Localization of the β-like globin gene cluster and the genes for parathyroid hormone and c-Harvey-ras 1 to region q14→q21 of rabbit chromosome 1 by in situ hybridization

Xu, J.; Hardison, R.C.

Cytogenetic and Genome Research 52(3-4): 157-161

1989


ISSN/ISBN: 1424-8581
DOI: 10.1159/000132868
Accession: 067768563

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Abstract
The rabbit beta-like globin gene cluster (HBBC), comprised of epsilon-, gamma-, delta-, and beta-globin genes (HBE, HBG, HBD, and HBB, respectively), has been mapped to chromosome 1, region q14----q21, by in situ hybridization using probes for rabbit HBE and HBG. Probes for the human parathyroid hormone gene (PTH) and the Harvey-ras 1 protooncogene (HRAS1) also localize to this region by in situ hybridization. Thus, these genes are syntenic in lagomorphs as well as four other mammalian orders (primates, rodents, carnivores, and artiodactyls). The mapping data in rabbits provide further evidence that this synteny is strongly conserved in the evolution of mammalian chromosomes.