+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Antioxidative activity and health benefits of anthocyanin rich fruit juice in healthy volunteers

Antioxidative activity and health benefits of anthocyanin rich fruit juice in healthy volunteers

Free Radical Research 2019: 1-281

Oxidative cell damage has been linked to the pathogenesis of numerous diseases such as atherosclerosis, type 2 diabetes, and cancer. The consumption of foods rich in polyphenols (eg anthocyanins) has been shown to exert preventive effects against such diseases. We investigated biological effects of anthocyanin-rich fruit juice in a 9-week, placebo-controlled intervention study with 57 healthy male volunteers. The study design encompassed an initial 1 week of wash-out, followed by 8 weeks of intervention period with anthocyanin-rich fruit juice or placebo. The anthocyanin-rich fruit juice demonstrated DNA-protective and antioxidant effects; however, the placebo beverage, rich in vitamin C, showed similar effects based on the tested biomarkers. A significant reduction in background and total DNA strand breaks was observed in both groups within 24 h as well as after 8 weeks of intervention. Only anthocyanin-rich fruit juice consumption provided a significant reduction in body fat and an increase in fat-free mass. The activity of superoxide dismutase (SOD) was significantly elevated after consumption of anthocyanin-rich fruit juice. Both groups showed decreased levels of LDL and total cholesterol (TC) within the first week of the intervention. Similar results in both groups could be explained by the relatively high vitamin C contents of both beverages (> 500 mg/L), which may have masked the effects of anthocyanins and other antioxidants in the studied juice. Taken together, anthocyanin-rich fruit juice as well as the placebo drink, both of which had high vitamin C content, can improve DNA integrity and might influence lipid metabolism in humans.

(PDF emailed within 0-6 h: $19.90)

Accession: 066783426

Download citation: RISBibTeXText

PMID: 31088176

DOI: 10.1080/10715762.2019.1618851

Related references

Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp in human healthy volunteers. Journal Of Agricultural And Food Chemistry: 17, 7796-7802, 2008

Inhibition of pancreatic cancer cell migration by plasma anthocyanins isolated from healthy volunteers receiving an anthocyanin-rich berry juice. European Journal of Nutrition 56(1): 203-214, 2015

Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers. Journal of Agricultural and Food Chemistry 56(17): 7796-7802, 2008

An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands. Biotechnology Journal 1(4): 388-397, 2006

Bolus consumption of a specifically designed fruit juice rich in anthocyanins and ascorbic acid did not influence markers of antioxidative defense in healthy humans. Journal of Agricultural and Food Chemistry 60(45): 11292-11300, 2013

Antioxidant, Anti-Inflammatory, and Postulated Cytotoxic Activity of Phenolic and Anthocyanin-Rich Fractions from Polana Raspberry ( Rubus idaeus L.) Fruit and Juice-In Vitro Study. Molecules 23(7), 2018

Fractionation of an anthocyanin-rich bilberry extract and in vitro antioxidative activity testing. Food Chemistry 167: 418-424, 2015

Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. Cancer Epidemiology, Biomarkers and Prevention 17(12): 3372-3380, 2008

Four-week ingestion of blood orange juice results in measurable anthocyanin urinary levels but does not affect cellular markers related to cardiovascular risk: a randomized cross-over study in healthy volunteers. European Journal of Nutrition 51(5): 541-548, 2012

Dietary anthocyanin-rich plants: biochemical basis and recent progress in health benefits studies. Molecular Nutrition and Food Research 56(1): 159-170, 2012

Optimization of solvent and ultrasound-assisted extraction for different anthocyanin rich fruit and their effects on anthocyanin compositions. Lebensmittel-Wissenschaft Und-Technologie / Food Science and Technology 72: 229-238, 2016

Determination of the total phenolic and anthocyanin contents and antimicrobial activity of Viburnum opulus fruit juice. Plant Foods for Human Nutrition 67(3): 256-261, 2013

Composition and potential health benefits of passion fruit juice. Abstracts of Papers American Chemical Society 222(1-2): AGFD17, 2001

Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults. American Journal of Clinical Nutrition 101(3): 506-514, 2015

Both red and blond orange juice intake decreases the procoagulant activity of whole blood in healthy volunteers. Thrombosis Research 132(2): 288-292, 2014