+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Exploitation of enrofloxacin-loaded docosanoic acid solid lipid nanoparticle suspension as oral and intramuscular sustained release formulations for pig



Exploitation of enrofloxacin-loaded docosanoic acid solid lipid nanoparticle suspension as oral and intramuscular sustained release formulations for pig



Drug Delivery 26(1): 273-280



In our previous study, enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) could be effectively delivered to cells in vitro. In this study, its properties and exploitation as possible oral and intramuscular sustained release formulations for pigs were studied after being made into suspension. The re-dispersed time and sedimentation rate of the nanosuspension were 55 s and 1, respectively. It showed good stability when stored away from light and sustained release in pH = 7.4 PBS buffer. The suspension exhibited no irritation at the injection site and good palatability. Compared with commercial injection and soluble powder, the nanosuspension increased the bioavailability of enrofloxacin by 1.63 and 2.38 folds, and extended the mean residence time (MRT) of the drug from 11.27 and 12.33 to 37.76 and 35.15 h after intragastric and intramuscular administration, respectively. These results suggest that docosanoic acid SLN suspension (DAS) might be a promising oral and intramuscular sustained release formulation to enhance the pharmacological activity of enrofloxacin.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066597842

Download citation: RISBibTeXText

PMID: 30880494

DOI: 10.1080/10717544.2019.1580798


Related references

Sunblocking efficiency of various TiO(2)-loaded solid lipid nanoparticle formulations(1). International Journal of Cosmetic Science 28(5): 371-378, 2008

Sucrose ester stabilized solid lipid nanoparticles and nanostructured lipid carriers. II. Evaluation of the imidazole antifungal drug-loaded nanoparticle dispersions and their gel formulations. Nanotechnology 25(10): 105102, 2014

Preparation, characterisation and antibacterial activity of a florfenicol-loaded solid lipid nanoparticle suspension. Iet Nanobiotechnology 9(6): 355-361, 2016

Methotrexate-loaded porous polymeric adsorbents as oral sustained release formulations. Materials Science and Engineering. C, Materials for Biological Applications 78: 598-602, 2018

Antihyperglycemic activities of extracts of the mistletoes Plicosepalus acaciae and P. curviflorus in comparison to their solid lipid nanoparticle suspension formulations. Zeitschrift für Naturforschung. C, Journal of Biosciences 69(9-10): 391-398, 2015

Formulation of novel sustained release rifampicin-loaded solid lipid microparticles based on structured lipid matrices from Moringa oleifera. Pharmaceutical Development and Technology 20(5): 546-554, 2016

Sustained release Curcumin loaded Solid Lipid Nanoparticles. Advanced Pharmaceutical Bulletin 6(1): 17-21, 2016

Chlorambucil loaded in mesoporous polymeric microspheres as oral sustained release formulations with enhanced hydrolytic stability. Materials Science and Engineering. C, Materials for Biological Applications 91: 564-569, 2018

Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. Aaps Pharmscitech 12(1): 62-76, 2011

Sustained release of liposome-encapsulated enrofloxacin after intramuscular administration in rabbits. American Journal of Veterinary Research 56(11): 1498-1501, 1995

Sustained release of piroxicam from solid lipid nanoparticle as an effective anti-inflammatory therapeutics in vivo. Drug Development and Industrial Pharmacy 43(1): 55-66, 2016

Sustained release ivermectin-loaded solid lipid dispersion for subcutaneous delivery: in vitro and in vivo evaluation. Drug Delivery 24(1): 622-631, 2017

Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases. International Journal of Nanomedicine 13: 1569-1583, 2018

Formulation development and evaluation of the anti-malaria properties of sustained release artesunate-loaded solid lipid microparticles based on phytolipids. Drug Delivery 22(5): 652-665, 2016

Single and multiple dose pharmacokinetic studies of oral sustained release and non-sustained release formulations of isosorbide-5-mononitrate in healthy volunteers. Arzneimittel-Forschung 48(6): 641-645, 1998