+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Relationship between Thrombotic Events and Peripheral Neutrophil-to-lymphocyte Ratio in Patients with Newly Diagnosed Essential Thrombocythemia



Relationship between Thrombotic Events and Peripheral Neutrophil-to-lymphocyte Ratio in Patients with Newly Diagnosed Essential Thrombocythemia



Zhongguo Shi Yan Xue Ye Xue Za Zhi 27(2): 534-538



To explore the role of neutrophil-to-lymphocyte ratio(NLR) in patients with newly diagnosed essential thrombocythemia(ET) and its relationship with thrombotic events. The clinical and follow-up data of 150 ET patients were retrospectively analyzed. The risk factors of thrombotic events and role of NLR by statistical methods. Age (P<0.01) and JAK2V617F mutation (P<0.01) were the independent risk factors for thrombotic events at diagnosis; WBC count (P<0.05), NLR (P<0.01), age (P<0.05) and thrombosis history at diagnosis (P<0.05) were independent risk factors for future thrombotic events. The ROC curve showed that NLR for prediction of future thrombotic events was suprior to other risk factors. The Kaplan-Meier analysis showed that the progress-free survival time in thrombotic events patients with higher NLR (median survival 22.3 months, 95% CI:17.8-26.8) was significantly shorter than that of patients with lower NLR (median survival 55.5 months, 95% CI:53.4-57.5) . After follow-up 60 months, the thrombosis progress-free survival in lower NLR patients reached 97.4%, while that in the patients with higher NLR was rate 46.7%. NLR at diagnosis is a better predictive parameter for future thrombotic events than other clinical parameters in ET patients, but without corralations with thrombosis at diagnosis. 原发性血小板增多症患者初诊初治时外周血粒淋比与血栓事件关系研究. 探讨初诊初治时中性粒细胞/淋巴细胞比值(NLR)对原发性血小板增多症(ET)患者血栓事件发生和进展的影响及临床意义。. 回顾性分析150例原发性血小板增多症患者临床和随访资料,用统计学方法分析血栓事件的危险因素。. 年龄(P=0.001) 和JAK2V617F突变(P=0.003)是诊断时血栓事件独立危险因素;年龄(P=0.037)、NLR(P<0.001)、WBC计数(P=0.047)及初诊时血栓病史(P=0.036)是随访过程中未来血栓事件进展的独立危险因素;ROC曲线表明,NLR对于血栓事件进展诊断效能要明显高于年龄、WBC计数以及初诊时血栓病史。Kaplan-Meier生存分析表明,高NLR组血栓事件无进展生存时间(中位生存时间22.3个月, 95% CI: 17.8-26.8) 明显低于低NLR组(中位生存时间55.5个月, 95% CI: 53.4-57.5)。低NLR组60个月血栓事件无进展生存率为97.4%,而高NLR组60个月血栓事件无进展生存率为46.7%。. ET患者初诊初治时外周血NLR水平较传统临床指标对未来血栓事件进展具有更好的诊断预测价值,但与诊断时已经发生的血栓事件没有明显相关性。.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 066702653

Download citation: RISBibTeXText

PMID: 30998166


Related references

Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension. Journal of International Medical Research 46(3): 940-950, 2018

Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. Bmc Endocrine Disorders 15: 9, 2015

Comparative effects of nebivolol and metoprolol on red cell distribution width and neutrophil/lymphocyte ratio in patients with newly diagnosed essential hypertension. Journal of Cardiovascular Pharmacology 62(4): 388-393, 2014

The relationship between neutrophil lymphocyte ratio with urinary protein and albumin excretion in newly diagnosed patients with type 2 diabetes. American Journal of the Medical Sciences 347(3): 217-220, 2014

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio before chemotherapy as potential prognostic factors in patients with newly diagnosed epithelial ovarian cancer. Esmo Open 1(2): E000039, 2016

Prognostic meaning of neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ration (LMR) in newly diagnosed Hodgkin lymphoma patients treated upfront with a PET-2 based strategy. Annals of Hematology 97(6): 1009-1018, 2018

The relationship of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in peripheral blood with ST-segment resolution and the clinical outcomes of STEMI patients receiving thrombolytic therapy. Romanian Journal of Internal Medicine 2018, 2018

Evaluation of the neutrophil-lymphocyte ratio in newly diagnosed nondiabetic hypertensive patients with ascending aortic dilatation. Blood Pressure Monitoring 21(4): 238-243, 2017

Association of neutrophil-lymphocyte ratio with impaired aortic elasticity in newly diagnosed and never-treated hypertensive patients. Blood Pressure Monitoring 20(3): 127-131, 2016

Neutrophil to lymphocyte ratio (NLR) improves the risk assessment of ISS staging in newly diagnosed MM patients treated upfront with novel agents. Annals of Hematology 94(11): 1875-1883, 2015

Evaluation of neutrophil-to-lymphocyte ratio in newly diagnosed patients receiving borte- zomib-based therapy for multiple myeloma. Cancer Biomarkers 22(1): 43-48, 2018

Prognostic value of baseline absolute lymphocyte concentration and neutrophil/lymphocyte ratio in dogs with newly diagnosed multi-centric lymphoma. Veterinary and Comparative Oncology 13(4): 337-347, 2016

The significance of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and lymphocyte-monocyte ratio in predicting peripheral arterial disease, peripheral neuropathy, osteomyelitis and amputation in diabetic foot infection. Diabetes Research and Clinical Practice 144: 118-125, 2018

The relationship between neutrophil-to-lymphocyte ratio and major cardiovascular events in elderly patients with chronic heart failure. Journal of Geriatric Cardiology 14(12): 780, 2018

Pre-treatment neutrophil-to-lymphocyte ratio predicts tumor pathology in newly diagnosed renal tumors. World Journal of Urology 34(12): 1693-1699, 2016