+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Surgical, Speech, and Audiologic Outcomes in Patients With Orofacial Cleft and Van der Woude Syndrome



Surgical, Speech, and Audiologic Outcomes in Patients With Orofacial Cleft and Van der Woude Syndrome



Journal of Craniofacial Surgery 2019



The purpose of this study was to investigate the surgical, speech, and audiologic outcomes in patients with Van der Woude syndrome (VWS) and compare them to patients with nonsyndromic cleft palate with or without cleft lip (NS-CP ± L) treated at the same institution. Retrospective chart review. A single children's hospital at a major academic institution. The records of 18 patients with VWS who had been treated at a single institution from 1989 to 2017 have been retrospectively examined. Thirty-eight patients with NS-CP ± L who were also treated at the same institution during that same time frame were selected to closely match sex and date of birth. Demographic, clinical, surgical, and speech pathology data were gathered from medical charts. By age 4, 88% of subjects with VWS and 76% of subjects with NS-CP ± L (P = 0.732) had been, or were actively involved in, speech therapy. By age 10, 100% of remaining subjects with VWS and 58% of remaining subjects with NS-CP ± L remained involved in speech therapy (P = 0.027).About 33% of patients with VWS and 16% of patients with NS-CP ± L had a secondary procedure for velopharyngeal dysfunction (VPD) (P = 0.171). The VWS group had more than twice the rate of secondary procedures for VPD repair, and a higher rate of continuing involvement for speech therapy at age 10. No differences were found in the rate of participation in speech therapy at or by age 4.

(PDF emailed within 1 workday: $29.90)

Accession: 066757134

Download citation: RISBibTeXText

PMID: 31058728


Related references

Anatomic Severity, Midfacial Growth, and Speech Outcomes in Van der Woude/Popliteal Pterygium Syndromes Compared to Nonsyndromic Cleft Lip/Palate. Cleft Palate-Craniofacial Journal 52(6): 676-681, 2014

Treatment Outcomes in Patients With Van der Woude and Popliteal Pterygium Syndromes Compared to Patients With Nonsyndromic Cleft Lip/Palate. Journal of Oral and Maxillofacial Surgery 71(9): E44-E45, 2013

Genetic analysis of two families with van der woude syndrome lip pits cleft palate and cleft lip syndrome. Acta Genetica Sinica 15(5): 396-400, 1988

Possible relationship between the van der Woude syndrome (vWS) locus and nonsyndromic cleft lip with or without cleft palate (NSCL/P). American Journal of Medical Genetics 104(1): 86-92, 2001

Possible relationship between the van der Woude syndrome locus and nonsyndromic cleft lip with or without cleft palate. American Journal of Human Genetics 69(4 Supplement): 575, 2001

Transmission/disequilibrium test approach at the van der Woude syndrome locus in familial nonsyndromic cleft lip with or without cleft palate. American Journal of Human Genetics 65(4): A255, 1999

An audiologic and otorhinologic study of cleft-lip and cleft-palate cases. I. Audiologic evaluation. A.M.A. Archives of Otolaryngology 64(1): 58-62, 1956

Association study between Van der Woude Syndrome causative gene GRHL3 and nonsyndromic cleft lip with or without cleft palate in a Chinese cohort. Gene 588(1): 69-73, 2017

Van der Woude syndrome (lip pits, cleft lip and cleft palate syndrome). Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi 5(2): 98-9, 157, 1989

Van der Woude syndrome- a syndromic form of orofacial clefting. Journal of Clinical and Experimental Dentistry 4(2): E125-E128, 2012

Identifying the effect of cleft type, deprivation and ethnicity on speech and dental outcomes in UK cleft patients: a multi-centred study. Journal of Plastic, Reconstructive and Aesthetic Surgery 67(12): 1637-1643, 2015

Centre-level variation in speech outcome and interventions, and factors associated with poor speech outcomes in 5-year-old children with non-syndromic unilateral cleft lip and palate: The Cleft Care UK study. Part 4. Orthodontics and Craniofacial Research 20 Suppl 2: 27-39, 2018

Ectodactylia-ectodermal dysplasia, cleft lip, jaw and palate syndrome (EEC syndrome). Association with van der Woude syndrome?. Deutsche Zeitschrift für Mund-, Kiefer- und Gesichts-Chirurgie 9(3): 225-226, 1985

Speech and Surgical Outcomes in Children With Veau Types III and IV Cleft Palate. Cleft Palate-Craniofacial Journal 55(3): 396-404, 2018

Long-Term Surgical and Speech Outcomes Following Palatoplasty in Patients With Treacher-Collins Syndrome. Journal of Craniofacial Surgery 27(6): 1408-1411, 2018