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Bilirubin: from an unimportant waste product to important myocardial infarction predictor



Bilirubin: from an unimportant waste product to important myocardial infarction predictor



Vnitrni Lekarstvi 64(12): 1148-1152



Bilirubin is the major catabolic product of heme degradation. It has long been regarded as an unimportant waste product. However, within the last twenty-five years, it has been demonstrated to play a very important role in maintaining the bodys redox equilibrium. Disturbances of this equilibrium - increased oxidative stress - are currently considered one of the major risk factors for the development of non-communicable diseases. Although the exact mechanism is not known, a number of human studies have proved a reduced incidence of a number of (especially cardiovascular but also cancer) diseases in individuals with mildly elevated bilirubin concentrations. Key words: bilirubin - cardiovascular disease - morbidity - mortality.

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Accession: 066446364

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PMID: 30704249


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