+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Predictors of fragility fracture and low bone mineral density in patients with a history of parental fracture

Predictors of fragility fracture and low bone mineral density in patients with a history of parental fracture

Osteoporosis and Sarcopenia 5(1): 6-10

Bone mineral density (BMD) and fragility fracture (FF) have high heritability, but few data exist on impact of other factors on families with fracture history. We aimed to evaluate predictors of FF and low BMD, in patients with family history of FF. This was a retrospective study on patients undergoing dual energy X-ray absorptiometry at a district general hospital (DGH), 2004-2016. Parameters recorded (in addition to standard dual energy X-ray absorptiometry parameters): age, smoking, alcohol, corticosteroids, aromatase inhibitors, Depo-Provera, hormone replacement therapy, rheumatoid arthritis, polymyalgia rheumatica, breast or prostate cancer, coeliac disease, and fracture site. Logistic regression was used to model fracture risk and site, and linear regression for impact of factors on L1-4 and femoral BMD. Factor analyses with polychoric correlation matrices and calculation of Eigenvalues were applied to determine association between fracture sites and associated risk factors. A total of 6053 patients were included, 91.1% female. 2094 had sustained at least one FF. Smoking, alcoholism, increased age, height, and fat mass increased FF risk. Sites analysed: femur, tibia/fibula, humerus, forearm, ribs, and vertebrae. Alcoholism, and increasing tissue thickness and fat mass significantly increased FF risk. Decreased right femoral and vertebral BMD increased overall FF risk. Our study confirms the effect of certain factors on vertebral BMD, but suggests a differential effect on the upper and lower spine, as well as in the dominant and nondominant hip. Different sites of fracture are associated with different risk factors, the most common sites of fracture being the peripheral long bones and vertebrae.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 066712018

Download citation: RISBibTeXText

PMID: 31008372

DOI: 10.1016/j.afos.2019.03.001

Related references

Familial history of osteoporotic fracture and individual risk of low bone mineral density and fracture The Chingford study. British Journal of Rheumatology 36(Suppl. 1): 117, 1997

Prediction of Bone Mineral Density and Fragility Fracture by Genetic Profiling. Journal of Bone and Mineral Research 32(2): 285-293, 2017

Prevalence and predictors of low bone mineral density and fragility fractures among HIV-infected patients at one Italian center after universal DXA screening: sensitivity and specificity of current guidelines on bone mineral density management. Aids Patient Care and Stds 29(4): 169-180, 2015

Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men. Osteoporosis International 22(1): 217-221, 2011

Correlation of serum uric acid with bone mineral density and fragility fracture in patients with primary osteoporosis: a single-center retrospective study of 253 cases. International Journal of Clinical and Experimental Medicine 8(4): 6291-6294, 2015

PUFAs, Bone Mineral Density, and Fragility Fracture: Findings from Human Studies. Advances in Nutrition 7(2): 299-312, 2016

Bone mineral density testing after fragility fracture: Informative test results likely. Canadian Family Physician Medecin de Famille Canadien 59(12): E564, 2013

Mandibular bone structure, bone mineral density, and clinical variables as fracture predictors: a 15-year follow-up of female patients in a dental clinic. Oral Surgery Oral Medicine Oral Pathology and Oral Radiology 116(3): 362-368, 2013

Bone mineral density and walking ability of elderly patients with hip fracture: a strategy for prevention of hip fracture. Injury 36(9): 1075-1079, 2005

Sister's fracture history may be associated with perimenopausal bone fragility and modifies the predictability of fracture risk. Osteoporosis International 20(4): 557-565, 2009

A model of fracture risk used to examine the link between bone mineral density and the impact of different therapeutic mechanisms on fracture outcomes in patients with osteoporosis. Journal of Pharmacokinetics and Pharmacodynamics 44(6): 599-609, 2017

Effect of a Fracture Liaison Service on the Rate of Subsequent Fracture Among Patients With a Fragility Fracture in the Norwegian Capture the Fracture Initiative (NoFRACT): A Trial Protocol. JAMA Network Open 1(8): E185701, 2018

Discrimination of vertebral fragility fracture with lumbar spine bone mineral density measured by quantitative computed tomography. Journal of Orthopaedic Translation 16: 33-39, 2019

Bone mineral density measurement and osteoporosis treatment after a fragility fracture in older adults: regional variation and determinants of use in Quebec. Bmc Musculoskeletal Disorders 6: 33, 2005

Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis. Journal of Biomechanics 46(4): 723-730, 2013