Chiroptical sensing of unprotected amino acids, hydroxy acids, amino alcohols, amines and carboxylic acids with metal salts

Lynch, C.án.C.; De Los Santos, Z.A.; Wolf, C.

Chemical Communications 55(44): 6297-6300

2019


ISSN/ISBN: 1364-548X
PMID: 31089587
DOI: 10.1039/c9cc02525a
Accession: 066784591

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Abstract
Optical chirality sensing of unprotected amino acids, hydroxy acids, amino alcohols, amines and carboxylic acids based on a practical mix-and-measure protocol with readily available copper, iron, palladium, manganese, cerium or rhodium salts is demonstrated. The generation of strong cotton effects allows quantitative ee analysis of small sample amounts with high speed. In contrast to previously reported assays the use of chromophoric reporter ligands and the control of metal coordination kinetics and redox chemistry are not necessary which greatly simplifies the sensing procedure with the benefit of reduced waste production and cost.