Synergistic Action of Angiotensin Ii, Insulin- Like Growth Factor-I, and Transforming Growth Factor- on Platelet-Derived Growth Factor-Bb, Basic Fibroblastic Growth Factor, and Epidermal Growth Factor-Induced Dna Synthesis in Vascular Smooth Muscle Cells
Ko, Y.; Stiebler, H.; Nickenig, G.; Wieczorek, A.J.; Vetter, H.; Sachinidis, A.
American Journal of Hypertension 6(6_Pt_1): 496-499
The effect of angiotensin II (AII), transforming growth factor-beta (TGF-beta), and insulin-like growth factor-I (IGF-I) on platelet-derived growth factor (PDGF)-BB-, basic fibroblastic growth factor (bFGF)-, and epidermal growth factor (EGF)-induced DNA synthesis in vascular smooth muscle cells (VSMCs) was investigated. TGF-beta, AII, IGF-I increased concentration-dependent cell protein. No increase in [3H]thymidine incorporation could be detected. TGF-beta, AII, and IGF-I enhanced PDGF-BB-, bFGF-, and EGF-induced DNA synthesis. Our results suggest that growth factors that possess a weak mitogenic effect on vascular smooth muscle cells such as TGF-beta, AII, and IGF-I may enhance the mitogenicity of PDGF-BB, bFGF, and EGF.