+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Benzophenone- and Indolecarboxylic Acids: Potent Type-2 Specific Inhibitors of Human Steroid 5.alpha.-Reductase



Benzophenone- and Indolecarboxylic Acids: Potent Type-2 Specific Inhibitors of Human Steroid 5.alpha.-Reductase



Journal of Medicinal Chemistry 38(1): 13-15




Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 067194862

Download citation: RISBibTeXText

DOI: 10.1021/jm00001a004


Related references

Benzophenone- and indolecarboxylic acids: potent type-2 specific inhibitors of human steroid 5 alpha-reductase. Journal of Medicinal Chemistry 38(1): 13-15, 1995

6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase. Journal of Medicinal Chemistry 36(26): 4313-4315, 1993

6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase. Journal of Medicinal Chemistry 36(26): 4313-4315, 1993

Type-1 steroid 5 alpha-reductase is functionally active in the hair follicle as evidenced by new selective inhibitors of either type-1 or type-2 human steroid 5 alpha-reductase. Experimental Dermatology 11(1): 52-58, 2002

Novel pyrroleacetic acids Selective inhibitors of human type 2 steroid 5 alpha-reductase. Abstracts of Papers American Chemical Society 212(1-2): MEDI 62, 1996

4-Aza-3-oxo-5-alpha-androst-1-ene-17-beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5-alpha-reductase Dramatic effect of N-aryl substituents on type 1 and type 2 5a-reductase inhibitory potency. Journal of Medicinal Chemistry 38(17): 3189-3191, 1995

4-Aza-3-oxo-5.alpha.-androst-1-ene-17.beta.-N-arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5.alpha.-Reductases. Dramatic Effect of N-Aryl Substituents on Type 1 and Type 2 5.alpha.-Reductase Inhibitory Potency. Journal of Medicinal Chemistry 38(17): 3189-3192, 1995

4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency. Journal of Medicinal Chemistry 38(17): 3189-3192, 1995

Potent inhibition of human steroid 5 alpha reductase ec 13130 by 3 androstene 3 carboxylic acids. Bioorganic Chemistry 17(3): 372-376, 1989

DELTA-1-4-oxasteroids Potent mechanism based inhibitors of human type 1 and type 2 5-alpha-reductase. Abstracts of Papers American Chemical Society 212(1-2): MEDI 60, 1996

Nonsteroidal inhibitors of human type I steroid 5-alpha-reductase. Journal of Medicinal Chemistry 36(3): 421-423, 1993

An efficient synthesis of 17-beta-carboxy-6-t-butoxycarbonyl-6-azaandrost-4-ene-3-one A key intermediate in the preparation of potent 6-azasteroid inhibitors of human steroid 5-alpha reductase. Abstracts of Papers American Chemical Society 207(1-2): MEDI 157, 1994

Slow, tight binding inhibitors of type II human steroid 5-alpha-reductase. Journal of Cellular Biochemistry Suppl. 0(18D): 238, 1994

Hydroxylation of 5 alpha-androstane-3 beta,17 beta-diol by rat prostate microsomes: potent inhibition by imidazole-type antimycotic drugs and lack of inhibition by steroid 5 alpha-reductase inhibitors. Archives of Biochemistry and Biophysics 296(2): 366-373, 1992

A comparison of steroidal and non-steroidal inhibitors of human steroid 5-alpha-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme. Bioorganic and Medicinal Chemistry Letters 6(4): 481-484, 1996