Histochemical Studies on Activity and Distribution of Acid Phosphatase, Non-specific Esterase, and E 600-resistant Esterase in Jejunal Mucosa During Acute Radiation Disease

Jonek, J.; Kośmider, S.; Kaiser, J.

International Journal of Radiation Biology 7(5): 411-419


ISSN/ISBN: 0955-3002
DOI: 10.1080/09553006314551381
Accession: 067322309

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Histochemical studies on activity and localization of some enzymes (acid phosphatase, non-specific esterase, E 600-resistant esterase) in the jejunal mucosa of guinea-pigs have been performed at certain stages of radiation disease induced by X-rays. Results obtained revealed a. positive correlation between acid-phosphatase activity and advances pf disease. The activity increase of this enzyme in the mucosal cells signifies intensifying catabolic processes. After irradiation, changes of thiolacetic esterase activity were observed which seem to be related to the stages of radiation and which may implicate fatty-acid metabolism. Reaction to E 600-resistant esterases increased linearly to time after irradiation, indicating catabolic activation in the intestinal mucosa.