Ocular disposition of poly-hexyl-2-cyano[3-14C]acrylate nanoparticles in the albino rabbit
International Journal of Pharmaceutics 23(2): 175-183
ISSN/ISBN: 0378-5173 DOI: 10.1016/0378-5173(85)90007-9
The disposition of poly-hexyl-2-cyanoacrylate nanoparticles in tears, aqueous humor, cornea and conjunctiva of albino rabbits was studied using radiotracer techniques. Results indicate that the majority of nanoparticles were drained away rapidly with a small percent adhering to corneal and conjunctival surfaces. The nanoparticles underwent degradation in collected tear samples. Within the time course of the study, the conjunctival nanoparticle level was fairly constant, while the corneal nanoparticle level decreased slowly. The radioactivity observed in the aqueous humor was presumably due to degradation of the nanoparticles rather than endocytosis of the intact nanoparticle. The mucolytic agent, N-acetyl-l-cysteine, had no effect on either the corneal nanoparticle level nor the radioactivity level observed in the aqueous humor, but it increased the conjunctival nanoparticle level.