute myeloid leukemia. Leukemia and Lymphoma 56(6): 1881-1883, 2015

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. Journal of Clinical Oncology 28(22): 3636-3643, 2010

Genetic changes including gene copy number alterations and their relation to prognosis in childhood acute myeloid leukemia. Leukemia and Lymphoma 51(1): 114-124, 2010

Gene expression and prognosis in acute myeloid leukemia. 2008

Gene expression profile related prognosis of acute myeloid leukemia. FASEB Journal 17(4-5): Abstract No 81 19, 2003

Gene expression profile related to prognosis of acute myeloid leukemia. Oncology Reports 18(6): 1395-1402, 2007

Correlation of CD11b and CD56 expression in adult acute myeloid leukemia with cytogenetic risk groups and prognosis. Annals of Hematology 93(9): 1483-1489, 2014

Correlation Between Isocitrate Dehydrogenase Gene Aberrations and Prognosis of Patients with Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis. Clinical Cancer Research 23(15): 4511-4522, 2017

Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia. Oncogene 23(4): 894-904, 29 January, 2004

NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia. Genes, Chromosomes & Cancer 52(7): 683-693, 2013

Effect of WT1 Gene High Expression and CD34 + and Auer + on Prognosis of Acute Myeloid Leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi 24(6): 1670-1674, 2016