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Synergistic Action of Angiotensin Ii, Insulin- Like Growth Factor-I, and Transforming Growth Factor- on Platelet-Derived Growth Factor-Bb, Basic Fibroblastic Growth Factor, and Epidermal Growth Factor-Induced Dna Synthesis in Vascular Smooth Muscle Cells

Ko, Y.; Stiebler, H.; Nickenig, G.; Wieczorek, A.J.; Vetter, H.; Sachinidis, A.

American Journal of Hypertension 6(6_Pt_1): 496-499

1993

ISSN/ISBN: 0895-7061
DOI: 10.1093/ajh/6.6.496
Accession: 067402920
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The effect of angiotensin II (AII), transforming growth factor-beta (TGF-beta), and insulin-like growth factor-I (IGF-I) on platelet-derived growth factor (PDGF)-BB-, basic fibroblastic growth factor (bFGF)-, and epidermal growth factor (EGF)-induced DNA synthesis in vascular smooth muscle cells (VSMCs) was investigated. TGF-beta, AII, IGF-I increased concentration-dependent cell protein. No increase in [3H]thymidine incorporation could be detected. TGF-beta, AII, and IGF-I enhanced PDGF-BB-, bFGF-, and EGF-induced DNA synthesis. Our results suggest that growth factors that possess a weak mitogenic effect on vascular smooth muscle cells such as TGF-beta, AII, and IGF-I may enhance the mitogenicity of PDGF-BB, bFGF, and EGF.

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Related References

Ko, Y.; Stiebler, H.; Nickenig, G.; Wieczorek, A.J.; Vetter, H.; Sachinidis, A. 1993: Synergistic action of angiotensin II, insulin-like growth factor-I, and transforming growth factor-beta on platelet-derived growth factor-BB, basic fibroblastic growth factor, and epidermal growth factor-induced DNA synthesis in vascular smooth muscle cells American Journal of Hypertension 6(6 Part 1): 496-499
Yon, K.O.; Stiebler, H.; Nickenig, G.; Wieczorek, A.J.; Vetter, H.; Sachinidis, A. 1993: Synergistic action of angiotensin II, insulin-like growth factor-I, and transforming growth factor-β on platelet-derived growth factor-BB, basic fibroblastic growht factor, and epidermal growth factor-induced DNA synthesis in vascular smooth muscle cells American Journal of Hypertension 6(6): 496-499
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