+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Making the Most of Innovation in Personalised Medicine: An EU Strategy for a Faster Bench to Bedside and Beyond Process

Making the Most of Innovation in Personalised Medicine: An EU Strategy for a Faster Bench to Bedside and Beyond Process

Public Health Genomics 21(3-4): 101-120

ISSN/ISBN: 1662-4246

PMID: 30947224

DOI: 10.1159/000497809

Personalised medicine promises to revolutionise healthcare, with its key goal of providing the right treatment to the right patient at the right time, and thus the potential of improving quality of life and helping to bring down healthcare costs. However, a major problem with broader implementation of personalised medicine is patient access to new drugs, devices and treatments. The fact that a new medicine or innovative product can sometimes take as long as 20 years to get from bench to bedside is not only clearly undesirable but is arguably unacceptable in the 21st century. This paper looks in detail at the issues surrounding development, continued investment, risk factors, testing and approval from both the industry perspective as well as that of the assessor and the decision maker/payer. It becomes clear that there is a lack of working in tandem that results in a double time frame (two times 10 years). This is simply because the key stakeholders, surprisingly, do not synergise their assessments of a new product. As well as causing delays in patient access, this can also affect investment confidence as industry waits too long for approval for its product to reach the market and its subsequent implementation into healthcare. Such a slow process undermines continued investment and contributes to a risk-averse environment, which in turn can have an impact on innovation. The solution appears to be uncomplicated, involving better coordination and collaboration between the different stakeholders working at various stages within the bench-to-bedside timeframe. We take the example of the network of the European Alliance for Personalised Medicine (EAPM) to demonstrate possible solutions using an innovative approach.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 066657139

Download citation: RISBibTeXText

Related references

Moving the genetics of inflammatory bowel diseases from bench to bedside: first steps towards personalised medicine. Gut 62(11): 1531-1533, 2013

Bench-to-Bedside and Bedside Back to the Bench; Seeking a Better Understanding of the Acute Pathophysiological Process in Severe Traumatic Brain Injury. Frontiers in Neurology 6: 47, 2015

Clopidogrel response variability and the advent of personalised antiplatelet therapy. A bench to bedside journey. Thrombosis and Haemostasis 106(2): 265-271, 2011

Health Informaticians Drive Innovation from Bench to Bedside. Biomedical Instrumentation and Technology 50(5): 371-375, 2016

From bedside to bench and back again: technology innovation in plastic surgery. Plastic and reconstructive surgery 124(4): 1355-1356, 2009

Bench-to-bedside and bedside back to the bench; coordinating clinical and experimental traumatic brain injury studies. Frontiers in Neurology 3: 3, 2012

Tissue banking for research--bench to bedside and back--myth, reality or fast fading reality at the dawn of a personalised healthcare era. Cell and Tissue Banking 12(1): 19-21, 2011

Innovation and Integration in Curriculum Reform: Lessons From Bench to Bedside and Beyond at the Uniformed Services University. Military Medicine 182(5): 1587-1589, 2017

Bench-to-Bedside; Clinical and Translational Research; Personalized Medicine; Precision Medicine-What's in a Name?. Clinical and Translational Science 8(3): 171-173, 2015

The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside. Journal of Biomedical Semantics 2 Suppl. 2: S1, 2011

The Three-Way Pendulum of Healthcare Innovation. Biomedicine Hub 2(Suppl. 1): 22-25, 2017

Pharmaceutical innovation: possibilities and limits of personalised medicine. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 51(6): 675-688, 2008

Innovation meets quality: moving cellular therapies at the National Institutes for Health from bench to bedside. CytoTherapy 6(6): 626-628, 2004

Translational research in women's health: from bedside to bench and from bench to bedside. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics 109(2): 83-84, 2010

Innovation in the imaging perianal fistula: a step towards personalised medicine. Therapeutic Advances in Gastroenterology 11: 1756284818775060, 2018