Early Versus Delayed Cyclosporine Treatment in Cardiac Recovery and Intestinal Injury During Resuscitation of Asphyxiated Newborn Piglets

Gill, R.; Lee, T.; Sergi, C.; Joynt, C.; Bigam, D.; Cheung, P.

Archives of Disease in Childhood 97(Suppl 2): A92-A93


ISSN/ISBN: 0003-9888
DOI: 10.1136/archdischild-2012-302724.0316
Accession: 067659889

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Background Recently, we have demonstrated that treating asphyxiated newborn piglets with intravenous cyclosporine immediately following resuscitation can improve cardiac function. However, immediate treatment may not be feasible for a large portion of newborns delivered in peripheral/rural hospitals. Therefore, our objective was to determine if delayed cyclosporine treatment was still effective in protecting asphyxiated piglets. We hypothesize that both early and delayed treatment with cyclosporine A would improve cardiac recovery during resuscitation of asphyxiated newborn piglets.