+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Assessing blink reflex circuits by three different afferent routes in Parkinson's disease

Assessing blink reflex circuits by three different afferent routes in Parkinson's disease

Clinical Neurophysiology 2019

Degeneration of nuclei of the brainstem, especially parts of the vagal nuclei complex and the reticular formation, in Parkinson's disease (PD) may in part be responsible for nonmotor signs like obstipation, cardiac dysfunction and rapid eye movement sleep behavior disorder (RBD). The aim of the study was to establish a new blink reflex (BR) variant involving the vagal nuclei complex and the reticular formation and to investigate BR comprehensively using 3 different afferent routes in PD. In this cross-sectional observational study in 30 PD patients and 30 age and sex matched healthy controls, BR was elicited by stimulation of the auricular branch of the vagus nerve (ABVN) and compared to conventional BR variants evoked by the trigeminal and median nerve. BRs could be elicited reliably by stimulation of ABVN in both groups. In none of the three BR variants, latencies or amplitudes differed between PD patients and controls. In PD, BR parameters were not related to cognition or presence of RBD. The present study did not provide evidence for malfunctioning of neural circuits subserving BRs elicited by three different afferents in PD. Brainstem circuits mediating these BR variants may be spared from neurodegeneration in PD.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 066446902

Download citation: RISBibTeXText

PMID: 30704843

DOI: 10.1016/j.clinph.2018.12.009

Related references

Buccopalpebral reflex in Parkinson disease and blink reflex study. Neurosciences 18(3): 252-257, 2013

Blink reflex in Huntingon's chorea and Parkinson's disease. Acta Neurologica Scandinavica 52(2): 145-157, 1975

Blink reflex in dyskinetic and nondyskinetic patients with Parkinson's disease. European Neurology 29(2): 67-70, 1989

Blink reflex in Parkinson's disease with levodopa-induced dyskinesia. Functional Neurology 4(3): 257-261, 1989

Effects of lisuride on blink reflex habituation in Parkinson disease. European Neurology 24(6): 374-379, 1985

Effects of Lisuride on Blink Reflex Habituation in Parkinson Disease. European Neurology 24(6): 374-379, 1985

An explanation for reflex blink hyperexcitability in Parkinson's disease. I. Superior colliculus. Journal of Neuroscience 16(22): 7308-7317, 1996

Pain threshold and polysynaptic components of the blink reflex in Parkinson's disease. Functional Neurology 4(2): 199-202, 1989

Abnormalities of prepulse inhibition do not depend on blink reflex excitability: a study in Parkinson's disease and Huntington's disease. Clinical Neurophysiology 115(7): 1527-1536, 2004

An explanation for reflex blink hyperexcitability in Parkinson's disease. II. Nucleus raphe magnus. Journal of Neuroscience 16(22): 7318-7330, 1996

Auditory effects on the electrically elicited blink reflex in patients with Parkinson's disease. Electroencephalography and Clinical Neurophysiology 89(2): 108-112, 1993

Huntington's chorea and Parkinson's disease. Physiopathological antagonism in relation to the blink reflex. Archivos de Neurobiologia 37(4): 337-354, 1974

Disinhibited Blink Reflex Recovery Is Related to Lateral Trunk Flexion in Parkinson Disease. Journal of Clinical Neurophysiology 35(4): 346-350, 2018

A correlation study between blink reflex habituation and clinical state in patients with Parkinson's disease. Journal of the Neurological Sciences 107(2): 155-159, 1992

Diagnostic value of blink reflex in multisystem atrophy, progressive supranuclear palsy and Parkinson disease. Neurologia i Neurochirurgia Polska 50(5): 336-341, 2017