+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Role of catecholamines in the pathogenesis of diabetic cardiomyopathy



Role of catecholamines in the pathogenesis of diabetic cardiomyopathy



Canadian Journal of Physiology and Pharmacology 2019



Although the sympathetic nervous system (SNS) plays an important role in the regulation of cardiac function, the over-activation of the SNS under stressful conditions including diabetes has been shown to result in the excessive production of circulating catecholamines as well as increase in the myocardial concentration of catecholamines. In this brief review, we provide of some evidence to suggest that the oxidation products of catecholamines such as aminochrome and oxyradicals, lead to metabolic derangements, Ca2+- handling abnormalities, increase in the availability of intracellular free Ca2+ as well as activation of proteases and changes in myocardial gene expression. These alterations due to elevated levels of circulatory catecholamines are associated with oxidative stress, subcellular remodeling and the development of cardiac dysfunction in chronic diabetes.

(PDF emailed within 0-6 h: $19.90)

Accession: 066627010

Download citation: RISBibTeXText

PMID: 30913398

DOI: 10.1139/cjpp-2019-0044


Related references

The permissive role of catecholamines in the pathogenesis of hamster cardiomyopathy. Advances in Myocardiology 4: 45-53, 1983

Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Biochemical Pharmacology 83(5): 653-660, 2012

Role of microRNAs in the pathogenesis of diabetic cardiomyopathy. Biomedical Reports 6(2): 140-145, 2017

The role of cardiac lipotoxicity in the pathogenesis of diabetic cardiomyopathy. Expert Review of Cardiovascular Therapy 12(3): 345-358, 2014

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy. Cardiovascular Diabetology 15: 44, 2016

A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy. Circulation 106(19 Supplement): II-206, November 5, 2002

Role of tissue transglutaminase in the pathogenesis of diabetic cardiomyopathy and the intervention effect of rutin. Experimental and Therapeutic Medicine 9(4): 1103-1108, 2015

A critical role for PPARa-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content. Proceedings of the National Academy of Sciences of the United States of America 100(3): 26-31, 2003

A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proceedings of the National Academy of Sciences of the United States of America 100(3): 1226-1231, 2003

Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria. Molecular and Cellular Biochemistry 386(1-2): 233-249, 2014

A case of transient left ventricular ballooning with pheochromocytoma, supporting pathogenetic role of catecholamines in stress-induced cardiomyopathy or takotsubo cardiomyopathy. International Journal of Cardiology 114(1): E15-E17, 2006

Catecholamines and cardiomyopathy: The pathogenesis and potential importance of myofibrillar degeneration. Human Pathology 1(1): 125-150, 1970

Mechanisms in the pathogenesis of diabetic cardiomyopathy. Current Opinion in Endocrinology & Diabetes 10(4): 251-255, 2003

Different gene expression in human heart tissue and progenitor cells from control and diabetic subjects: relevance to the pathogenesis of human diabetic cardiomyopathy. Surgical Technology International 19: 165-174, 2012

Hyperglycemia A key factor in the pathogenesis of diabetic cardiomyopathy. Circulation 94(8 SUPPL ): I593, 1996