Studies on lankacidin-group (T-2636) antibiotics. Ix. Preparation of 14C-labeled lankacidin C 14-proplonate

Hatano, K.; Harada, S.; Kishi, T.

The Journal of Antibiotics 28(1): 15-20


DOI: 10.7164/antibiotics.28.15
Accession: 068515669

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To investigate the metabolic fate of lankacidin C 14-propionate in experimental animals, the 14-C-labeled antibiotic was prepared by the fermentation of Streptomyces rochei var, volubilis in the presence of various 14-C-labeled organic carboxylic acids, amino acids and carbohydrates. Significant incorporation (20 similar to 40%) was observed with L-methionine-methyl-14-C. Lankacidin C 14-propionate-14-C (specific activity 49.6 muCi/mg) was obtained from lankacidin C-14-C and ethyl propionate by the action of an acylase of the streptomyces.