Delayed-Alternation Performance after Selective Lesions of the Medial and Sulcal Prefrontal Cortex of the Guinea Pig
Markowitsch, H.J.; Riess, R.
Brain, Behavior and Evolution 18(1-2): 96-104
ISSN/ISBN: 0006-8977 DOI: 10.1159/000121779
The sulcal or medial subdivision of the prefrontal cortex of the guinea pig was ablated after the animals had learned a spatial delayed-alternation task. Retention of this task was significantly impaired only after ablation of the medial prefrontal cortex. As the most critical cortical region for delayed-alternation performance in the rat is also situated in the medial prefrontal cortex, our findings suggest a close functional correspondence of the prefrontal cortices of these rodent species.