A Comparison of Infections in Mice with three Species of Schistosomes, Schistosoma Mansoni, Schistosoma Japonicum and Schistosomatium Douthitti1

Olivier, L.

American Journal of Epidemiology 55(1): 22-35


ISSN/ISBN: 0002-9262
DOI: 10.1093/oxfordjournals.aje.a119503
Accession: 067463844

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Olivier reports on his investigations which were primarily planned to compare the production of the pulmonary lesions provoked by Schistosoma mansoni, S. japonicum and Schistosomatium douthitti in mice. The methods employed for exposing the mice to infection, for counting the pulmonary hacmonrrhages and for recovering the worms from the lungs and from the portal system, are described in detail. All three species produced haemorrhages in the lungs on their migration through these organs to reach the portal system. Schistosomatium douthiiti and Schistosoma japonicum produced many conspicuous haemorrhages which disappeared rapidly while S. mansoni provoked fewer haemorrhages which were evident Tor some time. The author concludes that the two first species produce pulmonary haemorrhages in the mouse, during migration but that S. mansoni does not always do so. S. mansoni passes through the lungs less rapidly than do the other two. The number of worms recovered at the autopsies suggests that Schistosomatium douthitti and Schistosoma japonicum were more successful in establishing themselves in mice than was S. mansoni. Olivier suspects that the accumulation of S. mansoni in the lungs and their slow passage to the portal system may be due to the response of an abnormal host.