Involvement of -glutamyltransferase in amino-acid uptake by the lactating mammary gland of the rat

Coimbra, Joao Carlos; Pinto, Iraja Damiani; Wurdig, Norma Luiza; Do Carmo, Dermeval Aparecido

Biochemical Journal 194(1): 99-102


ISSN/ISBN: 0264-6021
DOI: 10.1042/bj1940099
Accession: 067224787

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1. Arteriovenous differences of amino acids across the lactating mammary gland have been measured in normal rats and in rats injected with serine--borate (an inhibitor of gamma-glutamyltransferase). 2. Comparison of the arteriovenous differences show that gamma-glutamyltransferase is involved in amino-acid uptake by the gland. 3. Reduced-glutathione content of isolated acini incubated with high concentrations of amino acids was lower than that of the controls. 4. High concentrations of amino acids had no effect on reduced-glutathione content of isolated acini when serine--borate was added to the incubation medium. 5. The findings provide evidence for the functioning of the gamma-glutamyl cycle in the lactating mammary gland in vivo.