+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells



The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells



Frontiers in Immunology 10: 680



The distinction between innate and adaptive immunity is one of the basic tenets of immunology. The co-operation between these two arms of the immune system is a major determinant of the resistance or susceptibility of the host following pathogen invasion. Hence, this interactive co-operation between cells of the innate and adaptive immunity is of significant interest to immunologists. The sub-population of CD4+ T cells with regulatory phenotype (regulatory T cells; Tregs), which constitute a part of the adaptive immune system, have been widely implicated in the regulation of the immune system and maintenance of immune homeostasis. In the last two decades, there has been an explosion in research describing the role of Tregs and their relevance in several immunopathologies ranging from inflammation to cancer. The majority of these studies focus on the role of Tregs on the cells of the adaptive immune system. Recently, there is significant interest in the role of Tregs on cells of the innate immune system. In this review, we examine the literature on the role of Tregs in immunology. Specifically, we focus on the emerging knowledge of Treg interaction with dendritic cells, macrophages, neutrophils, and γδ T cells. We highlight this interaction as an important link between innate and adaptive immune systems which also indicate the far-reaching role of Tregs in the regulation of immune responses and maintenance of self-tolerance and immune homeostasis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066726268

Download citation: RISBibTeXText

PMID: 31024539

DOI: 10.3389/fimmu.2019.00680


Related references

Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3. Journal of Immunology 184(12): 7162-7168, 2010

The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells. Journal of Reproductive Immunology 57(1-2): 61-79, October-November, 2002

Regulatory T cells and innate immune regulation in tumor immunity. Springer Seminars in Immunopathology 28(1): 17-23, 2006

CD4 T Cells Mediate Both Positive and Negative Regulation of the Immune Response to HIV Infection: Complex Role of T Follicular Helper Cells and Regulatory T Cells in Pathogenesis. Frontiers in Immunology 5: 681, 2015

The role of basophils as innate immune regulatory cells in allergy and immunotherapy. Human Vaccines and Immunotherapeutics 14(4): 815-831, 2017

Heat shock protein 60: regulatory role on innate immune cells. Cellular and Molecular Life Sciences 64(6): 742-751, 2007

The Regulatory Role of Va14 NKT Cells in Innate and Acquired Immune Response. Annual Review of Immunology 21 2003: 3-513, 2003

The regulatory role of V alpha 14 NKT cells in innate and acquired immune response. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme 47(16 Suppl): 2109-2116, 2003

Mechanisms of immune privilege for tumor cells by regulatory cytokines produced by innate and acquired immune cells. Seminars in Cancer Biology 12(4): 291-300, 2002

Superantigen-activated regulatory T cells inhibit the migration of innate immune cells and the differentiation of naive T cells. Journal of Immunology 183(5): 2946-2956, 2009

Integrating innate and adaptive immune cells: Mast cells as crossroads between regulatory and effector B and T cells. European Journal of Pharmacology 778: 84-89, 2016

Regulation of innate immune function in bovine oviduct epithelial cells in culture: the homeostatic role of epithelial cells in balancing Th1/Th2 response. Journal of Reproduction and Development 59(5): 470-478, 2014

Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions. Current Opinion in Pharmacology 26: 1-9, 2016

Impact of Regulatory T Cells on Innate Immune Cells in a Pre-Sensitized Heart Transplant Model. Annals of Transplantation 23: 246-251, 2018

Intratracheal delivery of alloantigen induces donor-specific hyporesponsiveness: dendritic cells play a pivotal role as regulatory cells. Transplantation Proceedings 33(1-2): 86, 2001