+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Stereotactic radiosurgery for the treatment of brain metastasis from gastrointestinal primary cancers



Stereotactic radiosurgery for the treatment of brain metastasis from gastrointestinal primary cancers



Journal of Radiosurgery and Sbrt 6(1): 27-34



We aimed to determine the efficacy of gamma knife stereotactic radiosurgery (SRS) to control brain metastases (BM) from GI primaries and report on the patient outcomes. We retrospectively evaluated patients who had undergone SRS at our institution for the treatment BM from GI primaries from 2000 to 2016. Actuarial rates for overall survival (OS) and local control (LC) were calculated. Survival rates were computed via the Kaplan-Meier method from the day of SRS. Multivariate analysis (MVA) using proportional hazards regression was done to determine prognostic factors for OS and LC. 53 patients with a total of 148 BM were treated with SRS. The median age at SRS was 60 years and the median treatment dose was 18 Gy. SRS was given as an adjuvant treatment to 30.4% of lesions. Twelve patients underwent second course of SRS for new/recurrent lesions at a median of 8 months from the first SRS (range 2-25.5). Twelve patients (22.6%) received salvage whole brain radiation. The median follow up time from the diagnosis of BM was 6 months. Local control rate at 6 months was 74.33% and 57.21% at 12 months. The OS at 1 year was 34% and 8% at 3 years. On MVA, higher GK dose was associated with better LC, and and >10 BM trended towards higher risk of local recurrence (LR). None of the tested factors proved to be significant for OS on MVA. No radiographic radionecrosis was observed on follow up MRI. SRS is a safe treatment modality for the management of CNS metastases from GI primary. Consideration for dose-escalated approaches may improve LC rates.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 066505196

Download citation: RISBibTeXText

PMID: 30775072


Related references

Stereotactic radiosurgery in the management of brain metastases from primary thyroid cancers. Journal of Neuro-Oncology 98(2): 249-252, 2010

Prognostic Importance of Cumulative Intracranial Tumor Volume in Patients with Gastrointestinal Brain Metastasis Treated with Stereotactic Radiosurgery. World Neurosurgery 2018, 2018

Fighting Cancer on All Fronts: Stereotactic Radiosurgery and the Role for Aggressive Primary Treatment in Non-Small Cell Lung Cancer Patients with One Brain Metastasis. World Neurosurgery 83(6): 1015-1016, 2015

Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases: A Randomized Controlled Trial. Yearbook of Oncology 2007: 204-205, 2007

Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 295(21): 2483-2491, 2006

Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone. International Journal of Radiation Oncology, Biology, Physics 68(5): 1388-1395, 2007

Outcomes Following Stereotactic Radiosurgery for the Treatment of Sarcomatous Brain Metastasis. International Journal of Radiation Oncology*biology*physics 96(2): E709-E710, 2016

Stereotactic radiosurgery in the treatment of brain metastases from gastrointestinal primaries. Journal of Neuro-Oncology 124(3): 439-446, 2016

Stereotactic Radiosurgery: Treatment of Brain Metastasis Without Interruption of Systemic Therapy. International Journal of Radiation Oncology, Biology, Physics 95(2): 735-742, 2017

P13.24 * A Comparison Of Two Stereotactic Radiosurgery Delivery Techniques In The Treatment Of Brain Metastasis. Neuro-Oncology 16(Suppl 2): ii71, 2014

Comparison of Fractionated Stereotactic Radiosurgery and Single-Fraction Stereotactic Radiosurgery for the Treatment of Brain Metastases. International Journal of Radiation Oncology*biology*physics 90(1): S319-S320, 2014

Tumor bed radiosurgery following resection and prior stereotactic radiosurgery for locally persistent brain metastasis. Frontiers in Oncology 5: 84, 2015

Image-guided positioning in intracranial non-invasive stereotactic radiosurgery for the treatment of brain metastasis. Tumori 98(5): 630-635, 2013

Cumulative Intracranial Tumor Volume and Number of Brain Metastasis as Predictors of Developing New Lesions After Stereotactic Radiosurgery for Brain Metastasis. World Neurosurgery 106: 666-675, 2017

SU-E-T-645: Treatment of Multiple Brain Metastases Using Stereotactic Radiosurgery with Single-Isocenter Volumetric Modulated Arc Therapy: Comparison with Conventional Dynamic Conformal Arc and Static Beam Stereotactic Radiosurgery. Medical Physics 39(6part20): 3854, 2012