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Expression of activator protein-1 in papillary thyroid carcinoma and its clinical significance



Expression of activator protein-1 in papillary thyroid carcinoma and its clinical significance



World Journal of Surgical Oncology 17(1): 25



The abnormal expression of activator protein-1(AP-1) has recently been investigated in a variety of tumors. While the relationship between AP-1 and thyroid cancer is poorly studied, our study was to evaluate the protein expression and clinical value of AP-1 in papillary thyroid carcinoma (PTC). The expression of AP-1 was examined by immunohistochemistry on paraffin-embedded tissues obtained from PTC and correspondent paracancerous tissues of 82 patients. Compared with paracancerous tissues, AP-1 expression was significantly elevated in PTC tissues and the positive rate was 79.3% (65/82). Our study found a linear trend relationship between the expression of AP-1 and tumor size. However, the differences in AP-1 expression among gender, age, lymph node metastasis, number of lesions, location of the lesion, and extrathyroid invasion are not statistically significant. The expression of AP-1 plays an important role in the proliferation process of PTC.

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Accession: 066446586

Download citation: RISBibTeXText

PMID: 30704487

DOI: 10.1186/s12957-019-1568-x


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