Semisynthetic cephalosporins. Iv Synthesis and structure activity relationships of parenterarry active 7- (4- (substituted methyl) phenyl) acetamido-3-cephem-4-carboxylic acids

Nudelman, A.; Haviv, F.; Patchornick, A.; Karoly-Hafely, E.; Braun-Bucholts, F.; Kaier, B.; Itzchaki, J.; Sasson, S.; Erickson, R.C.

The Journal of Antibiotics 34(10): 1311-1317


DOI: 10.7164/antibiotics.34.1311
Accession: 068515909

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A group of novel 4-substituted phenylacetic acids were prepared and coupled with several 7-amino-delta-3-cephems to afford a family of parenterally active cephalosporins. A compound designated 13I had the broadest spectrum of activity and the highest potency of the group against both Gram-positive and Gram-negative bacteria. The activity of 13I included high potency against penicillinase-producing staphylococci and activity against anaerobes, including Bacteroides fragilis.