+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Glyphosate and glyphosate-based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome



Glyphosate and glyphosate-based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome



Journal of Neuroendocrinology 31(9): E12731



Glyphosate is found in a large array of non-selective herbicides such as Roundup® (Monsanto, Creve Coeur, MO, USA) and is by far the most widely used herbicide. Recent work in rodent models suggests that glyphosate-based herbicides during development can affect neuronal communication and result in altered behaviours, albeit through undefined mechanisms of action. To our knowledge, no study has investigated the effects glyphosate or its formulation in herbicide on maternal behaviour and physiology. In the present study, relatively low doses of glyphosate (5 mg kg-1  d-1 ), Roundup® (5 mg kg-1  d-1 glyphosate equivalent), or vehicle were administered by ingestion to Sprague-Dawley rats from gestational day (GD) 10 to postpartum day (PD)22. The treatments significantly altered licking behaviour toward pups between PD2 and PD6. We also show in the dams at PD22 that Roundup exposure affected the maturation of doublecortin-immunoreactive new neurones in the dorsal dentate gyrus of the hippocampus of the mother. In addition, the expression of synaptophysin was up-regulated by glyphosate in the dorsal and ventral dentate gyrus and CA3 regions of the hippocampus, and down-regulated in the cingulate gyrus. Although a direct effect of glyphosate alone or its formulation on the central nervous system is currently not clear, we show that gut microbiota is significantly altered by the exposure to the pesticides, with significant alteration of the phyla Bacteroidetes and Firmicutes. This is the first study to provide evidence that glyphosate alone or in formulation (Roundup) differentially affects maternal behaviour and modulates neuroplasticity and gut microbiota in the mother.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 066763729

Download citation: RISBibTeXText

PMID: 31066122

DOI: 10.1111/jne.12731


Related references

Maternal glyphosate-based herbicide exposure alters antioxidant-related genes in the brain and serum metabolites of male rat offspring. NeuroToxicology 74: 121-131, 2019

Perinatal Exposure to Glyphosate and a Glyphosate-Based Herbicide Affect Spermatogenesis in Mice. Toxicological Sciences 169(1): 260-271, 2019

Exposure to a glyphosate-based herbicide formulation, but not glyphosate alone, has only minor effects on adult rat testis. Reproductive Toxicology 82: 25-31, 2018

Perinatal Glyphosate-Based Herbicide Exposure in Rats Alters Brain Antioxidant Status, Glutamate and Acetylcholine Metabolism and Affects Recognition Memory. Neurotoxicity Research 34(3): 363-374, 2018

Glyphosate and Aminomethylphosphonic Acid Content in Glyphosate-Resistant Soybean Leaves, Stems, and Roots and Associated Phytotoxicity Following a Single Glyphosate-Based Herbicide Application. Journal of Agricultural and Food Chemistry 67(22): 6133-6142, 2019

Glyphosate based- herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice. Neurotoxicology and Teratology 67: 44-49, 2018

Glyphosate based- herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice. Neurotoxicology and Teratology 67: 44-49, 2018

Exposure to a glyphosate-based herbicide affects agrobiont predatory arthropod behaviour and long-term survival. Ecotoxicology 19(7): 1249-1257, 2010

Acute exposure of a glyphosate-based herbicide affects the gills and liver of the Neotropical fish, Piaractus mesopotamicus. Environmental Toxicology and Pharmacology 34(2): 388-396, 2012

Potential accumulative effect of the herbicide glyphosate on glyphosate-tolerant maize rhizobacterial communities over a three-year cultivation period. Plos one 6(11): E27558, 2011

Chronic exposure to sub-lethal concentration of a glyphosate-based herbicide alters hormone profiles and affects reproduction of female Jundiá (Rhamdia quelen). Environmental Toxicology and Pharmacology 23(3): 308-313, 2007

Glyphosate-Resistant Horseweed (Conyza canadensis) Control Using Glyphosate-, Paraquat-, and Glufosinate-Based Herbicide Programs. Weed Technology 22(1): 16-21, 2008

Glyphosate-resistant horseweed (Conyza canadensis) control using glyphosate-, paraquat-, and glufosinate-based herbicide programs. Weed Technology 22(1): 16-21, 2008

Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelination. Acta Neuropathologica 136(6): 979-982, 2018

Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: Implication of glutamate excitotoxicity and oxidative stress. Toxicology 387: 67-80, 2017