+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cross-diagnostic analysis of cognitive control in mental illness: Insights from the CNTRACS consortium



Cross-diagnostic analysis of cognitive control in mental illness: Insights from the CNTRACS consortium



Schizophrenia Research 208: 377-383



In recent years, psychiatry research has increasingly focused on understanding mental illnesses from a cross-diagnostic, dimensional perspective in order to better align their neurocognitive features with underlying neurobiological mechanisms. In this multi-site study, we examined two measures of cognitive control (d-prime context and lapsing rate) during the Dot Probe Expectancy (DPX) version of the AX-Continuous Performance Task in patients with either schizophrenia (SZ), schizoaffective disorder (SZ-A), or Type I bipolar disorder (BD) as well as healthy control (HC) subjects. We hypothesized significantly lower d-prime context and higher lapsing rate in SZ and SZ-A patients and intermediate levels in BD patients relative to HC. 72 HC, 84 SZ, 77 SZ-A, and 58 BD patients (ages 18-56) were included in the final study sample. Significant main effects of diagnosis were observed on d-prime context (F(3,279) = 9.59, p < 0.001) and lapsing (F(3,279) = 8.08, p < 0.001). A priori linear contrasts suggesting intermediate dysfunction in BD patients were significant (p < 0.001), although post-hoc tests showed the BD group was only significantly different from HC on d-prime context. Group results for d-prime context remained significant after covarying for lapsing rate. Primary behavioral measures were associated with mania and disorganization symptoms as well as everyday functioning. These findings suggest a continuum of dysfunction in cognitive control (particularly d-prime context) across diagnostic categories in psychiatric illness. These results further suggest that lapsing and d-prime context, while related, make unique contributions towards explaining deficits in cognitive control in these disorders.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066446922

Download citation: RISBibTeXText

PMID: 30704863

DOI: 10.1016/j.schres.2019.01.018


Related references

Polygenic Burden Analysis of Longitudinal Clusters of Psychopathological Features In A Cross-Diagnostic Group of Individuals with Severe Mental Illness. European Neuropsychopharmacology 27: S401-S402, 2017

Polygenic Burden Analysis Of Longitudinal Clusters Of Psychopathological Features In A Cross-Diagnostic Group Of Individuals With Severe Mental Illness. European Neuropsychopharmacology 29: S995-S996, 2019

Mental illness: diagnostic title or derogatory term? (Attitudes towards mental illness) Developing a learning resource for use within a clinical call centre. A systematic literature review on attitudes towards mental illness. Journal of Psychiatric and Mental Health Nursing 15(8): 684-693, 2008

Common sense model of mental illness: Understanding the impact of cognitive and emotional representations of mental illness on recovery through the mediation of self-stigma. Psychiatry Research 246: 16-24, 2016

Transdiagnostic impairment of cognitive control in mental illness. Journal of Psychiatric Research 83: 37-46, 2016

Does improvement of cognitive functioning by cognitive remediation therapy effect work outcomes in severe mental illness? A secondary analysis of a randomized controlled trial. Psychiatry and Clinical Neurosciences 71(5): 301-308, 2017

The Effect of Mental Fatigue on Cognitive and Aerobic Performance in Adolescent Active Endurance Athletes: Insights from a Randomized Counterbalanced, Cross-Over Trial. Journal of Clinical Medicine 7(12):, 2018

Molecular neurobiology of mental illness A European consortium. American Journal of Human Genetics 59(4 Suppl. ): A227, 1996

A confirmatory factor analysis of the MATRICS consensus cognitive battery in severe mental illness. Schizophrenia Research 175(1-3): 79-84, 2016

Previous Mental Illness Diagnoses Predict Perceptions of Current Mental Illness: A Cultural and Gender Differences Analysis of the United States and India. International Journal of Mental Health 43(4): 61-75, 2014

Cross-National Analysis of Beliefs and Attitude Toward Mental Illness Among Medical Professionals From Five Countries. Psychiatric Quarterly 87(1): 63-73, 2016

Comorbidity of mental illness and chronic physical illness: A diagnostic and treatment conundrum. Perspectives in Psychiatric Care 54(3): 339-340, 2018

Cognitive therapy and serious mental illness. An interacting cognitive subsystems approach. Clinical Psychology & PsychoTherapy 6(5): 375-383, 1999

Investigation of the Montreal Cognitive Assessment (MoCA) as a cognitive screener in severe mental illness. Psychiatry Research 220(1-2): 664-668, 2014

Invoking and inscribing mental illness: A discursive analysis of diagnostic terminology in inpatient treatment planning meetings. Feminism & Psychology 23(1): 107-118, 2013