Airway Hyperresponsiveness through Synergy of T Cells and Nkt Cells

Jin, N.; Miyahara, N.; Roark, C.L.; French, J.D.; Aydintug, M.K.; Matsuda, J.L.; Gapin, L.; O'Brien, R.L.; Gelfand, E.W.; Born, W.K.

The Journal of Immunology 179(5): 2961-2968


DOI: 10.4049/jimmunol.179.5.2961
Accession: 068490755

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Mice sensitized and challenged with OVA were used to investigate the role of innate T cells in the development of allergic airway hyperresponsiveness (AHR). AHR, but not eosinophilic airway inflammation, was induced in T cell-deficient mice by small numbers of cotransferred gammadelta T cells and invariant NKT cells, whereas either cell type alone was not effective. Only Vgamma1+Vdelta5+ gammadelta T cells enhanced AHR. Surprisingly, OVA-specific alphabeta T cells were not required, revealing a pathway of AHR development mediated entirely by innate T cells. The data suggest that lymphocytic synergism, which is key to the Ag-specific adaptive immune response, is also intrinsic to T cell-dependent innate responses.