+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients



A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients



Hemodialysis International. International Symposium on Home Hemodialysis 2019



Among the most important risk factors for cardiovascular disease in hemodialysis patients are high concentrations of serum inflammation markers, lipid profiles, and oxidative stress. The present study aimed to investigate the effects of a synbiotic supplement on serum systemic inflammation, oxidative stress markers, and lipid profile in hemodialysis patients. Fifty hemodialysis patients were randomly allocated to synbiotic and placebo groups. The synbiotic group received 2 tablets per day of a synbiotic supplement (100 mg) Lactobacillus coagulans and fructo-oligosaccharides for 8 weeks; whereas the placebo group received a similar appearing placebo. At the beginning and end of the study, 5 mL blood was taken after 12-14 hours of fasting. Mean values of serum C-reactive protein (hs-CRP) and malondialdehyde (MDA) significantly decreased in the synbiotic group at the end compared to the beginning of the study (P = 0.01). This reduction was significant in comparison with changes in the placebo group (P = 0.01). The synbiotic supplement also reduced serum total cholesterol (P = 0.001) and low-density lipoprotein cholesterol (LDL-c; P = 0.001) compared to the placebo group. The synbiotic supplement used improves serum hs-CRP and MDA, total cholesterol and LDL-c in hemodialysis patients, which are known risk factors for cardiovascular disease.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066546186

Download citation: RISBibTeXText

PMID: 30821897

DOI: 10.1111/hdi.12748


Related references

Effects of alpha-lipoic acid supplementation on inflammation, oxidative stress, and serum lipid profile levels in patients with end-stage renal disease on hemodialysis. Journal of Renal Nutrition 22(2): 244-250, 2012

Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities. Hemodialysis International. International Symposium on Home Hemodialysis 17(2): 275-281, 2014

The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research 142: 303-313, 2019

Oxidative stress and inflammation in hemodialysis patients. American Journal of Kidney Diseases 38(6): 1408-1413, 2001

Omega-3 Fatty Acid Supplementation is Associated With Oxidative Stress and Dyslipidemia, but Does not Contribute to Better Lipid and Oxidative Status on Hemodialysis Patients. Journal of Renal Nutrition 27(5): 333-339, 2017

Effects of omega-3 fatty acid plus alpha-tocopherol supplementation on malnutrition-inflammation score, biomarkers of inflammation and oxidative stress in chronic hemodialysis patients. International Urology and Nephrology 48(11): 1887-1895, 2016

The association of oxidative stress and inflammation in hemodialysis patients. American Journal of Kidney Diseases 43(1): 192, 2004

Effects of synbiotic on anthropometry, lipid profile and oxidative stress in obese children. Beneficial Microbes 6(6): 775-782, 2016

The prognostic value of oxidative stress and inflammation in Chinese hemodialysis patients. Renal Failure 39(1): 54-58, 2016

Paricalcitol reduces oxidative stress and inflammation in hemodialysis patients. Bmc Nephrology 13: 159, 2013

Hypoalbuminemia, inflammation and oxidative stress are linked in hemodialysis patients. Journal of the American Society of Nephrology 13(Program and Abstracts Issue): 214A-215A, 2002

Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2. Journal of Nephrology 28(4): 495-501, 2016

Sleep apnea syndrome, inflammation and oxidative stress in hemodialysis patients. Hemodialysis International. International Symposium on Home Hemodialysis 22(2): 209-216, 2017

Abnormal lipid metabolism and oxidative stress in hemodialysis patients. Journal of Artificial Organs 4(1): 19-22, 2001

Reactive oxygen metabolites: a link between oxidative stress and inflammation in patients on hemodialysis. Blood Purification 25(2): 175-178, 2007