Regional sublocalization of the human thyroid peroxidase gene (Tpo) by tritium and fluorescence in situ hybridization to chromosome 2p25→p24

Barnett, P.S.; Jones, T.A.; McGregor, A.M.; Banga, J.P.; Sheer, D.

Cytogenetic and Genome Research 62(4): 188-189

1993


ISSN/ISBN: 1424-8581
DOI: 10.1159/000133471
Accession: 067768821

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Abstract
Thyroid peroxidase (TPO), the enzyme responsible for thyroid hormone synthesis, is a key autoantigen in autoimmune thyroid disease. Based on the results of a study using both isotopic and nonisotopic in situ hybridization, we assign the gene coding for human TPO to chromosome region 2p25-->p24.