+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis



Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis



Biomed Research International 2019: 1463896



Human papillomavirus (HPV) causes juvenile-onset recurrent respiratory papillomatosis (JORRP). Although HPV is common in children, the prevalence of JORRP is low. It is likely that other factors contribute to the pathogenesis of JORRP, during either activation or reactivation of a latent HPV infection. There is evidence that laryngopharyngeal reflux (LPR) might be such a risk factor for adult-onset recurrent respiratory papillomatosis. This study investigated if LPR might also be a risk factor for JORRP. Children with JORRP of the larynx that required microlaryngoscopy at a tertiary referral hospital were included in this prospective case-series study from November 2015 to November 2017. Using immunohistochemistry, HPV infection and pepsin associated with LPR were diagnosed from laryngeal biopsies. Eleven children (aged 4-14 years) were analyzed. No patient had a history of immunodeficiency or tobacco smoke exposure. All patients underwent at least three previous surgeries due to JORRP and had been vaccinated against HPV in the past. Five children were treated using antivirotics and immunomodulators. The only known maternal risk factor was that three mothers were primiparous. All 11 samples were infected with HPV (type 6 or 11). Pathologic LPR was diagnosed in 5/11 children (45.5%). LPR may be a risk factor for JORRP, contributing to its development by activating or reactivating a latent HPV infection. Results are in accordance with those from our previous study in adults.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066599236

Download citation: RISBibTeXText

PMID: 30881982

DOI: 10.1155/2019/1463896


Related references

Laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis (prospective case-control study). Clinical Otolaryngology 42(3): 597-601, 2017

A comparison of risk factors in juvenile-onset and adult-onset recurrent respiratory papillomatosis. Laryngoscope 102(1): 9, 1992

Risk factors for juvenile onset recurrent respiratory papillomatosis. Pediatric Infectious Disease Journal 17(5): 372-376, 1998

Risk factors of juvenile onset recurrent respiratory papillomatosis in the lower respiratory tract. Chinese Medical Journal 125(19): 3496-3499, 2012

Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy. European Annals of Otorhinolaryngology Head and Neck Diseases 136(1): 25-28, 2019

Risk factors for the development and severity of juvenile-onset recurrent respiratory papillomatosis: a systematic review. International Journal of Pediatric Otorhinolaryngology 78(2): 186-197, 2014

Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis. Histopathology 57(5): 768-770, 2010

Two cases of juvenile-onset and adult-onset recurrent respiratory papillomatosis. Nihon Kokyuki Gakkai Zasshi 49(9): 667-673, 2011

Recurrent Respiratory Papillomatosis (RRP)-Juvenile Onset. Clinical Medicine. Oncology 2: 481-486, 2008

Juvenile-onset recurrent respiratory papillomatosis. Advances in Oto-Rhino-Laryngology 73: 105-108, 2012

Juvenile-Onset Recurrent Respiratory Papillomatosis. Pediatric Asthma Allergy & Immunology 15(1): 59-62, 2001

The cost of juvenile-onset recurrent respiratory papillomatosis. Archives of Otolaryngology--Head and Neck Surgery 126(8): 935-939, 2000

Clinical study of juvenile-onset recurrent respiratory papillomatosis. Zhonghua Er Bi Yan Hou Ke Za Zhi 36(6): 458-462, 2001

National registry for juvenile-onset recurrent respiratory papillomatosis. Archives of Otolaryngology--Head and Neck Surgery 129(9): 976-982, 2003

Operative management of juvenile-onset recurrent respiratory papillomatosis. Operative Techniques in Otolaryngology-Head and Neck Surgery 23(2), 2012