+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Tissue-sparing properties of Mohs micrographic surgery for infiltrative basal cell carcinoma



Tissue-sparing properties of Mohs micrographic surgery for infiltrative basal cell carcinoma



Journal of the American Academy of Dermatology 80(6): 1700-1703



Mohs micrographic surgery (MMS) should lead to tissue sparing of healthy skin compared with standard surgical excision because smaller surgical margins are used. To quantify the tissue-sparing properties of MMS in primary basal cell carcinoma (BCC) with an infiltrative growth pattern. A prospective study including 256 primary BCCs with an infiltrative growth pattern was performed. Tumor sizes were measured in 2 perpendicular directions. Surface defect areas after MMS were measured. The suspected defect surface area with standard excision using a 5-mm margin was calculated. The primary outcome of this study was the size of the defect surface area spared with MMS compared with the calculated defect surface area with a standard excision. The median tumor size was 71 mm2, and the median defect size after MMS was 154 mm2. The median defect size calculated for standard surgical excision was 298 mm2. We have shown that MMS of BCC with an infiltrative growth pattern had a 46.4% tissue-sparing effect when compared with standard surgical excision (95% confidence interval, 43.4%-49.1%; P value < .001). Single-center study design. Lack of a randomized control group for ethical reasons. A rate of tissue sparing of 46% can be reached by using MMS for primary BCC with an infiltrative growth pattern.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066451915

Download citation: RISBibTeXText

PMID: 30710602

DOI: 10.1016/j.jaad.2019.01.057


Related references

Randomized comparison of Mohs micrographic surgery and surgical excision for small nodular basal cell carcinoma: tissue-sparing outcome. Dermatologic Surgery 35(9): 1349-1354, 2009

Photodynamic Therapy Followed by Mohs Micrographic Surgery Compared to Mohs Micrographic Surgery Alone for the Treatment of Basal Cell Carcinoma: Results of a Pilot Single-Blinded Randomised Controlled Trial. Journal of Cutaneous and Aesthetic Surgery 8(2): 88-91, 2015

Management of periocular basal cell carcinoma Mohs micrographic surgery versus radiotherapy I Mohs micrographic surgery. Survey of Ophthalmology 38(2): 193-203, 1993

Basal cell carcinoma in a patient with acquired immunodeficiency syndrome: treatment with Mohs micrographic surgery fixed-tissue technique. Journal of Dermatologic Surgery and Oncology 15(5): 545-551, 1989

Article: Basal Cell Carcinoma in a Patient with Acquired Immunodeficiency Syndrome: Treatment with Mohs Micrographic Surgery Fixed-Tissue Technique. The Journal of Dermatologic Surgery and Oncology 15(5): 545-551, 1989

Mohs' micrographic surgery for basal cell carcinoma. Clinical and Experimental Dermatology 24(2): 130-133, 1999

Mohs' micrographic surgery for basal-cell carcinoma of the face. Lancet 365(9466): 1227-1228, 2005

Mohs micrographic surgery for the basal cell carcinoma treatment. Virchows Archiv 439(3): 367, 2001

Mohs micrographic surgery for basal cell carcinoma of the scrotum. International Journal of Dermatology 57(6): 750-752, 2018

Mohs micrographic surgery for Basal cell carcinoma of the face. Archives of Dermatology 145(12): 1428-1430, 2009

Is curettage really necessary for basal cell carcinoma before Mohs micrographic surgery?. Dermatologic Surgery 30(5): 820; Author Reply 821-2, 2004

Mohs micrographic surgery for the treatment of basal cell carcinoma. Actas Dermo-Sifiliograficas 101(10): 853-857, 2010

An overview of Mohs micrographic surgery for the treatment of basal cell carcinoma. Dermatologic Clinics 29(2): 153, 2011

Management of periocular basal cell carcinoma by Mohs micrographic surgery. Journal of Dermatological Treatment 24(3): 232-234, 2013

Basal cell carcinoma of the vulva: treatment with Mohs micrographic surgery. Clinical and Experimental Dermatology 44(6): 651-653, 2019