+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Impaired Spatial Hearing in Amblyopia: Evidence for Calibration of Auditory Maps by Retinocollicular Input in Humans



Impaired Spatial Hearing in Amblyopia: Evidence for Calibration of Auditory Maps by Retinocollicular Input in Humans



Investigative Ophthalmology and Visual Science 60(4): 944-953



Evidence from animals and blind humans suggests that early visual experience influences the developmental calibration of auditory localization. Hypothesizing that unilateral amblyopia may involve cross-modal deficits in spatial hearing, we measured the precision and accuracy of sound localization in humans with amblyopia. All participants passed a standard hearing test. Experiment 1 measured sound localization precision for click stimuli in 10 adults with amblyopia and 10 controls using a minimum audible angle (MAA) task. Experiment 2 measured sound localization error (i.e., accuracy) for click train stimuli in 14 adults with amblyopia and 16 controls using an absolute sound localization task. In Experiment 1, the MAA (mean ± SEM) was significantly greater in the amblyopia group compared with controls (2.75 ± 0.30° vs. 1.69 ± 0.09°, P = 0.006). In Experiment 2, the overall sound localization error was significantly greater in the amblyopia group compared with controls (P = 0.047). The amblyopia group also showed significantly greater sound localization error in the auditory hemispace ipsilateral to the amblyopic eye (P = 0.036). At a location within this auditory hemispace, the magnitude of sound localization error correlated significantly with deficits in stereo acuity (P = 0.036). The precision and accuracy of sound localization are impaired in unilateral amblyopia. The asymmetric pattern of sound localization error suggests that amblyopic vision may interfere with the development of spatial hearing via the retinocollicular pathway.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066570133

Download citation: RISBibTeXText

PMID: 30849170

DOI: 10.1167/iovs.18-24908


Related references

Auditory localization, detection of spatial separateness, and speech hearing in noise by hearing impaired listeners. Journal of the Acoustical Society of America 102(4): 2343-2352, 1998

Auditory Spatial Discrimination and the Mismatch Negativity Response in Hearing-Impaired Individuals. Plos One 10(8): E0136299, 2016

Auditory and auditory-visual intelligibility of speech in fluctuating maskers for normal-hearing and hearing-impaired listeners. Journal of the Acoustical Society of America 125(5): 3358-3372, 2009

A comparison of auditory perception in hearing-impaired and normal-hearing listeners: an auditory scene analysis study. Iranian Red Crescent Medical Journal 15(11): E9477, 2014

Evidence against integration of spatial maps in humans. Animal Cognition 9(3): 207-217, 2006

Can basic auditory and cognitive measures predict hearing-impaired listeners' localization and spatial speech recognition abilities?. Journal of the Acoustical Society of America 130(3): 1542-1558, 2012

The auditory acclimatization effect in sensorineural hearing-impaired listeners: evidence for functional plasticity. Hearing Research 205(1-2): 131-142, 2005

Neuropsychological evidence of the functional integration of visual, auditory and proprioceptive spatial maps. Neuroreport 9(6): 1195-1200, 1998

Hearing training, hearing therapy and auditory rehabilitation in hearing impaired individuals during the last few centuries. Hno 60(10): 913-918, 2013

Evidence against integration of spatial maps in humans: generality across real and virtual environments. Animal Cognition 12(2): 237-247, 2008

Electrophysiological and Behavioral Evidence of Reduced Binaural Temporal Processing in the Aging and Hearing Impaired Human Auditory System. Trends in Hearing 22: 2331216518785733, 2018

Sources of variability of speech, spatial, and qualities of hearing scale (SSQ) scores in normal-hearing and hearing-impaired populations. International Journal of Audiology 55(2): 101-109, 2016

Hearing disability measured by the speech, spatial, and qualities of hearing scale in clinically normal-hearing and hearing-impaired middle-aged persons, and disability screening by means of a reduced SSQ (the SSQ5). Ear and Hearing 33(5): 615-616, 2013

Distortion product otoacoustic emission input/output functions in normal-hearing and hearing-impaired human ears. Journal of the Acoustical Society of America 110(6): 3119-3131, 2001

Distortion-product otoacoustic emission input/output characteristics in normal-hearing and hearing-impaired human ears. Journal of the Acoustical Society of America 126(2): 728-738, 2009