Formation of poly (butyl 2-cyanoacrylate) microcapsules and the microencapsulation of aqueous solutions of [125I]-labelled proteins
Wood, D.A.; Whateley, T.L.; Florence, A.T.
International Journal of Pharmaceutics 8(1): 35-43
Some features of the polymerization reaction of butyl 2-cyanoacrylate at different aqueous/organic solvent interfaces have been investigated. In particular, the effects of p H and the presence of protein on the formation of microcapsules by in situ interfacial polymerization of butyl 2-cyanoacrylate in w/o emulsions have been studied. [125I]-labelled proteins have been used to study the procedure as a method of microencapsulating enzymes or other proteins within potentially biodegradable membranes. Preliminary in vitro degradation studies suggest that degradation of the microcapsules is inhibited by low levels of their breakdown products, thus allowing the storage of the microcapsules as aqueous suspensions for prolonged periods in sealed containers.