EurekaMag PDF full texts Chapter 68,517

Puar, M.S.; Brambilla, R.; Jaret, R. 1982: Carbon-13 spin-lattice relaxation times of 16-membered macrolides: Ar-5(mycinamicins) antibiotics. The Journal of Antibiotics 35(3): 381-383

Oishi, H.; Noto, T.; Sasaki, H.; Suzuki, K.; Hayashi, T.; Okazaki, H.; Ando, K.; Sawada, M. 1982: Thiolactomycin, a new antibiotic. I. Taxonomy of the producing organism, fermentation and biological properties. The Journal of Antibiotics 35(4): 391-395

Sasaki, H.; Oishi, H.; Hayashi, T.; Matsuura, I.; Ando, K.; Sawada, M. 1982: Thiolactomycin, a new antibiotic. Ii. Structure elucidation. The Journal of Antibiotics 35(4): 396-400

Miyakawa, S.; Suzuki, K.; Noto, T.; Harada, Y.; Okazaki, H. 1982: Thiolactomycin, a new antibiotic. Iv. Biological properties and chemotherapeutic activity in mice. The Journal of Antibiotics 35(4): 411-419

Omura, S.; Tanaka, H.; Inokoshi, J.; Sakakibar, H.; Fujiwara, T. 1982: Binding of (3H)tetrahydroleucomycin A3 to Escherichia coli ribosomes and the effect of 3"-O-acyl derivatives of leucomycins on the binding. The Journal of Antibiotics 35(4): 491-496

Ikeda, H.; Tanaka, H.; Omura, S. 1982: Genetic and biochemical features of spiramycin biosynthesis in Streptomyces ambofaciens. Curing, protoplast regeneration and plasmid transfer. The Journal of Antibiotics 35(4): 507-516

Shirahata, K.; Kase, H.; Kitamura, S.; Iida, T. 1982: The structures of aminoglycoside antibiotics, Su-1,2, and 3. The Journal of Antibiotics 35(4): 520-523

Wei, T.T.; Byrne, K.M.; Warnick-Pickle, D.; Greenstein, M. 1982: Studies on the mechanism of action of gilvocarcin V and chrysomycin A. The Journal of Antibiotics 35(4): 545-548

Torh, T.; Tsuchiya, T.; Umezawa, S. 1982: Syntheses of 5-O-(2-O- and 3-O-(6-amino-6-deoxy-.Beta.-L-idopyranosyl)-.Beta.-D-ribofuranosyl)-1-N-((S)-4-amino-2-hydroxybutanoyl)-3'-deoxyparomamine. The Journal of Antibiotics 35(1): 58-61

Takaya, T.; Tozuka, Z.; Takasugi, H.; Kamiya, T.; Nakano, H. 1982: Studies on .Beta.-lactam antibiotics. V. Effect on antimicrobial activity of 2- and/or 3-methyl group(s) in a cephem nucleus. The Journal of Antibiotics 35(5): 585-588

Traxler, P.; Schup, T..; Wehrli, W. 1982: 16,17-Dihydrorifamycin S and 16,17-dihydro-17-hydroxyrifamycin S. Two novel rifamycins from a recombinant strain C 5/42 of Nocardia mediterranei. The Journal of Antibiotics 35(5): 594-601

Nimi, O.; Kubota, H.; Sugiyama, M. 1982: Effect of arginine on gramicidin S biosynthesis by Bacillus brevis. The Journal of Antibiotics 35(5): 615-621

Bedeschi, A.; Crugnola, A.; Giudici, F.; Perrone, E.; Nannini, G.; Meinardi, G. 1982: Cephalosporins. V. Synthesis and in vitro activity of some 7-(2-methoxymino-(substituted thio)alkanoyl)amino cephalosporanic acid derivatives. The Journal of Antibiotics 35(6): 712-720

Shibamoto, N.; Sakamoto, M.; Iguchi, H.; Tone, H.; Fukagawa, Y.; Ishikura, T. 1982: Pharmacological studies on Carbapenem antibiotics. I. Metabolism of Ps-5 in animal tissues. The Journal of Antibiotics 35(6): 721-728

Nakagawa, M.; Hirota, A.; Sakai, H.; Isogai, A. 1982: Terrecyclic acid A, a new antibiotic from Aspergillus terreus. I. Taxonomy, production, and chemical and biological properties. The Journal of Antibiotics 35(7): 778-782

Hirota, A.; Nakagawa, M.; Sakai, H.; Isogai, A. 1982: Terrecyclic acid A, a new antibiotic from Aspergillus terreus. Ii. Structure of terrecyclic acid A. The Journal of Antibiotics 35(7): 783-787

Mcgahren, W.J.; Barbatschi, F.; Kuck, N.A.; Morton, G.O.; Hardy, B.; Ellestad, G.A. 1982: Glycocinnamoylspermidines, a new class of antibiotics. Vi. Preparation and characterization of the semisynthetic iprocinodine. The Journal of Antibiotics 35(7): 794-799

Elson, S.W.; Oliver, R.S.; Bycroft, B.W.; Faruk, E.A. 1982: Studies on the biosynthesis of clavulanic acid. Iii. Incorporation of Dl-(3,4-13C2)glutamic acid. The Journal of Antibiotics 35(1): 81-86

Riff, L.J.; Thomason, J.L. 1982: Comparative aminoglycoside inactivation by .Beta.-lactam antibiotics. Effect of a Cephalosporin and six Penicillins on five aminoglycosides. The Journal of Antibiotics 35(7): 850-857

Parker, W.L.; Rathnum, M.L.; Liu, W.-C. 1982: Sq 26,517 - A .Beta.-lactone produced by a Bacillus species. The Journal of Antibiotics 35(7): 900-902

Sharma, M.N.; Kumar, V.; Remers, W.A. 1982: Aminoglycoside Antibiotics. 5. Regiospecific Synthesis of 1-N-[(S)-4-Amino-2-Hydroxybutyryl]- 2"-Deoxykanamycin B from Neamine. The Journal of Antibiotics 35(7): 905-912

Mezes, P.S.F.; Clarke, A.J.; Dmitrienko, G.I.; Viswanatha, T. 1982: The inactivation of Bacillus cereus 569/H .Beta.-lactamase by 6-.Beta.-(trifluoromethanesulfonyl)amidopenicillanic acid sulfone: pH dependence and stoichiometry. The Journal of Antibiotics 35(7): 918-920

Tamaoki, T.; Kasai, M.; Shirahata, K.; Tomita, F. 1982: Tetrocarcins E1,E2,F and F-1, new antibiotics. Fermentation, isolation and characterization. The Journal of Antibiotics 35(8): 979-984

Costa, A.; Botta, G.A. 1983: Configuration of the methoxyimino group and penetration ability of cefotaxime and its structural analogues. The Journal of Antibiotics 36(8): 1007-1012

Alpegiani, M.; Casabuona, F.; Giorgi, R.; Nannini, G.; Perrone, E.; Meinardi, G.; Bianchi, A.; Monti, G. 1983: Cephalosporins. Vi. Synthesis and structure-activity relationships of new 7.Beta.-((Z)-2-alkoxyimino-2-(2-aminothiazol-4-yl)acetamido)-cephalosporins with a tetrazolopyridazine at the 3-position. The Journal of Antibiotics 36(8): 1013-1019

Csendes, I.; Müller, B.W.; Tosch, W. 1983: Cephalosporin antibiotics. Synthesis and antimicrobial activity of 7.Beta.-(2-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxyiminoacetamido)cephalosporin derivatives. The Journal of Antibiotics 36(8): 1020-1033

Mine, Y.; Watanabe, Y.; Tawara, S.; Yokota, Y.; Nishida, M.; Goto, S.; Kuwahara, S. 1983: Immunoactive Peptides, Fk-156 and Fk-565. Iii. The Journal of Antibiotics 36(8): 1059-1066

Omura, S.; Iwai, Y.; Nakagawa, A.; Iwata, R.; Takahashi, Y.; Shimizu, H.; Tanaka, H. 1983: Thiotetromycin,a new antibiotic. Taxonomy,production,isolation,and physicochemical and biological properties. The Journal of Antibiotics 36(2): 109-114

Ikemoto, T.; Matsunaga, H.; Konishi, K.; Okazaki, T.; Enokita, R.; Torikata, A. 1983: Aculeximycin, a new antibiotic from Streptosporangium albidum. I. taxonomy of producing organism and fermentation. The Journal of Antibiotics 36(9): 1093-1096

Marquez, J.A.; Horan, A.C.; Kalyanpur, M.; Lee, B.K.; Loebenberg, D.; Miller, G.H.; Patel, M.; Waitz, J.A. 1983: The hazimicins, a new class of antibiotics taxonomy, fermentation, isolation, characterizacs. taand biological properties. The Journal of Antibiotics 36(9): 1101-1108

Inouye, S.; Kojima, M.; Shomura, T.; Iwamatsu, K.; Niwa, T.; Kondo, Y.; Niida, T.; Ogawa, Y.; Kusama, K. 1983: Discovery,isolation and structure of novel cephamycins of Streptomyces chartreusis. The Journal of Antibiotics 36(2): 115-124

Gerth, K.; Jansen, R.; Reifenstahl, G.; Höfle, G.; Irschik, H.; Kunze, B.; Reichenbach, H.; Thierbach, G. 1983: The myxalamids, new antibiotics from Myxococcus xanthus (Myxobacterales) I. production, physico-chemical and biological properties, and mechanism of action. The Journal of Antibiotics 36(9): 1150-1156

Sakagami, K.; Mishina, T.; Kuroda, T.; Hatanaka, M.; Ishimaru, T. 1983: Synthetic cephalosporins the synthesis and antibacterial activities of 7-(2-(2-(amino-1,3,4-thiadiazol-5-yl)acetamido)cephalosporins. The Journal of Antibiotics 36(9): 1205-1210

Hayashi, T.; Okutomi, T.; Suzuki, S.; Okazaki, H. 1983: Inhibition of nucleic acid biosynthesis in procaryotic and eucaryotic cells by cyanocycline A. The Journal of Antibiotics 36(9): 1228-1235

Singh, P.D.; Johnson, J.H.; Ward, P.C.; Wells, J.S.; Trejo, W.H.; Sykes, R.B. 1983: Sq 28,332,a new monobactam produced by a Flexibacter sp. Taxonomy,fermentation,isolation,structure determination and biological properties. The Journal of Antibiotics 36(10): 1245-1251

Cooper, R.; Bush, K.; Principe, P.A.; Trejo, W.H.; Wells, J.S.; Sykes, R.B. 1983: Two new monobactam antibiotics produced by a Flexibacter sp. I. Taxonomy,fermentation,isolation and biological properties. The Journal of Antibiotics 36(10): 1252-1257

Ezaki, N.; Koyama, M.; Shomura, T.; Tsuruoka, T.; Inouye, S. 1983: Pyrrolomycins C,D and E,new members of pyrrolomycins. The Journal of Antibiotics 36(10): 1263-1267

Iwai, Y.; Kimura, K.; Takahashi, Y.; Hinotozawa, K.; Shimizu, H.; Tanaka, H.; Omura, S. 1983: Om-173,new nanaomycin-type antibiotics produced by a strain of streptomyces. Taxonomy,production,isolation and biological properties. The Journal of Antibiotics 36(10): 1268-1274

Westley, J.W.; Liu, C.-M.; Blount, J.F.; Sello, L.H.; Troupe, N.; Miller, P.A. 1983: Isolation and characterization of a novel polyether antibiotic of the pyrrolether class,antibiotic X-14885A. The Journal of Antibiotics 36(10): 1275-1278

Ikeda, Y.; Shimada, Y.; Honjo, K.; Okumoto, T.; Munakata, T. 1983: Safracins,new antitumor antibiotics Iii. biological activity. The Journal of Antibiotics 36(10): 1290-1294

Kido, Y.; Hamakado, T.; Yoshida, T.; Anno, M.; Motoki, Y. 1983: Isolation and characterization of ancovenin,a new inhibitor of angiotensin I converting enzyme,produced by Actinomycetes. The Journal of Antibiotics 36(10): 1295-1299

Becker, A.M.; Herlt, A.J.; Hilton, G.L.; Kibby, J.J.; Rickards, R.W. 1983: 3-Amino-5-hydroxybenzoic acid in antibiotic biosynthesis Vi. Directed biosynthesis studies with ansamycin antibiotics. The Journal of Antibiotics 36(10): 1323-1328

Sano, H.; Inoue, M.; Yamashita, K.; Okachi, R.; Omura, S. 1983: Chemical modification of spiramycins I. Synthesis of the acetal derivatives of neospiramycin I. The Journal of Antibiotics 36(10): 1336-1344

Erickson, R.C.; Baumann, R.J.; Gibson, C.B.; Hoffman, P.F. 1983: In vitro and in vivo evaluation of Mdl 19,592,an oral cephalosporin. The Journal of Antibiotics 36(10): 1345-1356

Basker, M.J.; Boon, R.J.; Box, S.J.; Brown, A.G.; Davis, P.; Ponsford, R.J.; Southgate, R.; Spear, S.R. 1983: Comparative biological properties of some synthetic olivanic acid analogues. The Journal of Antibiotics 36(10): 1357-1371

Kobaru, S.; Tsunakawa, M.; Hanada, M.; Konishi, M.; Tomita, K.; Kawaguchi, H. 1983: Bu-2743E,a leucine aminopeptidase inhibitor,produced by Bacillus circulans. The Journal of Antibiotics 36(10): 1396-1398

Nishio, M.; Yasuda, N.; Nakamura, S. 1983: Neo-enactins A,B1 and B2,new antifungal antibiotics potentiating polyene antifungal antibiotics. The Journal of Antibiotics 36(10): 1399-1401

Tozuka, Z.; Takaya, T. 1983: Studies on tomaymycin. I The structure determination of tomaymycin on the basis of Nmr spectra. The Journal of Antibiotics 36(2): 142-146

Dolak, L.A.; Castle, T.M.; Hannon, B.R.; Argoudelis, A.D.; Reusser, F. 1983: Fermentation,isolation,characterization and structure of nitrosofungin. The Journal of Antibiotics 36(11): 1425-1430

Ezaki, N.; Koyama, M.; Kodama, Y.; Shomura, T.; Tashiro, K.; Tsuruoka, T.; Inouye, S.; Sakai, S.-I. 1983: Pyrrolomycins F1,F2a,F2b and F3,new metabolites produced by the addition of bromide to the fermentation. The Journal of Antibiotics 36(11): 1431-1438

Winkelmann, G.; Allgaier, H.; Lupp, R.; Jung, G. 1983: Iturin Al - A new long chain iturin a possessing an unusual high content of C16-.Beta.-amino acids. The Journal of Antibiotics 36(11): 1451-1457

Hoshino, T.; Sekine, Y.; Fujiwara, A. 1983: Microbial Conversion of Anthracycline Antibiotics I. Microbial Conversion of Aclacinomycin Bto Aclacinomycin a. The Journal of Antibiotics 36(11): 1458-1459

Hoshino, T.; Fujiwara, A. 1983: Microbial conversion of anthracycline antibiotics Ii. Characterization of the microbial conversion products of auramycinone by Streptomyces coeruleorubidus Atcc 31276. The Journal of Antibiotics 36(11): 1463-1467

Nakamura, G.; Isono, K. 1983: A new species of Actinomadura producing a polyether antibiotic,cationomycin. The Journal of Antibiotics 36(11): 1468-1472

Yoshioka, T.; Kojima, I.; Isshiki, K.; Watanabe, A.; Shimauchi, Y.; Okabe, M.; Fukagawa, Y.; Ishikura, T. 1983: Structures of Oa-6129A,B1,B2 and C,new carbapenem antibiotics produced by Streptomyces sp. Oa-6129. The Journal of Antibiotics 36(11): 1473-1482

Koyama, M.; Ezaki, N.; Tsuruoka, T.; Inouye, S. 1983: Structural studies on pyrrolomycins C,D and E. The Journal of Antibiotics 36(11): 1483-1489

Marsili, L.; Franceschi, G.; Ballabio, M.; Oronzo, G.; Vigevani, A.; Ungheri, D.; Bruna, C.D.; Sanfilippo, A. 1983: Novel rifamycins. Iii Synthesis and antibacterial activity of 3-amidino- and of 4-aminoimidazolo(4,5-c)rifamycin derivatives. The Journal of Antibiotics 36(11): 1495-1501

Bruna, C.D.; Schioppacassi, G.; Ungheri, D.; Jabès, D.; Morvillo, E.; Sanfilippo, A. 1983: Lm 427,a new spiropiperidylrifamycin: In vitro and in vivo studies. The Journal of Antibiotics 36(11): 1502-1506

Takahashi, K.; Tomita, F. 1983: Gilvocarcins,new antitumor antibiotics 5. Biosynthesis of gilvocarcins: Incorporation of 13C-labeled compounds into gilvocarcin aglycones. The Journal of Antibiotics 36(11): 1531-1535

Nadkarni, S.R.; Patel, M.V.; Reddy, G.C.S.; Reden, J.; Ganguli, B.N. 1983: In vitro synergy of actithiazic acid,an antimetabolite of biotin,combined with cephalexin. The Journal of Antibiotics 36(11): 1567-1568

Kawai, H.; Hayakawa, Y.; Nakagawa, M.; Imamura, K.; Tanabe, K.; Shimazu, A.; Seto, H.; Otake, N. 1983: Arugomycin,a new anthracycline antibiotic. The Journal of Antibiotics 36(11): 1569-1571

Umezawa, H.; Aoyagi, T.; Ohuchi, S.; Okuyama, A.; Suda, H.; Takita, T.; Hamada, M.; Takeuchi, T. 1983: Arphamenines A and B,new inhibitors of aminopeptidase B,produced by bacteria. The Journal of Antibiotics 36(11): 1572-1575

Stampwala, S.S.; Bunge, R.H.; Hurley, T.R.; Willmer, N.E.; Brankiewicz, A.J.; Steinman, C.E.; Smitka, T.A.; French, J.C. 1983: Novel antitumor agents Ci-920,Pd113,270 and Pd113,271. Ii. Isolation and characterization. The Journal of Antibiotics 36(12): 1601-1605

Fukushima, K.; Arai, T.; Mori, Y.; Tsuboi, M.; Suzuki, M. 1983: Studies on peptide antibiotics, leucinostatins. I. Separation, physico-chemical properties and biological activities of leucinostatins A and B. The Journal of Antibiotics 36(12): 1606-1612

Box, S.J.; Gilpin, M.L.; Gwynn, M.; Hanscomb, G.; Spear, S.R.; Brown, A.G. 1983: Mm14201, a new epoxyquinone derivative with antibacterial activity produced by a species of Streptomyces. The Journal of Antibiotics 36(12): 1631-1637

Shoji, J.''ichi; Sakazaki, R.; Matsumoto, K.; Tanimoto, T.; Terui, Y.; Kozuki, S.; Kondo, E. 1983: Isolation of 7.Beta.-(5-hydroxy-5-carboxyvarelamido)-3-hydroxymethyl-3-cephem-4-carboxylic acid from Streptomyces sp. The Journal of Antibiotics 36(2): 167-169

Tozuka, Z.; Yazawa, H.; Murata, M.; Takaya, T. 1983: Studies on tomaymycin. Iii. Syntheses and antitumor activity of tomaymycin analogs. The Journal of Antibiotics 36(12): 1699-1708

Tillman, A.M.; Cane, D.E. 1983: Pentalenolactone F,a new metabolite isolated from Streptomyces. Isolation and structure elucidation. The Journal of Antibiotics 36(2): 170-172

Kawashima, A.; Nakagawa, M.; Hayakawa, Y.; Kawai, H.; Seto, H.; Otake, N. 1983: Studies on the differentiation inducers of myeloid leukemic cells Ii. Citrinin,a new inducer of the differentiation of M1 cells. The Journal of Antibiotics 36(2): 173-174

Takeda, K.; Kawaguchi, K.; Okanishi, M. 1983: Extraction, cloning and physical maps of plasmid Dnas from Streptomyces noursei. The Journal of Antibiotics 36(12): 1743-1747

Hayashi, M.; Kinoshita, K.; Sudate, Y.; Satoi, S.; Sakakibara, H.; Harada, K.-I.; Suzuki, M. 1983: Mycinamicins,new macrolide antibiotics. Vii Structures of minor components,mycinamicin Vi and Vii. The Journal of Antibiotics 36(2): 175-178

Omura, S.; Otoguro, K.; Tanaka, H. 1983: The mode of action of a novel 18-membered macrolide, virustomycin A (Am-2604A), on Trichomonas foetus. The Journal of Antibiotics 36(12): 1755-1761

Curran, W.V.; Ross, A.A. 1983: 7.Beta.-(2-(2-Aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido)-3-((1,2,3-thiadiazol-5-yl)thiomethyl)ceph-3-em-4-carboxylic acid. A new potent cephalosporin derivative. The Journal of Antibiotics 36(2): 179-180

Meyers, E.; Cooper, R.; Trejo, W.H.; Georgopapadakou, N.; Sykes, R.B. 1983: Em5519,a new broad-spectrum antibiotic produced by Pseudomonas fluorescens. The Journal of Antibiotics 36(2): 190-193

Hosono, K.; Suzuki, H. 1983: Acylpeptides,the inhibitors of cyclic adenosine 3',5'-monophosphate phosphodiesterase. The Journal of Antibiotics 36(2): 194-196

Wakamiya, T.; Shiba, T. 1983: Semisynthesis of di-.Beta.-lysylcapreomycin Iia,a capreomycin analog effective against viomycin-resistant Mycobacterium. The Journal of Antibiotics 36(2): 197-199

Pruess, D.L.; Kellett, M. 1983: Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity. The Journal of Antibiotics 36(3): 208-212

EVANSJr., R.H.; Ax, H.; Jacoby, A.; Williams, T.H.; Jenkins, E.; Scannell, J.P. 1983: Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. Ii. Fermentation, isolation and structure. The Journal of Antibiotics 36(3): 213-216

Iwamatsu, K.; Inouye, S.; Tsuruoka, T.; Mizutani, K.; Omoto, S.; Ogino, H.; Miyauchi, K.; Watanabe, T.; Niida, T. 1983: Synthesis and biological activity of 7.Beta.-(2-amino-2-carboxy)- ethylthioacetamido-7.Alpha.-methoxycephalosporin derivatives. The Journal of Antibiotics 36(3): 229-241

Yasuda, N.; Iwagami, H.; Nakanishi, E.; Nakamiya, T.; Sasaki, Y.; Murata, T. 1983: Synthesis and antibacterial activity of 6- and 7- (2-(5-carboxyimidazole-4-carboxamido)phenylacetamido)-penicillins and cephalosporins. The Journal of Antibiotics 36(3): 242-249

Liu, C.-M.; Hermann, T.E.; Downey, A.; Prosser, B.L.T.; Schildknecht, E.; Palleroni, N.J.; Westley, J.W.; Miller, P.A. 1983: Novel polyether antibiotics X-14868A,B,C,and D produced by a Nocardia. Discovery,fermentation,biological as well as ionophore properties and taxonomy of the producing culture. The Journal of Antibiotics 36(4): 343-350

Sehgal, S.N.; Baker, H.; Eng, C.P.; Singh, K.; Véezina, C. 1983: Demethoxyrapamycin (Ay-24,668),a new antifungal antibiotic. The Journal of Antibiotics 36(4): 351-354

Sehgal, S.N.; Czerkawski, H.; Kudelski, A.; Pandev, K.; Saucier, R.; Vézina, C. 1983: Ravidomycin (Ay-25,545),a new antitumor antibiotic. The Journal of Antibiotics 36(4): 355-361

Spagnoli, R.; Cappelletti, L.; Toscano, L. 1983: Biological conversion of erythronolide B,an intermediate of erythromycin biogenesis,into new "hybrid" macrolide antibiotics. The Journal of Antibiotics 36(4): 365-375

Tani, K.; Yamaguchi, T. 1983: Studies on a new antibiotic M-92 produced by Micromonospora V. Mechanism of action of the component Va-2. The Journal of Antibiotics 36(4): 391-397

Mak, C.-P.; Prasad, K.; Turnowsky, F. 1983: Synthesis and .Beta.-lactamase inhibitory activities of some clavulanic acid analogues. The Journal of Antibiotics 36(4): 398-406

Okazaki, T.; Ono, M.; Aoki, A.; Fukuda, R. 1983: Milbemycins,a new family of macrolide antibiotics: Producing organism and its mutants. The Journal of Antibiotics 36(4): 438-441

Hamada, M.; Kondo, S.; Nakamura, H.; Ikeda, T.; Ikeda, D.; Iinuma, K.; Gomi, S.; Ikeda, Y.; Takeuchi, T.; Umezawa, H. 1983: A new antibiotic,3,6-dihydroxyindoxazene. The Journal of Antibiotics 36(4): 445-447

Iinuma, H.; Nakamura, H.; Naganawi, H.; Masuda, T.; Takano, S.; Takeuchi, T.; Umezawa, H.; Iitaka, Y.; Obayashi, A. 1983: Basidalin,a new antibiotic from basidiomycetes. The Journal of Antibiotics 36(4): 448-450

Ishii, K.; Kondo, S.; Nishimura, Y.; Hamada, M.; Takeuchi, T.; Umezawa, H. 1983: Decilorubicin,a new anthracycline antibiotic. The Journal of Antibiotics 36(4): 451-453

Ishii, K.; Nishimura, Y.; Kondo, S.; Umezawa, H. 1983: Decilonitrose and 4-O-succinyl-L-diginose,sugar components of decilorubicin. The Journal of Antibiotics 36(4): 454-456

Takahashi, K.; Tomita, F. 1983: Dc-52, a novel antitumor antibiotic. 2. Isolation, physico-chemical characteristics and structure determination. The Journal of Antibiotics 36(5): 468-470

Takeuchi, M.; Itoh, Y.; Enokita, R.; Torikata, A.; Iwado, S.; Haneishi, T. 1983: New antibiotic, isohematinic acid. I. Taxonomy of producing organism, fermentation and isolation. The Journal of Antibiotics 36(5): 493-496

Itoh, Y.; Takeuchi, M.; Shimizu, K.; Takahashi, S.; Terahara, A.; Haneishi, T. 1983: New antibiotic, isohematinic acid. Ii. Physico-chemical properties, structural elucidation and biological activities. The Journal of Antibiotics 36(5): 497-501

Yamada, H.; Jimpo, K.; Tobiki, H.; Komatsu, T.; Noguchi, H.; Irie, K.; Nakagome, T. 1983: New broad-spectrum cephalosporins with anti-pseudomonal activity. I. Synthesis and antibacterial activity of 7.Beta.-(D-2-((4-hydroxy-1,5-naphthyridine-3-carbonylamino)- and(4-hydroxypyridine-3-carbonylamino))-2-(4-hydoxyphenyl)acetamido)cephalosporins. The Journal of Antibiotics 36(5): 522-531

Yamada, H.; Tobiki, H.; Jimpo, K.; Gooda, K.; Takeuchi, Y.; Ueda, S.; Komatsu, T.; Okuda, T.; Noguchi, H.; Irie, K.; Nakagome, T. 1983: New broad-spectrum cephalosporins with anti-pseudomonal activity. Ii. Synthesis and antibacterial activity of 7.Beta.-(2-acylamino-2-(4-hydroxyphenyl)acetamido)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl)ceph-3-em-4-carboxylic acids. The Journal of Antibiotics 36(5): 532-542

Yamada, H.; Tobiki, H.; Jimpo, K.; Komatsu, T.; Okuda, T.; Noguchi, H.; Nakagome, T. 1983: New broad-spectrum cephalosporins with anti-pseudomonal activity. Iii. Synthesis and antibacterial activity of 7.Beta.-(D-2-(4-hydroxy-6-methylpyridine-3-carbonylamino)-2-(4-hydroxyphenyl)acetamido)-3-(methyl or substituted methyl)-ceph-3-em-4-carboxylic acids. The Journal of Antibiotics 36(5): 543-551

Irschik, H.; Gerth, K.; Kemmer, T.; Steinmetz, H.; Reichenbach, H. 1983: The myxovalargins, new peptide antibiotics from Myxococcus fulvus (myxobacterales). I. Cultivation, isolation, and some chemical and biological properties. The Journal of Antibiotics 36(1): 6-12

Erizawa, N.; Nakagawa, K.; Tsujita, Y.; Terahara, A.; Uwano, H. 1983: 3.Alpha.-Hydroxy-Ml-236B(3.Alpha.-hydroxycompactin), microbial transformation product of Ml-236B (compactin). The Journal of Antibiotics 36(5): 608-610

Celozzi, E.; Pelak, B.A.; Stapley, E.O.; Gadebusch, H.H. 1983: Quaternary heterocyclylamino .Beta.-lactams. Iv. Comparison of the in vivo antibacterial activities of L-640,876, mecillinam, cefoxitin and cefotaxime. The Journal of Antibiotics 36(1): 64-69

Jacks, T.M.; Schleim, K.D.; Miller, B.M.; Shungu, D.L.; Weinberg, E.; Gadebusch, H.H. 1983: Quaternary heterocyclylamino .Beta.-lactams. V. L-640,876 treatment of induced enterotoxigenic colibacillosis (scours) in calves and piglets. The Journal of Antibiotics 36(1): 70-75

Veiga, M.; Fabregas, J. 1983: Tetrafungin, a new polyene macrolide antibiotic. I. Fermentation, isolation, characterization, and biological properties. The Journal of Antibiotics 36(7): 770-775

Takasugi, H.; Kochi, H.; Masugi, T.; Nakano, H.; Takaya, T. 1983: Studies on .Beta.-lactam antibiotics. Vii. Effect on antibacterial activity of the oxime O-substituents with various functional groups in the 7.Beta.-((Z)-2-(2-amino-4-thiazolyl)-2-oxyiminoacetamido)cephalosporins. The Journal of Antibiotics 36(7): 846-854

Serizawa, N.; Serizawa, S.; Nakagawa, K.; Furuya, K.; Okazaki, T.; Terahara, A. 1983: Microbial hydroxylation of Ml-236B (compactin) Studies on microorganisms capable of 3.Beta.-hydroxylation of Ml-236B. The Journal of Antibiotics 36(7): 887-891

Magae, J.; Nagai, K.; Ando, K.; Yamasaki, M.; Tamura, G. 1983: Effects of an antitumor agent, ascofuranone, on the macromolecular syntheses of intact cells. The Journal of Antibiotics 36(7): 892-899

Tanaka, A.; Morita, J.; Komano, T. 1983: Aclacinomycin A-inhibition of phage .Phi.X174 Dna synthesis in vitro. The Journal of Antibiotics 36(7): 900-906

Serizawa, N.; Nakagawa, K.; Tsujita, Y.; Terahara, A.; Kuwano, H.; Tanaka, M. 1983: 6.Alpha.-Hydroxy-iso-Ml-236B (6.Alpha.-hydroxy-iso-compactin) and Ml-236A, Microbial transformation products of Ml-236B. The Journal of Antibiotics 36(7): 918-920

Franceschi, G.; Foglio, M.; Alpegiani, M.; Battistini, C.; Bedeschi, A.; Perrone, E.; Zarini, F.; Arcamone, F.; Bruna, C.D.; Sanfilippo, A. 1983: Synthesis and biological properties of sodium (5R,6S,8R)-6.Alpha.-hydroxyethyl-2-carbamoyloxymethyl-2-penem-3-carboxylate (Fce 22101) and its orally absorbed esters Fce 22553 and Fce 22891. The Journal of Antibiotics 36(7): 938-941

Mishima, H.; Ide, J.; Muramatsu, S.; Ono, M. 1983: Milbemycins, a new family of macrolide antibiotics. Structure determination of milbemycins D,E,F,G,H,J and K. The Journal of Antibiotics 36(8): 980-990

Ono, M.; Mishima, H.; Takiguchi, Y.; Terao, M.; Kobayashi, H.; Iwasaki, S.; Okuda, S. 1983: Milbemycins, a new family of macrolide antibiotics. Studies on the biosynthesis of milbemycins .Alpha.2, .Alpha.4 and D using 13C labeled precursors. The Journal of Antibiotics 36(8): 991-1000

Hashizume, T.; Park, W.; Matsuhashi, M. 1984: The affinity of impienem (N-formimidoylthienamycin) for the penicillin-binding proteins of Staphylococcus aureus. Binding and release. The Journal of Antibiotics 37(9): 1049-1053

Iwaki, H.; Nakayama, Y.; Takahashi, M.; Uetsuki, S.; Kido, M.; Fukuyama, Y. 1984: Structures of rishirilides A and B, .Alpha.2-macroglobulin inhibitors produced by Streptomyces rishiriensis Ofr-1056. The Journal of Antibiotics 37(9): 1091-1093

Kurath, P.; Rosenbrook, W.; Dunnigan, D.A.; Mcalpine, J.B.; Egan, R.S.; Stanaszek, R.S.; Cirovic, M.; Mueller, S.L.; Washburn, W.H. 1984: Lysinomicin, a new aminoglycoside antibiotic. Ii. Structure and stereochemistry. The Journal of Antibiotics 37(10): 1130-1143

Tohyama, H.; Miyadoh, S.; Ito, M.; Shomura, T.; Ito, T.; Ishikawa, T.; Kojima, M. 1984: A new indole N-glycoside antibiotic Sf-2140 from an Actinomadura. I. Taxonomy and fermentation of producing microorganism. The Journal of Antibiotics 37(10): 1144-1148

Lee, M.D.; Fantini, A.A.; Morton, G.O.; James, J.C.; Borders, D.B.; Testa, R.T. 1984: New antitumor antibiotic, Ll-C10037.Alpha. fermentation, isolation and structure determination. The Journal of Antibiotics 37(10): 1149-1152

Takesako, K.; Beppu, T. 1984: Studies on new antifungal antibiotics, guanidylfungins A and B. Ii. Structure elucidation and biosynthesis. The Journal of Antibiotics 37(10): 1170-1186

Fukagawa, Y.; Mutoh, Y.; Ishikura, T.; Lein, J. 1984: Deepoxidation of 16-membered epoxyenone macrolide antibiotics. I. Microbial deepoxidation and subsequent isomerization of deltamycins A1, A2, A3, A4 (carbomycin A) and X. The Journal of Antibiotics 37(2): 118-126

Marsili, L.; Franceschi, G.; Ballabio, M.; Vioglio, S.; Vigevani, A.; Ungheri, D.; Bruna, C.D.; Sanfilippo, A. 1984: Novel rifamycins. Iv. 3-Aminomethylazinomethylrifamycins, a new class of rifamycins, endowed with remarkable antibacterial activity. The Journal of Antibiotics 37(10): 1209-1212

Mutoh, Y.; Shimauchi, Y.; Fukagawa, Y.; Ishikura, T.; Lein, J. 1984: Deepoxidation of 16-membered epoxyenone macrolide antibiotics. Ii. Chemical deepoxidation by dissolving metal reduction. The Journal of Antibiotics 37(2): 127-129

Yamashita, M.; Tsurumi, Y.; Hosoda, J.; Komori, T.; Kohsaka, M.; Imanaka, H. 1984: Chryscandin, a novel peptidyl nucleoside antibiotic. I Taxonomy, fermentation, isolation and characterization. The Journal of Antibiotics 37(11): 1279-1283

Fukagawa, Y.; Okabe, M.; Azuma, S.; Kojima, I.; Ishikura, T.; Kubo, K. 1984: Studies on the biosynthesis of carbapenem antibiotics. I. Biosynthetic significance of the Oa-6129 group of carbapenem compounds as the direct precursors for Ps-5, epithienamycins A and C and Mm 17880. The Journal of Antibiotics 37(11): 1388-1393

Kubo, K.; Ishikura, T.; Fukagawa, Y. 1984: Studies on the biosynthesis of carbapenem antibiotics. Ii. Isolation and functions of a specific acylase involved in the depantothenylation of the Oa-6129 compounds. The Journal of Antibiotics 37(11): 1394-1402

Imai, S.; Seto, H.; Sasaki, T.; Tsuruoka, T.; Ogawa, H.; Satoh, A.; Inouye, S.; Niida, T.; Otake, N. 1984: Studies on the biosynthesis of bialaphos (Sf-1293) 4. Production of phosphonic acid derivatives, 2-hydroxyetheylphosphonic acid,hydroxymethylphosphonic acid and phosphonoformic acid by blocked mutants of Streptomyces hygroscopicus Sf-1293 and their roles in the biosynthesis of bialaphos. The Journal of Antibiotics 37(11): 1505-1508

Karwowski, J.P.; Jackson, M.; Bobik, T.A.; Prokop, J.F.; Theriault, R.J. 1984: Spenolimycin, a new spectinomycin-type antibiotic. I. Discovery, taxonomy and fermentation. The Journal of Antibiotics 37(12): 1513-1518

Mcalpine, J.B.; Brill, G.M.; Spanton, S.G.; Mueller, S.L.; Stanaszek, R.S. 1984: Spenolimycin, a new spectinomycin-type antibiotic. Ii. Isolation and structure determination. The Journal of Antibiotics 37(12): 1519-1524

Ono, H.; Nozaki, Y.; Katayama, N.; Okazaki, H. 1984: Cephabacins, new cephem antibiotics of bacterial origin. I. Discovery and taxonomy of the producing organisms and fermentation. The Journal of Antibiotics 37(12): 1528-1535

Harada, S.; Tsubotani, S.; Ono, H.; Okazaki, H. 1984: Cephabacins, new cephem antibiotics of bacterial origin. Ii. Isolation and characterization. The Journal of Antibiotics 37(12): 1536-1545

Nozaki, Y.; Okonogi, K.; Katayama, N.; Ono, H.; Harada, S.; Kondo, M.; Okazaki, H. 1984: Cephabacins, new cephem antibiotics of bacterial origin. Iv. Antibacterial activities, stability to .Beta.-lactamases and mode of action. The Journal of Antibiotics 37(12): 1555-1565

Bunge, R.H.; Hurley, T.R.; Smitka, T.A.; Willmer, N.E.; Brankiewicz, A.J.; Steinman, C.E.; French, J.C. 1984: Pd 114,759 and Pd 115,028, novel antitumor antibiotics with phenomenal potency. I. Isolation and characterization. The Journal of Antibiotics 37(12): 1566-1571

Brufani, M.; Cellai, L.; Marchi, E.; Segre, A. 1984: The synthesis of 4-deoxypyrido(1',2'-1,2)imidazo(5,4-c)rifamycin Sv derivatives. The Journal of Antibiotics 37(12): 1611-1622

Brufani, M.; Cellai, L.; Cerrini, S.; Fedeli, W.; Marchi, E.; Segre, A.; Vaciago, A. 1984: X-ray crystal structure of 4-deoxy-3'-bromopyrido(1',2'-1,2)imidazo(5,4-c)rifamycin S. The Journal of Antibiotics 37(12): 1623-1627

Itoh, S.; Odakura, Y.; Kase, H.; Satoh, S.; Takahashi, K.; Iida, T.; Shirahata, K.; Nakayama, K. 1984: Biosynthesis of astromicin and related antibiotics. I. Biosynthetic studies by bioconversion experiments. The Journal of Antibiotics 37(12): 1664-1669

Odakura, Y.; Kase, H.; Itoh, S.; Satoh, S.; Takasawa, S.; Takahashi, K.; Shirahata, K.; Nakayama, K. 1984: Biosynthesis of astromicin and related antibiotics. Ii. Biosynthetic studies with blocked mutants of Micromonospora olivasterospora. The Journal of Antibiotics 37(12): 1670-1680

Limbert, M.; Bartlett, R.R.; Dickneite, G.; Klesel, N.; Schorlemmer, H.U.; Seibert, G.; Winkler, I.; Schrinner, E. 1984: Cefodizime, an aminothiazolyl cephalosporin. Iv. Influence on the immune system. The Journal of Antibiotics 37(12): 1719-1726

Dixon, R.A.; Edmondson, R.A.; Hardy, K.D.; Milner, P.H. 1984: The synthesis and antibacterial activity of some .Beta.-lactamase stable 6.Alpha.-(hydroxymethyl)penicillins. The Journal of Antibiotics 37(12): 1729-1731

Dixon, R.A.; Hardy, K.D.; Kaura, A.C.; Milner, P.H.; Taylor, A.W. 1984: The synthesis and antibacterial activities of novel 7.Alpha. substituted cephalosporins. The Journal of Antibiotics 37(12): 1732-1735

Konishi, M.; Hatori, M.; Tomita, K.; Sugawara, M.; Ikeda, C.; Nishiyama, Y.; Imanishi, H.; Miyaki, T.; Kawaguchi, H. 1984: Chicamycin, a new antitumor antibiotic. I. Production, isolation and properties. The Journal of Antibiotics 37(3): 191-199

Inamura, N.; Fujitsu, T.; Nakahara, K.; Abiko, M.; Horii, Y.; Hashimoto, S.; Aoki, H. 1984: Potentiation of tumoricidal properties of murine macrophages by Nocardia rubra cell wall skeleton (N-Cws). The Journal of Antibiotics 37(3): 244-252

Nakao, M.; Nishi, T.; Kondo, M.; Fugono, T.; Imada, A.; Tsuchiya, K. 1984: Relevance of in vitro antibacterial activities and pharmacokinetic properties of antipseudomonal .Beta.-lactam antibiotics to their therapeutic effects on urinary tract infection caused by Pseudomonas aeruginosa P 9 in mice. The Journal of Antibiotics 37(3): 275-284

Kaneko, T.; Wong, H.; Doyle, T.W. 1984: A total synthesis of chicamycin A. A new pyrrolo(1,4)benzodiazepine antitumor agent. The Journal of Antibiotics 37(3): 300-302

Cavalleri, B.; Pagani, H.; Volpe, G.; Selva, E.; Parenti, F. 1984: A-16686, a new antibiotic from Actinoplanes I. Fermentation, isolation and preliminary physico-chemical characteristics. The Journal of Antibiotics 37(4): 309-317

Pallanza, R.; Berti, M.; Scotti, R.; Randisi, E.; Arioli, V. 1984: A-16686, a new antibiotic from actinoplanes Ii. Biological properties. The Journal of Antibiotics 37(4): 318-324

Allen, T.E.; Brown, D.J.; Cowden, W.B.; Grigg, G.W.; Hart, N.K.; Lamberton, J.A.; Lane, A. 1984: Amplification of the antitumor activity of phleomycins in rats and mice by heterocyclic analogues of purines. The Journal of Antibiotics 37(4): 376-383

Ogawa, Y.; Mori, H.; Yamada, N.; Kon, K. 1984: The absolute structures of rubeomycins A and A1 (carminomycins Ii and Iii) and rubeomycins B and B1 (4-hydroxybaumycinols A1 and A2). The Journal of Antibiotics 37(1): 44-56

Kunze, B.; Kemmer, T.; Höfle, G.; Reichenbach, H. 1984: Stigmatellin, a new antibiotic from Stigmatella aurantiaca (Myxobacterales). I. Production, physico-chemical and biological properties. The Journal of Antibiotics 37(5): 454-461

Watanabe, K.; Furumai, T.; Sudoh, M.; Yokose, K.; Maruyama, H.B. 1984: New .Alpha.-amylase inhibitor, trestatins. Iv. Taxonomy of the producing strains and fermentation of trestatin A. The Journal of Antibiotics 37(5): 479-486

Shindoh, Y.; Nakano, M.M.; Ogawara, H. 1984: Pock-forming plasmids isolated from Streptomyces roseochromogenus. The Journal of Antibiotics 37(5): 512-517

Goto, J.; Sakane, K.; Nakai, Y.; Eraji, T.; Kamiya, T. 1984: Studies of 7.Beta.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. I. Synthesis and structure-activity relationships in the aminopyridine series. The Journal of Antibiotics 37(5): 532-545

Goto, J.; Sakane, K.; Nakai, Y.; Teraji, T.; Amiya, T. 1984: Studies of 7.Beta.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. Ii. Synthesis and structure-activity relationships in the aminopyrimidine series. The Journal of Antibiotics 37(5): 546-556

Goto, J.; Sakane, K.; Teraji, T. 1984: Studies of 7.Beta.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. Iii. Synthesis and structure-activity relationships in the aminothiadiazole series. The Journal of Antibiotics 37(5): 557-571

Okuda, T.; Yoneyama, Y.; Fujiwara, A.; Furumai, T. 1984: Penitricin, a new class of antibiotic produced by Penicillium aculeatum. I. Taxonomy of the producer strain and fermentation. The Journal of Antibiotics 37(7): 712-717

Okuda, T.; Yokose, K.; Furumai, T.; Maruyama, H.B. 1984: Penitricin, a new class of antibiotic produced by Penicillium aculeatum. Ii. Isolation and characterization. The Journal of Antibiotics 37(7): 718-722

Samanta, A.K.; Bose, S.K. 1984: Mycoversilin, a New Antifungal Antibiotic. The Journal of Antibiotics 37(7): 728-732

Samanta, A.K.; Bose, S.K.; Mahato, S.B. 1984: Mycoversilin, a new antifungal antibiotic. Ii. Structure elucidation. The Journal of Antibiotics 37(7): 733-737

Sang, H.; Inoue, M.; Omura, S. 1984: Chemical modification of spiramycins. Ii. Synthesis and antimicrobial activity of 4'-deoxy derivatives of neospiramycin I and their 12-(Z)-isomers. The Journal of Antibiotics 37(7): 738-749

Sano, H.; Sunazuka, T.; Tanaka, H.; Yamashita, K.; Okachi, R.; Omura, S. 1984: Chemical modification of spiramycins. Iv. Synthesis and in vitro and in vivo activities of 3", 4"-diacylates and 3, 3" ,4"-triacylates of spiramycin I. The Journal of Antibiotics 37(7): 760-772

Westley, J.W.; Liu, C.-M.; Sello, L.H.; Troupe, N.; Blount, J.F.; Chiu, A.-M.; Todaro, L.J.; Miller, P.A.; Liu, M. 1984: Isolation and characterization of antibotic X-14931A, the naturally occurring 19-deoxyaglycone of dianemycin. The Journal of Antibiotics 37(7): 813-815

Seto, H.; Noguchi, H.; Sankawa, U.; Iitaka, Y. 1984: Studies on the Biosynthesis of Pentalenolactone. The Journal of Antibiotics 37(7): 816-817

Smitka, T.A.; Bunge, R.H.; Bloem, R.J.; French, J.C. 1984: Two new trichothecenes, Pd113,325 and Pd113,326. The Journal of Antibiotics 37(8): 823-828

Limbert, M.; Klesel, N.; Seeger, K.; Seibert, G.; Winkler, I.; Schrinner, E. 1984: Cefodizime, an aminothiazolylcephalosporin. I. In vitro activity. The Journal of Antibiotics 37(8): 892-900

Klesel, N.; Limbert, M.; Seeger, K.; Seibert, G.; Winkler, I.; Schrinner, E. 1984: Cefodizime, an aminothiazolylcephalosporin. Ii. Comparative studies on the pharmacokinetic behavior in laboratory animals. The Journal of Antibiotics 37(8): 901-909

Seibert, G.; Limbert, M.; Klesel, N. 1984: Synergistic activity in vitro of the new cephalosporin antibiotic Hr810 with gentamicin and amikacin against multiresistant pathogens. The Journal of Antibiotics 37(8): 929-930

Yoshimoto, A.; Johdo, O.; Takatsuki, Y.; Ishikura, T.; Sawa, T.; Takeuchi, T.; Umezawa, H. 1984: New anthracycline antibiotics obtained by microbial glycosidation of .Beta.-isorhodomycinone and .Alpha.2-rhodomycinone. The Journal of Antibiotics 37(8): 935-938

Sugawara, K.; Numata, K.-I.; Konishi, M.; Kawaguchi, H. 1984: Empedopeptin (Bmy-28117), a new depsipeptide antibiotic. Ii. Structure determination. The Journal of Antibiotics 37(9): 958-964

Kido, Y.; Hamakado, T.; Anno, M.; Miyagawa, E.; Motoki, Y.; Wakamiya, T.; Shiba, T. 1984: Isolation and characterization of I5B2, a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp. The Journal of Antibiotics 37(9): 965-969

Huang, L.; Albers-Schonberg, G.; Monaghan, R.L.; Jakubas, K.; Pong, S.S.; Hensens, O.D.; Burg, R.W.; Ostlind, D.A.; Conroy, J.; Stapley, E.O. 1984: Discovery, production and purification of the Na+,K+ activated Atpase inhibitor, L-681,110 from the fermentation broth of Streptomyces sp. Ma-5038. The Journal of Antibiotics 37(9): 970-975

Harada, K.-I.; Kimura, I.; Takami, E.; Suzuki, M. 1984: Structural investigation of the antibiotic sporaviridin. X. Isolation and characterization of components of N-acetylsporaviridins. The Journal of Antibiotics 37(9): 976-983

Yamanaka, H.; Takasugi, H.; Masugi, T.; Kochi, H.; Miyai, K.; Takaya, T. 1985: Studies on .Beta.-lactam antibiotics. Viii. Structure-activity relationships of 7.Beta.-((Z)-2-carboxymethoxyimino-2-arylacetamido)-3-cephem-4-carboxylic acids. The Journal of Antibiotics 38(8): 1068-1076

Jizba, J.V.; Sedmera, P.; Vanek, Z.; Drautz, H.; Zähner, H. 1985: Two thiolactones from Streptomyces Tue 2476. The Journal of Antibiotics 38(1): 111-112

Tsubotani, S.; Hida, T.; Ono, H.; Harada, S. 1985: Cephabacin M1-6, new 7-methoxycephem antibiotics of bacterial origin. Ii. Isolation, characterization and structural determination. The Journal of Antibiotics 38(9): 1152-1165

Uchida, T.; Imoto, M.; Watanabe, Y.; Miura, K.; Dobashi, T.; Matsuda, N.; Sawa, T.; Naganawa, H.; Hamada, M.; Takeuchi, T.; Umezawa, H. 1985: Saquaymycins, new aquayamycin-group antibiotics. The Journal of Antibiotics 38(9): 1171-1181

Komori, T.; Sakane, K.; Setoi, H.; Kawai, Y.; Teraji, T.; Kohsaka, M.; Imanaka, H. 1985: Structure activity relationships of synthetic antibiotic analogues of chryscandin. The Journal of Antibiotics 38(9): 1182-1203

Chan, J.A.; Shultis, E.A.; Dingerdissen, J.J.; Debrosse, C.W.; Roberts, G.D.; Snader, K.M. 1985: Chlorocardicin, a monocyclic .Beta.-lactam from a Streptomyces sp. Ii. Isolation, physico-chemical properties and structure determination. The Journal of Antibiotics 38(2): 139-144

Yoshida, K.; Iwami, M.; Umehara, Y.; Nishikawa, M.; Uchida, I.; Kohsaka, M.; Aoki, H.; Imanaka, H. 1985: Studies on Wb-3559 A,B,C and D, new potent fibrinolytic agents. I. Discovery, identification, isolation and characterization. The Journal of Antibiotics 38(11): 1469-1475

Uchida, I.; Yoshida, K.; Kawai, Y.; Takase, S.; Itoh, Y.; Tanaka, H.; Kohsaka, M.; Imanaka, H. 1985: Studies on Wb-3559 A,B,C and D, new potent fibrinolytic agents. Ii. Structure elucidation and synthesis. The Journal of Antibiotics 38(11): 1476-1486

Ogawara, H.; Uchino, K.; Akiyama, T.; Watanabe, S.-I. 1985: A new 5'-nucleotidase inhibitor, nucleoticidin. I. Taxonomy, fermentation, isolation and biological properties. The Journal of Antibiotics 38(2): 153-156

Uchino, K.; Ogawara, H.; Akiyama, T.; Fukuchi, A.; Shibata, S.; Takahashi, K.; Narui, T. 1985: A new 5'-nucleotidase inhibitor, nucleoticidin. Ii. Physico-chemical properties and structure elucidation. The Journal of Antibiotics 38(2): 157-160

Sowinski, P.; Kolodziejczyk, P.; Borowski, E. 1985: The structure of amphotericin A. I. Mass spectrometric analysis of dodecahydroamphotericin A. The Journal of Antibiotics 38(2): 169-174

Sowinski, P.; Pawlak, J.K.; Borowski, E.; Iwashita, T. 1985: The structure of amphotericin A. Ii. The complete structure of the antibiotic. The Journal of Antibiotics 38(2): 175-180

Vikmon, M.; Stadler-Szöke, Ã.; Szejtli, J. 1985: Solubilization of amphotericin B with .Gamma.-cyclodextrin. The Journal of Antibiotics 38(12): 1822-1824

Sano, H.; Tanaka, H.; Yamashita, K.; Okachi, R.; Omura, S. 1985: Chemical modification of spiramycins. V. Synthesis and antibacterial activity of 3'- or 4'"-de-N-methylspiramycin I and their N-substituted derivatives. The Journal of Antibiotics 38(2): 186-196

Yamada, T. 1985: Binding of (14C)tuberactinomycin O to ribosomes from Mycobacterium smegmatis. The Journal of Antibiotics 38(2): 266-269

Horii, S.; Fukase, H.; Higashide, E.; Yoneda, M.; Nishida, H.; Sakai, H.; Hirota, A.; Isogai, A. 1985: Structure of alahopcin(nourseimycin), a new dipeptide antibiotic. The Journal of Antibiotics 38(3): 302-311

Kanai, F.; Isshiki, K.; Umezawa, Y.; Morishima, H.; Naganawa, H.; Takita, T.; Takeuchi, T.; Umezawa, H. 1985: Vanoxonin, a new inhibitor of thymidylate synthetase. Ii. Structure determination and total synthesis. The Journal of Antibiotics 38(1): 31-38

Endo, A.; Hasumi, K.; Nakamura, T.; Kunishima, M.; Masuda, M. 1985: Dihydromonacolin L and monacolin X. new metabolites those inhibit cholesterol biosynthesis. The Journal of Antibiotics 38(3): 321-327

Cooper, R.; Wells, J.S.; Sykes, R.B. 1985: Novel Potentiators of -Lactam Antibiotics. The Journal of Antibiotics 38(4): 449-454

Rickards, R.W.; Wu, J.-P. 1985: Fujianmycins A and B, new benz(a)anthraquinone antibiotics from a Streptomyces species. The Journal of Antibiotics 38(4): 513-515

Shearer, M.C.; Actor, P.; Bowie, B.A.; Grappel, S.F.; Nash, C.H.; Newman, D.J.; Oh, Y.K.; Pan, C.H.; Nisbet, L.J. 1985: Aridicins, novel glycopeptide antibiotics. I. Taxonomy, production and biological activity. The Journal of Antibiotics 38(5): 555-560

Sitrin, R.D.; Chan, G.W.; Dingerdissen, J.J.; Holl, W.; Hoover, J.R.E.; Valenta, J.R.; Webb, L.; Snader, K.M. 1985: Aridicins, novel glycopeptide antibiotics. Ii. Isolation and characterization. The Journal of Antibiotics 38(5): 561-571

Ogawara, H.; Uchino, K.; Akiyama, T.; Watanabe, S.-I. 1985: New 5'-nucleotidase inhibitors, melanocidin A and melanocidin B. I. Taxonomy, fermentation, isolation and biological properties. The Journal of Antibiotics 38(5): 587-591

Uchino, K.; Ogawara, H.; Akiyama, T.; Fukuchi, A.; Shibata, S.; Takahashi, K.; Narui, T. 1985: New 5'-nucleotidase inhibitors, melanocidin A and melanocidin B. Ii. Physico-chemical properties and structure elucidation. The Journal of Antibiotics 38(5): 592-598

Okuda, T.; Furumai, T. 1985: Penitricin, a new class of antibiotic produced by Penicillium aculeatum. Iv. Biosynthesis. The Journal of Antibiotics 38(5): 631-635

Hotta, K.; Yamashita, F.; Okami, Y.; Umezawa, H. 1985: New antibiotic-producing streptomycetes, selected by antibiotic resistance as a marker. Ii. Features of a new antibiotic-producing clone obtained after fusion treatment. The Journal of Antibiotics 38(1): 64-69

Komori, T.; Ezaki, M.; Kino, E.; Kohsaka, M.; Aoki, H.; Imanaka, H. 1985: Lavendomycin, a new antibiotic. I. Taxonomy, isolation and characterization. The Journal of Antibiotics 38(6): 691-698

Burton, G.; Basker, M.J.; Bentley, P.H.; Best, D.J.; Dixon, R.A.; Harrington, F.P.; Kenyon, R.F.; Lashford, A.G.; Taylor, A.W. 1985: Preparation and structure-activity relationships of some 6.Alpha.-substituted penicillins. The Journal of Antibiotics 38(6): 721-739

Cassinelli, G.; Ballabio, M.; Arcamone, F.; Casazza, A.M.; Podesta, A. 1985: New anthracycline glycosides obtained by the nitrous acid deamination of daunorubicin, doxorubicin and their configurational analogues. The Journal of Antibiotics 38(7): 856-867

Umeda, Y.; Moriguchi, M.; Kuroda, H.; Nakamura, T.; Iinuma, H.; Takeuchi, T.; Umezawa, H. 1985: Synthesis and antitumor activity of spergualin analogues. I. Chemical modification of 7-guanidino-3-hydroxyacyl moiety. The Journal of Antibiotics 38(7): 886-898

Hayakawa, Y.; Iwakiri, T.; Imamura, K.; Seto, H.; Otake, N. 1985: Studies on the isotetracenone antibiotics. Ii. Kerriamycins A,B and C, new antitumor antibiotics. The Journal of Antibiotics 38(7): 960-963

Dall''asta, L.; Comini, A.; Garegnani, E.; Alberti, D.; Coppi, G. 1986: Antibacterial activity of some cephalosporins and their 7.Alpha.-methoxy derivatives. The Journal of Antibiotics 39(7): 1004-1006

Yamanaka, H.; Kawabata, K.; Miyai, K.; Takasugi, H.; Kamimura, T.; Mine, Y.; Takaya, T. 1986: Studies on .Beta.-lactam antibiotics. X. Synthesis and structure-activity relationships of 7.Beta.-((Z)-2-(2-amino-4-thiazolyl)-2-(carboymethoxyimino)acetamido)cephalosporin derivatives. The Journal of Antibiotics 39(1): 101-110

Singh, P.D.; Johnson, J.H.; Aklonis, C.A.; O''sullivan, J. 1986: Sq30,957, a new antibiotic produced by Penicillium funiculosum. Taxonomy, fermentation, isolation, structure determination, synthesis and antibacterial activity. The Journal of Antibiotics 39(8): 1054-1058

Hurley, T.R.; Smitka, T.A.; Wilton, J.H.; Bunge, R.H.; Hokanson, G.C.; French, J.C. 1986: Pd113,618 and Pd118,309, new pactamycin analogs. The Journal of Antibiotics 39(8): 1086-1091

Wheeler, W.J.; Deeter, J.B.; Finley, D.R.; Kinnick, M.D.; Koehler, R.; Obsorne, H.E.; Ott, J.T.; Swartzendruber, J.K.; Wishka, D.G. 1986: The synthesis and biological evaluation of 7.Beta.-(2-(5-amino-(1,2,4)oxadiazol-3-yl)-2-Z-methoximinoacetamido)cephalosporin derivatives. The Journal of Antibiotics 39(1): 111-120

Girijavallabhan, V.M.; Ganguly, A.K.; Liu, Y.-T.; Pinto, P.A.; Patel, N.; Hare, R.H.; Miller, G.H. 1986: A new class of penems. C-2-N-substituted compounds. Synthesis and antibacterial activity. The Journal of Antibiotics 39(8): 1187-1190

Wheeler, W.J.; Finley, D.R.; Messenger, R.J.; Koehler, R.; Ott, J.T. 1986: The synthesis and biological evaluation of 7.Beta.-(2-(2-aminooxazol-4-yl)-2-Z-methoximinoacetamido)cephalosporin antibiotics. The Journal of Antibiotics 39(1): 121-127

Furukawa, M.; Arimoto, M.; Nakamura, S.; Ejima, A.; Higashi, Y.; Tagawa, H. 1986: Semisynthetic .Beta.-lactam antibiotics. I Synthesis and antibacterial activity of 7.Beta.-(2-aryl-2-(aminoacetamido)acetamido)cephalosporins. The Journal of Antibiotics 39(9): 1225-1235

Arimoto, M.; Ejima, A.; Watanabe, T.; Tagawa, H.; Furukawa, M. 1986: Semisynthetic .Beta.-lactam antibiotics. Ii Synthesis and antibacterial activity of 7.Beta.-(2-(acylamino)-2-(2-aminothiazol-4-yl)acetamido)cephalosporins. The Journal of Antibiotics 39(9): 1236-1242

Arimoto, M.; Hayano, T.; Soga, T.; Yoshioka, T.; Tagawa, H.; Furukawa, M. 1986: Semisynthetic .Beta.-lactam antibiotics. Iii Synthesis and antibacterial activity of 7.Beta.-(2-(2-aminothiazol-4-yl)-2-(substituted carbamoylmethoxyimino)acetamido)cephalosporins. The Journal of Antibiotics 39(9): 1243-1256

Yoshimura, Y.; Hamaguchi, N.; Yashiki, T. 1986: Preparation of 1-acyloxyethyl esters of 7-(2-(2-aminothiazol-4-yl)acetamido)-3-(((1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl)thio)methyl)ceph-3-em-4-carboxylic acid (cefotiam) and their oral absorption in mice. The Journal of Antibiotics 39(9): 1329-1342

Shimotohno, K.; Seto, H.; Otake, N.; Imai, S.; Satoh, A. 1986: Studies on the biosynthesis of bialaphos (Sf-1293). 7 The absolute configuration of 2-phosphinomethylmalic acid, a biosynthetic intermediate of bialaphos. The Journal of Antibiotics 39(9): 1356-1359

Burton, G.; Best, D.J.; Dixon, R.A.; Kenyon, R.F.; Lashford, A.G. 1986: Studies on 6.Alpha.-substituted penicillins. Ii Synthesis and structure-activity relationships of 6.Beta.-(2-aryl-2-sulfoacetamido)-6.Alpha.-methoxy penicillanic acids. The Journal of Antibiotics 39(10): 1419-1429

Guest, A.W.; Harrington, F.P.; Milner, P.H.; Ponsford, R.J.; Smale, T.C.; Stachulski, A.V.; Basker, M.J.; Slocombe, B. 1986: Structure-activity relationships of some 6.Alpha.-formamido penicillins. The Journal of Antibiotics 39(10): 1498-1501

Kawamoto, I.; Endo, R.; Sugawara, S. 1986: Synthesis and antimicrobial activity of a new penem, sodium (5R,6S)-2-(2-fluoroethylthio)-6-((1R)-1-hydroxyethyl)penem-3-carboxylate. The Journal of Antibiotics 39(11): 1551-1556

Poyser, J.P.; Edwards, R.L.; Anderson, J.R.; Hursthouse, M.B.; Walker, N.P.C.; Sheldrick, G.M.; Whalley, A.J.S. 1986: Punctatins A,D,E, and F (antibiotics M95464, M167906, M171950, and M189122), isomeric allylic alcohols from the fungus Poronia punctata: X-ray crystal structures of D and of E acetonide. The Journal of Antibiotics 39(1): 167-169

Yamaguchi, A.; Nemoto, M.; Adachi, A.; Inaba, T.; Sawai, T. 1986: Delayed inactivation of Citrobacter freundii cephalosporinase by 6.Beta.-(3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)penicillin sulfone. The Journal of Antibiotics 39(12): 1744-1753

Basker, M.J.; Branch, C.L.; Finch, S.C.; Guest, A.W.; Milner, P.H.; Pearson, M.J.; Ponsford, R.J.; Smale, T.C. 1986: Studies on semi-synthetic 7.Alpha.-formamidocephalosporins. I Structure-activity relationships in some semi-synthetic 7.Alpha.-formamidocephalosporins. The Journal of Antibiotics 39(12): 1788-1791

Branch, C.L.; Basker, M.J.; Pearson, M.J. 1986: Studies on semi-synthetic 7.Alpha.-formamidocephalosporins. Ii Synthesis and antibacterial activity of some 7.Alpha.-formamidoceph-3-em-1-oxide and 7.Alpha.-formamido-1-oxadethiaceph-3-em derivatives. The Journal of Antibiotics 39(12): 1792-1795

Amato, M.; Iinuma, H.; Naganawa, H.; Yamagishi, Y.; Amada, M.; Masuda, T.; Umezawa, H.; Abe, Y.; Hori, M. 1986: Isolation and properties of valanimycin, a new azoxy antibiotic. The Journal of Antibiotics 39(2): 184-191

Yoshida, C.; Tanaka, K.; Hattori, R.; Fukuoka, Y.; Komatsu, M.; Kishimoto, S.; Saikawa, I. 1986: Studies on Monocyclic -Lactam Antibiotics. The Journal of Antibiotics 39(2): 215-229

Ohi, N.; Aoki, B.; Moro, K.; Kuroki, T.; Sugimura, N.; Noto, T.; Nehashi, T.; Matsumoto, M.; Okazaki, H.; Matsunaga, I. 1986: Semisynthetic .Beta.-lactam antibiotics. Ii. Effect on antibacterial activity of ureido N-substituents in the 6-((R)-2-(3-(3,4-dihydroxybenzoyl)-1-ureido)-2-phenylacetamido)penicillanic acids. The Journal of Antibiotics 39(2): 242-250

Ling, D.; Shield, L.S.; RINEHARTJr., K.E.N.N.E.T.H.L. 1986: Isolation and structure determination of crisamicin A, a new antibiotic from Micromonospora purpureochromogenes subsp. halotolerans. The Journal of Antibiotics 39(3): 345-353

Kawabata, K.; Yamanaka, H.; Takasugi, H.; Takaya, T. 1986: Studies on .Beta.-lactam antibiotics. Xiii. Synthesis and structure-activity relationships of 7.Beta.-((Z)-2-aryl-2-carboxymethoxyiminoacetamido)-3-vinylcephalosporins. The Journal of Antibiotics 39(3): 404-414

Kern, D.L.; Schaumberg, J.P.; Hokanson, G.C.; French, J.C. 1986: Pd 116,779, a new antitumor antibiotic of the benz(a)anthraquinone class. The Journal of Antibiotics 39(3): 469-470

Best, D.J.; Burton, G.; Harrington, F.P.; Lowther, J. 1986: Preparation and antibacterial activity of a series of 6.Alpha.-methoxy pyrimidinylureidopenicillins. The Journal of Antibiotics 39(3): 483-485

Martin, D.G.; Mizsak, S.A.; Nielsen, J.W. 1986: Acivicin (At125, U42126): Isolation and structure of an alkali-induced contaminant. The Journal of Antibiotics 39(4): 603-605

Vanittanakom, N.; Loeffler, W.; Koch, U.; Jung, G. 1986: Fengycin - A novel antifungal lipopeptide antibiotic produced by Bacillus subtilis F-29-3. The Journal of Antibiotics 39(7): 888-901

Yoshida, C.; Tanaka, K.; Todo, Y.; Hattori, R.; Fukuoka, Y.; Komatsu, M.; Saikawa, I. 1986: Studies on monocyclic .Beta.-lactam antibiotics. Iv. Synthesis and antibacterial activity of (3S,4R)-3-(2-(2-aminothiazol-4-yl)-(Z)-2-(O-substituted oxyimino)acetamido)-4-methyl-1-(1H-tetrazol-5-yl)-2-azetidinones. The Journal of Antibiotics 39(1): 90-100

Yoshimoto, A.; Fujii, S.; Johdo, O.; Kubo, K.; Ishikura, T.; Naganawa, H.; Sawa, T.; Takeuchi, T.; Umezawa, H. 1986: Intensely potent anthracycline antibiotic oxaunomycin produced by a blocked mutant of the daunorubicin-producing microorganism. The Journal of Antibiotics 39(7): 902-909

Mcalpine, J.B.; Tuan, J.S.; Brown, D.P.; Greener, K.D.; Whittern, D.N.; Buko, A.; Katz, L. 1987: New antibiotics from genetically engineered actinomycetes. I. 2-norerythromycins, isolation and structural determinations. The Journal of Antibiotics 40(8): 1115-1122

Ando, T.; Miyashiro, S.; Hirayama, K.; Kida, T.; Shibai, H.; Murai, A.; Udaka, S. 1987: New streptothricin-group antibiotics, An-201 I, Ii and Iii. Ii. Chemical structures. The Journal of Antibiotics 40(8): 1140-1145

Traxler, P.; Tosch, W.; Zak, O. 1987: Papulacandins - Synthesis and biological activity of papulacandin B derivatives. The Journal of Antibiotics 40(8): 1146-1164

Parra, M.G.D.L.; Hutchinson, C.R. 1987: Macrolide biosynthesis: Stereochemistry of the hydroxylation of brefelding C. The Journal of Antibiotics 40(8): 1170-1174

Ishimaru, T.; Kanamaru, T.; Ohta, K.; Okazaki, H. 1987: Fibrostatins, new inhibitors of prolyl hydroxylase. I. Taxonomy, isolation and characterization. The Journal of Antibiotics 40(9): 1231-1238

Ohta, K.; Kasahara, F.; Ishimaru, T.; Wada, Y.; Kanamaru, T.; Okazaki, H. 1987: Structures of fibrostatins, new inhibitors of prolyl hydroxylase. The Journal of Antibiotics 40(9): 1239-1248

Sakagami, K.; Watanabe, T.; Fukatsu, S.; Nitta, H.; Hatanaka, M.; Ishimaru, T. 1987: Synthetic cephalosporins. Ii. The synthesis and oral activity of 7-(R-2-amino-2-(3-chloro-4-hydroxyphenyl)acetamido)-3-methylthio-3-cephem-4-carboxylic acid and related compounds. The Journal of Antibiotics 40(9): 1325-1330

Bieber, L.W.; Filho, Ã.A.D.S.; Méllo, J.F.D.; Lima, O.G.D.; Nascimento, M.S.D.; Veith, H.J.; Saal, W.V.D. 1987: Desaminoanthracyclines from the antibotic complex ciclamycin. The Journal of Antibiotics 40(9): 1335-1338

Hayakawa, Y.; Adachi, K.; Komeshima, N. 1987: New antitumor antibotics, anguinomycins A and B. The Journal of Antibiotics 40(9): 1349-1352

Omura, S.; Tomoda, H.; Kumagai, H.; Greenspan, M.D.; Yodkovitz, J.B.; Chen, J.S.; Alberts, A.W.; Martin, I.; Mochales, S.; Monaghan, R.L.; Chabala, J.C.; Schwartz, R.E.; Patchett, A.A. 1987: Potent inhibitory effect of antibiotic 1233A on cholesterol biosynthesis which specifically blocs 3-hydroxy-3-methylglutaryl coenzyme A synthase. The Journal of Antibiotics 40(9): 1356-1357

Patel, M.; Gullo, V.P.; Hegde, V.R.; Horan, A.C.; Marquez, J.A.; Vaughan, R.; Puar, M.S.; Miller, G.H. 1987: A new tetracycline antibiotic from a Dactylosporangium species. Fermentation, isolation and structrure elucidation. The Journal of Antibiotics 40(10): 1414-1418

Manome, T.; Hoshino, E. 1987: Clonning of Dna fragments containing Streptomyces promoter activity. The Journal of Antibiotics 40(10): 1440-1447

Nemoto, K.; Hayashi, M.; Ito, J.; Abe, F.; Takita, T.; Nakamura, T.; Takeichi, T.; Umezawa, H. 1987: Effects of spergualin in autoimmune disease mice. The Journal of Antibiotics 40(10): 1448-1451

Maehr, H.; Evans, R.H. 1987: Identity of borreliden with treponemycin. The Journal of Antibiotics 40(10): 1455-1456

Hamashima, Y.; Kubota, T.; Minami, K.; Ishikura, K.; Konoike, T.; Yoshioka, M.; Yoshida, T.; Nakashimizu, H.; Motokawa, K. 1987: Synthesis and biological properties of 7.Beta.-((Z)-2-(2-amino-4-thiazolyl)-4-carboxy-2-butenoylamino)-3-cephem-4-carboxylic acid (7432-S), a new oral cephem antibiotic. The Journal of Antibiotics 40(10): 1468-1470

Cullen, W.P.; Celmer, W.D.; Chappel, L.R.; Huang, L.H.; Maeda, H.; Nishiyama, S.; Shibakawa, R.; Tone, J.; Watts, P.C. 1987: Cp-54,883 a novel chlorine-containing polyether antibiotic produced by a new species of Actinomadura: Taxonomy of the producing culture, fermentation, physico-chemical and biological properties of the antibiotic. The Journal of Antibiotics 40(11): 1490-1495

Sala, A.; Chiarino, D.; Napoletano, M.; Albini, E.; Carenzi, A.; Bella, D.B. 1987: Synthesis and antibacterial properties of 7-(2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetamido)cephalosporanic acid derivatives. The Journal of Antibiotics 40(11): 1555-1562

Perrone, E.; Alpegiani, M.; Bedeschi, A.; Giudici, F.; Zarini, F.; Franceschi, G.; Bruna, C.D.; Jabes, D.; Meinardi, G. 1987: Novel quaternary ammonium penems: The ((pyridinio)methyl)phenyl derivatives. The Journal of Antibiotics 40(11): 1636-1639

Lee, M.D.; Fantini, A.A.; Kuck, N.A.; Greenstein, M.; Testa, R.T.; Borders, D.B. 1987: New antitumor antibiotic, Ll-D05139.Beta.. Fermentation. isolation, structure determination and biological activities. The Journal of Antibiotics 40(12): 1657-1663

Zimmerman, S.B.; Schwartz, C.D.; Monaghan, R.L.; Pelak, B.A.; Weissberger, B.; Gilfillan, E.C.; Mochales, S.; Hernandez, S.; Currie, S.A.; Tejera, E.; Stapley, E.O. 1987: Difficidin and oxydifficidin: Novel broad spectrum antibacterial antibiotics produced by Bacillus subtilis. I.Production, taxonomy and antibacterial activity. The Journal of Antibiotics 40(12): 1677-1681

Zhang, J.; Wolfe, S.; Demain, A.L. 1987: Effect of ammonium as nitrogen source on production of .Delta.-(L-.Alpha.-aminoadiply)-L-cysteinyl-D-valine synthetase by Cephalosporium acremonium C-10. The Journal of Antibiotics 40(12): 1746-1750

Magae, J.; Nagai, K.; Suzuki, S.; Yamasaki, M.; Ando, K.; Tamura, G. 1987: Macrophage-specific effect on lipid metabolism by an antibiotic, ascofuranone. The Journal of Antibiotics 40(2): 202-208

Oki, N.; Aoki, B.; Kuroki, T.; Matsumoto, M.; Kojima, K.; Nehashi, T. 1987: Semisynthetic .Beta.-lactam antibiotics. Iii. Effect on antibacterial activity and Comt-susceptibility of chlorine-introduction into the catechol nucleus of 6-((R)-2-(3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid. The Journal of Antibiotics 40(1): 22-28

Carter, G.T.; Nietsche, J.A.; Goodman, J.J.; Torrey, M.J.; Dunne, T.S.; Borders, D.B.; Testa, R.T. 1987: Ll-F42248.Alpha., a novel chlorinated pyrrole antibiotic. The Journal of Antibiotics 40(2): 233-236

Barber, J.; Chapman, A.C.; Howard, T.D. 1987: The use of sodium (2-2H3,1,2-13C2)acetate in determining the biosynthetic origins of hydrogen atoms in fungal metabolites : The biosynthesis of citrinin by Penicillium citrinum. The Journal of Antibiotics 40(2): 245-248

Nakagawa, A.; Omura, S.; Kushida, K.; Shimizu, H.; Lukacs, G. 1987: Structure of cervinomycin, a novel xantone antibiotic active against anaerobe and mycoplasma. The Journal of Antibiotics 40(3): 301-308

Deeg, M.; Hagenmaier, H.; Kretschmer, A. 1987: Chemical modifications of bafilomycin-type 16-membered dienlactone macrolides. The Journal of Antibiotics 40(3): 320-328

Argoudelis, A.D.; Baczynskyj, L.; Mizsak, S.A.; Shilliday, F.B.; Spinelli, P.A.; Dezwaan, J. 1987: Paldimycins A and B and antibiotics 273a2.Alpha. and 273a2.Beta.. Synthesis and characterization. The Journal of Antibiotics 40(4): 419-436

Kase, H.; Kaneko, M.; Yamada, K. 1987: K-13, a novel inhibitor of angiotensin I converting enzyme produced by Micromonospora halophytica subsp. exilisia. I Fermentation, isolation and biological properties. The Journal of Antibiotics 40(4): 450-454

Yasuzawa, T.; Shirahata, K.; Sano, H. 1987: K-13, a novel inhibitor of angiotensin I converting enzyme produced by Micromonospora halophytica subsp. exilisia. Ii Structure determination. The Journal of Antibiotics 40(4): 455-458

Sano, S.; Ikai, K.; Yoshikawa, Y.; Nakamura, T.; Obayashi, A. 1987: Of4949, new inhibitors of aminopeptidase A. Iv Effects of Of4949 and its derivatives on enzyme systems. The Journal of Antibiotics 40(4): 512-518

Omura, S.; Otoguro, K.; Imamura, N.; Kuga, H.; Takahashi, Y.; Masuma, R.; Tanaka, Y.; Tanaka, H.; Xue-Hui, S.; En-Tai, Y. 1987: Jietacins A and B, new nematocidal antibiotics from a stretomyces sp. Taxonomy, isolation, and physico-chemical and biological properties. The Journal of Antibiotics 40(5): 623-629

Branch, C.L.; Basker, M.J.; Finch, S.C.; Guest, A.W.; Harrngton, F.P.; Kaura, A.C.; Knott, S.J.; Milner, P.H.; Pearson, M.J. 1987: Studies on semi-synthetic 7.Alpha.-formamidocephalosporins. Iii. Synthesis and antibacterial activity of some 7.Beta.-(D-2-(aryl)-2-((4-ethyl-2,3-dioxopiperazin-1-yl)-carbonylamino)acetamido)-7.Alpha.-formamido-ceph-3-em-4-carboxylate derivatives. The Journal of Antibiotics 40(5): 646-651

Radios, L.; Kajtar-Peredy, M.; Casinovi, C.G.; Rossi, C.; Ricci, M.; Tuttobello, L. 1987: Leucinostatins H and K, two novel peptide antibiotics with tertiay amine-oxide terminal group from Paecilomyces marquandii Isolation, structure and biological activity. The Journal of Antibiotics 40(5): 714-716

Jung, M. 1987: Conversion of shikimic acid into 2-crotonyloxymethyl-(4R,5R,6S)-4,5,6-trihydroxycyclohex-2-ene analogous to a glyoxalase I inhibitor. The Journal of Antibiotics 40(5): 720-722

Mitsuyama, J.; Takahata, M.; Yasuda, T.; Saikawa, I. 1987: The mechanism of action of piperacillin-analogues in vitro. Effect of the carbon number at the N-4 position of 2,3-dioxopiperazine on the outer membrane permeability, stability to .Beta.-lactamase and binding affinity to penicillin-binding proteins. The Journal of Antibiotics 40(6): 868-872

Dellweg, H.; Kurz, J.; Pflüger, W.; Schedel, M.; Vobis, G.; Wünsche, C. 1988: Rodaplutin, a new peptidylnuleoside from Nocardioides albus. The Journal of Antibiotics 41(8): 1145-1147

Shibahara, S.; Okonogi, T.; Murai, Y.; Kudo, T.; Yoshida, T.; Kondo, S.; Christensen, B.G. 1988: Synthesis of a novel 2.Beta.-methyl-1-oxacephalosporin, Ocp-9-176. The Journal of Antibiotics 41(8): 1154-1157

Seto, H.; Furihata, K.; Ohuchi, M. 1988: Particular utility of the Hmbc technique to polypropionate derived polypropionate derived metabolites as exemplified by erythromycin A. The Journal of Antibiotics 41(8): 1158-1160

Kondo, S.; Yasui, K.; Natsume, M.; Katayama, M.; Marumo, S. 1988: Isolation, physico-chemical properties and biological activity of pamamycin-607, an aerial mycelium-inducing substance from Streptomyces alboniger. The Journal of Antibiotics 41(9): 1196-1204

Itoh, J.; Watabe, H.-O.; Ishii, S.; Gomi, S.; Nagasawa, M.; Yamamoto, H.; Shomura, T.; Sezaki, M.; Kondo, S. 1988: Sibanomicin, a new pyrrolo(1,4)benzodiazepine antitumor antibiotic produced by a Micromonospora sp. The Journal of Antibiotics 41(9): 1281-1284

Lattrell, R.; Blumbach, J.; Duerckheimer, W.; Fehlhaber, H.-W.; Fleischmann, K.; Kirrstetter, R.; Mencke, B.; Scheunemann, K.-H.; Schrinner, E.; Schwab, W.; Seeger, K.; Seibert, G.; Wieduwilt, M. 1988: Synthesis and structure-activity relationships in the cefpirome series. I. 7-(2-(2-Aminothiazol-4-yl)-2-(Z)-oxyiminoacetamido)-3-((substituted-1-pyridinio)methyl)-ceph-3-em-4-carboxylates. The Journal of Antibiotics 41(10): 1374-1394

Lattrell, R.; Duerckheimer, W.; Limbert, M. 1988: Synthesis and structure-activity relationships in the cefpirome series. Iii. 7.Alpha.-Methoxy and 7.Alpha.-formamido analogues of cefpirome. The Journal of Antibiotics 41(10): 1409-1417

Carter, G.T.; Phillipson, D.W.; Goodman, J.J.; Dunne, T.S.; Borders, D.B. 1988: Ll-E19020.Alpha. and .Beta., novel growth promoting agents: Isolation, characterization and structures. The Journal of Antibiotics 41(10): 1511-1514

Yoshioka, T.; Kiyoshima, K.; Maeda, M.; Sakamoto, M.; Ishikura, T.; Fukagawa, Y.; Sawa, T.; Hamada, M.; Naganawa, H.; Takeuchi, T. 1988: Synthesis and structure-activity studies of new 4"-O-acyltylosin derivatives of therapeutic interest. The Journal of Antibiotics 41(11): 1617-1628

Ishimaru, T.; Kanamaru, T.; Takahashi, T.; Okazaki, H. 1988: Inhibition of prolyl hydroxylase activity and collagen biosynthesis by fibrostatin C, a novel inhibitor produced by Streptomyces catenulae subsp. griseospora No. 23924. The Journal of Antibiotics 41(11): 1668-1674

Yokoo, C.; Goi, M.; Onodera, A.; Murata, M.; Nagate, T.; Watanabe, Y.; Sota, K. 1988: Studies on cephalosporin antibiotics. I. Synthesis, antibacterial activity and oral absorption of new 3-(O-substituted)-7.Beta.-(D-.Alpha.-amino-.Alpha.-(4-hydroxyphenyl)acetamido)cephalosporins. The Journal of Antibiotics 41(2): 170-180

Roy, K.; Mukhopadhyay, T.; Reddy, G.C.S.; Desikan, K.R.; Rupp, R.H.; Ganguli, B.N. 1988: Aranorosin, a novel antibiotic from Pseudoarachiniotus roseus. I. Taxonomy, fermentation, isolation, chemical and biological properties. The Journal of Antibiotics 41(12): 1780-1784

Arimoto, M.; Yokohama, S.; Sudou, M.; Ichikawa, Y.; Hayano, T.; Tagawa, H.; Furukawa, M. 1988: Semisynthetic .Beta.-lactam antibiotics. Iv. Synthesis and antibacterial activity of 7.Beta.-(2-(hetero aromatic methoxyimino)-2-(2-aminothiazol-4-yl)acetamido)cephalosporins. The Journal of Antibiotics 41(12): 1795-1811

Yokoo, C.; Goi, M.; Onodera, A.; Murata, M.; Nagate, T.; Watanabe, Y.; Sota, K. 1988: Studies on cephalosporin antibiotics. Ii. Synthesis, antibacterial activity and oral absorption of 3-alkoxycarbonylmethoxy-7.Beta.-((Z)-2-(2-aminothiazol-4-yl)-2-(O-substituted oxyimino)acetamido)cephalosporins. The Journal of Antibiotics 41(2): 181-192

Barber, J.; Carver, J.A.; Leberman, R.; Tebb, G.M.V. 1988: The molecular basis of kirromycin(mocimycin) action. A 1H Nmr study using deuterated elongation factor Tu. The Journal of Antibiotics 41(2): 202-206

Tomoda, H.; Kumagai, H.; Takahashi, Y.; Tanaka, Y.; Iwai, Y.; Omura, S. 1988: F-244(1233A), a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A synthase. Taxonomy of producing strain, fermentation, isolation and biological properties. The Journal of Antibiotics 41(2): 247-249

Tanaka, Y.; Kimura, K.; Komagata, Y.; Tsuzuki, K.; Tomoda, H.; Omura, S. 1988: Radioimmuno assay for erythromycin derivatives. The Journal of Antibiotics 41(2): 258-260

Kawaguchi, T.; Azuma, M.; Horinouchi, S.; Beppu, T. 1988: Effect of B-factor and its analogues on rifamycin biosynthesis in Nocardia sp. The Journal of Antibiotics 41(3): 360-365

Takeda, U.; Okada, T.; Takagi, M.; Gomi, S.; Itoh, J.; Sezaki, M.; Ito, M.; Miyadoh, S.; Shomura, T. 1988: Sf2446, new benzo(a)naphthacene quinone antibiotics. I. Taxonomy and fermentation of the producing strain, isolation and characterization of antibiotics. The Journal of Antibiotics 41(4): 417-424

Gomi, S.; Sasaki, T.; Itoh, J.; Sezaki, M. 1988: Sf2446, new benzo(a)naphthacene quinone antibiotics. Ii. The structural elucidation. The Journal of Antibiotics 41(4): 425-432

Miyashiro, S.; Yamanaka, S.; Takayama, S.; Shibai, H. 1988: Novel macrocyclic antibiotics: Megovalicins A, B, C, D, G and H. I. Screening of antibiotics-producing myxobacteria and production of megovalicins. The Journal of Antibiotics 41(4): 433-438

Otoguro, K.; Oiwa, R.; Iwai, Y.; Tanaka, H.; Omura, S. 1988: Screening for new antitrichimonal substances of microbial origin and antitrichomonal activity of trichostatin A. The Journal of Antibiotics 41(4): 461-468

Carter, G.T.; Nietsche, J.A.; Hertz, M.R.; Williams, D.R.; Siegel, M.M.; Morton, G.O.; James, J.C.; Borders, D.B. 1988: Ll-F28249 antibiotic complex: A new family of antiparastic macrocyclic lactones. Isolation, characterization and structures of Ll-F28249 .Alpha., .Beta., .Gamma., .Lambda.. The Journal of Antibiotics 41(4): 519-529

Umemura, E.; Tsuchiya, T.; Umezawa, S. 1988: Synthesis of 1-N-(D-threo- and racemic erythro-3-amino-2-hydroxybutanoyl)-2',3'-dideoxykanamycin A. The Journal of Antibiotics 41(4): 530-537

Tanaka, H.; Tanaka, M.; Nakai, A.; Yamadat, S.-Z.; Ishida, N.; Otani, T.; Torii, S. 1988: Synthesis and .Beta.-lactamase inhibitory properties of 2.Beta.-(thio-substituted methyl)-penam 1,1-dioxides. The Journal of Antibiotics 41(4): 579-582

Kaneda, M.; Naid, T.; Kitahara, T.; Nakamura, S.; Hirata, T.; Suga, T. 1988: Carbazomycins G and H, novel carbazomycin congeners containing a quinol moiety. The Journal of Antibiotics 41(5): 602-608

Banks, R.M.; Donald, A.C.; Hannan, P.C.T.; O''hanlon, P.J.; Rogers, N.H. 1988: Antimycoplasmal activities of the speudomonic acids and structure-activity relationships of monic acid A derivatives. The Journal of Antibiotics 41(5): 609-613

Taft, C.S.; Selitrennikoff, C.P. 1988: Ly121019 inhibits Neurospora crassa growth and (1-3)-.Beta.-D-glucan synthase. The Journal of Antibiotics 41(5): 697-701

Schmitt, S.M.; Salzmann, T.N.; Shih, D.H.; Christensen, B.G. 1988: The synthesis of 2-(functionalized methyl)-1.Beta.-methylcarbapenems. The Journal of Antibiotics 41(6): 780-787

Sasaki, T.; Yoshida, J.; Itoh, M.; Gomi, S.; Shomura, T.; Sezaki, M. 1988: New antibiotics Sf2315A and B produced by an Excellospora sp. I. Taxonomy of the strain, isolation and characterization of antibiotics. The Journal of Antibiotics 41(7): 835-842

Okada, H.; Yamamoto, K.; Tsutano, S.; Nakamura, S. 1988: A new group of antibiotics, hydroxamic acid antimycotic antibiotics. I. Precursor-initiated changes in productivity and biosynthesis of neoenactions Nl1 and Nl2. The Journal of Antibiotics 41(7): 869-874

Sasaki, J.; Mizoue, K.; Morimoto, S.; Adachi, T.; Omura, S. 1988: Microbial transformation of 6-O-methylerythromycin derivatives. The Journal of Antibiotics 41(7): 908-915

Tsuchiya, T.; Takagi, Y.; Umezawa, S.; Takeuchi, T.; Komuro, K.; Nosaka, C.; Umezawa, H.; Fukatsu, S.; Yoneta, T. 1988: Synthesis and antitumor activities of 14-O-acyl derivatives of 7-O-(2,6-dideoxy-2-fluoro-.Alpha.-l-talopyranosyl) adriamycinone. The Journal of Antibiotics 41(7): 988-991

Fushimi, S.; Furihata, K.; Seto, H. 1989: Studies of new phosphate ester antifungal antibiotics phoslactomycins. Ii. Structure elucidation of phoslactomycins A to F. The Journal of Antibiotics 42(7): 1026-1036

Lee, M.D.; Manning, J.K.; Williams, D.R.; Kuck, N.A.; Testa, R.T.; Borders, D.B. 1989: Calicheamicins, a novel family of antitumor antibiotics. 3. Isolation, purification and characterization of calicheamicins .Beta.1Br, .Gamma.1Br, .Alpha.2I, .Alpha.3I, .Beta.1I, .Gamma.1I and .Delta.1I. The Journal of Antibiotics 42(7): 1070-1087

Nishimura, S.; Sasaki, H.; Yasuda, N.; Matsumoto, Y.; Kamimura, T.; Sakane, K.; Takaya, T. 1989: Synthesis and biological activity of 7.Alpha.-hydroxyethyl-1-oxacephem derivatives. The Journal of Antibiotics 42(7): 1124-1132

Rohr, J.; Beale, J.M.; Floss, H.G. 1989: Urdamycins, new angucycline antibiotics from Streptomyces fradiae. Iv. Biosynthetic studies of urdamycins A-D. The Journal of Antibiotics 42(7): 1151-1157

Nakayama, O.; Yagi, M.; Tanaka, M.; Kiyoto, S.; Okuhara, M.; Kohsaka, M. 1989: Ws-9659 A and B, novel testosterone 5.Alpha.-reductase inhibitors isolated from a Streptomyces. I. Taxonomy, fermentation, isolation, physico-chemical characteristics. The Journal of Antibiotics 42(8): 1221-1229

Nakayama, O.; Shigematsu, N.; Katayama, A.; Takase, S.; Kiyoto, S.; Hashimoto, M.; Kohsaka, M. 1989: Ws-9659 A and B, novel testosterone 5.Alpha.-reductase inhibitors isolated from a Streptomyces. Ii. Structural elucidation of Ws-9659 A and B. The Journal of Antibiotics 42(8): 1230-1234

Nakayama, O.; Arakawa, H.; Yagi, M.; Tanaka, M.; Kiyoto, S.; Okuhara, M.; Kohsaka, M. 1989: Ws-9659 A and B, novel testosterone 5.Alpha.-reductase inhibitors isolated from a Streptomyces. Iii. Biological characteristics and pharmacological characteristics. The Journal of Antibiotics 42(8): 1235-1240

Trani, A.; Ferrari, P.; Pallanza, R.; Ciabatti, R. 1989: Thioureas and isothiouronium salts of the aglycone of teicoplanin. I. Synthesis and biological activity. The Journal of Antibiotics 42(8): 1268-1275

Takagi, Y.; Park, H.-I.; Tsuchiya, T.; Umezawa, S.; Takeuchi, T.; Komuro, K.; Nosaka, C. 1989: Syntheses and antitumor activities of 7-O-(3-amino-2,3,6-trideoxy-2-fluoro-.Alpha.-L-talopyranosyl)daunomycinone and -adriamycinone. The Journal of Antibiotics 42(8): 1315-1317

Takagi, Y.; Kobayashi, N.; Tsuchiya, T.; Umezawa, S.; Takeuchi, T.; Komuro, K.; Nosaka, C. 1989: Syntheses and antitumor activities of 7-O-(6-deoxy-2-O-methyl-.Alpha.-L-talopyranosyl)-daunomycinone and -adriamycione. The Journal of Antibiotics 42(8): 1318-1320

Yaginuma, S.; Asahi, A.; Morishita, A.; Hayashi, M.; Tsujino, M.; Takada, M. 1989: Isolation and characterization of new thiol protease inhibitors estatins A and B. The Journal of Antibiotics 42(9): 1362-1369

Fernández-Cañó, J.M.; Reglero, A.; Martínez-Bianco, H.; Luengo, J.M. 1989: I. Uptake of phenylacetic acid by Penicillium chrysogenum Wis 54-1255: A critical regulatory point in benzylpenicillin biosynthesis. The Journal of Antibiotics 42(9): 1398-1409

Fernández-Cañó, J.M.; Reglero, A.; Martínez-Bianco, H.; Ferrero, M.A.; Luengo, J.M. 1989: Ii. Phenylacetic acid transport system in Penicillium chrysogenum Wis 54-1255: Molecular specificity of its induction. The Journal of Antibiotics 42(9): 1410-1415

Martínez-Blanco, H.; Reglero, A.; Ferrero, M.A.; Fernández-Cañó, J.M.; Luengo, J.M. 1989: Iii. Repression of phenylacetic acid transport system in Penicillium chrysogenum Wis 54-1255 by free amino acids and ammonium salts. The Journal of Antibiotics 42(9): 1416-1423

Ruggeri, C.; Laborde, M.D.L.A.; Dessinges, A.; Ming, L.; Olesker, A.; Lukacs, G. 1989: Synthesis and antibacterial activity of 9-O-((2-methoxyethoxy)methyl)-oximes of tylosin and demycarosyltylosin. The Journal of Antibiotics 42(9): 1443-1445

Maiese, W.M.; Lechevalier, M.P.; Lechevalier, H.A.; Korshalla, J.; Goodman, J.; Wildey, M.J.; Kuck, N.; Conner, S.D.; Greenstein, M. 1989: Ll-E19020.Alpha. and .Beta., animal growth promoting antibiotics: Taxonomy, fermentation and biological activity. The Journal of Antibiotics 42(10): 1489-1493

Yoshioka, T.; Watanabe, A.; Chida, N.; Fukagawa, Y. 1989: Conversion of Oa-6129 B2 into (5R,6R)-6-((R)-1-fluoroethyl)-7-oxo-3-((N.N.N-trimethyl-carbamimidoyl)methyl)thio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid (88617). The Journal of Antibiotics 42(10): 1520-1522

Inouye, Y.; Yamaguchi, K.; Take, Y.; Nakamura, S. 1989: Jnhibition of avian myeloblastosis virus reverse transcriptase by flavones and isoflavones. The Journal of Antibiotics 42(10): 1523-1525

Matson, J.A.; Claridge, C.; Bush, J.A.; Titus, J.; Bradner, W.T.; Doyle, T.W.; Horan, A.C.; Patel, M. 1989: At2433-A1, At2433-A2, At2433-B1, and At2433-B2 novel antitumor antibiotic compounds produced by Actinomadura melliaura. Taxonomy, fermentation, isolation and biological properties. The Journal of Antibiotics 42(11): 1547-1555

Imamura, N.; Kuga, H.; Otoguro, K.; Tanaka, H.; Omura, S. 1989: Structures of jietacines: Unique .Alpha.,.Beta.-unsaturated azoxy antibiotics. The Journal of Antibiotics 42(1): 156-158

Pandey, R.C.; Toussaint, M.W.; Mcguire, J.C.; Thomas, M.C. 1989: Maggiemycin and anhydromaggiemycin: Two novel anthracyclinone antitumor antibiotics. Isolation, structures, partical synthesis and biological properties. The Journal of Antibiotics 42(11): 1567-1577

Nishimura, S.; Yasuda, N.; Sasaki, H.; Matsumoto, Y.; Kamimura, T.; Sakane, K.; Takaya, T. 1989: Synthesis and .Beta.-lactamase inhibitory activity of 7.Alpha.-hydroxyethyl cephem derivatives. The Journal of Antibiotics 42(1): 159-162

Osada, H.; Sonoda, T.; Kusakabe, H.; Isono, K. 1989: Epiderstain, a new inhibitor of the mitogenic activity induced by epidermal growth factor. I. Taxonomy, fermentation, isolation and characterization. The Journal of Antibiotics 42(11): 1599-1606

Kiyoshima, K.; Sakamoto, M.; Nomura, H.; Yoshioka, T.; Okamoto, R.; Sawa, T.; Naganawa, H.; Takeuchi, T. 1989: Structure-activity relationship studies on 4"-O-acyltylosin derivatives: Significance of their 23-O-mycinosyl and 4"-O-acyl moieties in antimicrobial activity against macrolide-resistant microbes. The Journal of Antibiotics 42(11): 1661-1672

Wichmann, C.F.; Liesch, J.M.; Schwartz, R.E. 1989: L-671,329, a new antifungal agent. Iii. Structure determination. The Journal of Antibiotics 42(2): 168-173

Chaiet, L.; Fromtling, R.A.; Garrity, G.M.; Monaghan, R.L.; Hensens, O.D.; Valiant, M.E.; Zink, D.L. 1989: L-681,572-a new antifungal agent. Isolation, characterization, and biological activity. The Journal of Antibiotics 42(11): 1718-1721

Shoji, J.''ichi; Sakazaki, R.; Hattori, T.; Matsumoto, K.; Uotani, N.; Yoshida, T. 1989: Isolation and characterization of agglomerinsA, B, C and D. The Journal of Antibiotics 42(12): 1729-1733

Nakagawa, M.; Hsu, Y.-H.; Hirota, A.; Shima, S.; Nakayama, M. 1989: Myrocin C, a new diterpene antitumor antibiotic from Myrothecium verrucaria. I. Taxonomy of the producing strain, fermentation, isolation and biological properties. The Journal of Antibiotics 42(2): 218-222

Kaneko, I.; Kamoshida, K.; Takahashi, S. 1989: Complestain, a potent anti-complement substance produced by Streptomyces lavendulae. I. Fermentation, isolation and biological characterization. The Journal of Antibiotics 42(2): 236-241

Kelemen, G.H.; Financsek, I.; Járai, M. 1989: Efficient transformation of Micromonospora purpurea with pIj 702 plasmid. The Journal of Antibiotics 42(2): 325-328

Rickards, R.W. 1989: Revision of the structures of the benzo(a)naphthacene quinone metabolites G-2N and G-2A from bacteria of the genus Frankia. The Journal of Antibiotics 42(2): 336-339

Davies, D.T.; Harrington, F.P.; Knott, S.J.; Southgate, R. 1989: Synthesis and biological activity of a series of piperazine-2,3-dione containing penicillins and 6.Alpha.-formamidopenicillins. I. Derivatives substituted at C(5) or C(6) of the piperazine ring. The Journal of Antibiotics 42(3): 367-373

Tsou, H.-R.; Ahmed, Z.H.; Fiala, R.R.; Bullock, M.W.; Carter, G.T.; Goodman, J.J.; Borders, D.B. 1989: Biosynthetic origin of the carbon skeleton and oxygen atoms of the Ll-F28249.Alpha., apoent antiparasitic macrolide. The Journal of Antibiotics 42(3): 398-406

Hidaka, T.; Mori, M.; Imai, S.; Hara, O.; Nagaoka, K.; Seto, H. 1989: Studies on the biosynthesis of bialaphos (Sf-1293). 9. Biochemical mechanism of C-P bond formation in bialaphos: Discovery of phosphoenolpyruvate phosphomutase which catalyzes the formation of phosphonopyruvate from phosphoenolpyruvete. The Journal of Antibiotics 42(3): 491-494

Fernandes, P.B.; Swanson, R.N.; Hardy, D.J.; Hanson, C.W.; Mcdaniel, D.; Beyer, J.; Chen, R.H. 1989: Coumamidines, new broad spectrum antibiotics of the cinodine type. Iii. Microbiologic activity of coumamidine .Gamma.1. The Journal of Antibiotics 42(4): 538-541

Li, Z.; Rawlings, B.J.; Harrison, P.H.; Vederas, J.C. 1989: Production of new polyene antibiotics by Streptomyces cellulosae after addition of ethyl(Z)-16-phenylhexadec-9-enoate. The Journal of Antibiotics 42(4): 577-584

Ajito, K.; Atsumi, S.; Ikeda, D.; Kondo, S.; Takeuchi, T.; Umezawa, K. 1989: Inhibition of human immunodeficiency virus-associated reverse transcriptase by 14-O-acyladriamycins. The Journal of Antibiotics 42(4): 611-619

Hatanaka, H.; Kino, T.; Asano, M.; Goto, T.; Tanaka, H.; Okuhara, M. 1989: Fk-506 related compounds produced by Streptomyces tsukubaensis No.9993. The Journal of Antibiotics 42(4): 620-622

Gilpin, M.L.; Balchin, J.; Box, S.J.; Tyler, J.W. 1989: Mm47755, a new benz(a)anthracene antibiotic from a streptomycete. The Journal of Antibiotics 42(4): 627-628

Singh, R.; Singh, M.P.; Micetich, R.G. 1989: Synthesis and in vitro antibacterial activity of sodium 6.Beta.-(2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido)penicillinate, it's 1.Beta.-sulfoxide and 1,1-dioxide. The Journal of Antibiotics 42(4): 637-639

Isono, F.; Katayama, T.; Inukai, M.; Haneishi, T. 1989: Mureidomycins A-D, novel peptidylnucleoside antibiotics with spheroplast forming activity. Iii. Biological properties. The Journal of Antibiotics 42(5): 674-679

Iwami, M.; Nakayama, O.; Terano, H.; Kohsaka, M. 1989: New antitumor antibiotic, Fr-900462. I. Taxonomy of the producing strain. The Journal of Antibiotics 42(5): 680-685

Naruse, N.; Tenmyo, O.; Tomita, K.; Konishi, M.; Miyaki, T.; Kawaguchi, H.; Fukase, K.; Wakamiya, T.; Shiba, T. 1989: Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin. The Journal of Antibiotics 42(6): 837-845

Maiese, W.M.; Lechevalier, M.P.; Lechevalier, H.A.; Korshalla, J.; Goodman, J.; Wildey, M.J.; Kuck, N.; Greenstein, M. 1989: Ll-E19085.Alpha.,a novel antibiotic from Micromonospora citrea: Taxonomy, fermentation and biological activity. The Journal of Antibiotics 42(6): 846-851

Lauer, U.; Anke, T.; Sheldrick, W.S.; Scherer, A.; Steglich, W. 1989: Antibiotics from Basidiomycetes. Xxxi. Aleurodiscal: An antifungal sesterterpenoid from Aleurodiscus mirabilis (Berk. & Curt.) Hoehn. The Journal of Antibiotics 42(6): 875-882

Fehr, T.; Kuhn, M.; Loosli, H.-R.; Ponelle, M.; Boelsterli, J.J.; Walkinshaw, M.D. 1989: 2-Epimutalomycin and 28-epimutalomycin, two new polyether antibiotics from Stereptomyces mutabilis. Derivatization of mutalomycin and the structure elucidation of two minor metabolites. The Journal of Antibiotics 42(6): 897-902

Nielsen, J.B.K.; Kaplan, L. 1989: A resting cell system for efrotomycin biosynthesis. The Journal of Antibiotics 42(6): 944-951

Oishi, K.; Matsumoto, K.; Yamamoto, M.; Morito, T.; Yoshida, T. 1989: Stimulatory effect of cefodizime on macrophage-mediated phagocytosis. The Journal of Antibiotics 42(6): 989-992

Corbett, D.F.; Frydrych, C.H.; Southgate, R.; Basker, M.J. 1990: Synthesis and biological activity of some 6.Alpha.-formamido penicillins modified in the 2.Beta.-methyl group. The Journal of Antibiotics 43(8): 1042-1044

Sakagami, K.; Atsumi, K.; Tamura, A.; Yoshida, T.; Nishihata, K.; Fukatsu, S. 1990: Synthesis and oral activity of Me 1207, a new orally active cephalosporin. The Journal of Antibiotics 43(8): 1047-1050

Nishimura, S.; Yasuda, N.; Sasaki, H.; Matsumoto, Y.; Kamimura, T.; Sakane, K.; Takaya, T. 1990: Synthesis and .Beta.-lactamase inhibitory activity of 7.Alpha.-hydroxyethyl cephem sulfone and sulfoxide derivatives. The Journal of Antibiotics 43(1): 114-117

Katano, K.; Ogino, H.; Iwamatsu, K.; Nakabayashi, S.; Yoshida, T.; Komiya, I.; Tsuruoka, T.; Inouye, S.; Kondo, S. 1990: Synthesis and biological activity of (cyclopentenopyridinium)thiomethylcephalosporins. The Journal of Antibiotics 43(9): 1150-1159

Schaeffer, J.M.; Frazier, E.G.; Bergstrom, A.R.; Williamson, J.M.; Liesch, J.M.; Goetz, M.A. 1990: Cochlioquinone A, a nematocidal agent which competes for specific (3H)ivermectin binding sites. The Journal of Antibiotics 43(9): 1179-1182

Nishikawa, M.; Yoshida, K.; Okamoto, M.; Kohsaka, M. 1990: Studies on Wf-3681, a novel aldose reductase inhibitor. Iii. Effects of Wf-3681 and its derivatifves on sorbitol accumulation in diabetic rats. The Journal of Antibiotics 43(9): 1186-1188

Nishimura, S.; Yasuda, N.; Sasaki, H.; Sakane, K.; Takaya, T. 1990: Synthesis and antibacterial activity of 7.Beta.-(1-(2-aminothiazol-4-yl)-1-cyclopropanecarboxyamido)cephem derivatives. The Journal of Antibiotics 43(10): 1278-1285

Morris, S.J.; Thurston, D.E.; Nevell, T.G. 1990: Evaluation of the electrophilicity of Dna-binding pyrrolo(2,1-c)(1,4)benzodiazepines by Hplc. The Journal of Antibiotics 43(10): 1286-1292

Fox, K.R. 1990: Footprinting studies of the interaction of quinomycin antibiotic Uk63052 with Dna: comparison with echinimycin. The Journal of Antibiotics 43(10): 1307-1315

Nakagawa, K.; Torikata, A.; Sato, K.; Tsukamoto, Y. 1990: Microbial conversion of milvemycins: 30-Oxidation of milbemycin A4 and related compounds by Amycolata autotrophica and Amycolatopsis mediterranei. The Journal of Antibiotics 43(10): 1321-1328

Tahara, M.; Okabe, T.; Furihata, K.; Tanaka, N.; Yamaguchi, H.; Nishimura, T.; Suzuki, H. 1990: Resorpthiomycin, a novel antitumor antibiotic. Ii. Physico-chemical properties and structure elucidation. The Journal of Antibiotics 43(2): 135-137

Sawada, Y.; Tsuno, T.; Yamamoto, H.; Nishio, M.; Konishi, M.; Oki, T. 1990: Pradimicins M, N, O and P, new dihydrobenzo(a)naphthacenequinones produced by blocked mutants of Actinomadura hibisca P157-2. The Journal of Antibiotics 43(11): 1367-1374

Hara, M.; Mokudai, T.; Kobayashi, E.; Gomi, K.; Nakano, H. 1990: The kapurimycins, new antitumor antibiotics produced by Strepromyces. Producing organism, fermentation, isolation and biological activities. The Journal of Antibiotics 43(12): 1513-1518

Kamachi, H.; Okita, T.; Okuyama, S.; Hoshi, H.; Naito, T. 1990: Improved synthesis of an ester-type prodrug, 1-acetoxyethyl 7-((Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-((Z)-1-propenyl)-3-cephem-4-carboxylate (Bmy-28271). The Journal of Antibiotics 43(12): 1564-1572

Nakamura, T.; Komagata, D.; Murakawa, S.; Sakai, K.; Endo, A. 1990: Isolation and biosynthesis of 3.Alpha.-hydroxy-3,5-dihydromonacolin L. The Journal of Antibiotics 43(12): 1597-1600

Nakayama, O.; Yagi, M.; Kiyoto, S.; Okuhara, M.; Kohsaka, M. 1990: Riboflavin, a testosterone 5.Alpha.-reductase inhibitor. The Journal of Antibiotics 43(12): 1615-1616

Taft, C.S.; Selitrennikoff, C.P. 1990: Cilofungin inhibition of (1-3)-.Beta.-glucan synthase: The lipophilic side chain is essential for inhibition of enzyme activity. The Journal of Antibiotics 43(4): 433-437

Nakagomi, K.; Sakai, S.; Tanaka, H.; Tomizuka, N.; Kawakami, Y.; Nakajima, T. 1990: Studies on inhibotors of rat mast cell degranulation produced by microorganisms. Ii. Structure elucidation of eurocidins D and E. The Journal of Antibiotics 43(5): 470-476

Morimoto, S.; Adachi, T.; Misawa, Y.; Nagate, T.; Watanabe, Y.; Omura, S. 1990: Chemical modification of erythromycins. Iv. Synthesis and biological properties of 6-O-methylerythromycin B. The Journal of Antibiotics 43(5): 544-549

Kunimoto, S.; Komuro, K.; Nosaka, C.; Tsuchiya, T.; Fukatsu, S.; Takeuchi, T. 1990: Biological activities of new anthracyclines containing fluorine, Fad 104 and its metabolites. The Journal of Antibiotics 43(5): 556-565

Best, D.J.; Burton, G.; Davies, D.T.; Elder, J.S.; Smale, T.C.; Southgate, R.; Stachulski, A.V.; Basker, M.J.; Knott, S.J. 1990: Structure-activity relationships of some arylglycine analogues and catechol isosteres of Brl 36650, a 6.Alpha.-formamido penicillin. The Journal of Antibiotics 43(5): 574-577

Grabley, S.; Hammann, P.; Raether, W.; Wink, J.; Zeeck, A. 1990: Secondary metabolites by chemical screening. Ii. Amycins A and B, two novel niphimycin analogs isolated from a high producer strain of elaiophylin and nigericin. The Journal of Antibiotics 43(6): 639-647

Sanglier, J.-J.; Traber, R.; Buck, R.H.; Hofmann, H.; Kobel, H. 1990: Isolation of (4R)-4-((E)-2-butenyl)-4-methyl-L-threonine, the characteristic structural element of cyclosporins, from a blocked mutant of Tolypocladium inflatum. The Journal of Antibiotics 43(6): 707-714

Kamachi, H.; Okita, T.; Yamasaki, T.; Naito, T. 1990: Direct introduction of a formamido group into the 7.Alpha.(6.Alpha.)-position of cephalosporins (pencillins). The Journal of Antibiotics 43(7): 820-829

Römmele, G.; Wirz, G.; Solf, R.; Vosbeck, K.; Gruner, J.; Wehrli, W. 1990: Resistance of Escherichia coli to rifampicin and sorangicin A - a comparison. The Journal of Antibiotics 43(1): 88-91

Grzybowska, J.; Borowski, E. 1990: Hydrazides-a novel type of derivatives of polyene macrolide antifungal antibiotics. The Journal of Antibiotics 43(7): 907-908

O''sullivan, J.; Mccullough, J.; Johnson, J.H.; Bonner, D.P.; Clark, J.C.; Dean, L.; Trejo, W.H. 1990: Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. I. Taxonomy, fermentation, isolation, physico-chemical and biological characterization. The Journal of Antibiotics 43(8): 913-919

Hara, O.; Hutchinson, C.R. 1990: Cloning of midecamycin (Mls)-resistance genes from Streptomyces mycarofacines, Streptomyces lividans and streptomyces coelicolor A3(2). The Journal of Antibiotics 43(8): 977-991

Miyoshi-Saitoh, M.; Morisaki, N.; Tokiwa, Y.; Iwasaki, S.; Konishi, M.; Saitoh, K.; Oki, T. 1991: Dynamicins O, P and Q: Novel antibiotics related to dynemicin a isolation, characterization and biological activity. The Journal of Antibiotics 44(10): 1037-1044

Kojiri, K.; Arakawa, H.; Satoh, F.; Kawamura, K.; Okura, A.; Suda, H.; Okanishi, M. 1991: New antitumor substances, Be-12406A and Be-12406B, produced by a streptomycete. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. The Journal of Antibiotics 44(10): 1054-1060

Yoshida, S.; Aoyagi, T.; Harada, S.; Matsuda, N.; Ikeda, T.; Naganawa, H.; Hamada, M.; Takeuchi, T. 1991: Production of 2-methyl-4(3H)-quinazolinone, an inhibitor of poly(Adp-ribose) synthetase, by bacterium. The Journal of Antibiotics 44(1): 111-112

Johdo, O.; Watanabe, Y.; Ishikura, T.; Yoshimoto, A.; Naganawa, H.; Sawa, T.; Takeuchi, T. 1991: Anthracycline metabolites from Streptomyces violaceus A262. Ii. New anthracycline epelmycins produced by a blocked mutant strain Su2-730. The Journal of Antibiotics 44(10): 1121-1129

Johdo, O.; Watanabe, Y.; Ishikura, T.; Yoshimoto, A.; Naganawa, H.; Sawa, T.; Takeuchi, T. 1991: Anthracycline metabolites from Streptomyces violaceus A262. Iii. New anthracycline obelmycins produced by a variant strain Se2-2385. The Journal of Antibiotics 44(10): 1130-1140

Balkovec, J.M.; Szymonifka, M.J.; Heck, J.V.; Ratcliffe, R.W. 1991: Basic carbapenem analogs: Synthesis and in vitro activity of 1.Beta.-methyl-2-(pyridylmethylthio)-carbapenems. The Journal of Antibiotics 44(10): 1172-1177

Batta, G.; Sztaricskai, F.; Kövér, K.E.; Rüdel, C.; Berdnikova, T.F. 1991: An Nmr study of eremomycin and its derivatives. The Journal of Antibiotics 44(11): 1208-1221

Ubukata, M.; Tanaka, C.; Osada, H.; Isono, K. 1991: Respinomycin Al, a new anthracycline antibiotic. The Journal of Antibiotics 44(11): 1274-1276

Seto, H.; Hidaka, T.; Kuzuyama, T.; Shibahara, S.; Usui, T.; Sakanaka, O.; Imai, S. 1991: Studies on the biosynthesis of fosfomycin. 2. Conversion of 2-hydoxypropylphosphonic acid to fosfomycin by blocked mutants of Streptomyces wedmorensis. The Journal of Antibiotics 44(11): 1286-1288

Konishi, M.; Ohkuma, H.; Matsumoto, K.; Saitoh, K.; Miyaki, T.; Oki, T.; Kawaguchi, H. 1991: Dynemicins, new antibiotics with the 1,5-diyn-3-ene and anthraquinone subunit. I. Productin, isolation and physico-chemical properties. The Journal of Antibiotics 44(12): 1300-1305

Karwowski, J.P.; Jackson, M.; Maus, M.L.; Kohl, W.L.; Humphrey, P.E.; Tillis, P.M. 1991: Dynaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. I. Taxonomy of the producing organisms, fermentation and antimicrobial activity. The Journal of Antibiotics 44(12): 1312-1317

Nishimura, T.; Yoshimura, Y.; Yamaoka, M.; Kawai, T.; Miyake, A. 1991: Studies on condensed-heterocyclic azolium cephalosporins. I. Synthesis and antibacterial activity of 7.Beta.-(2-(2-aminothiazol-4-yl)-2(Z)-alkoxyiminoacetamido)-3-(imidazo(1,2-a)pyridinium-1-yl)methyl-3-cephem-4-carboxylates. The Journal of Antibiotics 44(12): 1371-1393

Yoshimura, Y.; Miyake, A.; Nishimura, T.; Kawai, T.; Yamaoka, M. 1991: Studies on condensed-heterocyclic azolium cephalosporins. Ii. Synthesis and antibacterial activity of 7.Beta.-(2-(2-aminothiazol-4-yl)-2(Z)-alkoxyiminoacetamido)-3-(condensed-heterocyclic azolium)methyl-3-cephem-4-carboxylates. The Journal of Antibiotics 44(12): 1394-1405

Asano, N.; Tanaka, K.; Kameda, Y.; Matsui, K. 1991: All eight possible mono-.Beta.-D-glucosides of validoxylamine A. Ii. Biological activites. The Journal of Antibiotics 44(12): 1417-1421

Yokoo, C.; Goi, M.; Onodera, A.; Fukushima, H.; Nagate, T. 1991: Studies on cephalosporin antibiotics. Iv. Synthesis, antibacterial activity and oral absorption of new 3-(2-substituted-vinylthio)-7.Beta.-((Z)-2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido)cephalosporins. The Journal of Antibiotics 44(12): 1422-1431

Mikami, Y.; Yazawa, K.; Maeda, A.; Uno, J.; Kubo, A.; Saito, N.; Kawakami, N. 1991: Antifungal activity of Sl-1, a .Beta.-nitrostyrene type pigment and its synthetic congeners. The Journal of Antibiotics 44(12): 1454-1456

Ayer, S.W.; Isaac, B.G.; Luchsinger, K.; Makkar, N.; Tran, M.; Stonard, R.J. 1991: Cis-2-Amino-1-hydroxycyclobutane-1-acetic acid, a herbicidal antimetabolite produced by streptomyces rochei A 13018. The Journal of Antibiotics 44(12): 1460-1462

Yoshida, T.; Nakamoto, S.; Sakazaki, R.; Matsumoto, K.; Terui, Y.; Sato, T.; Arita, H.; Matsutani, S.; Inoue, K.; Kudo, I. 1991: Thielocins A1.Alpha. and A1.Beta., novel phospholipase A2 inhibitors from ascomycetes. The Journal of Antibiotics 44(12): 1467-1470

Weber, W.; Fischli, W.; Hochuli, E.; Kupfer, E.; Weibel, E.K. 1991: Anantin-A peptide antagonist of the atrial natriuretic factor(Anf). I. Producing organism, fermentation, isolation and biological activity. The Journal of Antibiotics 44(2): 164-171

Wyss, D.F.; Lahm, H.-W.; Manneberg, M.; Labhardt, A.M. 1991: Anantin-A peptide antagonist of the atrial natriuretic factor(Anf). Ii. Determination of the primary sequence by Nmr on the basis of proton assignments. The Journal of Antibiotics 44(2): 172-180

Staley, A.L.; Rinehart, K.L. 1991: Biosynthesis of the streptovaricins: 3-Amino-5-hydroxybenzoic acid as a precursor to the meta-C7N unit. The Journal of Antibiotics 44(2): 218-224

Baldwin, J.E.; Bird, J.W.; Field, R.A.; O''callaghan, N.M.; Schofield, C.J.; Willis, A.C. 1991: Isolation and partial characterisation of Acv synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in Acv synthetase. The Journal of Antibiotics 44(2): 241-248

Kasai, M.; Kono, M.; Shirahata, K. 1991: The derivation of a novel mitomycin skeleton: 3.Alpha.-Alkoxymitomycin. The Journal of Antibiotics 44(3): 301-308

Kara, M.; Takiguchi, T.; Ashizawa, T.; Gomi, K.; Nakano, H. 1991: Sapurimycin, new antitumor antibiotic produced by Streptomyces. Producing organism, fermentation, isolation and biological properties. The Journal of Antibiotics 44(1): 33-39

Sawa, R.; Matsuda, N.; Uchida, T.; Ikeda, T.; Sawa, T.; Naganawa, H.; Hamada, M.; Takeuchi, T. 1991: Dioxamycin, a new benz(a)anthraquinone antibiotic. The Journal of Antibiotics 44(4): 396-402

Nishikawa, M.; Yoshida, K.; Okamoto, M.; Itoh, Y.; Kohsaka, M. 1991: Studies on Wf-3681, a novel aldose reductase inhibitor. Iv. Effect of Fr-62765, a derivative of Wf-3681, on the diabetic neuropathy in rats. The Journal of Antibiotics 44(4): 441-444

Maring, C.J.; Freiberg, L.A.; Lartey, P.A.; Grampovnik, D.J.; Edwards, C.M.; Hardy, D.J.; Swanson, R.; Fernandes, P.B. 1991: Synthesis and antimicrobial activities of 9(S)-N,N-dimethyl-amino-9-deoxo-10,11,12,13-tetra-hydroniddamycin. The Journal of Antibiotics 44(4): 448-450

Vanmiddlesworth, F.; Omstead, M.N.; Schmatz, D.; Bartizal, K.; Fromtling, R.; Bills, G.; Nollstadt, K.; Honeycutt, S.; Zweerink, M.; Garrity, G.; Wilson, K. 1991: L-687, 781, a new member of the papulacandin family of .Beta.-1,3-d-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity. The Journal of Antibiotics 44(1): 45-51

Iwasaki, H.; Kamisango, K.-I.; Kuboniwa, H.; Sasaki, H.; Matsubara, S. 1991: 3'-Deoxytalopiericidin A1, a novel analog of antitumor antibiotics from oligotroph. The Journal of Antibiotics 44(4): 451-452

Yokoo, C.; Goi, M.; Onodera, A.; Murata, M.; Nagate, T.; Watanabe, Y. 1991: Studies on cephalosporin antibiotics. Iii. Synthesis, antibacterial activity and oral absorption of new 3-(substituted-alkylthio)-7.Beta.-((Z)-2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido)cephalosporins. The Journal of Antibiotics 44(5): 498-506

Nishida, F.; Mori, Y.; Sonobe, C.; Suzuki, M.; Meevootisom, V.; Flegel, T.W.; Thebtaranonth, Y.; Intararuangsorn, S. 1991: Structure elucidation of glycosidic antibiotics glykenins from basidiomycetes sp. The Journal of Antibiotics 44(5): 541-545

Ohki, H.; Inamoto, Y.; Kawabata, K.; Kamimura, T.; Sakane, K. 1991: Synthesis and antifungal activity of Fr 109615 analogs. The Journal of Antibiotics 44(5): 546-549

Aoyagi, T.; Yoshida, S.; Matsuda, N.; Ikeda, T.; Hamada, M.; Takeuchi, T. 1991: Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus Bmi156-14F1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. The Journal of Antibiotics 44(6): 573-578

Ishii, T.; Hida, T.; Ishimaru, T.; Iinuma, S.; Sudo, K.; Muroi, M.; Kanamaru, T.; Okazaki, H. 1991: Tan-931, a novel nonsteroidal aromatase inhibitor produced by Penicillium funiculosum No.8974. I. Taxonomy, fermentation, isolation, characterization and biological activities. The Journal of Antibiotics 44(6): 589-599

Hida, T.; Ishii, T.; Kanamaru, T.; Muroi, M. 1991: Tan-931, a novel nonsteroidal aromatase inhibitor produced by Penicillium funiculosum No.8974. Ii. Structure elucidation, chemical modification and biological activity. The Journal of Antibiotics 44(6): 600-612

Yamasaki, T.; Narita, Y.; Hoshi, H.; Aburaki, S.; Kamei, H.; Naito, T.; Kawaguchi, H. 1991: Synthesis and biological activity of 1-N-(4-(substituted)amidino and guanidino-2-hydroxybutyryl)kanamycins A and B. The Journal of Antibiotics 44(6): 646-658

Ozasa, T.; Yoneda, T.; Hirasawa, M.; Suzuki, K.; Tanaka, K.; Kadota, S.; Iwanami, M. 1991: Thiazocins, new aldose reductase inhibitors from Actinosynnema sp. 1. Fermentation, isolation and characterization. The Journal of Antibiotics 44(7): 768-773

Isaac, B.G.; Ayer, S.W.; Stonard, R.J. 1991: The isolation of .Alpha.-methylene-.Beta.-alanine, a herbicidal microbial metabolite. The Journal of Antibiotics 44(7): 795-796

Nakagawa, K.; Sato, K.; Okazaki, T.; Torikata, A. 1991: Microbial conversion of milbemycins: 13.Beta., 29-dihydroxylation of milbemycins by soil isolate Streptomyces cavourensis. The Journal of Antibiotics 44(7): 803-805

Itoh, Y.; Shimura, H.; Ito, M.; Watanabe, N.; Yamagishi, M.; Tamai, M.; Hanada, K. 1991: A novel hepatoprotective .Nu.-lactone, Mh-031. I. Discovery, isolation, physico-chemical properties and structural elucidation. The Journal of Antibiotics 44(8): 832-837

Nakayama, E.; Watanabe, K.; Miyauchi, M.; Fujimoto, K.; Muramatsu, S.; Yasuda, H.; Fukami, M.; Ide, J. 1991: Cephalosporin antibiotics. Ii. Synthesis and biological properties of Cs-461 and related compounds. The Journal of Antibiotics 44(8): 864-869

Tanaka, K.; Matsutani, S.; Matsumoto, K.; Yoshida, T. 1992: A novel type of phospholipase A2 inhibitor, thielocin A1.Beta., and mechanism of action. The Journal of Antibiotics 45(7): 1071-1078

Hoff, H.; Drautz, H.; Fiedler, H.-P.; Zähner, H.; Schultz, J.E.; Keller-Schierlein, W.; Philipps, S.; Ritzau, M.; Zeeck, A. 1992: Metabolic products of microorganisms. 261. Obscurolides, a novel class of phosphodiesterase inhibitors from streptomyces. I. Production, isolation, structural elucidation and biological activity of obscurolides A1 to A4. The Journal of Antibiotics 45(7): 1096-1107

Dirlam, J.P.; Bordner, J.; Cullen, W.P.; Jefferson, M.T.; Presseau-Linabury, L. 1992: The structure of Cp-96, 797, a polyether antibiotic related to K-41 A and produced by Streptomyces sp. The Journal of Antibiotics 45(7): 1187-1189

Nakayama, E.; Fujimoto, K.; Muramatsu, S.; Ide, J. 1992: Synthesis and antibacterial activity of 7-(2-(2-aminooxazol-4-yl)-(z)-2-alkoxyiminoacetamido)-cephalosporin antibiotics. The Journal of Antibiotics 45(7): 1193-1194

Boeck, L.D.; Berry, D.M.; Mertz, F.P.; Wetzel, R.W. 1992: A 10255, a complex of novel growth-promoting thiopeptide antibiotics produced by a strain of Streptomyces gardneri. Taxonomy and fermentation studies. The Journal of Antibiotics 45(8): 1222-1230

Boeck, L.D.; Favret, M.E.; Wetzel, R.W. 1992: Biosynthesis of thiopeptide antibiotic A10255 in stirred reactors using a chemically difined medium supplemented with continuous nutrient feeds. The Journal of Antibiotics 45(8): 1278-1285

Bannister, B.; Zapotocky, B.A. 1992: Protorubradirin, an antibiotic containing a C-nitroso-sugar fragment, is the true secondary metabolite produced by Streptomyces achromogenes var. rubradiris. Rubradirin, described earlier, is its photo-oxidation product. The Journal of Antibiotics 45(8): 1313-1324

Ikai, Y.; Oka, H.; Hayakawa, J.; Harada, K.-I.; Suzuki, M. 1992: Structural characterization of bacitracin components by frit-fast atom bombardment(Fab) liquid chromatography/mass spectrometry(Lc/Ms). The Journal of Antibiotics 45(8): 1325-1334

Hensens, O.D.; White, R.F.; Goegelman, R.T.; Inamine, E.S.; Patchett, A.A. 1992: The preparation of (2-deutero-3-fluoro-D-alA8)cyclosporin A by directed biosynthesis. The Journal of Antibiotics 45(1): 133-135

Hedtmann, U.; Fehlhaber, H.-W.; Sukatsch, D.A.; Weber, M.; Hoffmann, D.; Kraemer, H.P. 1992: The new cytotoxic antibiotic cytorhodin X, an unusual anthracyclinone-9.Alpha.-glycoside. The Journal of Antibiotics 45(8): 1373-1375

Kunze, B.; Trowitzsch-Kienast, W.; Höfle, G.; Reichenbach, H. 1992: Nannochelins A, B and C, new iron-chelating compounds from Nannocystis exedens (myxobacteria). Production, isolation,physico-chemical and biological properties. The Journal of Antibiotics 45(2): 147-150

Tsunakawa, M.; Kotake, C.; Yamasaki, T.; Moriyama, T.; Konishi, M.; Oki, T. 1992: New antiviral antibiotics, cycloviracins B1 and B2. Ii. Structure determination. The Journal of Antibiotics 45(9): 1472-1480

Phillips, L.; Wellington, E.M.H.; Rees, S.B.; Jun, L.S.; King, G.P. 1992: The distribution of Dna sequences hybridizing with antibiotic production and resistance gene probes within type strains and wild isolates of Streptomyces species. The Journal of Antibiotics 45(9): 1481-1491

Dirlam, J.P.; Bordner, J.; Chang, S.-P.; Grizzuti, A.; Nelson, T.H.; Tynan, E.J.; Whipple, E.B. 1992: The isolation and structure of Cp-120, 509, a new polyether antibiotic related to semduramicin and produced by mutants of Actinomadura roseorufa. The Journal of Antibiotics 45(9): 1544-1548

Roy, K.; Vijayakumar, E.K.S.; Mukhopadhyay, T.; Chatterjee, S.; Bhat, R.G.; Blumbach, J.; Ganguli, B.N. 1992: Aranorosinol A and aranorosinol B, two new metabolities from Pseudoarachniotus roseus: Production, isolation, structure elucidation and biological properties. The Journal of Antibiotics 45(10): 1592-1598

Yoshimoto, A.; Johdo, O.; Tone, H.; Okamoto, R.; Naganawa, H.; Sawa, T.; Takeuchi, T. 1992: Production of new anthracycline antibiotics 1-hydroxyoxaunomycin and 6-deoxyoxaunomycine by limited biosynthetic conversion using a daunorubicin-negative mutant. The Journal of Antibiotics 45(10): 1609-1617

Tomoda, H.; Huang, X.-H.; Caoa, J.; Nishida, H.; Nagao, R.; Okuda, S.; Tanaka, H.; Omura, S.; Arai, H.; Inoue, K. 1992: Inhibition of acyl-CoA: Cholesterol acyltransferase activity by cyclodepsiptide antibiotics. The Journal of Antibiotics 45(10): 1626-1632

Ikeda, Y.; Ikeda, D.; Kondo, S. 1992: Total syntheses of bellenamine and its isomers. The Journal of Antibiotics 45(10): 1677-1680

Komagata, D.; Sawa, R.; Kinoshita, N.; Imada, C.; Sawa, T.; Naganawa, H.; Hamada, M.; Okami, Y.; Takeuchi, T. 1992: Isolation of glutathione-S- transferase inhibitors. The Journal of Antibiotics 45(10): 1681-1683

Horn, W.S.; Smith, J.L.; Bills, G.F.; Raghoobar, S.L.; Helms, G.L.; Kurtz, M.B.; Marrinan, J.A.; Frommer, B.R.; Thornton, R.A.; Mandala, S.M. 1992: Sphingofungins F and F: Novel serinepalmitoyl transferase inhibitors from Paecilomyces variotii. The Journal of Antibiotics 45(10): 1692-1696

Ogita, T.; Sato, A.; Enokita, R.; Suzuki, K.; Ishii, M.; Negishi, T.; Okazaki, T.; Tamak, K.; Tanzawa, K. 1992: Matlystatins, new inhibitors of typeIv collagenases for Actinomadura atramentaria. I. Taxonomy, fermentation, isolation, and physico-chemical properties of matlystatin-group compounds. The Journal of Antibiotics 45(11): 1723-1732

Tanzawa, K.; Ishii, M.; Ogita, T.; Shimada, K. 1992: Matlystatins, new inhibitors of type Iv collagenases from Actinomadura atramentaria. Ii. Biological activities. The Journal of Antibiotics 45(11): 1733-1737

Koyama, Y.; Huang, S.-P.; Ikeda, D.; Kondo, S.; Takeuchi, T. 1992: Synthesis and activity of 3-(isoxazolin-5-yl)- and 3-(isoxazol-4-yl) cephalosporins. The Journal of Antibiotics 45(12): 1930-1938

Huang, S.-P.; Koyama, Y.; Ikeda, D.; Kondo, S.; Takeuchi, T. 1992: Synthesis and activity of potent 3-(isoxazolidin-5-yl)- and 3-(isoxazolidinium-5-yl) cephalosporins. The Journal of Antibiotics 45(12): 1939-1948

Adefarati, A.A.; Hensens, O.D.; Jones, E.T.T.; Tkacz, J.S. 1992: Pneumocandins from Zalerion arboricola. V. Glutamic acid- and leucine-derived amino acids in pneumocandin A0(L-671,329) and distinct origins of the substituted proline residues in pneumocandins A0 and B0. The Journal of Antibiotics 45(12): 1953-1957

Koyama, Y.; Huang, S.-P.; Ikeda, D.; Kondo, S.; Takeuchi, T. 1992: Orally active pivaloyloxymethyl 3-(isoxazolidin-5-yl) cephalosporins. The Journal of Antibiotics 45(12): 1966-1969

Otsuka, T.; Takase, S.; Terano, H.; Okuhara, M. 1992: New angiogenesis inhibitors, Wf-16775A1 and A2. The Journal of Antibiotics 45(12): 1970-1973

Hidaka, T.; Hidaka, M.; Seto, H. 1992: Studies on the biosynthesis of bialaphos(Sf-1293). 14. Nucleotide sequence of phosphoenolpyruvate phosphomutase gene isolated from a bialaphos producing organism, Streptomyces hygroscopicus, and its expression in Streptomyces lividans. The Journal of Antibiotics 45(12): 1977-1980

Schüz, T.C.; Fiedler, H.-P.; Zähner, H.; Rieck, M.; König, W.A. 1992: Metabolic products of microorganisms. 263 Nikkomycins Sz, Sx, Soz and Sox, new intermediates associated to the nikkomycin biosynthesis of Streptomyces tendae. The Journal of Antibiotics 45(2): 199-206

Takagi, Y.; Sohtome, H.; Tsuchiya, T.; Umezawa, S.; Takeuchi, T. 1992: Synthesis of 7-O-(2,6-dideoxy-2-fluoro-4-O-(3-fluorotetrahydropyran-2-yl)-.Alpha.-L-talopyranosyl)daunomycinone. The Journal of Antibiotics 45(3): 355-362

Roberts, J.L.; Bevilacqua, P.F.; Keith, D.D.; Pawson, B.A.; Pruess, D.L.; Rossman, P.L. 1992: 6.Alpha.-Hydroxypenicillanic acid-S(S)-oxide and analogues: Synthesis and antimicrobial activity. The Journal of Antibiotics 45(3): 363-373

Meier, R.-M.; Tamm, C. 1992: Studies directed towards the biosynthesis of the C7N-unit of rifamycin B: Incorporation of (14C(G))quinic acid and (1,2-13C2)glycerol. The Journal of Antibiotics 45(3): 400-410

Liu, W.C.; Barbacid, M.; Bulgar, M.; Clark, J.M.; Crosswell, A.R.; Dean, L.; Doyle, T.W.; Fernandes, P.B.; Huang, S.; Manne, V.; Pirnik, D.M.; Wells, J.S.; Meyers, andE. 1992: 10'-Desmethoxystreptonigrin, a novel analog of streptonigrin. The Journal of Antibiotics 45(4): 454-457

Nishimura, T.; Yoshimura, Y.; Miyake, A. 1992: Studies on condensed-heterocyclic azolium cephalosporins. Iii. Synthesis and antibacterial activity of 7.Beta.-(2-(2-amino-5-substituted-thiazol-4-yl)-2(Z)-alkoxyiminoacetamido)-3-(condensed-heterocyclic azolium)methyl-3-cephem-4-carboxylates. The Journal of Antibiotics 45(4): 485-499

Kumagai, H.; Tomoda, H.; Omura, S. 1992: Biosynthesis of antibiotic 1233A (F-244) and preparation of (14C) 1233A. The Journal of Antibiotics 45(4): 563-567

Chen, T.S.; Arison, B.H.; Wicker, L.S.; Inamine, E.S. 1992: Microbial transformation of immunosuppressive compounds. Ii. Specific desmethylation of 13-methoxy group of Fk 506 and Fr 900520 by Actinomycete sp. Atcc 53828. The Journal of Antibiotics 45(4): 577-580

Adam, S.; Then, R.; Angehrn, P. 1992: Methylene (2S, 5R)-6-(3-formylallylidene)penicillanate pivalate, a prodrug of a new .Beta.-lactamase inhibitor. The Journal of Antibiotics 45(4): 587-588

Dawson, M.J.; Farthing, J.E.; Marshall, P.S.; Middleton, R.F.; O''neill, M.J.; Shuttleworth, A.; Stylli, C.; Tait, R.M.; Taylor, P.M.; Wildman, H.G.; Buss, A.D.; Langley, D.; Hayes, M.V. 1992: The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. The Journal of Antibiotics 45(5): 639-647

Maxell, M.A.; Bishop, B.F.; Bryce, P.; Oration, K.A.F.; Kara, H.; Monday, R.A.; Pacey, M.S.; Perry, D.A.; Kojima, Y.; Maeda, H.; Nishiyama, S.; Tone, J.; Huang, L.H. 1992: C-13.Beta.-Acyloxymilbemycine, a new family of macrolides. Discovery, structural determination and hological properties. The Journal of Antibiotics 45(5): 659-670

Shigematsu, N.; Tsujii, E.; Kayakiri, N.; Takase, S.; Tanaka, H.; Tada, T. 1992: Wf11605, an antagonist of leukotriene B4 produced by a fungus. Ii. Structure determination. The Journal of Antibiotics 45(5): 704-708

Miyake, A.; Yoshimura, Y.; Yamaoka, M.; Nishimura, T.; Hashimoto, N.; Imada, A. 1992: Studies on condensed-heterocyclic azolium cephalosporins. Iv. Synthesis and antibacterial activity of 7.Beta.-(2-(5-amino-1,2,4-thiadizol-3-yl)-2(Z)-alkoxyiminoacetamido)-3-(condensed-heterocyclic azolium)methyl cephalosporins including Sce-2787. The Journal of Antibiotics 45(5): 709-720

Yamauchi, N.; Kakinuma, K. 1992: Biochemical studies on 2-deoxy-scyllo-inosose, an early intermediate in the biosynthesis of 2-deoxystreptamine. I. Chemical synthesis of 2-deoxy-scyllo-inosose and (2,2-2H2)-2-deoxy-scyllo-inosose. The Journal of Antibiotics 45(5): 756-766

Yamauchi, N.; Kakinuma, K. 1992: Biochemical studies on 2-deoxy-scyllo-inosose, an early intermediate in the biosynthesis of 2-deoxystreptamine. Iii. Confirmation of in vitro synthesis of 2-deoxy-scyllo-inosose, the earliest intermediate in the biosynthesis of 2-deoxystreptamine, using cell free preparations of Streptomyces fradiae. The Journal of Antibiotics 45(5): 774-780

Alpegiani, M.; Bedeschi, A.; Zarini, F.; Bruna, C.D.; Jabes, D.; Perrone, E.; Franceschi, G. 1992: Synthesis and biologicalproperties of Fce 25199, a new oral penem. The Journal of Antibiotics 45(5): 797-801

Morishita, A.; Murofushi, S.; Ishizawa, K.; Mutoh, N.; Yaginuma, S. 1992: Isolation and characterization of sporeamicin B. The Journal of Antibiotics 45(5): 809-812

Hakoda, S.; Tsubotani, S.; Iwasa, T.; Suzuki, M.; Kondo, M.; Harada, S. 1992: Production and biological activities of a new antifungal antibiotic, Tan-950A. The Journal of Antibiotics 45(6): 854-860

Vanmiddlesworth, F.; Giacobbe, R.A.; Lopez, M.; Garrity, G.; Bland, J.A.; Bartizal, K.; Fromtling, R.A.; Polishook, J.; Zweerink, M.; Edison, A.M.; Rozdilsky, W.; Wilson, K.E.; Monaghan, R.L. 1992: Sphingofungins A,B,C, and d; a new family of antifungal agents. I. Fermentation, isolation, and biological activity. The Journal of Antibiotics 45(6): 861-867

Kishimura, Y.; Kawashima, A.; Kagamizono, T.; Yamagishi, M.; Matsumoto, K.; Kawashima, Y.; Hanada, K. 1992: Pi-200 and Pi-201, new platelet aggregation inhibitors produced by Streptomyces sp. A7498. Taxonomy, fermentation, isolation, physico-chemical properties, structure determination and biological properties. The Journal of Antibiotics 45(6): 892-898

Yokoo, C.; Onodera, A.; Fukushima, H.; Numata, K.; Nagate, T. 1992: Studies on cephalosporin antibiotics. V. Synthesis, antibacterial activity and oral absorption of new 3-((Z)-2-methoxycarbonylvinylthio)-7.Beta.-((Z)-2-(2-aminothiazol-4-yl)-2-(oxyimino)acetamido)cephalosporins. The Journal of Antibiotics 45(6): 932-939

Patchett, A.A.; Taub, D.; Hensens, O.D.; Goegelman, R.T.; Yang, L.; Dumont, F.; Peterson, L.; Sigal, N.H. 1992: Analogs of cyclosporin A modified at the D-Ala8 position. The Journal of Antibiotics 45(1): 94-102

Sunagawa, M.; Matsumura, H.; Inoue, T.; Yamaga, H.; Fukasawa, M. 1992: Synthesis and biological properties of 1.Beta.-methyl-carbapenems with N-methylpyrrolidinylthio group at C-2 position. The Journal of Antibiotics 45(6): 971-976

Goda, S.K.; Akhtar, M. 1992: Neomycin biosynthesis: The incorporation of D-6-deoxy-glucose derivatives and variously labelled glucose into the 2-deoxystreptamine ring. Postulated involvement of 2-deoxyinosose synthase in the biosynthesis. The Journal of Antibiotics 45(6): 984-994

Watanabe, J.; Fujisaki, N.; Fujimori, K.; Anzai, Y.; Oshima, S.; Sano, T.; Ohtsuka, T.; Watanabe, K.; Okuda, T. 1993: Tetronothiodin, a novel cholecystokinin type-B recepter antagonist produced by Streptomyces sp. Nr0489. I. Taxonomy, yield improvement and fermentation. The Journal of Antibiotics 46(1): 1-10

Chatterjee, S.; Vijayakumar, E.K.S.; Franco, C.M.M.; Blumbach, J.; Ganguli, B.N.; Fehlhaber, H.-W.; Kogler, H. 1993: On the structures of alisamycin, a new member of the manumycin class of antibiotics. The Journal of Antibiotics 46(6): 1027-1030

Ando, O.; Nakajima, M.; Hamano, K.; Itoi, K.; Takahashi, S.; Takamatsu, Y.; Sato, A.; Enokita, R.; Okazaki, T.; Haruyama, H.; Kinoshita, T. 1993: Isolation on trehalamine, the aglycon of trehazolin, from microbial broths and characterization of trehazolin related compounds. The Journal of Antibiotics 46(7): 1116-1125

Namiki, Y.; Kihara, N.; Koda, S.; Hane, K.; Yasuda, T. 1993: Tautomeric phenomenon of a novel potent immunosuppressant(Fk506) in solution. I. Isolation and structure determination of tautomeric compounds. The Journal of Antibiotics 46(7): 1149-1155

Ueno, M.; Amemiya, M.; Yamazaki, K.; Iijima, M.; Osono, M.; Someno, T.; Iinuma, H.; Hamada, M.; Ishizuka, M.; Takeuchi, T. 1993: Delaminomycins, novel extracellular matrix receptor antagonist. The Journal of Antibiotics 46(7): 1156-1162

Watanabe, Y.; Adachi, T.; Asaka, T.; Kashimura, M.; Matsunaga, T.; Morimoto, S. 1993: Chemical modification of erythromycins. Xii. A facile synthesis of clarithromycin(6-O-methylerythromycin A) via 2'-silylethers of erythromycin a derivatives. The Journal of Antibiotics 46(7): 1163-1167

Omura, S.; Tomoda, H.; Kim, Y.K.; Nishida, H. 1993: Pyripyropenes, highly potent inhibitiors of Acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. The Journal of Antibiotics 46(7): 1168-1169

Kuroda, K.; Yoshida, M.; Uosaki, Y.; Ando, K.; Kawamoto, I.; Oishi, E.; Onuma, H.; Yamada, K.; Matsuda, Y. 1993: As-183, a novel inhibitor of acyl-CoA: Cholesterol acyltranseferase produced by Scedosporium sp. Spc-15549. The Journal of Antibiotics 46(8): 1196-1202

Guest, A.W.; Adams, R.G.; Basker, M.J.; Brain, E.G.; Branch, C.L.; Harrington, F.P.; Neale, J.E.; Pearson, M.J.; Zomaya, I.I. 1993: Synthesis and biological activity of 3-(N-substituted pyridinium-4-thiomethyl)-7.Alpha.-formamido cephalosporins. The Journal of Antibiotics 46(8): 1279-1288

Branch, C.L.; Adams, R.G.; Brain, E.G.; Guest, A.W.; Harrington, F.P.; Knott, S.J.; Pearson, M.J.; Zomaya, I.I. 1993: Synthesis and biological properties of some 3-((N-subtstituted-amino)pyridinium-4-thiomethyl)-7-((2-amino-thiazol-4-yl)-2-(Z)-(methoxyimino)acetamido)ceph-3-em-4-carboxylates. The Journal of Antibiotics 46(8): 1289-1299

Yamazaki, T.; Tatee, T.; Aoyama, T.; Kojima, F.; Takeuchi, T.; Aoyagi, T. 1993: Bequinostating C and D, new inhibitors of glutathione S-transferase, produced by Steptomyces sp. Mi384-Df12. The Journal of Antibiotics 46(8): 1309-1311

Chen, T.S.; So, L.; White, R.; Monaghan, R.L. 1993: Microbial hydroxylation and glucuronidation of the angiotensin Ii(A Ii) receptor antagonist Mk 954. The Journal of Antibiotics 46(1): 131-134

Kurokawa, T.; Suzuki, K.; Hayaoka, T.; Nakagawa, T.; Izawa, T.; Kobayashi, M.; Harada, N. 1993: Cyclophostin, acetylocholinesterase inhibitor from Streptomyces lavendulae. The Journal of Antibiotics 46(8): 1315-1318

Hori, Y.; Abe, Y.; Nakajima, H.; Takase, S.; Fujita, T.; Goto, T.; Okuhara, M.; Kohsaka, M. 1993: Wb2838 (3-chloro-4-(2-amino-3-chlorophenyl)-pyrrole): Non-steroidal androgen-receptor antagonist produced by a Pseudomonas. The Journal of Antibiotics 46(9): 1327-1333

Imoto, M.; Kakeya, H.; Sawa, T.; Hayashi, C.; Hamada, M.; Takeuchi, T.; Umezawa, K. 1993: Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy,isolation, and characterization. The Journal of Antibiotics 46(9): 1342-1346

Takahashi, S.; Miyaoka, H.; Tanaka, K.; Enokita, R.; Okazaki, T. 1993: Milbemycins .Alpha.11, .Alpha.l2, .Alpha.13, .Alpha.14, and .Alpha.15: A new family of milbemycins from Streptomyces hygroscopicus subsp. aureolacrimosus. Taxonomy, fermentation, isolation, structure elucidation and biological properties. The Journal of Antibiotics 46(9): 1364-1371

Fabre, B.; Velours, J.; Etienne, G.; Legendre, F.; Tiraby, G. 1993: Cl307-24, a new antibiotic complex from Saccharopolyspora aurantiafa sp. nov. Ii. Physico-chemical and biological properties. The Journal of Antibiotics 46(9): 1421-1427

Sakata, N.; Mase, T.; Ikeno, S.; Hori, M.; Otani, T. 1993: The ammo acid sequence of actinoxanthin apoprotein deduced from the base sequence of the gene. The Journal of Antibiotics 46(9): 1475-1477

Kuzuyama, T.; Hidaka, T.; Imai, S.; Seto, H. 1993: Studies on the biosynthesis of fosfomycin. 5. Cloning of genes for fosfomycin biosynthesis. The Journal of Antibiotics 46(9): 1478-1480

Nagashima, K.; Toki, S.; Nakanishi, S.; Kase, H.; Matsuda, Y. 1993: Neurite formation in Ng108-15 neuroblastoma*glioma hybrid cells by Ks-505a, a potent inhibitor of brain Cyclic nucleotide phosphodiesterase. The Journal of Antibiotics 46(9): 1481-1483

Ueki, T.; Numata, K.-I.; Ada, Y.S.; Nakajima, T.; Fukagawa, Y.; Oki, T. 1993: Studies on the mode of antifungal action of pradimicin antibiotics. I.Lectin-mimic binding of Bmy-28864 to yeast mannan in the presence of calcium. The Journal of Antibiotics 46(1): 149-161

Kohama, T.; Miyaoka, H.; Torikata, A.; Inukai, M.; Kaneko, I.; Shiraishi, A. 1993: Screening method for colony-stimulating factor inducers using a human hone marrow stromal cell line, Km-102. The Journal of Antibiotics 46(10): 1494-1502

Hayakawa, Y.; Matsuoka, M.; Shin-Ya, K.; Seto, H. 1993: Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. 1. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity. The Journal of Antibiotics 46(10): 1557-1562

Hayakawa, Y.; Shin-Ya, K.; Furihata, K.; Seto, H. 1993: Quinolidomicins Al, A2 and B1, novel 60-membered macrolide antibiotics. Ii. Structure elucidation. The Journal of Antibiotics 46(10): 1563-1569

Furumai, T.; Yamamoto, H.; Narita, Y.; Hasegawa, T.; Aburaki, S.; Kakushima, M.; Oki, T. 1993: Microbial modification of pradimicins at C- 11 leading to 11-O-demethyl- and 11-O-L-xylosylpradimicins A and Fa-I. The Journal of Antibiotics 46(10): 1589-1597

Morisaki, N.; Iwasaki, S.; Yazawa, K.; Mikami, Y.; Maeda, A. 1993: Inactivated products of rifampicin by pathogenic Nocardia spp.: Structures of glycosylated and phosphorylated metaholites of rifampicin and 3-formylrifamycin Sv. The Journal of Antibiotics 46(10): 1605-1610

Uchida, H.; Nakakita, Y.; Enoki, N.; Abe, N.; Nakamura, T.; Munekata, M. 1993: A novel compound related to chartreusin from a mutant of Strepfomyces chartreusis. The Journal of Antibiotics 46(10): 1611-1615

Kobinata, K.; Koshino, H.; Kudo, T.; Isono, K.; Osada, H. 1993: Rk-397, a new oxo pentaene antihiotic. The Journal of Antibiotics 46(10): 1616-1618

Kunze, B.; Jansen, R.; Pridzun, L.; Jurkiewicz, E.; Hunsmann, G.; Höfle, G.; Reichenbach, H. 1993: Thiangazole, a new thiazoline antibiotic from Polyangium sp. (myxodacteria): Production, antimicrobial activity and mechanism of action. The Journal of Antibiotics 46(11): 1752-1755

Nair, M.G.; Chandra, A.; Thorogood, D.L. 1993: Griseulin, a new nitro-containing bioactive metabolite produced by Streptomces spp. The Journal of Antibiotics 46(11): 1762-1763

Hasumi, K.; Shinohara, C.; Iwanaga, T.; Endo, A. 1993: Lateritin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Gibberella lateritium Ifo 7188. The Journal of Antibiotics 46(12): 1782-1787

Shiozawa, H.; Kagasaki, T.; Kinoshita, T.; Haruyama, H.; Domon, H.; Utsui, Y.; Kodama, K.; Takahashi, S. 1993: Thiomarinol, a new hybrid antimicrobial antibiotic produced by a marine bacterium. Fermentation, isolation, structure, and antimicrobial activity. The Journal of Antibiotics 46(12): 1834-1842

Tabata, N.; Tomoda, H.; Iwai, Y.; Omura, S. 1993: Hynapenes A, B and C, new anticoccidial agents produced by Penicillium sp. Ii. Structure elucication. The Journal of Antibiotics 46(12): 1854-1858

Nakata, M.; Chong, C.; Niwata, Y.; Toshima, K.; Tatsuta, K. 1993: A family of cyclophellitolanalogs: Synthesis and evaluation. The Journal of Antibiotics 46(12): 1919-1922

Uosaki, Y.; Kawada, S.-Z.; Nakano, H.; Saitoh, Y.; Sano, H. 1993: Uct4B, a new antitumor antibiotic with topoisomerase Ii mediated Dna cleavage activity. The Journal of Antibiotics 46(2): 235-240

Liu, C.-M.; Westley, J.W.; Chu, J.; Hermann, T.E.; Liu, M.; Palleroni, N. 1993: Three Novel polyether antibiotics X-14889A, C, and D from a streptomycete. Taxonomy of the producing ogranism, fermentation production and biological properties of the antibiotics. The Journal of Antibiotics 46(2): 275-279

Kume, M.; Kubota, T.; Kimura, Y.; Nakashimizu, H.; Motokawa, K. 1993: Orally active cephalosporins. Iii. Synthesis and structure-activity relationships of new 3-heterocyclicthiomethylthio-7.Beta.-((Z)-2(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-cephem-4-carboxylic acids. The Journal of Antibiotics 46(2): 316-330

Anderson, R.K.; Chapman, P.C.; Cosham, S.C.; Davies, J.S.; Grinter, T.J.; Harris, M.A.; Merrikin, D.J.; Mitchell, C.A.; Ponsford, R.J.; Smith, C.F.; Stachulski, A.V. 1993: Synthesis and structure-activity relationships of some 6.Beta.-acrylamido penicillins. The Journal of Antibiotics 46(2): 331-342

Atkins, R.J.; Ponsford, R.J.; Sxachulski, A.V. 1993: Stereoselective synthesis of Brl56173, a bicyclic acrylic penicillin highly stable to .Beta.-lactamases. The Journal of Antibiotics 46(2): 362-365

Yarbrough, G.G.; Taylor, D.P.; Rowlands, R.T.; Crawford, M.S.; Lasure, L.L. 1993: Screening microbial metabolites for new drugs. Theoretical and practical issues. The Journal of Antibiotics 46(4): 535-544

Ahmed, Z.H.; Fiala, R.R.; Bullock, M.W. 1993: Incorporation of carbon-14 in the biosynthesis of the macrolide antibiotic, Il-F28249-.Alpha.. The Journal of Antibiotics 46(4): 614-622

Malabarba, A.; Ciabatti, R.; Kettenring, J.; Scotti, R.; Candiani, G.; Berti, M.; Pallanza, R.; Goldstein, B.P. 1993: N63-carboxamides of N15-alkyl and N15, N15-dialkyl derivatives of teicoplanin and deglucoteicoplanin. The Journal of Antibiotics 46(4): 668-675

Naruse, N.; Yamamoto, S.; Yamamoto, H.; Kondo, S.; Masuyoshi, S.; Numata, K.-I.; Fukagawa, Y.; Oki, T. 1993: .Beta.-Cyanoglutamic acid, a new antifungal amino acid from a streptomycete. The Journal of Antibiotics 46(4): 685-686

Toda, S.; Yamamoto, S.; Tenmyo, O.; Tsuno, T.; Hasegawa, T.; Rosser, M.; Oka, M.; Sawada, Y.; Konishi, M.; Oki, T. 1993: A new neuritogenetic compound Bu-4514N produced. The Journal of Antibiotics 46(6): 875-883

Mine, Y.; Watanabe, Y.; Sakamoto, H.; Hatano, K.; Wakai, Y.; Kamimura, T.; Tawara, S.; Matsumoto, S.; Matsumoto, F.; Kuwahara, S. 1993: In vivo antibacterial activity of Fk307, a novel parenteral broad-spectrum cephalosporin. The Journal of Antibiotics 46(1): 88-98

Ubukata, M.; Uzawa, J.; Osada, H.; Isono, K. 1993: Respinomycins A1, A2, B, C and D, a novel group of anthracycline antibiotics. Ii. Physico-chemical properties and structure elucidation. The Journal of Antibiotics 46(6): 942-951

Ueno, M.; Someno, T.; Sawa, R.; Iinuma, H.; Naganawa, H.; Ishizuka, M.; Takeuchi, T. 1993: Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. Ii. Physico-chemical properties and structure elucidation of delaminomycin A. The Journal of Antibiotics 46(6): 979-984

Jung, F.; Boucherot, D.; Delvare, C.; Olivier, A.; Davies, G.M.; Betts, M.J.; Brown, R.; Stevenson, R.; Joseph, M.; Kingston, J.F.; Pittam, J.D. 1993: Synthesis and structure-activity relationships of new cephalosporins with aminoimidazoles at C-7. Effect of the pKa of the C-7 aminoimidazole on antibacterial spectrum and .Beta.-lactamase stability. The Journal of Antibiotics 46(6): 992-1012

Yanagisawa, M.; Sakal, A.; Adachi, K.; Sano, T.; Watanabe, K.; Tanaka, Y.; Okuda, T. 1994: Hispidospermidin, a novel phospholipase C inhibitor produced by Chaefosphaeronema hispidulum (Cda) Moesz Nr 7127. I. Screening, taxonomy, and fermentation. The Journal of Antibiotics 47(1): 1-5

Nishimura, Y.; Kudo, T.; Kondo, S.; Takeuchi, T.; Tsuruoka, T.; Fukuyasu, H.; Shibahara, S. 1994: Totally syntheticanalogues of siastatin B. Iii. Trifluoroacetamide analogues having inhibitory activity for tumor metastasis. The Journal of Antibiotics 47(1): 101-107

Tanaka, H.; Kominato, K.; Yamamoto, R.; Yoshioka, T.; Nishida, H.; Tone, H.; Okamoto, R. 1994: Synthesis of donorubicin-cyclodentrin conjugates. The Journal of Antibiotics 47(9): 1025-1029

Im, C.; Maiti, S.N.; Micetich, R.G.; Daneshxalab, M.; Atchison, K.; Phillips, O.A.; Kunugita, C. 1994: Synthesis and .Beta.-lactamase inhibitory activity of 6-((1-heteroarylthioethyl-1,2,3-triazol4-yl)methylene)-penam sulfones. The Journal of Antibiotics 47(9): 1030-1040

Hornback, W.J.; Munroe, J.E.; Counter, F.T. 1994: Synthesis and in vitro antibacterial activities of 3-thiazol 4 yl-carba-l-dethiacephalosporins. The Journal of Antibiotics 47(9): 1052-1064

Shindo, K.; Yamagishi, Y.; Okada, Y.; Kawai, H. 1994: Collismycins A and B, novel non-steroidal inhibitors of denamethasone-glucocorticoid receptor binding. The Journal of Antibiotics 47(9): 1072-1074

Murakawa, S.; Sakai, K.; Endo, A. 1994: Isolation of 3.Alpha.-hydroxy-3,5-dihydro Ml-236C (sodium salt) from Paecilomyces viridis L-68. The Journal of Antibiotics 47(1): 108-109

Shimanaka, K.; Takahashi, Y.; Iinuma, H.; Naganawa, H.; Takeuchi, T. 1994: Novel antibiotic, amythiamicins. Iii. Structure elucidations of amythiamicins A, B and C. The Journal of Antibiotics 47(10): 1153-1159

Barow, C.J.; Sedlock, D.M.; Sun, H.H.; Cooper, R.; Gillum, A.M. 1994: Win 66306, a new neuroknin antagonist produced by an Aspergillus species: Fermentation, isolation and physico-chemical properties. The Journal of Antibiotics 47(11): 1182-1187

Sunagawa, M.; Sasaki, A.; Yamaga, H.; Shinagawa, H.; Sumita, Y.; Nouda, H. 1994: Novel quaternary ammonium carbapenems: 1.Beta.-Methyl-2-(5'-substituted pyrrolidinylthio)carbapenems. The Journal of Antibiotics 47(11): 1337-1340

Hayakawa, Y.; Ishigami, K.; Shin-Ya, K.; Seto, H. 1994: Menoxymycins A and B, new antitumor antibiotics generating active oxygen in tumor cells. The Journal of Antibiotics 47(11): 1344-1347

Fujita, T.; Hatanaka, H.; Hayashi, K.-I.; Shigematsu, N.; Takase, S.; Okamoto, M.; Okuhara, M.; Shimatani, K.; Satoh, A. 1994: Fr 901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. I. Producing organism, fermentation, isolation, physico-chemical and biological properties. The Journal of Antibiotics 47(12): 1359-1364

Fujita, T.; Shinguh, Y.; Yamazaki, A.; Nakahara, K.; Okamoto, M.; Okuhara, M. 1994: Fr 901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. Ii. Pharmacological effect of Fr 901451. The Journal of Antibiotics 47(12): 1365-1368

Gomi, S.; Amano, S.; Sato, E.; Miyadoh, S.; Kodama, Y. 1994: Novel antibiotics Sf2738A,B and C, and their analogs produced by Streptomyces sp. The Journal of Antibiotics 47(12): 1385-1394

Obregon, A.-M.; Escalante, L.; Gonzalez, R.; Rodriguez, R.; Sanche, S. 1994: Physiological studies of gentamicin: phosphate repression of antibiotic formation. The Journal of Antibiotics 47(12): 1442-1446

Kinashi, H.; Mori, E.; Hatani, A.; Nimi, O. 1994: Isolation and characterization of linear plasminds from lankacidin-producing Streptomyces species. The Journal of Antibiotics 47(12): 1447-1455

Lau, R.C.M.; Rinehart, K.L. 1994: Berninamycins B,C, and D, minor metabolites from Streptomyces bernensis. The Journal of Antibiotics 47(12): 1466-1472

Tomoda, H.; Kim, Y.K.; Nishida, H.; Masuma, R.; Omura, S. 1994: Pyripyropenes, novel inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties. The Journal of Antibiotics 47(2): 148-153

Kim, Y.K.; Tomoda, H.; Nishida, H.; Sunazuka, T.; Obata, R.; Omura, S. 1994: Pyripyropenes, novel inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. Ii. Structure elucidation of pyripyropenes A, B, C and D. The Journal of Antibiotics 47(2): 154-162

Chen, T.S.; Petuch, B.; White, R.; Dezeny, G.; Li, X.; Arison, B.; Beattie, T.; Colwell, L.; Dumont, F.; Monaghan, R. 1994: Microbial transformations of immunosuppressive compounds. Iv. Hydroxylation and hemiketal formation of ascomycin(immunomycin) by Streptomyces sp. Ma6970(Atcc No.55281). The Journal of Antibiotics 47(12): 1557-1559

Kuroda, K.; Morishita, Y.; Saito, Y.; Ikuina, Y.; Ando, K.; Kawamoto, I.; Matsuda, Y. 1994: As-186 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase from Pencillium asperosporum Ky1635. The Journal of Antibiotics 47(1): 16-22

Shinohara, C.; Hasumi, K.; Takei, Y.; Endo, A. 1994: Gypsetin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata Ifo 9228. I. Fermentation, isolation, physico-chemical properties and biological activity. The Journal of Antibiotics 47(2): 163-167

Amade, P.; Mallea, M.; Bouaïcha, N. 1994: Isolation, Structural Identification And Biological Activity Of Two Metabolites Produced By Penicillium olsonii Bainier And Sartory. The Journal of Antibiotics 47(2): 201-208

Gerth, K.; Bedorf, N.; Irschik, H.; Höfle, G.; Reichenbach, H. 1994: The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (myxobacteria). I. Soraphen A1.Alpha.: Fermentation, isolation, biological properties. The Journal of Antibiotics 47(1): 23-31

Naito, S.; Nanba, T.; Owatari, Y.; Nakada, Y.; Muramatsu, S.; Ide, J. 1994: Milbemycin derivaties: Modification at the C-5 position. The Journal of Antibiotics 47(2): 233-242

Morishita, Y.; Chiba, S.; Tsukuda, E.; Tanaka, T.; Ogawa, T.; Yamasaki, M.; Yoshida, M.; Kawamoto, I.; Matsuda, Y. 1994: Res-701-1,a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. Re-701. I. Characterization of producing strain, fermentation, isolation, physico-chemical and biological properties. The Journal of Antibiotics 47(3): 269-275

Mcalpine, J.B.; Karwowski, J.P.; Jackson, M.; Mullally, M.M.; Hochlowski, J.E.; Premachandran, U.; Burres, N.S. 1994: Mlr-52,(4'-dementhylamino-4',5'-dihydroxystaurosporine), a new inhibitor of protein kinase C with immunosuppressive activity. The Journal of Antibiotics 47(3): 281-288

Shu, Y.-Z.; Huang, S.; Wang, R.R.; Lam, K.S.; Klohr, S.E.; Volk, K.J.; Pirnik, D.M.; Wells, J.S.; Fernandes, P.B.; Patel, P.S. 1994: Manumycins E,F and G, new members of manumycin class antibiotics, from Streptomyces sp. The Journal of Antibiotics 47(3): 324-333

Malkina, N.D.; Dudnik, Y.V.; Lysenkova, L.N.; Lazhko, E.I.; Galatenko, O.''gaA.; Katrukha, G.S. 1994: 167-A,a new antibiotic produced by a mutant of an inactive wild strain of Amycolata autotrophica. The Journal of Antibiotics 47(3): 342-348

Kamiyama, T.; Shimma, N.; Ohtsuka, T.; Nakayama, N.; Itezono, Y.; Nakada, N.; Watanabe, J.; Yokose, K. 1994: Cyclothialidine, a novel Dna gyrase inhibitor. Ii. Isolation, charactenzation and structure elucidation. The Journal of Antibiotics 47(1): 37-45

Sakata, N.; Oka, T.; Ikeno, S.; Hori, M.; Yamaguchi, K.; Inouye, Y.; Nakamura, S. 1994: Nucleotide sequnce of the phenomycin gene from Streptoverticillium baldacci Ma 564-C1. The Journal of Antibiotics 47(3): 370-371

Oleynek, J.J.; Sedlock, D.M.; Barrow, C.J.; Appell, K.C.; Casiano, F.; Haycock, D.; Ward, S.J.; Kaplita, P.; Gillum, A.M. 1994: Win 64821, a novel neurokinin antagonist produced by an Aspergillus sp. The Journal of Antibiotics 47(4): 399-410

Hara, R.; Nakai, E.-I.; Hisamichi, H.; Nagano, N. 1994: Studies on .Beta.-lactam antibiotics. Iv. An improved synthesis of 3-(isothiazolylythiomethyl)cephalosporins and its application to new derivatives. The Journal of Antibiotics 47(4): 477-486

Yun, B.-S.; Hidaka, T.; Furihata, K.; Seto, H. 1994: Promothiocins A and B, novel thiopeptides with A tip A promoter inducing activity produced by Streptomyces sp. Sf2741. The Journal of Antibiotics 47(4): 510-514

Sun, H.H.; Barrow, C.J.; Sedlock, D.M.; Gillum, A.M.; Cooper, R. 1994: Benzomalvins, new suhstance P inhibitors from a Penicillium sp. The Journal of Antibiotics 47(5): 515-522

Decker, H.; Summers, R.G.; Hutchinson, C.R. 1994: Overproduction of the acyl carrier protein component of a type Ii polyketide synthase stimulates production of tetracenomycin biosynthetic intermediates in Stteptomyces glaucescens. The Journal of Antibiotics 47(1): 54-63

Gomi, S.; Imamura, K.-I.C.H.I.; Yaguchi, T.; Kodama, Y.; Minowa, N.; Koyama, M. 1994: Pe1018, a novel insecticidal compound produced by Humicola sp. The Journal of Antibiotics 47(5): 571-580

Sato, T.; Shibazaki, M.; Yamaguchi, H.; Abe, K.; Matsumoto, H.; Shimizu, M. 1994: Novel Candida albicans aspartyl protease inhibitor. Ii. A new pepstatin-ahpatinin group inhibitor,Yf-044-D. The Journal of Antibiotics 47(5): 588-590

Chatterjee, S.; Nadkarni, S.R.; Vijayakumar, E.K.S.; Patel, M.V.; Gangul, B.N.; Fehlhaber, H.-W.; Vertesy, L. 1994: Napsamycins, new Pseudomonas active antibiotics of the mureidomycin family from Streptomyces sp. Hil Y-82, 11372. The Journal of Antibiotics 47(5): 595-598

Park, H.; Lee, J.Y.; Lee, Y.S.; Park, J.O.; Koh, S.B.; Ham, W.-H. 1994: Synthesis and biological activities of C-3 heterocyclyl carhon substituted new cephalosporins. The Journal of Antibiotics 47(5): 606-608

Wildfeuer, M.E. 1994: Aqueous acetylation of desacetyl glutaryl 7-aminocephalosporanic acid (7Aca) and speculation on the origin of desacetyl cephalosponn C in fermentation broth. The Journal of Antibiotics 47(1): 64-71

Kobayashi, S.; Tsuchiya, K.; Harada, T.; Nishide, M.; Kurokawa, T.; Nakagawa, T.; Shimada, N.; Kobayashi, K. 1994: Pironetin, a novel plant growth regulator produced by Streptomyces sp. Nk 10958. I. Taxonomy, production, isolation and preliminary characterization. The Journal of Antibiotics 47(6): 697-702

Morris, S.A.; Schwartz, R.E.; Sesin, D.F.; Masurekar, P.; Hallada, T.C.; Schmatz, D.M.; Bartizal, K.; Hensens, O.D.; Zink, D.L. 1994: Pneumocandin Do, a new antifungal agent and potent inhibitor of Pneumocystis carinii. The Journal of Antibiotics 47(7): 755-764

Koiso, Y.; Li, Y.; Iwasaki, S.; Hanaka, K.; Kobayashi, T.; Sonoda, R.; Fujita, Y.; Yaegashi, H.; Sato, Z. 1994: Ustiloxins, antimitotic cydic peptides from false smut balls on rice panicles caused by Ustilaginoidea virens. The Journal of Antibiotics 47(7): 765-773

Tsuchiya, K.S.; Arita, M.; Hori, M.; Otani, T. 1994: Monoclonal antibody raised against apoprotein of C-1027: Effect on biochemical and biological activities of the holoantibiotic. The Journal of Antibiotics 47(7): 787-791

Fujiu, M.; Sawairi, S.; Shimada, H.; Takaya, H.; Aoki, Y.; Okuda, T.; Yokose, K. 1994: Azoxybacilin, a novel antifungal agent produced by Bacillus cereus Nr2991. Production, isolation and structure elucidation. The Journal of Antibiotics 47(7): 833-835

Kadam, S.; Mcalpine, J.B. 1994: Dorrigocins: Novel antifungal antibiotics that change the morphology of ras-transformed Nih/3T3 cells to that of normal cells. Iii. Biological properties and mechanism of action. The Journal of Antibiotics 47(8): 875-880

Kunze, B.; Jansen, R.; Höfle, G.; Reichenbach, H. 1994: Crocacin, a new electron transport inhibitor from Chondromyces cracatus (myxobacteria). Production, isolation, physico-chemical and biological properties. The Journal of Antibiotics 47(8): 881-886

Steinberg, D.A.; Bernan, V.S.; Montenegro, D.A.; Abbanat, D.R.; Pearce, C.J.; Korshalla, J.D.; Jacobus, N.V.; Petersen, P.J.; Mroczenski-Wildey, M.J.; Maiese, W.M.; Greensteiin, M. 1994: Glycothiohexides, novel antibiotics produced by "Sebekia" sp. I.-14E605. L Taxonomy, fermentation and biological evaluation. The Journal of Antibiotics 47(8): 887-893

Mae, T.; Nmoto, K.; Sugawara, Y.; Abe, F.; Takeuchi, T. 1994: Therapeutic studies of the combination of deoxyspergualin and prednisolone in Mrl/lpr mice with advanced lupus-like disease. The Journal of Antibiotics 47(1): 90-94

Hida, T.; Muroi, M.; Tanida, S.; Harada, S. 1994: Structures of dnacin A1 and B1, new naphthyridinomycin-type antitumor antibiotics. The Journal of Antibiotics 47(8): 917-921

Maruyama, M.; Nishida, C.; Takahashi, Y.; Naganawa, H.; Hamada, M.; Takeuchi, T. 1994: 3'-O-.Alpha.-D-Forosaminyl-( + )-griseusin A from Srreptomyces griseus. The Journal of Antibiotics 47(8): 952-954

Kageyama, S.; Tsuchiya, T. 1994: Synthesis of 2-C-methyl derivatives of 3,4'-dideonymycaminosyltylonolide, a novel type of 16-membered macrolide antibiotic. The Journal of Antibiotics 47(8): 955-956

Yun, B.-S.; Hidaka, T.; Furihata, K.; Seto, H. 1994: Microbial metabolites with tip A promoter inducing activity. Ii. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. Dd84. The Journal of Antibiotics 47(9): 969-975

Maeda, A.; Nagai, H.; Yazawa, K.; Tanaka, Y.; Imai, T.; Mikami, Y.; Kuramochi, T.; Yamazaki, C. 1994: Three new reduced anthracycline related compounds from pathogenic Nocardia brasilfensis. The Journal of Antibiotics 47(9): 976-981

Fredenhagen, A.; Angst, C.; Peter, H.H. 1995: Digestion of Rhizocticins to (Z)-L-2-amino-5-phosphono-3-pentenoic acid:Revision of the Absolute Configuration of Plumbemycins A and B. The Journal of Antibiotics 48(9): 1043-1045

Ohki, H.; Kawabata, K.; Okuda, S.; Kamimura, T.; Sakane, K. 1995: Studies on 3'-Quaternary Ammonium Cephalosporins Ii. Synthesis and Antibacterial Activity of 7.Beta.-((Z)-2-(2-Aminothiazol-4-yl)-2- methoxyiminoacetamido)cephalosporin Derivatives Bearing Various Quaternary Ammonium Methyl Groups at the 3 Position. The Journal of Antibiotics 48(9): 1049-1051

Yoshimura, S.; Tsurumi, Y.; Takase, S.; Okuhara, M. 1995: W S75624 A and B, New Endothelin Converting Enzyme Inhibitors Isolated from Saccharothrix sp. No. 75624. Ii. Structure Elucidation of W S75624 A and B. The Journal of Antibiotics 48(10): 1073-1075

Coval, S.J.; Puar, M.S.; Phife, D.W.; Terracciano, J.S.; Patel, M. 1995: Ch57404, an Antifungal Agent Possessing the Rare Sodaricin Skeleton and a Tricyclic Sugar Moiety. The Journal of Antibiotics 48(10): 1171-1172

Ubukata, M.; Rani, B.R.; Cui, C.-B.; Osada, H. 1995: Preparation of Optically Active Epiderstatin and Its Stereoisomers. Epiderstatin is Not a Real Inhibitor of the Mitogenic Activity Induced by Epidermal Growth Factor. The Journal of Antibiotics 48(10): 1176-1178

Eshita, S.M.; Roberto, N.H.; Beale, J.M.; Mamiya, B.M.; Workman, R.F. 1995: Bacillomycin Lc, a New Antibiotic of the Iturin Group: Isolation, Structures, and Antifungal Activities of the Congeners. The Journal of Antibiotics 48(11): 1240-1247

Kunze, B.; Jansen, R.; Sasse, F.; Höfle, G.; Reichenbach, H. 1995: Chondramides A - D, New Antifungal and Cytostatic Depsipeptides from Chondromyces crocatus (Myxobacteria). Production, Physico-chemical and Biological Properties. The Journal of Antibiotics 48(11): 1262-1266

Carter, G.T.; Tischler, M.; West, R.R.; Bailey, A.E. 1995: Base-catalyzed Isomerism in Elfamycin Antibiotics. Structures of Ganefromycins .Epsilon. and .Epsilon.1. The Journal of Antibiotics 48(11): 1312-1319

Broom, N.J.P.; Elder, J.S.; Hannan, P.C.T.; Pons, J.E.; O''hanlon, P.J.; Walker, G.; Wilson, J.; Woodall, P. 1995: The Chemistry of Pseudomonic Acid. Part 14. Synthesis and In Vivo Biological Activity of Heterocyclyl Substituted Oxazole Derivatives. The Journal of Antibiotics 48(11): 1336-1344

Sakemi, S.; Inagaki, T.; Kaneda, K.; Hirai, H.; Iwata, E.; Sakakibara, T.; Yamauchi, Y.; Norcia, M.; Wondrack, L.M.; Sutcliffe, J.A.; Kojima, N. 1995: Cj-12,371 and Cj-12,372, Two Novel Dna Gyrase Inhibitors. Fermentation, Isolation, Structural Elucidation and Biological Activities. The Journal of Antibiotics 48(2): 134-142

Hayashi, K.-I.; Dombou, M.; Sekiya, M.; Nakajima, H.; Fujita, T.; Nakayama, M. 1995: Thermorubin and 2-Hydroayphenyl Acetic Acid, Aldose Reductase Inhibitors. The Journal of Antibiotics 48(11): 1345-1346

Choi, K.I.; Cha, J.H.; Pae, A.N.; Cho, Y.S.; Kang, H.-Y.; Koh, H.Y.; Chang, M.H. 1995: Studies on New Catechol Containing Cephalosponns. I. Synthesis and Structure-activity Relationships of Cephalosponns Having a Catechol Moiety at the C-3 Position. The Journal of Antibiotics 48(11): 1371-1374

Cui, C.-B.; Kakeya, H.; Okada, G.; Onose, R.; Ubukata, M.; Takahashi, I.; Isono, K.; Osada, H. 1995: Tryprostatins A and B, Novel Mammalian Cell Cycle Inhibitors Produced by Aspergdlus fumigatus. The Journal of Antibiotics 48(11): 1382-1384

Stadler, M.; Anke, H.; Sterner, O. 1995: Metabolites with Nematicidal and Antimicrobial Activities from the Ascomycete Lachnum papyraceum(Karst.) Karst. V. Production, Isolation and Biological Activities of Bromine-containing Mycorrhizin and Lachnumon Derivatives and Four Additional New Bioactive Metabolites. The Journal of Antibiotics 48(2): 149-153

Stadler, M.; Anke, H.; Shan, R.; Sterner, O. 1995: New Metabolites with Nematicidal and Antimicrobial Activities from the Ascomycete Lachnum papyraceum(Karst.) Karsts. Vi. Structure Determination of Non-halogenated Metabolites Structurally Related to Mycorrhizin A. The Journal of Antibiotics 48(2): 154-157

Stabler, M.; Anke, H.; Sterner, O. 1995: New Metabolites with Nematicidal and Antimicrobial Activities from the Ascomycete Lachnum papyraceum(Karst.) Karst. Vii. Structure Determination of Brominated Lachnumon and Mycorrhizin A Derivatives. The Journal of Antibiotics 48(2): 158-161

Saitoh, K.; Furumai, T.; Oki, T.; Nishida, F.; Harada, K.-I.; Suzuki, M. 1995: Pradimicin S,A New Pradimicin Analog. Iii. Application of the Frit-Fab Lc/Ms Technique to the Elucidation of the Pradimicin S Biosynthetic Pathway. The Journal of Antibiotics 48(2): 162-168

Tsurumi, Y.; Fujie, K.; Nishikawa, M.; Kiyoto, S.; Okuhara, M. 1995: Biological and Pharmacological Properties of Highly Selective New Endothelin Converting Enzyme Inhibitor Ws79089B Isolated from Streptosporangium roseum No.79089. The Journal of Antibiotics 48(2): 169-174

Fredenhagen, A.; Hug, P.; Sauter, H.; Peter, H.H. 1995: Paeciloquinones A,B,C,D,E and F: New Potent Inhibitors of Protein Tyrosine Kinase Produced by Paecilomyces carneus. Ii. Characterization and Structure Determination. The Journal of Antibiotics 48(3): 199-204

Yamada, H.; Shiomi, K.; Xu, Q.; Nagai, T.; Shibata, M.; Oya, I.; Takahashi, Y.; Omura, S. 1995: New Glycosidases Inhibitors, Panosialins D and wD Produced by Streptomyces sp. Oh-5186. The Journal of Antibiotics 48(3): 205-210

Sasse, F.; Steinmetz, H.; Höfle, G.; Reichenbach, H. 1995: Antibiotics from gliding bacteria. No.61. Gephyronic Acid, a Novel Inhibitor of Eukaryotic Protein Synthesis from Archangium gephyra (Myxobacteria). Production, Isolation, Physico-chemical and Biological Properties, and Mechanism of Action. The Journal of Antibiotics 48(1): 21-25

Irschik, H.; Schummer, D.; Gerth, K.; Höfle, G.; Reichenbach, H. 1995: Antibiotics from gliding bacteria. No.60. The Tartrolons, New Boron-containing Antibiotics from a Myxobacterium, Sorangium cellulosum. The Journal of Antibiotics 48(1): 26-30

Stabler, M.; Anke, H.; Sterner, O. 1995: Metabolites with Nematicidal and Antimicrobial Activities from the Ascomycete Lachnum papyraceum(Karst.) Karst. Iii. Production of Novel Isocoumarin Derivatives, Isolation, and Biological Activities. The Journal of Antibiotics 48(3): 261-266

Stabler, M.; Anke, H.; Sterner, O. 1995: New Metabolites with Nematicidal and Antimicrobial Activities from the Ascomycete Lachnum papyraceum(Karst.) Karst. Iv. Structural Elucidation of Novel Isocoumarin Derivatives. The Journal of Antibiotics 48(3): 267-270

Chu, M.; Truumees, I.; Patel, M.; Blood, C.; Das, P.R.; Puar, M.S. 1995: Sch S0673 and Sch 50676, Two Novel Antitumor Fungal Metabolites. The Journal of Antibiotics 48(4): 329-331

Stefanelli, S.; Cavaletti, L.; Sarubbi, E.; Ragg, E.; Colombo, L.; Selva, E. 1995: Ge20372 Factor A and B. New Hiv-l Protease Inhibitors, Produced by Strcptomyccs sp. Atcc 55925. The Journal of Antibiotics 48(4): 332-334

Igarashi, M.; Sasao, C.; Yoshida, A.; Naganawa, H.; Hamada, M.; Takeuchi, T. 1995: Ochracenomicins A, B and C, New Benz(a)anthraquinone Antibiotics from Amicolatopsis sp. The Journal of Antibiotics 48(4): 335-337

Alvi, K.A.; Reeves, C.D.; Peterson, J.; Lein, J. 1995: Isolation and Identification of a New Cephem Compound from Pcnicillium chrysogcnum Strains Expressing Deacetoxycephalosporin C Synthase Activity. The Journal of Antibiotics 48(4): 338-340

Zapf, S.; Hoßfeld, M.; Anke, H.; Velten, R.; Steglich, W. 1995: Darlucins A and B, New Isocyanide Antibiotics from Sphaerellopsis filum(Darluca filum). The Journal of Antibiotics 48(1): 36-41

Adams, R.G.; Brain, E.G.; Branch, C.L.; Guest, A.W.; Harrington, F.P.; Mizen, L.; Neale, J.E.; Pearson, M.J.; Simpson, I.N.; Smulders, H.; Zomaya, I.I. 1995: Structure-activity Relationships within a Series of C(7)-Substitutedoxyiminocephalosporins Containing the C(3)-Methylaminopyridiniumthiomethyl Substituent. Synthesis and Biological Properties of Brl 57342 and Some Close Analogues. The Journal of Antibiotics 48(5): 417-424

Kobayashi, H.; Sunaga, R.; Furihata, K.; Morisaki, N.; Iwasaki, S. 1995: Isolation and Structures of an Antifungal Antibiotic, Fusarielin A, and Related Compounds Produced by a Flusarium sp. The Journal of Antibiotics 48(1): 42-52

Cane, D.E.; Luo, G.; Khosla, C.; Kao, C.M.; Katzc, L. 1995: Erythromycin Biosynthesis. Highly Efficient Incorporation of Polyketide Chain Elongation Intermediates into 6-Deoxyerythronolide B in an Engineered Streptomyces Host. The Journal of Antibiotics 48(7): 647-651

Paris, J.-M.; Francois, J.; Molherat, C.; Albano, F.; Robin, M.; Vuilhorgne, M.; Barriere, J.-C. 1995: Unusual Transformation of the 3-Hydroxy-picolinoyl Residue of Pristinamycin Ia. The Journal of Antibiotics 48(7): 676-682

Arai, N.; Shiomi, K.; Tomoda, H.; Tabata, N.; Yang, D.J.; Masuma, R.; Kawakubo, T.; Omura, S. 1995: Isochromophilones Iii -Vi, Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium multicolor Fo-3216. The Journal of Antibiotics 48(7): 696-702

Matsuzaki, K.; Ikeda, H.; Masuma, R.; Tanaka, H.; Omura, S. 1995: Isochromophilones I and Ii, Novel Inhibitors against gpl20-Cd4 Binding Produced by Penicillium multicolor Fo-2338. I. Screening, Taxonomy, Fermentation, Isolation and Biological Activity. The Journal of Antibiotics 48(7): 703-707

Matsuzaki, K.; Tanaka, H.; Omura, S. 1995: Isochromophilones I and Ii, Novel Inhibitors against gpl20-Cd4 Binding Produced byPenicillium multicolor Fo-2338. Ii. Structure Elucidation. The Journal of Antibiotics 48(7): 708-713

Pyl, D.V.D.; Cans, P.; Debernard, J.J.; Herman, F.; Lelievre, Y.; Tahraoui, L.; Vuilhorgne, M.; Leboul, J. 1995: Rpr113228, a Novel Farnesyl Protein Transferase Inhibitor Produced by Chrysosporium lobatum. The Journal of Antibiotics 48(7): 736-737

Oohata, N.; Hori, Y.; Yamagishi, Y.; Fujita, T.; Takase, S.; Yamashita, M.; Terano, H.; Okuhara, M. 1995: A New Aromatase Inhibitor, Fr901537. I. Taxonomy, Fermentation, Isolation, Physicochemical Characteristics and Biological Activities. The Journal of Antibiotics 48(8): 757-762

Yon, C.; Suh, J.-W.; Chang, J.-H.; Lim, Y.; Lee, C.-H.; Lee, Y.-S.; Lee, Y.-W. 1995: Al072, A Novel Anti-Legionella Antibiotic Produced by Streptomycessp. The Journal of Antibiotics 48(8): 773-779

Irschik, H.; Augustiniak, H.; Gerth, K.; Höfle, G.; Reichenbach, H. 1995: Antibiotics from gliding bacteria. No. 68. The Ripostatins, Novel Inhibitors of Eubacterial Rna Polymerase Isolated from Myxobacteria. The Journal of Antibiotics 48(8): 787-792

Murata, H.; Suzuki, K.; Tabayashi, T.; Hattori, C.; Takada, Y.; Harada, K.-I.; Suzuki, M.; Ikemoto, T.; Smbuya, T.; Haneishi, T.; Torikata, A.; Ixezono, Y.; Nakayama, N. 1995: Structural Elucidation of Aculeximycin. Iii. Planar Structure of Aculeximycin, Belonging to a New Class of Macrolide Antibiotics. The Journal of Antibiotics 48(8): 838-849

Sakuda, S.; Otsubo, Y.; Yamada, Y. 1995: Structure of Patulodin, a New Azaphilone Epoxide, Produced by Penidllium urticae. The Journal of Antibiotics 48(1): 85-86

Murata, H.; Ohama, I.; Harada, K.-I.; Suzuki, M.; Ikemoto, T.; Shibuya, T.; Haneishi, T.; Torikata, A.; Itezono, Y.; Nakayama, N. 1995: Structural Elucidation of Aculeximycin. Iv. Absolute Structure of Aculeximycin, Belonging to a New Class of Macrolide Antibiotics. The Journal of Antibiotics 48(8): 850-862

Pereira, E.R.; Fabre, S.; Sancelme, M.; Prudhomme, M.; Rapp, M. 1995: Antimicrobial Activities of Indolocarbazole and Bis-indole Protein Kinase C Inhibitors. Ii. Substitution on Maleimide Nitrogen with Functional Groups Bearing a Labile Hydrogen. The Journal of Antibiotics 48(8): 863-868

Tamaki, K.; Matsubara, A.; Tanzawa, K.; Sugimura, Y. 1995: Total Synthesis and Inhibitory Activity against Gelatinase B of Yl 01869P. The Journal of Antibiotics 48(1): 87-88

Engler, M.; Anke, T.; Klostermeyer, D.; Steglich, W. 1995: Hydroxystrobilurin A, a New Antifungal E-.Beta.-Methoxyacrylate from a Pterula species. The Journal of Antibiotics 48(8): 884-885

Irschik, H.; Jansen, R.; Gerth, K.; Höfle, G.; Reichenbach, H. 1995: Antibiotics from gilding bacteria. No.67. Sorangiolid A, a New Antibiotic Isolated from the Myxobacterium Sorangium cellulosumSo ce 12. The Journal of Antibiotics 48(8): 886-887

Sumita, Y.; Yamaga, H.; Sunagawa, M. 1995: The Effect of 1.Beta.-Methyl Substituent and the Basicity in C-2 Side Chain in Carbapenem Antibiotics on the Activity against Pseudomonas aeruginosa oprD2 and nalB Mutants. The Journal of Antibiotics 48(1): 89-91

Shiozawa, H.; Kagasaki, T.; Torikata, A.; Tanaka, N.; Fujimoto, K.; Hata, T.; Furukawa, Y.; Takahashi, S. 1995: Thiomarinols B and C,New Antimicrobial Antibiotics Produced by a Marine Bacterium. The Journal of Antibiotics 48(8): 907-909

Pairet, L.; Wrigley, S.K.; Chetland, I.; Reynolds, E.E.; Hayes, M.A.; Holloway, J.; Ainsworth, A.M.; Katzer, W.; Cheng, X.M.; Hupe, D.J.; Charlton, P.; Doherty, A.M. 1995: Azapbilones with Endothelin Receptor Binding Activity Produced by Penicillium sclerotiorum: Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activity. The Journal of Antibiotics 48(9): 913-923

Kamiyama, T.; Umino, T.; Itezono, Y.; Nakamura, Y.; Satoh, T.; Yokose, K. 1995: Sulfobacins A and B, Novel von Willebrand Factor Receptor Antagonists. Ii. Structural Elucidaffon. The Journal of Antibiotics 48(9): 929-936

Cai, Y.; Fredenhagen, A.; Hug, P.; Peter, H.H. 1996: The Shurosporine Producing Strain Streptomyces longisporoflavus Produces Metabolites Related to K-252a. Proposal for Biosynthetic Intermediates of K-252a. The Journal of Antibiotics 49(10): 1060-1062

Yamada, R.; Seto, M.; Sasaki, Y.; Sunazuka, T.; Harigaya, Y.; Iwai, Y.; Omura, S. 1996: Synthesis and Anti-platelet Aggregation Activity of Water-soluble Shurosporine Derivatives. The Journal of Antibiotics 49(10): 1070-1072

Tanaka, T.; Tsukuda, E.; Ochiai, K.; Kondo, H.; Teshiba, S.; Matsuda, Y. 1996: Ei-1511-3, -5 and Ei-1625-2, Novel Interleukin-1.Beta. Converting Enzyme Inhibitors Produced by Streptomyces sp. E-1511 and E-1625. I. Taxonomy of Producing Strain, Fermentation and Isolation. The Journal of Antibiotics 49(11): 1073-1078

Uosaki, Y.; Agatsuma, T.; Tanaka, T.; Saitoh, Y. 1996: Ei-1511-3, -S and Ei-1625-2, Novel Interleukin-l.Beta. Conveffing Enzyme Inhibitors Produced by Streptomyces sp. E-1511 and E-1625. Ii. Structure Determination. The Journal of Antibiotics 49(11): 1079-1084

Tanaka, T.; Tsukuda, E.; Uosaki, Y.; Matsuda, Y. 1996: Ei-1511-3, -5 and Ei-1625-2, Novel Interleukin-1.Beta. Converting Enzyme Inhibitors Produced by Streptomyces sp. E-1511 and E-1625. Iii. Biochemical Properties of Ei-1511-3, -5 and Ei 1625-2. The Journal of Antibiotics 49(11): 1085-1090

Sasaki, J.; Mizoue, K.; Morimoto, S.; Omura, S. 1996: Microbial Glycosylation of Macrolide Antibiotics by Streptomyces hygroscopicus Atcc 31080 and Distribution of a Macrolide Glycosyl Transferasein Several Streptomyces Strains. The Journal of Antibiotics 49(11): 1110-1118

Miroshnikova, O.V.; Berdnikova, T.F.; Olsufyeva, E.N.; Pavlov, A.Y.; Reznikova, M.I.; Preobrazhenskaya, M.N.; Ciabatti, R.; Malabarba, A.; Colombo, L. 1996: A Modification of the N-Terminal Amino Acid in me Eremomycin Aglycone. The Journal of Antibiotics 49(11): 1157-1161

Kim, J.-S.; Shin-Ya, K.; Eishima, J.; Furihata, K.; Seto, H. 1996: A Novel Neuronal Cell Protecting Substance, Naphthomycinol, Produced byStreptomyces sp. Pf7. The Journal of Antibiotics 49(11): 1172-1174

Sunagawa, M.; Matsumura, H.; Sasaki, A.; Yamaga, H.; Sumita, Y.; Nouda, H. 1996: Structure-activity Relationship of 1.Beta.-Methyl-carbapenem to Its Antibacterial Activity: Effectof the C-2 Side Chain and the 1.Beta.-Methyl Group. The Journal of Antibiotics 49(11): 1175-1178

Hara, R.; Itahana, H.; Hisamichi, H.; Fukuoka, S.; Nagano, N. 1996: Synthesis and Biological Activity of New Cephem Compounds with a 3-(2-Butenyl)- and a 3-(1,3-Butadienyl)groupat Their 3-Position. The Journal of Antibiotics 49(11): 1179-1181

Roy, K.; Chatterjee, S.; Deshmukh, S.K.; Vijayakumar, E.K.S.; Ganguli, B.N.; Fehlhaber, H.-W. 1996: Orbuticin, a New Secondary Metabolite from Acremonium butyrit. The Journal of Antibiotics 49(11): 1186-1187

Lee, J.Y.; Lee, Y.S.; Suk, D.W.; Woo, E.-R.; Chung, B.Y.; Park, H. 1996: Syntbesis and Biological Activity of Quaternary Ammoniopropenylcephalosporins with Hydroxylated Alicyclic or Alipbatic Amines. The Journal of Antibiotics 49(12): 1286-1289

Kamigiri, K.; Suzuki, Y.; Shibazaki, M.; Morioka, M.; Suzuki, K.-I.; Tokunaga, T.; Setiawan, B.; Rantiatmodjo, R.M. 1996: Kalimantacins A, B and C, Novel Antibiotics from Alealigenes sp. Yl-02632S. I. Taxonomy, Fermentation, Isolation and Biological Propertie. The Journal of Antibiotics 49(2): 136-139

Pavlov, A.Y.; Berdnikova, T.F.; Olsufyeva, E.N.; Miroshnikova, O.V.; Filipposyanz, S.T.; Preobrazhenskaya, M.N.; Sottani, C.; Colombo, L.; Goldstein, B.P. 1996: Carboxamides and Hydrazide of Glycopeptide Antibiotic Eremomycin Synthesis and Antibacterial activity. The Journal of Antibiotics 49(2): 194-198

Iso, Y.; Irie, T.; Nishino, Y.; Motokawa, K.; Nishitani, Y. 1996: A Novel 1.Beta.-Methylcarbapenem Antibiotic, S-4661.Synthesis and Structure-activity Relationships of 2-(5-Substituted Pyrrolidin-3-ylthio)-1.Beta.-methylcarbapenems. The Journal of Antibiotics 49(2): 199-209

Mukhopadhyay, T.; Roy, K.; Sawant, S.N.; Deshmukh, S.K.; Ganguli, B.N.; Fehlhaber, H.W. 1996: On an Unstable Antifungal Metabolite from Trichoderma koningii Isolation and Structure Elucidation of a New Cyclopentenone Derivative(3-Dimethylamino-S-hydroxy-5-vinyl-2-cyclopenten-1-one). The Journal of Antibiotics 49(2): 210-211

Yang, D.-J.; Tomoda, H.; Tabata, N.; Masuma, R.; Omura, S. 1996: New Isochromophilones Vii and Viii Produced by Penicillium sp. Fo 1164. The Journal of Antibiotics 49(3): 223-229

Tsukuda, E.; Tanaka, T.; Ochiai, K.; Kondo, H.; Yoshida, M.; Agatsuma, T.; Saitoh, Y.; Teshiba, S.; Matsuda, Y. 1996: Ei-1507-1 and -2, Novel Interleukin-1.Beta. Converting Enzyme Inhibitors Produced by Streptomyces sp. E-1507. The Journal of Antibiotics 49(4): 333-339

Matsuura, N.; Onose, R.; Osada, H. 1996: Morphology Reversion Activity of Phosmidosine and Phosmidosine B, a Newly Isolated Derivative, on src Transformed Nrk Cells. The Journal of Antibiotics 49(4): 361-365

Sakamoto, K.; Tsujii, E.; Abe, F.; Nakanishi, T.; Yamashita, M.; Shigematsu, N.; Izumi, S.; Okuhara, M. 1996: Fr901483, a Novel Immunosuppressant Isolated from Cladobotryum sp. No. 11231. Taxonomy of the Producing Organism, Fermentation, Isolation,Physico-chemical Properties and Biological Activities. The Journal of Antibiotics 49(1): 37-44

Uchida, R.; Shiomi, K.; Inokoshi, J.; Sunazuka, T.; Tanaka, H.; Iwai, Y.; Takayanagi, H.; Omura, S. 1996: Andrastins A-C, New Protein Farnesyltransferase Inbibitors Produced by Penicillium sp. Fo-3929. Ii. Structure Elucidation and Biosynthesis. The Journal of Antibiotics 49(5): 418-424

Takahashi, I.; Miyaji, H.; Yoshida, T.; Sato, S.; Mizukami, T. 1996: Selective Inhibition of Il-Gene Expression by 2Trichostatin A, a Potent Inhibitor of Mammalian Histone Deacetylase. The Journal of Antibiotics 49(5): 453-457

Griesgraber, G.; Sun Or, Y.; Chu, D.T.W.; Nilius, A.M.; Johnson, P.M.; Flamm, R.K.; Henry, R.F.; Plattner, J.J. 1996: 3-Keto-11,12-carbazate Derivatives of 6-0-Methylerythromycin A Synthesis and In Vitro Activity. The Journal of Antibiotics 49(5): 465-477

Iso, Y.; Irie, T.; Iwaki, T.; Kii, M.; Sendo, Y.; Motokawa, K.; Nishitani, Y. 1996: Synthesis and Modification of a Novel 1.Beta.-Methyl Carbapenem Antibiotic, S-4661. The Journal of Antibiotics 49(5): 478-484

Cai, Y.; Fredenhagen, A.; Hug, P.; Meyer, T.; Peter, H.H. 1996: Further Minor Metabolites of Staurosporine Produced by a Streptomyces longisporofiavus Strain. The Journal of Antibiotics 49(6): 519-526

Kurihara, K.-I.; Ajito, K.; Shibahara, S.; Ishizuka, T.; Hara, O.; Araake, M.; Omoto, S. 1996: Cladinose Analogues of Sixteen-membered Macrolide Antibiotics. I. Synthesis of 4-0-Alkyl-L-cladinose Analogues via Glycosylation. The Journal of Antibiotics 49(6): 582-592

Nouda, H.; Matsumura, H.; Tanio, T.; Sunagawa, M. 1996: Structural Eeatures of Carbapenem Compounds for Nephrotoxicity: Effect of C-2 Side Chain. The Journal of Antibiotics 49(6): 603-606

Kogen, H.; Tago, K.; Kaneko, S.; Hamano, K.; Onodera, K.; Haruyama, H.; Minagawa, K.; Kinoshita, T.; Ishikawa, T.; Tanimoto, T.; Tsujita, Y. 1996: Schizostatin, a Novel Squalene Synthase Inhibitor Produced by the Mushroom, Schizophylllum commune. Ii. Structure Elucidation and Total Synthesis. The Journal of Antibiotics 49(7): 624-630

Hotta, K.; Ogata, T.; Ishikawa, J.; Okanishi, M.; Mizuno, S.; MoRiOKA, M.; Naganawa, H.; Okami, Y. 1996: Mechanismm of Multiple Aminoglycoside Resistance of Kasugamycin-producing Streptomyces kasugaensis Mb273: Involvement of Two Types of Acetyltransferases in Resistance to Astromicin Group Antibiotics. The Journal of Antibiotics 49(7): 682-688

Vincendon, P.; Corti, E.; Guindani, A.; Brunati, C.; Sponga, F.; Sxefanelli, S.; Denaro, M.; Pelton, P.; Ganzhorn, A.; Islam, K. 1996: An Automated High Volume Assay to Screen for Inhibitors of myo-lnositol Monophosphatase from Microbial Eermentation Broths. The Journal of Antibiotics 49(7): 710-712

Kuno, F.; Shiomi, K.; Otoguro, K.; Sunazuka, T.; Omura, S. 1996: Arisugacins A and B, Novel and Selective Acetylcholinesterase Inhibitors from Penicillium sp. F0-4259. Ii. Structure Elucidation. The Journal of Antibiotics 49(8): 748-751

Izumida, H.; Imamura, N.; Sano, H. 1996: A Novel Chitinase Inhibitor from a Marine Bacterium, Pseudomonassp. The Journal of Antibiotics 49(1): 76-80

Pfefferle, C.; Kempter, C.; Metzger, J.W.; Fiedler, H.-P. 1996: (E)-4-Oxonon-2-enoic Acid, an Antibiotically Active Fatty Acid Produced by Streptomyces olivaceus Tue 4018. The Journal of Antibiotics 49(8): 826-828

Setti, E.L.; Reddy, N.A.V.; Phillips, O.A.; Czajkowski, D.P.; Atchison, K.; Atwal, H.; Micetich, R.G.; Maiti, S.N.; Kunugita, C.; Hyodo, A. 1996: Studies on Penam Sulfones. I. Synthesis and .Beta.-Lactamase Inhibitory Activity of 2.Beta.-Alkoxycarbonyl Penicillanic Acid Sulfones. The Journal of Antibiotics 49(9): 944-946

Takamatsu, S.; Kim, Y.-P.; Hayashi, M.; Hiraoka, H.; Natori, M.; Komiyama, K.; Omura, S. 1996: Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule. Ii. Physicochemical Properties and Structural Elucidation. The Journal of Antibiotics 49(1): 95-98

Shinohara, C.; Hasumi, K.; Hatsumi, W.; Endo, A. 1996: Staplabin, a Novel Fungal Triprenyl Phenol which Stimulates the Binding of Plasminogen to Fibrin and U937 Cell. The Journal of Antibiotics 49(10): 961-966

West, R.R.; Ness, J.V.; Varming, A.-M.; Rassing, B.; Biggs, S.; Gasper, S.; Mckernan, P.A.; Piggott, J. 1996: Zg-1494.Alpha., a Novel Platelet-activating Factor Acetyltransferase Inhibitor from Penicilium rubrum, Isolation, Structure Elucidation and Biological Activity. The Journal of Antibiotics 49(10): 967-973

Hayakawa, Y.; Sohda, K.-Y.; Furihata, K.; Kuzuyama, T.; Shin-Ya, K.; Seto, H. 1996: Studies on New Antitumor Antibiotics, Leptofuranins A, B, C and D. I. Taxonomy, Fermentation, Isolation and Biological Activities. The Journal of Antibiotics 49(10): 974-979

Dabrah, T.T.; Harwood, H.J.; Huang, L.H.; Jankovich, N.D.; Kaneko, T.; Li, J.-C.; Lindsey, S.; Moshier, P.M.; Subashi, T.A.; Therrien, M.; Watts, P.C. 1997: Cp-225,917 and Cp-263,114, Novel Ras Farnesylation Inhibitors from an Unidentified Fungus. I. Taxonomy, Fermentation, Isolation, and Biochemical Properties. The Journal of Antibiotics 50(1): 1-7

Tsunoo, A.; Kamijo, M.; Taketomo, N.; Sato, Y.; Ajisaka, K. 1997: Roseocardin, a Novel Cardiotonic Cyclodepsipeptide from Trichothecium roseum Tt103. The Journal of Antibiotics 50(12): 1007-1013

Graupner, P.R.; Thornburgh, S.; Mathieson, J.T.; Chapin, E.L.; Kemmitt, G.M.; Brown, J.M.; Snipes, C.E. 1997: Dihydromaltophilin; A Novel Fungicidal Tetramic Acid Containing Metabolite from Streptomyces sp. The Journal of Antibiotics 50(12): 1014-1019

Igarashi, M.; Kinoshita, N.; Ikeda, T.; Kameda, M.; Hamada, M.; Takeuchi, T. 1997: Resormycin, a Novel Herbicidal and Antifungal Antibiotic Produced by a Strain of Streptomyces platensis. I. Taxonomy, Production, Isolation and Biological Properties. The Journal of Antibiotics 50(12): 1020-1025

Igarashi, M.; Nakamura, H.; Naganawa, H.; Takeuchi, T. 1997: Resormycin, a Novel Herbicidal and Antifungal Antibiotic Produced by a Strain of Streptomyces platensis. Ii. Structure Elucidation of Resormycin. The Journal of Antibiotics 50(12): 1026-1031

Peng, Y.; Yashphe, J.; Demain, A.L. 1997: Biotransformation of Compactin to Pravastatin by Actinomadura sp. 2966. The Journal of Antibiotics 50(12): 1032-1035

Tanaka, Y.; Komaki, H.; Yazawa, K.; Mikami, Y.; Nemoto, A.; Tojyo, T.; Kadowaki, K.; Shigemori, H.; Kobayashi, J.'ichi 1997: Brasilinolide A, a New Macrolide Antibiotic Produced by Nocardia brasiliensis: Producing Strain, Isolation and Biological Activity. The Journal of Antibiotics 50(12): 1036-1041

Watanabe, M.; Tohyama, H.; Hiratani, T.; Watabe, H.; Inoue, S.; Kondo, S.-I.; Takeuchi, T.; Yamaguchi, H. 1997: Mode of Antifungal Action of Benanomicin A in Saccharomyces cerevisiae. The Journal of Antibiotics 50(12): 1042-1051

Ueki, M.; Taniguchi, M. 1997: The Mode of Action of Uk-2A and Uk-3A, Novel Antifungal Antibiotics from Streptomyces sp. 517-02. The Journal of Antibiotics 50(12): 1052-1057

Masuoka, Y.; Shin-Ya, K.; Furihata, K.; Hayakawa, Y.; Seto, H. 1997: A Novel Substance with Tgf-.Beta. like Activity, Diheteropeptin, Produced by a Fungus, Diheterospora sp. The Journal of Antibiotics 50(12): 1058-1060

Chu, M.; Truumees, I.; Mierzwa, R.; Patel, M.; Puar, M.S. 1997: Sch 56396: A New c-fos Proto-oncogene Inhibitor Produced by the Fungus Tolypocladium sp. The Journal of Antibiotics 50(12): 1061-1063

Ryu, G.; Hwang, S.; Kim, S.-K. 1997: 16-Methyloxazolomycin, a New Antimicrobial and Cytotoxic Substance Produced by a Streptomyces sp. The Journal of Antibiotics 50(12): 1064-1066

Takamatsu, S.; Kim, Y.-P.; Enomoto, A.; Hayashi, M.; Tanaka, H.; Komiyama, K.; Omura, S. 1997: Madindolines, Novel Inhibitors of Il-6 Activity from Streptomyces sp. K93-0711. Ii. Physico-chemical Properties and Structural Elucidation. The Journal of Antibiotics 50(12): 1069-1072

O'shea, M.G.; Rickards, R.W.; Rothschild, J.M.; Lacey, E. 1997: Absolute Configurations of Macrolide Antibiotics of the Bafilomycin and Leucanicidin Groups. The Journal of Antibiotics 50(12): 1073-1077

Lee, H.-W.; Kim, E.-N.A.M.; Kang, T.W.O.N.; Ahn, S.-K.I.L.; Choi, N.-H.E.E.; Kim, J.-W.; Hong, C.I.L. 1997: Synthesis and Structure-activity Relationship of 2-(5-Substituted pyrrolidin-4-ylthio)-1.Beta.-carbapenems. The Journal of Antibiotics 50(12): 1078-1082

Oh, W.K.E.U.N.; Lee, H.S.U.N.; Kim, B.Y.E.O.N.; Ahn, S.C.H.E.O.L.; Kang, D.O.O.K.; Kim, Y.H.A.E.; Mheen, T.I.C.K.; Ahn, J.S.E.O.G. 1997: Crm-51005, a New Phospholipase C Inhibitor Produced by Unidentified Fungal Strain Mt51005. The Journal of Antibiotics 50(12): 1083-1085

Hashizume, T.; Nakamura, K.; Nakagawa, S. 1997: Affiniffes of Bo-2727 for Bacterial Penicillin-binding Proteins and Morphological Change of Gram-negative Rods. The Journal of Antibiotics 50(2): 139-142

Chino, M.; Nishikawa, K.; Tsuchida, T.; Sawa, R.; Nakamura, H.; Nakamura, K.T.; Muraoka, Y.; Ikeda, D.; Naganawa, H.; Sawa, T.; Takeuchi, T. 1997: Heliquinomycin, a New Inhibitor of Dna Helicase, Produced by Streptomyces sp. Mj929-Sf2.Ii. Structure Determination of Heliquinomycin. The Journal of Antibiotics 50(2): 143-146

Ajito, K.; Kurihara, K.-I.; Shibahara, S.; Hara, O.; Okonogi, T.; Kikuchi, N.; Araake, M.; Suzuki, H.; Omoto, S.; Inouye, S. 1997: Cladinose Analogues of Sixteen-membered Macrolide Antibiotics.Iv. Improved Therapeutic Effects of 4-O-Acyl-L-cladinose Analogues of Sixteen-membered Macrolide Antibiotics. The Journal of Antibiotics 50(2): 150-161

Kanazawa, K.; Nouda, H.; Sunagawa, M. 1997: Structure-activity Relationships of Carbapenem Compounds to Anti-Haemophilus influenzae Activity and Affinity for Penicillin-binding Proteins Effect of 1.Beta.-Methyl Group and C-2 Side Chain. The Journal of Antibiotics 50(2): 162-168

Brown, R.P.A.; Aplin, R.T.; Schofield, C.J.; Frydrych, C.H. 1997: Mass Spectrometric Studies on the Inhibition of Tem-2.Beta.-Lactamase by Clavulanic Acid Derivatives. The Journal of Antibiotics 50(2): 184-185

Tanaka, Y.; Yoshida, H.; Enomoto, Y.; Shiomi, K.; Shinose, M.; Takahashi, Y.; Liu, J.-R.; Omura, S. 1997: Malolactomycins C and D,New 40-Membered Macrolides Active against Botrytis. The Journal of Antibiotics 50(3): 194-200

Kishimoto, K.; Park, Y.S.; Okabe, M.; Akiyama, S.-I. 1997: Effect of Ferrous Ion on Amino Acid Metabolism in Mildiomycin Production by Streptoverticillium rimofaeiens. The Journal of Antibiotics 50(3): 206-211

Kajimura, Y.; Kaneda, M. 1997: Fusaricidins B, C and D, New Depsipeptide Antibuotics Produced by Bacillus Polymyxa Kt-8: Isolation, Structure Elucidation and Biological Activity. The Journal of Antibiotics 50(3): 220-228

Ryoo, I.-J.; Song, K.-S.; Kim, J.-P.; Kim, W.-G.; Koshino, H.; Yoo, I.-D. 1997: A New Cytotoxic Phenylthiazoline, 4-Methylaeruginoic Acid, from Strcptomyces sp. Kctc 9303. The Journal of Antibiotics 50(3): 256-258

Tsuchiya, K.; Kobayashi, S.; Nishikiori, T.; Nakagawa, T.; Tatsuta, K. 1997: Nk10958P, a Novel Plant Growth Regulator Produced by Strcptomyces sp. The Journal of Antibiotics 50(3): 259-260

Tsuchiya, K.; Kobayashi, S.; Nishikiori, T.; Nakagawa, T.; Tatsuta, K. 1997: Epopromycins, Novel Cell Wall Synthesis Inhibitors of Plant Protoplast Produced by Strcptomyces sp. Nk04000. The Journal of Antibiotics 50(3): 261-263

Reddy, N.A.V.; Setti, E.L.; Phillips, O.A.; Czajkowski, D.P.; Atwal, H.; Atchison, K.; Micetich, R.G.; Maiti, S.N.; Kunugita, C.; Hyodo, A. 1997: Studies on Penam Sulfones. Ii. Synthesis and .Beta.-Lactamase Inhibitory Activity of 2.Beta.-Carboxamide Penicillanic Acid Sulfones. The Journal of Antibiotics 50(3): 276-278

Engler, M.; Anke, T.; Sterner, O. 1997: Pterulinic Acid and Pterulone, Two Novel Inhibitors of Nadh: Ubiquinone Oxidoreductase (Complex I) Produced by a Pterla Species. Ii. Physico-chemical Properties and Structure Elucidationt. The Journal of Antibiotics 50(4): 330-333

Lee, H.-J.; Chung, M.-C.; Lee, C.-H.; Yun, B.-S.; Chun, H.-K.; Kho, Y.-H. 1997: Gelastatins A and B, New Inhibitors of Gelatinase A from Westerdykella multispora E50733. The Journal of Antibiotics 50(4): 357-359

Kudo, F.; Yamauchi, N.; Suzuki, R.; Kakinuma, K. 1997: Biochemical Studies on 2-deoxy-scyllo-inosose, an early intermediate in biosynthesis of 2-dexystreptamin. Part Vi. Kinetic Isotope Effect and Reaction Mechanism of 2-Deoxy-scyllo-inosose Synthase Derived from Butirosin-producing Bacillus circulans. The Journal of Antibiotics 50(5): 424-428

Oda, K.; Nishi, T. 1997: Stereospecific Synthesis of a l.Beta.-Methylcarbapenem Intermediate. The Journal of Antibiotics 50(5): 446-448

Shiozawa, H.; Shimada, A.; Takahashi, S. 1997: Thiomarinols D, E, F and G, New Hybrid Antimicrobial Antibiotics Produced by a Marine Bacterium;Isolation, Structure, and Antimicrobial Activity. The Journal of Antibiotics 50(5): 449-452

Sunazuka, T.; Hirose, T.; Zhi-Ming, T.; Uchida, R.; Shiomi, K.; Harigaya, Y.; Omura, S. 1997: Syntheses and Absolute Structures of Novel Protein Earnesyltransferase Inhibitors, Kurasoins A and B. The Journal of Antibiotics 50(5): 453-455

Pusecker, K.; Laatsch, H.; Helmke, E.; Weyland, H. 1997: Marine Bacteria. Ix. Dihydrophencomycin Methyl Ester, a New Phenazine Derivative from a Marine Streptomycetet. The Journal of Antibiotics 50(6): 479-483

Fujii, N.; Tanaka, F.; Yamashita, Y.; Ashizawa, T.; Chiba, S.; Nakano, H. 1997: Uce6, a New Antitumor Antibiotic with Topoisomerase I-mediated Dna Cleavage Activity Produced by Actinomycetes: Producing Organism,Fermentation, Isolation and Biological Activity. The Journal of Antibiotics 50(6): 490-495

Hayashi, S.F.; Norcia, L.J.L.; Seibel, S.B.; Silvia, A.M. 1997: Structure-activity Relationships of Hygromycin A and Its Analogs: Protein Synthesis Inhibition Activity in a Cell Free System. The Journal of Antibiotics 50(6): 514-521

Johdo, O.; Yoshioka, T.; Takeuchi, T.; Yoshimoto, A. 1997: Isolation of New Anthracyclines 10-O-Rhodosaminyl .Beta.-Rhodomycinone and .Beta.-Isorhodomycinone from Mild-acid Treated Culture of Obelmycin-producing Stereptomyces violaceus. The Journal of Antibiotics 50(6): 522-525

Taddei, A.; Zeeck, A. 1997: Biosynthesis of Albocycline: Origin of the Carbon Skelton. The Journal of Antibiotics 50(6): 526-528

Ohtake, N.; Yamada, K.; Mano, E.; Okamoto, O.; Ushijima, R.; Nakagawa, S. 1997: 1.Beta.-Methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 1. Synthesis and Antibacterial Activity of B0-2502A and lts Related Compoundsf. The Journal of Antibiotics 50(7): 567-585

Ohtake, N.; Okamoto, O.; Kato, S.; Ushijima, R.; Fukatsu, H.; Nakagawa, S. 1997: 1.Beta.-Methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 2. Synthesis and Antibacterial Activity of 5-Aminopropyl and 5-Aminopropenyl Pyrrolidine Derivatives. The Journal of Antibiotics 50(7): 586-597

Ohtake, N.; Okamoto, O.; Mitomo, R.; Kato, Y.; Yamamoto, K.; Haga, Y.; Fukatsu, H.; Nakagawa, S. 1997: 1,a-Methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 3. Synthesis and Antibacterial Activity of Bo-2727 and Its Related Compounds. The Journal of Antibiotics 50(7): 598-613

Sunagawa, M.; Matsumura, H.; Sasaki, A.; Yamaga, H.; Kltamura, Y.; Sumita, Y.; Nouda, H. 1997: Structure-activity Relationships of 1.Beta.-Methyl-carbapenems to Antimicrobial Activity: Effect of C-6 Substituent. The Journal of Antibiotics 50(7): 621-627

Woo Kim, J.; Adachi, H.; Shin-Ya, K.; Hayakawa, Y.; Seto, H. 1997: Apopto Udin, a New Apoptosis Inducer in Transiormed Cells from Nocardiopsis sp. The Journal of Antibiotics 50(7): 628-630

Nonaka, N.; Asai, Y.; Nishio, M.; Takahashi, K.; Okuda, T.; Tanaka, S.; Sugita, T.; Ohnuki, T.; Komatsubara, S. 1997: Tmc-2A, -2B and -2C, Novel Dipeptidyl Peptidase Iv Inhibitors Produced by Aspergillus oryzae A374. I.Taxonomy of Producing Strains, Fermentation, and Biochemical Properties. The Journal of Antibiotics 50(8): 646-652

Sakai, Y.; Yoshida, T.; Tsujita, T.; Ochiai, K.; Agatsuma, T.; Saitoh, Y.; Tanaka, F.; Akiyama, T.; AKiNAGA, S.; Mizukami, T. 1997: Ge3, a Novel Hexadepsipeptide Antitumor Antibiotic, Produced by Streptomyces sp.I. Taxonomy, Production, Isolation, Physico-chemical Properties, and Biological Activities. The Journal of Antibiotics 50(8): 659-664

Panzone, G.; Trani, A.; Ferrari, P.; Gastaldo, L.; Colombo, L. 1997: Isolation and Structure Elucidation of 7,8-Dideoxy-6-oxo griseorhodin C Produced by Actinoplanes ianthinogenes. The Journal of Antibiotics 50(8): 665-670

Hirosawa, S.; Nishizuka, T.; Kondo, S.; Ikeda, D.; Takeuchi, T. 1997: A Synthehc Approach to Benanomicin A. 1. Synthesis of 5,6-Dihydrobenzo(a)naphthacenequinone. The Journal of Antibiotics 50(8): 685-689

Kuwahara, A.; Nishikiori, T.; Shimada, N.; Nakagawa, T.; Fukazawa, H.; Mizuno, S.; Uehara, Y. 1997: Na22598Al, a Novel Antitumor Substance Produced by Streptomyces sp. Na22598. The Journal of Antibiotics 50(8): 712-713

Nishizuka, T.; Hirosawa, S.; Hamada, M.; Kondo, S.; Ikeda, D.; Takeuchi, T. 1997: Selective Deoxygenation and O-Methylation of Benanomicin A: Synthesis of 9-Deoxy-, 9-0-Methyl- and 14-0-Methylbenanomicin A. The Journal of Antibiotics 50(9): 765-769

Ueki, M.; Taniguchi, M. 1997: Uk-1, a Novel Cytotoxic Metabolite from Strcptomyces sp. 517-02. Iii. Antibacterial Action of Demethyl Uk-1. The Journal of Antibiotics 50(9): 788-790

Ritzau, M.; Vettermann, R.; Fleck, W.F.; Gutsche, W.; Dornberger, K.; Grafe, U. 1997: Benaphthamycin, a New Dihydrobenzo(a)naphthacenequinone Antibiotic from Strcptomyces sp. Hki-0057. The Journal of Antibiotics 50(9): 791-793

Dekker, K.A.; Inagaki, T.; Gootz, T.D.; Kaneda, K.; Nomura, E.; Sakakibara, T.; Sakemi, S.; Sugie, Y.; Yamauchi, Y.; Yoshikawa, N.; Kojima, N. 1997: Cj-12,954 and Its Congeners, New Anti-Helicobacter pylori Compounds Produced by Phanerochaete velutina:Fermentation, Isolation, Structural Elucidation and Biological Activities. The Journal of Antibiotics 50(10): 833-839

Naranda, A.; Lopotar, N.; Kelneric, Z. 1997: Nwe Dihydro and Tetrahydro Derivatives of Desmycosin. Iii. The Opening of Oxirane Ring of 12,13-Epoxydesmycosin. The Journal of Antibiotics 50(10): 860-865

Fehr, T.; Quesniaux, V.F.J.; Sanglier, J.-J.; Oberer, L.; Gschwind, L.; Ponelle, M.; Schilling, W.; Wehrli, S.; Enz, A.; Zenke, G.; Schuler, W. 1997: Cymbimicin A and B, Two Novel Cyclophilin-binding Structures Isolated from Actinomycetes. The Journal of Antibiotics 50(11): 893-899

Matsumoto, N.; Tsuchida, T.; Umekita, M.; Kinoshita, N.; Iinuma, H.; Sawa, T.; Hamada, M.; Takeuchi, T. 1997: Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis. I. Taxonomy, Fermentation, Isolation and Antimicrobial Activities. The Journal of Antibiotics 50(11): 900-905

Matsumoto, N.; Iinuma, H.; Sawa, T.; Takeuchi, T.; Hirano, S.-I.; Yoshioka, T.; Ishizuka, M. 1997: Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis. Ii. Effect on Type Ii Collagen-induced Arthritis in Mice. The Journal of Antibiotics 50(11): 906-911

Matsumoto, N.; Tsuchida, T.; Sawa, R.; Iinuma, H.; Nakamura, H.; Naganawa, H.; Sawa, T.; Takeuchi, T. 1997: Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis. Iii. Physico-chemical Properties and Structure Determination. The Journal of Antibiotics 50(11): 912-915

Izumida, H.; Adachi, K.; Mihara, A.; Yasuzawa, T.; Sano, H. 1997: Hydroxyakalone, a Novel Xanthine Oxidase Inhibitor Produced by a Marine Bacterium, Agrobacterium aurantiacum. The Journal of Antibiotics 50(11): 916-918

Fang, F.; Ui, H.; Shiomi, K.; Masuma, R.; Yamaguchi, Y.; Zhang, C.G.; Zhang, X.W.; Tanaka, Y.; Omura, S. 1997: Two New Components of the Aspochalasins Produced by Aspergillus sp. The Journal of Antibiotics 50(11): 919-925

Igarashi, M.; Kinoshita, N.; Ikeda, T.; Nakagawa, E.; Hamada, M.; Takeuchi, T. 1997: Formamicin, a Novel Antifungal Antibiotic Produced by a Strain of Saccharothrix sp. I. Taxonomy, Production, Isolation and Biological Properties. The Journal of Antibiotics 50(11): 926-931

Ben-Josef, A.M.; Manavathu, E.K.; Platt, D.; Sobel, J.D. 1997: In Vitro Antifungal Activity of Can-296: A Naturally Occurring Complex Carbohydrate. The Journal of Antibiotics 50(11): 937-943

Sugawara, T.; Tanaka, A.; Imai, H.; Naga, K.; Suzuki, K. 1997: Ym-47515, a Novel Isonitrile Antibiotic from Micromonospora echinospora subsp. echinospora. The Journal of Antibiotics 50(11): 944-948

Yoshikawa, K.; Takadera, T.; Adachi, K.; Nishijima, M.; Sanc, H. 1997: Korormicin, a Novel Antibiotic Specifically Active against Marine Gram-negative Bacteria, Produced by a Marine Bacterium. The Journal of Antibiotics 50(11): 949-953

Lee, S.; Sauerbrei, B.; Niggemann, J.; Egelkrout, E. 1997: Biosynthetic Studies on the .Alpha.-Glucosidase Inbibitor Acarbose in Actinoplanes sp.: Source of the Maltose Unit. The Journal of Antibiotics 50(11): 954-960

Kinoshita, K.; Sasaki, T.; Awata, M.; Takada, M.; Yaginuma, S. 1997: Structure of Sporostatin (M5032), an Inhibitor of Cyclic Adenosine 3,5-Monophosphate Phosphodiesterase. The Journal of Antibiotics 50(11): 961-964

Ivanova, V.; Gushterova, A. 1997: Malonylniphimycin: Macrolide Antibiotic from Streptomyces hygroscopicus B-7: Physico-chemical Properties and Structure Elucidation. The Journal of Antibiotics 50(11): 965-969

Koguchi, Y.; Nishio, M.; Kotera, J.; Omori, K.; Ohnuki, T.; Komatsubara, S. 1997: Trichostatin A and Herboxidiene Up-regulate the Gene Expression of Low Density Lipoprotein Receptor. The Journal of Antibiotics 50(11): 970-971

Ohashi, H.; Ishikawa, M.; Ito, J.; Ueno, A.; Gleich, G.J.; Kita, H.; Kawai, H.; Fukamachi, H. 1997: Sulochrin Inhibits Eosinophil Degranulation. The Journal of Antibiotics 50(11): 972-974

Yamashita, K.; Kinoshita, K. 1997: X-Ray Crystallographies of Leucomycin A5 and Rokitamycin Monomethylacetal. The Journal of Antibiotics 50(11): 975-978

Orihara, N.; Furihata, K.; Seto, H. 1997: Studies on the Biosynthesis of Terpenoidal Compounds Produced by Actinomycetes. 2. Biosynthesis of Carquinostatin B via the Non-mevalonate Pathway in Streptomyees exfoliatus. The Journal of Antibiotics 50(11): 979-981

Hegde, V.R.; Dai, P.; Chu, M.; Patel, M.; Bryant, R.; Terracciano, J.; Das, P.R.; Puar, M.S. 1997: Neurokinin Receptor Inhibitors: Fermentation, Isolation, Physico-chemical Properties, Structure and Biological Activity. The Journal of Antibiotics 50(12): 983-991

Yano, H.; Nakanishi, S.; Ikuina, Y.; Ando, K.; Yoshida, M.; Saitoh, Y.; Matsuda, Y. 1997: Ms-681a, b, c and d, New Inhibitors of Myosin Light Chain Kinase from Myrothecium sp. Ky6568. I. Characterization of Producing Strain and Production, Isolation and Biological Activities. The Journal of Antibiotics 50(12): 992-997

Ikuina, Y.; Bando, C.; Yoshida, M.; Yano, H.; Saitoh, Y. 1997: Ms-681a, b, c and d, New Inhibitors of Myosin Light Chain Kinase from Myrothecium sp. Ii. Physico-chemical Properties and Structure Elucidation. The Journal of Antibiotics 50(12): 998-1006

Matsuzaki, K.; Tahara, H.; Inokoshi, J.; Tanaka, H.; Masuma, R.; Omura, S. 1998: New Brominated and Halogen-less Derivatives and Structure-activity Relationship of Azaphilones Inhibiting gp120-Cd4 Binding. The Journal of Antibiotics 51(11): 1004-1011

Kennedy, T.C.; Webb, G.; Cannell, R.J.P.; Kinsman, O.S.; Middleton, R.F.; Sidebottom, P.J.; Taylor, N.L.; Dawson, M.J.; Buss, A.D. 1998: Novel Inhibitors of Fungal Protein Synthesis Produced by a Strain of Graphium putredinis Isolation, Characterisation and Biological Properties. The Journal of Antibiotics 51(11): 1012-1018

Ono, M.; Sakuda, S.; Ikeda, H.; Furihata, K.; Nakayama, J.; Suzuki, A.; Isogai, A. 1998: Structures and Biosynthesis of Aflastatins: Novel Inhibitors of Aflatoxin Production by Aspergillus parasiticus. The Journal of Antibiotics 51(11): 1019-1028

Pacey, M.S.; Dirlam, J.P.; Geldart, R.W.; Leadlay, P.F.; Mcarthur, H.A.I.; Mccormick, E.L.; Monday, R.A.; O'connell, T.N.; Staunton, J.; Winchester, T.J. 1998: Novel Erythromycins from a Recombinant Saccharopolyspora erythraea Strain Nrrl 2338 pIg1. I. Fermentation, Isolation and Biological Activity. The Journal of Antibiotics 51(11): 1029-1034

Yokomizo, K.; Miyamoto, Y.; Nagao, K.; Kumagae, E.; Habib, E.-S.E.; Suzuki, K.; Harada, S.; Uyeda, M. 1998: Fattiviracin A1, a Novel Antiviral Agent Produced by Streptomyces microflavus Strain No. 2445. Ii. Biological Properties. The Journal of Antibiotics 51(11): 1035-1039

Härtl, A.; Stelzner, A.; Schlegel, R.; Heinze, S.; Hülsmann, H.; Fleck, W.; Gräfe, U. 1998: Discovery of New Homologous Pamamycins by Mass Spectrometry and post mortem Inhibitory Action on Autolysis of Chicken Embryo Chorioallantoic Membrane Blood Vessels. The Journal of Antibiotics 51(11): 1040-1046

Sato, T.; Hanada, T.; Arioka, M.; Morita, T.-I.; Koshino, H.; Uramoto, M.; Yamasaki, M.; Kitamoto, K. 1998: S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans. Ii. Structure Elucidation. The Journal of Antibiotics 51(11): 1047-1050

Takahashi, S.; Uchida, K.; Kakinuma, N.; Hashimoto, R.; Yanagisawa, T.; Nakagawa, A. 1998: The Structures of Pyridovericin and Pyridomacrolidin, New Metabolites from the Entomopathogenic Fungus, Beauveria bassiana. The Journal of Antibiotics 51(11): 1051-1054

Hülsmann, H.; Heinze, S.; Ritzau, M.; Schlegel, B.; Gräfe, U. 1998: Isolation and Structure of Peptaibolin, a New Peptaibol from Sepedonium Strains. The Journal of Antibiotics 51(11): 1055-1058

Hasumi, K.; Ohyama, S.; Kohyama, T.; Ohsaki, Y.; Takayasu, R.; Endo, A. 1998: Isolation of Smtp-3, 4, 5 and -6, Novel Analogs of Staplabin, and Their Effects on Plasminogen Activation and Fibrinolysis. The Journal of Antibiotics 51(12): 1059-1068

Ishiyama, D.; Futamata, K.; Futamata, M.; Kasuya, O.; Kamo, S.; Yamashita, F.; Kanazawa, S. 1998: Novel Selective Inhibitors for Human Topoisomerase I, Bm2419-1 and -2 Derived from Saintopin. The Journal of Antibiotics 51(12): 1069-1074

Matsumoto, N.; Momose, I.; Umekita, M.; Kinoshita, N.; Chino, M.; Iinuma, H.; Sawa, T.; Hamada, M.; Takeuchi, T. 1998: Diperamycin, a New Antimicrobial Antibiotic Produced by Streptomyces griseoaurantiacus Mk393-Af2. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities. The Journal of Antibiotics 51(12): 1087-1092

Rickards, R.W.; Rothschild, J.M.; Lacey, E. 1998: Structure of Actinotetraose Hexatiglate, a Unique Glucotetraose from an Actinomycete Bacterium. The Journal of Antibiotics 51(12): 1093-1098

Kimura, K.-I.; Ikeda, Y.; Kagami, S.; Yoshihama, M.; Suzuki, K.; Osada, H.; Isono, K. 1998: Selective Inhibition of the Bacterial Peptidoglycan Biosynthesis by the New Types of Liposidomycins. The Journal of Antibiotics 51(12): 1099-1104

Yamashita, N.; Shin-Ya, K.; Furihata, K.; Hayakawa, Y.; Seto, H. 1998: New Ravidomycin Analogues, Fe35A and Fe35B, Apoptosis Inducers Produced by Streptomyces rochei. The Journal of Antibiotics 51(12): 1105-1108

Singh, M.P.; Zaccardi, J.; Greenstein, M. 1998: Ll-49F233.Alpha., a Novel Antibiotic Produced by an Unknown Fungus: Biological and Mechanistic Activities. The Journal of Antibiotics 51(12): 1109-1112

Shibata, K.; Hanafi, M.; Fujii, J.; Sakanaka, O.; Iinuma, K.; Ueki, M.; Taniguchi, M. 1998: Uk-2A, B, C and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02. Iii. Absolute Configuration of an Antifungal Antibiotic, Uk-2A, and Consideration of Its Conformation. The Journal of Antibiotics 51(12): 1113-1116

Choi, K.I.; Cha, J.H.; Pae, A.N.; Cho, Y.S.; Chang, M.H.; Koh, H.Y. 1998: Studies on Novel 3-lsoxazolylvinylcephalosporins: I. Synthesis and Biological Activity of 7-(2-(2-Aminothiazol-4-yl)-2-(alkoxy)-iminoacetamido) Derivatives. The Journal of Antibiotics 51(12): 1117-1121

Choi, K.I.; Cha, J.H.; Pae, A.N.; Cho, Y.S.; Kim, Y.; Chang, M.H.; Park, S.H.; Park, S.Y.; Kim, D.; Jeong, D.Y.; Kim, Y.H.; Kong, J.Y.; Koh, H.Y. 1998: Studies on Novel 3-lsoxazolylvinylcephalosporins: Ii. Synthesis and Biological Activity of 7-(2-(2-Aminothiazol-4-yl)-2-hydroxyiminoacetamido) Derivatives. The Journal of Antibiotics 51(12): 1122-1125

Kakeya, H.; Morishita, M.; Kobinata, K.; Osono, M.; Ishizuka, M.; Osada, H. 1998: Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone. The Journal of Antibiotics 51(12): 1126-1128

Sterner, O.; Thines, E.; Eilbert, F.; Anke, H. 1998: Glisoprenins C, D and E, New Inhibitors of Appressorium Eormation in Magnaporthe grisea, from Cultures of Gliocladium roseum. 2. Structure Determination. The Journal of Antibiotics 51(2): 228-231

Katahira, R.; Uosaki, Y.; Ogawa, H.; Yamashita, Y.; Nakano, H.; Yoshida, M. 1998: Uch9, a New Antitumor Antibiotic Produced byStreptomyces. Ii. Structure Elucidation of Uch9 by Mass and Nmr Spectroscopy. The Journal of Antibiotics 51(3): 267-274

Albaugh, D.; Albert, G.; Bradford, P.; Cotter, V.; Froyd, J.; Gaughran, J.; Kirsch, D.R.; Lai, M.; Rehnig, A.; Sieverding, E.; Silverman, S. 1998: Cell Wall Active Antifungal Compounds Produced by the Marine Fungus Hypoxylon oceanicum Ll-15G256. Iii. Biological Properties of 15G256.Gamma.. The Journal of Antibiotics 51(3): 317-322

Farooq Biabani, M.A.; Baake, M.; Lovisetto, B.; Laatsch, H.; Helmke, E.; Weyland, H. 1998: Marine Bacteria. X. Anthranilamides: New Antimicroalgal Active Substances from a Marine Streptomyces Sp. The Journal of Antibiotics 51(3): 333-340

Ikeno, S.; Tsuji, T.; Higashide, K.; Kinoshita, N.; Hamada, M.; Hori, M. 1998: A 7.6 kb Dna Region from Streptomyces kasugaensis M338-M1 Includes Some Genes Responsible for Kasugamycin Biosynthesis. The Journal of Antibiotics 51(3): 341-352

Kurome, T.; Inoue, T.; Takesako, K.; Kato, I.; Inami, K.; Shiba, T. 1998: Syntheses Antifungal Aureobasidin A Analogs with Alkyl Chains for Structure-activity Relationship. The Journal of Antibiotics 51(3): 359-367

Azami, H.; Matsuda, K.; Tsutsumi, H.; Kamimura, T.; Murata, M. 1998: Synthesis and Antibacterial Activity of Novel 4-Pyrrolidinylthio Carbapenems Ii:2-Alkyl and 2-Arylthiomethyl Derivatives. The Journal of Antibiotics 51(3): 374-377

Kajiura, T.; Furumai, T.; Igarashi, Y.; Hori, H.; Higashi, K.; Ishiyama, T.; Uramoto, M.; Uehara, Y.; Oki, T. 1998: Signal Transduction Inhibitors, Hibarimicins A, B, C, D and G Produced by Microbispora. 1. Taxonomy, Fermentation, Isolation and Physico-chemical and Biological Properties. The Journal of Antibiotics 51(4): 394-401

Onuki, H.; Miyashige, H.; Hasegawa, H.; Yamashita, S. 1998: Nhssoia, a Novel Anthranilamide Derivative from a Marine Fungus Penicillium sp. The Journal of Antibiotics 51(4): 442-444

Tanaka, Y.; Fang, F.; Zhang, C.G.; Zhang, X.W.; Omura, S. 1998: Heme-dependent Radical Generation from Antimalarial Fungal Metaholites, Radicicol and Heptelidic acid. The Journal of Antibiotics 51(4): 451-453

Mani, N.; Sanchet, P.; Jiang, Z.-D.; Mcnaney, C.; Decenzo, M.; Knighti, B.; Stankis, M.; Kuranda, M.; Rothstein, D.M. 1998: Screening Systems for Detecting Inhibitors of Cell Wall Transglycosylation in Enterococcus.Cell Wall Transglycosylation Inhibitors in Enterococcus. The Journal of Antibiotics 51(5): 471-479

Jinno, S.; Hata, K.; Shimidzu, N.; Okita, T. 1998: Phaffiaol, a New Antioxidant Isolated from a Yeast Phaffia rhodozym. The Journal of Antibiotics 51(5): 508-511

Goto, M.; Masegi, M.-A.; Yamauchi, T.; Chiba, K.-I.; Kuboi, Y.; Harada, K.; Naruse, N. 1998: K1115 A, a New Anthraquinone Derivative that Inhibits the Binding of Activator Protein-1(Ap-1) to its Recognition Sites. I. Biological Activities. The Journal of Antibiotics 51(6): 539-544

Naruse, N.; Goto, M.; Watanabe, Y.; Terasawa, T.; Dobashi, K. 1998: K1115 A, a New Anthraquinone that Inhibits the Binding of Activator Protein-1(Ap-1) to its Recognition Sites. Ii. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Determination. The Journal of Antibiotics 51(6): 545-552

Tomoda, H.; Tabata, N.; Masuma, R.; Si, S.-Y.; Omura, S. 1998: Erabulenols, Inhibitors of Cholesteryl Ester Transfer Protein Produced by Penicillium sp. Fo-5637. I. Production, Isolation and Biological Properties. The Journal of Antibiotics 51(7): 618-623

Yoshimura, S.; Otsuka, T.; Takase, S.; Okamoto, M.; Okada, S.; Hemmi, K. 1998: Wa8242A1, A2 and B, Novel Secretary Phospholipase A2 Inhibitors Produced by Streptomyces violaeeusniger. Iii. Structure Elucidation and Total Synthesis of Wa8242B. The Journal of Antibiotics 51(7): 655-664

Höltzel, A.; Kempter, C.; Metzger, J.W.; Jung, G.; Groth, I.; Fritz, T.; Fiedler, H.-P. 1998: Spirofungin, a New Antifungal Antibiotic from Streptomyces violaceusniger Tue 4113. The Journal of Antibiotics 51(8): 699-707

Yamashita, N.; Harada, T.; Shin-Ya, K.; Seto, H. 1998: 6-HydroxytetranguloL a Ncw Cpp32 Protease Inducer Produced by Streptomyca sp. The Journal of Antibiotics 51(1): 79-81

Daferner, M.; Anke, T.; Hellwig, V.; Steglich, W.; Sterner, O. 1998: Strobilurin M, Tetrachloropyrocatechol and Tetrachloropyrocatechol Methyl Ether: New Antibiotics from a Mycena Species. The Journal of Antibiotics 51(9): 816-822

Yeo, W.-H.; Lee, O.-K.; Yun, B.-S.; Woo, J.-S.; Kim, Y.-K.; Park, E.-K.; Kim, S.-S.; Kim, Y.-H.; Kim, S.-K.; Yoo, I.-D.; Whang, K.-S.; Yu, S.-H. 1998: 1-Hydroxycrisamicin A, a New Isochromanquinone Antibacterial Antibiotic, Produced by Mknomonospora sp. Sa246. The Journal of Antibiotics 51(1): 82-84

Komatsu, Y.; Takahashi, O.; Hayashi, H. 1998: Identification of the Anthracycline Antibiotic 44-O(.Beta.-D Glucopyranuronosyl)-.Epsilon.-Rhodomycinone, Produced by Streptomyca ruber Jcm3131, as an Up-regulator of Mhc Class-I Molecules in B16/Bl6 Cells. The Journal of Antibiotics 51(1): 85-88

Sato, T.; Hanada, T.; Arioka, M.; Ando, K.; Sugiyama, J.; Uramoto, M.; Yamasaki, M.; Kitamoto, K. 1998: S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans I. Producing Strain, Fermentation, Isolation and Biological Activity. The Journal of Antibiotics 51(10): 897-901

Tsukamoto, M.; Nakajima, S.; Arakawa, H.; Sugiura, Y.; Suzuki, H.; Hirayama, M.; Kamiya, S.; Teshima, Y.; Kondo, H.; Kojiri, K.; Suda, H. 1998: A New Antitumor Antibiotic, Be-19412A, Produced by a Streptomycete. The Journal of Antibiotics 51(10): 908-914

Igarashi, Y.; Takagi, K.; Kajiura, T.; Furumai, T.; Oki, T. 1998: Glucosylquestiomycin, a Novel Antibiotic from Microbispora sp. Tp-A0184: Fermentation, Isolation, Structure Determination,Synthesis and Biological Activities. The Journal of Antibiotics 51(10): 915-920

Vértesy, L.; Aretz, W.; Ehlers, E.; Hawser, S.; Isert, D.; Knauf, M.; Kurz, M.; Schiell, M.; Vogel, M.; Wink, J. 1998: H1 and H3, Novel Antifungal Heptaene Antibiotics Produced by Streptomyces sp. Hag 003874. The Journal of Antibiotics 51(10): 921-928

Kato, A.; Nakaya, S.; Kokubo, N.; Aiba, Y.; Ohashi, Y.; Hirata, H.; Fujii, K.; Harada, K.-I. 1998: A New Anti-Mrsa Antibiotic Complex, Wap-8294A. I. Taxonomy, Isolation and Biological Activities. The Journal of Antibiotics 51(10): 929-935

Ki, S.W.; Kasahara, K.; Kwon, H.J.; Eishima, J.; Takesako, K.; Cooper, J.A.; Yoshida, M.; Horinouchi, S. 1998: Identification of Radicicol as an Inhibitor of In Vivo Ras/Raf Interaction with the Yeast Two-hybrid Screening System. The Journal of Antibiotics 51(10): 936-944

Snyder, N.J.; Cooper, R.D.G.; Briggs, B.S.; Zmijewski, M.; Mullen, D.L.; Kaiser, R.E.; Nicas, T.I. 1998: Enzymatic Deacylation of Teicoplanin Followed by Reductive Alkylation: Synthesis and Antibacterial Activity of New Glycopeptides. The Journal of Antibiotics 51(10): 945-951

Yeo, W.-H.; Yun, B.-S.; Kim, S.-S.; Park, E.-K.; Kim, Y.-H.; Yoo, I.-D.; Yu, S.-H. 1998: Gtri-02, a New Lipid Peroxidation Inhibitor from Micromonospora sp. Sa246. The Journal of Antibiotics 51(10): 952-953

Kawamoto, S.; Zhang, D.; Ochi, K. 1998: Sequence Analysis of the Ribosomal L11 Protein Gene (rplK=relC) in Streptomyees lavendulae Using a Deletion Allele. The Journal of Antibiotics 51(10): 954-957

Hooper, A.M.; Rickards, R.W. 1998: 3-Amino-5-hydroxybenzoic Acid in Antibiotic Biosynthesis. Xii. Origin of the Oxygen Functionality of the Ansamycin Antibiotic Actamycin. The Journal of Antibiotics 51(10): 958-962

Kakeya, H.; Morishita, M.; Ikeno, A.; Kobinata, K.; Yano, T.; Osada, H. 1998: Factumycin and Its New Derivative Rk-1009 Enhance Threonine-phosphorylation of a 60-kDa Protein in Streptomyces griseus. The Journal of Antibiotics 51(10): 963-966

Sassa, T.; Kinoshita, H.; Nukina, M.; Sugiyama, T. 1998: Acremolactone A, a Novel Herbicidal Epoxydihydropyranyl .Gamma.-Lactone from Acremonium roseum I4267. The Journal of Antibiotics 51(10): 967-969

Osada, H. 1998: Bioprobes for Investigating Mammalian Cell Cycle Control. The Journal of Antibiotics 51(11): 973-982

Saito, T.; Aoki, F.; Hirai, H.; Inagaki, T.; Matsunaga, Y.; Sakakibara, T.; Sakemi, S.; Suzuki, Y.; Watanabe, S.; Suga, O.; Sujaku, T.; Smogowicz, A.A.; Truesdell, S.J.; Wong, J.W.; Nagahisa, A. 1998: Erinacine E as a Kappa Opioid Receptor Agonist and Its New Analogs from a Basidiomycete, Hericium ramosum. The Journal of Antibiotics 51(11): 983-990

Suzuki, K.; Nagao, K.; Monnai, Y.; Yagi, A.; Uyeda, M. 1998: Topostatin, a Novel Inhibitor of Topoisomerases I and Ii Produced by Thermomonospora alba Strain No. 1520. I. Taxonomy, Fermentation, Isolation and Biological Activities. The Journal of Antibiotics 51(11): 991-998

Suzuki, K.; Yahara, S.; Kido, Y.; Nagao, K.; Hatano, Y.; Uyeda, M. 1998: Topostatin, a Novel Inhibitor of Topoisomerases I and Ii Produced by Thermomonospora alba Strain No. 1520. Ii. Physico-chemical Properties and Structure Elucidation. The Journal of Antibiotics 51(11): 999-1003

Norcia, L.J.L.; Silvia, A.M.; Dirlam, J.P.; Schnur, R.C.; Bergeron, J.M.; Retsema, J.A.; Hayashi, S.F. 1999: In Vitro Microbiological Characterization of Novel Cyclic Homopentapeptides, Cp-101,680 and Cp-163,234, for Animal Health Use. The Journal of Antibiotics 52(11): 1007-1016

Kanzaki, H.; Imura, D.; Sashida, R.; Kobayashi, A.; Kawazu, K. 1999: Effective Production of Dehydro Cyclic Dipeptide Albonoursin Exhibiting Pronuclear Fusion Inhibitory Activity. I. Taxonomy and Fermentation. The Journal of Antibiotics 52(11): 1017-1022

Bormann, C.; Kálmánczhelyi, A.; Süßmuth, R.; Jung, G. 1999: Production of Nikkomycins Bx and Bz by Mutasynthesis with Genetically Engineered Streptomyces tendae Tue901. The Journal of Antibiotics 52(2): 102-108

Anderson, M.G.; Rickards, R.W.; Lacey, E. 1999: Structures of Flagranones A, B and C, Cyclohexenoxide Antibiotics from the Nematode-trapping Fungus Duddingtonia flagrans. The Journal of Antibiotics 52(11): 1023-1028

Heinisch, L.; Roemer, E.; Jütten, P.; Haas, W.; Werner, W.; Möllmann, U. 1999: Semisynthetic Derivatives of Madurahydroxylactone and Their Antibacterial Activities. The Journal of Antibiotics 52(11): 1029-1041

Tabata, N.; Tomoda, H.; Yamaguchi, Y.; Masuma, R.; Bamberger, M.J.; Omura, S. 1999: Inhibition of Cholesteryl Ester Transfer Protein by Fungal Metabolites, L681,512. The Journal of Antibiotics 52(11): 1042-1045

Asai, A.; Yamashita, Y.; Ando, K.; Kakita, S.; Kita, K.; Suzuki, Y.; Mihara, A.; Ashizawa, T.; Mizukami, T.; Nakano, H. 1999: Uct1072s, New Antitumor Antibiotics with Topoisomerase Ii Mediated Dna Cleavage Activity, from Aspergillus sp. The Journal of Antibiotics 52(11): 1046-1049

Sztaricskai, F.; Batta, G.; Dinya, Z.; Hornyák, M.; Röth, E.; Masuma, R.; Omura, S. 1999: Structural Modification of the Lincolnycin Antibiotic. The Journal of Antibiotics 52(11): 1050-1055

Koguchi, Y.; Kohno, J.; Suzuki, S.-I.; Nishio, M.; Takahashi, K.; Ohnuki, T.; Komatsubara, S. 1999: Tmc-86A, B and Tmc-96, New Proteasome Inhibitors from Streptomyces sp. Tc 1084 and Saccharothrix sp. Tc 1094. I. Taxonomy, Fermentation, Isolation, and Biological Activities. The Journal of Antibiotics 52(12): 1069-1076

Dombrowski, A.; Jenkins, R.; Raghoobar, S.; Bills, G.; Polishook, J.; Peláez, F.; Burgess, B.; Zhao, A.; Huang, L.; Zhang, Y.; Goetz, M. 1999: Production of a Family of Kinase-inhibiting Lactones from Fungal. The Journal of Antibiotics 52(12): 1077-1085

Zhao, A.; Lee, S.H.; Moiena, M.; Jenkins, R.G.; Patrick, D.R.; Huber, H.E.; Goetz, M.A.; Hensens, O.D.; Zink, D.L.; Vilella, D.; Dombrowski, A.W.; Lingham, R.B.; Huang, L. 1999: Resorcylic Acid Lactones. Naturally Occurring Potent and Sclective Inbibitors. The Journal of Antibiotics 52(12): 1086-1094

Inokoshi, J.; Shiomi, K.; Masuma, R.; Tanaka, H.; Yamada, H.; Omura, S. 1999: Funalenone, a Novel Collagenase Inbibitor Produced by Aspergillus niger. The Journal of Antibiotics 52(12): 1095-1100

Tomoda, H.; Tabata, N.; Shinose, M.; Takahashi, Y.; Woodruff, H.B.; Omura, S. 1999: Ferroverdins, Inhibitors of Cholesteryl Ester Transfer Protein Produccd by Streptomyces sp. Wk-5344. I. Production, Isolation and Biological Properties. The Journal of Antibiotics 52(12): 1101-1107

Tabata, N.; Tomoda, H.; Omura, S. 1999: Ferroverdins, Inhibitors of Cholesteryl Ester Transfer Protein Produced by Streptomyces sp. Wk-5344. Ii. Structure Elucidation. The Journal of Antibiotics 52(12): 1108-1113

Kohno, J.; Asai, Y.; Nishio, M.; Sakurai, M.; Kawano, K.; Hiramatsu, H.; Kameda, N.; Kishi, N.; Okuda, T.; Komatsubara, S. 1999: Tmc-171A, B, C and Tmc-154, Novel Polyketide Antibiotics Produced by Gliocledjum sp. Tc 1304 and Tc 1282. The Journal of Antibiotics 52(12): 1114-1123

Maul, C.; Sattler, I.; Zerlin, M.; Hinze, C.; Koch, C.; Maier, A.; Grabley, S.; Thiericke, R. 1999: Biomolecular-chemical Screening. A Novel Screening Approach for the Diseovery of Biologically Active Seeondary Metabolites. Iii. New Dna-binding Metabolites. The Journal of Antibiotics 52(12): 1124-1134

Yano, H.; Kuga, A.; Irinoda, K.; Okamoto, R.; Kobayashi, T.; Inoue, M. 1999: Presence of Genes for .Beta.-Lactamases of Two Different Classes on a Single Plasmid from a Clinical Isolate of Serrtia marcescens. The Journal of Antibiotics 52(12): 1135-1139

Krajewska, D.; Rózanski, A. 1999: Synthcsis and Properties of the Pyrrole Analogs of cnoramphenicol. The Journal of Antibiotics 52(12): 1140-1142

Mandic, Z.; Naranda, A.; Lopotar, N.; Duic, L..; Ivekovic, D.; Tkalcec, M. 1999: Tylosin Derivatives. V. Electrochemical Opening of Oxirane Ring. The Journal of Antibiotics 52(12): 1143-1145

Tatsuta, K.; Takano, S.; Ikeda, Y.; Nakano, S.; Miyazaki, S. 1999: The Total Synthesis and Absolute Structure of Antifungal Antibiotics (-)-Pf 1163A and B. The Journal of Antibiotics 52(12): 1146-1151

Kishi, K.; Ohki, H.; Okuda, S.; Kawabata, K.; Sakane, K.; Matsumoto, Y.; Matsumoto, S.; Tawara, S. 1999: Synthesis and Biological Properties of a Novel Cephalosporin Fr86521 Having Potent Activity Against Methicillin-resistant Staphylococcus aureus (Mrsa). The Journal of Antibiotics 52(12): 1152-1155

Nakakoshi, M.; Kimura, K.-I.; Nakajima, N.; Yoshihama, M.; Uramoto, M. 1999: Sna-4606-1, a New Member of Elaiophylins with Enzyme Inhibition Activity Against Testosterone 5.Alpha.-Reductase. The Journal of Antibiotics 52(2): 175-177

Ito, M.; Sakai, N.; Ito, K.; Mizobe, F.; Hanada, K.; Mizoue, K.; Bhandari, R.; Eguchi, T.; Kakinuma, K. 1999: A Novel Fungal Metabolite Ng-061 Enhances and Mimics Neurotrophic Effect of Nerve Growth Factor(Ngf) on Neurite Outgrowth in Pc12 Cells. The Journal of Antibiotics 52(3): 224-230

Bhandari, R.; Eguchi, T.; Serine, A.; Ohashi, Y.; Kakinuma, K.; Ito, M.; Mizoue, K. 1999: Structure of Ng-061, a Novel Potentiator of Nerve Growth Factor(Ngf) Isolated from Penicillium minioluteum F-4627. The Journal of Antibiotics 52(3): 231-234

Afonso, A.; Hon, F.; Brambilla, R. 1999: Structure Elucidation of Sch 20562, a Glucosidic Cyclic Dehydropeptide Lactone. The Major Component of W-10 Antifungal Antibiotic. The Journal of Antibiotics 52(4): 383-397

Afonso, A.; Hon, F.; Brambilla, R.; Puar, M.S. 1999: Structure Elucidation of Sch 20561, a Cyclic Dehydropeptide Lactone. A Major Component of W-10 Antifungal Antibiotic. The Journal of Antibiotics 52(4): 398-406

Coimbra, Joao Carlos; Pinto, Iraja Damiani; Wurdig, Norma Luiza; Do Carmo, Dermeval Aparecido 1999: Effect of Thiazinotrienomycin B, an Ansamycin Antibiotic, on the Function of Epidermal Growth Factor Receptor in Human Stomach Tumor Cells. The Journal of Antibiotics 52(5): 485-490

Kasai, M.; Hatano, S.; Kitagawa, M.; Yoshimi, A.; Shirahase, H.; Nishimura, K.-I.; Kakeya, N. 1999: As-924, a Novel Bifunctional Prodrug of Ceftioxime. The Journal of Antibiotics 52(5): 491-500

Fukami, A.; Taniguchi, Y.; Nakamura, T.; Rho, M.-C.; Kawaguchi, K.; Hayashi, M.; Komiyama, K.; Omura, S. 1999: New Members of the Macrocphelides from Microsphaeropsis sp. Fo-5050 Iv. The Journal of Antibiotics 52(5): 501-504

Nara, F.; Tanaka, M.; Hosoya, T.; Suzuki-Konagai, K.; Ogita, T. 1999: Scyphostatin, a Neutral Sphingomyelinase Inhibitor from a Discomycete, Trichopeziza mollissima: Taxonomy of the Producing Organism, Fermentation, Isolation, and Physico-chemical roperties. The Journal of Antibiotics 52(6): 525-530

Nara, F.; Tanaka, M.; Masuda-Inoue, S.; Yamasato, Y.; Doi-Yoshioka, H.; Suzuki-Konagai, K.; Kumakura, S.; Ogita, T. 1999: Biological Activities of Scyphostatin, a Neutral Sphingomyelinase Inhibitor from a Discomycete, Trichopeziza mollisima. The Journal of Antibiotics 52(6): 531-535

Otsuka, T.; Muramatsu, Y.; Higaki, T.; Nakanishi, T.; Takase, S.; Hatanaka, H.; Okamoto, M.; Hino, M.; Hashimoto, S. 1999: Wf14861, a New Cathepsins B and L Inhibitor Produced by Colletotrichum sp. I. Taxonomy, Production, Purification and Structure lucidation. The Journal of Antibiotics 52(6): 536-541

Hamada, M.; Sonotake, E.; Yamamoto, S.; Moriguchi, S. 1999: Conagenin Derived from Streptomyces roseosporus Enhances Macrophag Functions. The Journal of Antibiotics 52(6): 548-551

Bormann, C.; Lauer, B.; Kálmánczhelyi, A.; Süßmuth, R.; Jung, G. 1999: Novel Nikkomycins Lx and Lz Produced by Genetically Engineered Streptomyces tendae Tue901. The Journal of Antibiotics 52(6): 582-585

Fujita, K.-I.; Nagamine, Y.; Ping, X.; Taniguchi, M. 1999: Mode of Action of Anhydrofulvic Acid against Candida utilis Atcc 42402 under Acidi Condition. The Journal of Antibiotics 52(7): 628-634

Schiewe, H.-J.; Zeeck, A. 1999: Cineromycins, .Gamma.-Butyrolactones and Ansamycins by Analysis of the Secondary Metabolite Pattern Created by a Single Strain of Strepomycest. The Journal of Antibiotics 52(7): 635-642

Matsumoto, T.; Ishiyama, A.; Yamaguchi, Y.; Masuma, R.; Ui, H.; Shiomi, K.; Yamada, H.; Omura, S. 1999: Novel Cyclopentanone Derivatives Pentenocins A and B, with Interleukin-1 .Beta. Converting Enzyme Inhibitory Activity, Produced by Trichoderma hamatum Fo-6903. The Journal of Antibiotics 52(8): 754-757

Iijima, M.; Someno, T.; Ishizuka, M.; Sawa, R.; Naganawa, H.; Takeuchi, T. 1999: Ic202B and C, New Siderophores with Immunosuppressive Activity Produced by Streptoalloteichus sp. 1454-19. The Journal of Antibiotics 52(9): 775-780

Momose, I.; Iinuma, H.; Kinoshita, N.; Momose, Y.; Kunimoto, S.; Hamada, M.; Takeuchi, T. 1999: Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. Mk73-Nf4. I. Taxonomy, Isolation, Physico-chemical Properties and Biological Activities. The Journal of Antibiotics 52(9): 781-786

Momose, I.; Hirosawa, S.; Nakamura, H.; Naganawa, H.; Iinuma, H.; Ikeda, D.; Takeuchi, T. 1999: Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. Mk73-Nf4. Ii. Structure Determination. The Journal of Antibiotics 52(9): 787-796

Nosaka, C.; Kunimoto, S.; Takeuchi, T. 1999: The Decrease of Cytochrome c Oxidase Activity by 15-Deoxyspergualin Results in Enhancement of Xtt Reduction in Cultured Cells. The Journal of Antibiotics 52(9): 803-808

Sunada, A.; Nakajima, M.; Ikeda, Y.; Kondo, S.; Hotta, K. 1999: Enzymatic 1-N-Acetylation of Paromomycin by an Actinomycete Strain #8 with Multiple Aminoglycoside Resistance and Paromomycin Sensitivity. The Journal of Antibiotics 52(9): 809-814

Tabata, N.; Ohyama, Y.; Tomoda, H.; Abe, T.; Namikoshi, M.; Omura, S. 1999: Structure Elucidation of Roselipins, Inhibitors of Diacylglycerol Acyltransferase Produced by Gliocladium roseum Kf-1040. The Journal of Antibiotics 52(9): 815-826

Tanaka, M.; Nara, F.; Yamasato, Y.; Ono, Y.; Ogita, T. 1999: F-11334s, New Inhibitors of Membrane-bound Neutral Sphingomyelinase. The Journal of Antibiotics 52(9): 827-830

Gracey, H.E.; Montgomery, S.H.; Liu, J.-H.; Nilius, A.; Celebuski, J.E. 1999: Preparation and In Vitro Antibacterial Activity of 6-O-Methylerythromycin D. The Journal of Antibiotics 52(9): 831-834

Suouro, T.; Yanai, M. 1999: Solid-Phase Synthesis of Cyclooctadepsipeptide N-4909 Using a Cyclization-Cleavage Method with Oxime Resin. The Journal of Antibiotics 52(9): 835-838

Ku, Y.-Y.; Riley, D.; Grieme, T.; Niliusc, A. 1999: Synthesis and Antibacterial Activities of Novel 12-D-Methylerythromycin A Derivatives. The Journal of Antibiotics 52(10): 908-912

Maier, A.; Maul, C.; Zerlin, M.; Sattler, I.; Grabley, S.; Thiericke, R. 1999: Biounolecular-chemical Screening. A Novel Screening Approach for the Discovery of Biologically Active Secondary Metabolites. I. Screening Strategy and Validation. The Journal of Antibiotics 52(11): 945-951

Maier, A.; Maul, C.; Zerlin, M.; Grabley, S.; Thiericke, R. 1999: Bionrolecular-chemical Screening. A Novel Screening Approach for the Discovery of Biologically Active Secondary Metabolites. Ii. Application Studies with Pure Metabolites. The Journal of Antibiotics 52(11): 952-959

Akagawa, H.; Takano, Y.; Ishii, A.; Mizuno, S.; Izui, R.; Sameshima, T.; Kawamura, N.; Dobashi, K.; Yoshioka, T. 1999: Stresgenin B, an Inhibitor of Heat-induced Heat Shock Protein Gene Expression, Produced by Streptomyces sp. A-9. The Journal of Antibiotics 52(11): 960-970

Takeuchi, H.; Asai, N.; Tanabe, K.; Kozaki, T.; Fujita, M.; Sakai, T.; Okuda, A.; Naruse, N.; Yamamoto, S.; Sameshima, T.; Heida, N.; Dobashi, K.; Baba, M. 1999: Em2487, a Novel Anti-Hiv-1 Antibiotic, Produced by Streptomyces sp. Mer-2487. Taxonomy, Fermentation, Biological Properties, Isolation and Structure Elucidation. The Journal of Antibiotics 52(11): 971-982

Acebal, C.; Cañedo, L.M.; Puentes, J.L.F.ández; Baz, J.P.; Romero, F.; Calle, F.D.L.; Grávalos, M.D.G.ía; Rodriguez, P. 1999: Agrochelin, a New Cytotoxic Antibiotic from a Marine Agrobacterium Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity. The Journal of Antibiotics 52(11): 983-987

Hinkley, S.F.; Fettinger, J.C.; Dudley, K.; Jarvis, B.B. 1999: Memnobotrins and Memnoconols. Novel Metabolites from Memnoniella echinata. The Journal of Antibiotics 52(11): 988-997

Martin, J.F. 2000: .Alpha.-Aminoadipyl-cysteinyl-valine Synthetases in .Beta.-Lactam Producing Organisms. The Journal of Antibiotics 53(10): 1008-1021

Glinka, T.W.; Cho, A.; Zhang, Z.J.; Ludwikow, M.; Griffith, D.; Hum, K.; Hecker, S.J.; Dudley, M.N.; Lee, V.J.; Chamberland, S. 2000: Sar Studies of Anti-Mrsa Non-zwitterionic 3-Heteroarylthiocephems. The Journal of Antibiotics 53(10): 1045-1052

Ishikawa, T.; Iizawa, Y.; Okonogi, K.; Miyake, A. 2000: Studies on Anti-Mrsa Parenteral Cephalosporins. I. Synthesis and Antibacterial Activity of 7.Beta.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-hydroxyiminoacetamido]-3-(substituted imidazo [1,2-b]-pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds. The Journal of Antibiotics 53(10): 1053-1070

Ishikawa, T.; Kamiyama, K.; Matsunaga, N.; Tawada, H.; Iizawa, Y.; Okonogi, K.; Miyake, A. 2000: Studies on Anti-Mrsa Parenteral Cephalosporins. Ii. Synthesis and Antibacterial Activity of 7.Beta.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-(substituted imidazo [1,2-b]pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds. The Journal of Antibiotics 53(10): 1071-1085

Arcamone, F.M.; Auramura, M.; Perrotta, E.; Crea, A.; Manzini, S.; Poma, D.; Salimbeni, A.; Triolo, A.; Maggi, C.A. 2000: Synthesis and Biological Activity of the Penem Antibiotic Men 10700 and Its Orally Absorbed Ester Men 11505. The Journal of Antibiotics 53(10): 1086-1095

Igarashi, M.; Hayashi, C.; Homma, Y.; Hattori, S.; Kinoshita, N.; Hamada, M.; Takeuchi, T. 2000: Tubelactomicin A, a Novel 16-Membered Lactone Antibiotic, from Nocardia sp. I. Taxonomy, Production, Isolation and Biological Properties. The Journal of Antibiotics 53(10): 1096-1101

Igarashi, M.; Nakamura, H.; Naganawa, H.; Takeuchi, T. 2000: Tubelactomicin A, a Novel 16-Membered Lactone Antibiotic, from Nocardia sp. Ii. Structure Elucidation. The Journal of Antibiotics 53(10): 1102-1107

Ohyama, T.; Kurihara, Y.; Ono, Y.; Ishikawa, T.; Miyakoshi, S.; Hamano, K.; Araei, M.; Suzuki, T.; Igari, H.; Suzuki, Y.; Inukai, M. 2000: Arborcandins A, B, C, D, E and F, Novel 1,3-.Beta.-Glucan Synthase Inhibitors. Production and Biological Activity. The Journal of Antibiotics 53(10): 1108-1116

Igarashi, Y.; Ogawa, M.; Sato, Y.; Saito, N.; Yoshida, R.; Kunoh, H.; Onaka, H.; Furumai, T. 2000: Fistupyrone, a Novel Inhibitor of the Infection of Chinese Cabbage by Alternaria brassicicola, from Streptomyces sp. Tp-A0569. The Journal of Antibiotics 53(10): 1117-1122

Eilbert, F.; Anke, H.; Sterner, P. 2000: Neobulgarones A-F from Cultures of Neobulgaria pura, New Inhibitors of Appressorium Formation of Magnaporthe grisea. The Journal of Antibiotics 53(10): 1123-1129

Nakae, K.; Yoshimoto, Y.; Sawa, T.; Homma, Y.; Hamada, M.; Takeuch, T.; Imoto, M. 2000: Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. Mk929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities. The Journal of Antibiotics 53(10): 1130-1136

Silberborth, S.; Erkel, G.; Anke, T.; Sierner, O. 2000: The Irpexans, a New Group of Biologically Active Metabolites Produced by the Basidiomycete Irpex sp. 93028. The Journal of Antibiotics 53(10): 1137-1144

Chen, G.; Wang, G.-Y.-S.; Li, X.; Waters, B.; Davies, J. 2000: Enhanced Production of Microbial Metabolites in the Presence of Dimethyl Sulfoxide. The Journal of Antibiotics 53(10): 1145-1153

Hoshi, M.; Endo, T. 2000: Microbial and Chemical Conversion of Antibiotic K41. Ii. Preparation of K41-Da1, -Da2 and -Da3, Deamicetosyl Derivatives of Antibiotic K41. The Journal of Antibiotics 53(10): 1154-1157

Ota, Y.; Tamegai, H.; Kudo, F.; Kuriki, H.; Koike-Takeshita, A.; Eouchi, T.; Kakinuma, K. 2000: Butirosin-biosynthetic Gene Cluster from Bacillus circulans. The Journal of Antibiotics 53(10): 1158-1167

Hotta, K.; Sunada, A.; Ikeda, Y.; Kondo, S. 2000: Double Stage Activity in Aminoglycoside Antibiotics. The Journal of Antibiotics 53(10): 1168-1174

Uchida, K.; Nishiyama, Y.; Yokota, N.; Yamaguchi, H. 2000: In Vitro Antifungal Activity of a Novel Lipopeptide Antifungal Agent, Fk463, Against Various Fungal Pathogens. The Journal of Antibiotics 53(10): 1175-1181

Knauth, P.; Reichenbach, H. 2000: On the Mechanism of Action of the Myxobacterial Fungicide Ambruticin. The Journal of Antibiotics 53(10): 1182-1190

Kim, Y.B.; Ki, S.W.; Yosnida, M.; Horinouchi, S. 2000: Mechanism of Cell Cycle Arrest Caused by Histone Deacetylase Inhibitors in Human Carcinoma Cells. The Journal of Antibiotics 53(10): 1191-1200

Rho, M.-C.; Hayashi, M.; Fukami, A.; Obata, R.; Sunazuka, T.; Tomoda, H.; Komiyama, K.; Omura, S. 2000: Reversal of Multidrug Resistance by 7-O-Benzoylpyripyropene A in Multidrug-Resistant Tumor Cells. The Journal of Antibiotics 53(10): 1201-1206

Kovács-Kulyassa, Ã.; Herczegh, P.; Sztaricskai, F.J.; Szabó, P. 2000: Cephalosporin Podand Derivatives. The Journal of Antibiotics 53(10): 1207-1211

Fukami, A.; Nakamura, T.; Kawaguchi, K.; Rho, M.-C.; Matsumoto, A.; Takahashi, Y.; Shiomi, K.; Hayashi, M.; Komiyama, K.; Omura, S. 2000: A New Antimicrobial Antibiotic from Actinoplanes capillaceus sp. K95-5561T. The Journal of Antibiotics 53(10): 1212-1214

Fukami, A.; Nakamura, T.; Kim, Y.-P.; Shiomi, K.; Hayashi, M.; Nagai, T.; Yamada, H.; Komiyama, K.; Omura, S. 2000: A New Anti-influenza Virus Antibiotic, 10-Norparvulenone from Microsphaeropsis sp. Fo-5050. The Journal of Antibiotics 53(10): 1215-1218

Oohori, M.; Otoguro, K.; Sunazuka, T.; Kunihiko, S.; Iwai, Y.; Omura, S. 2000: Effect of 14-Membered Ring Macrolide Compounds on Rat Leucocyte Chemotaxis and the Structure-activity Relationships. The Journal of Antibiotics 53(10): 1219-1222

Yamamoto, H.; Kawabata, K.; Tawara, S.; Takasugi, H.; Tanaka, H. 2000: Fr 192752, a Novel Orally Active Cephalosporin Synthesis and Biological Properties. The Journal of Antibiotics 53(10): 1223-1227

Nakae, K.; Yoshimoto, Y.; Ueda, M.; Sawa, T.; Takahashi, Y.; Naganawa, H.; Takeuchi, T.; Imoto, M. 2000: Migrastatin, a Novel 14-Membered Lactone from Streptomyces sp. Mk929-43F1. The Journal of Antibiotics 53(10): 1228-1230

Tatsuta, K.; Takahashi, M.; Tanaka, N.; Chikauchi, K. 2000: Novel Synthesis of (+)-4-Acetoxy-3-hydroxyethyl-2-azetidinone from Carbohydrate. A Formal Total Synthesis of (+)-Thiehamycin. The Journal of Antibiotics 53(10): 1231-1234

Kakinuma, N.; Iwai, H.; Takahashi, S.; Hamano, K.; Yanagisawa, T.; Nagai, K.; Tanaka, K.; Suzuki, K.; Kirikae, F.; Kirikae, T.; Nakagawa, A. 2000: Quinolactacins A, B and C. Novel Quinolone Compounds from Penicillium sp. Epf-6. I. Taxonomy, Production, Isolation and Biological Properties. The Journal of Antibiotics 53(11): 1247-1251

Takahashi, S.; Kakinuma, N.; Iwai, H.; Yanagisawa, T.; Nagai, K.; Suzuki, K.; Tokunaga, T.; Nakagawa, A. 2000: Quinolactacins A, B and C. Novel Quinolone Compounds from Penicillium sp. Epf-6. Ii. Physico-chemical Properties and Structure Elucidation. The Journal of Antibiotics 53(11): 1252-1256

Kanzaki, H.; Yanagisawa, S.; Nitoda, T. 2000: Biosynthetic Intermediates of the Tetradehydro Cyclic Dipeptide Albonoursin Produced by Streptomyces albulus Ko-23. The Journal of Antibiotics 53(11): 1257-1264

Sakuda, S.; Ono, M.; Ikeda, H.; Nakamura, T.; Inagaki, Y.; Kawachi, R.; Nakayama, J.; Suzuki, A.; Isogai, A.; Nagasawa, H. 2000: Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus. The Journal of Antibiotics 53(11): 1265-1271

Berge, J.M.; Broom, N.J.P.; Houge-Frydrych, C.S.V.; Jarvest, R.L.; Mensah, L.; Mcnair, D.J.; O'hanlon, P.J.; Pope, A.J.; Rittenhouse, S. 2000: Synthesis and Activity of Analogues of Sb-219383. Novel Potent Inhibitors of Bacterial Tyrosyl tRna Synthetase. The Journal of Antibiotics 53(11): 1282-1292

Berg, A.; Görls, H.; Dörfelt, H.; Walther, G.; Schlegel, B.; Gräfe, U. 2000: Aureoquinone, a New Protease Inhibitor from Aureobasidium sp. The Journal of Antibiotics 53(11): 1293-1295

Nozawa, O.; Okazaki, T.; Morimoto, S.; Chen, Z.-X.; He, B.-M.; Mizoue, K. 2000: Waol B, a New Trihydrofuran Derivative with Cytocidal Activity, isolated from Myceliophthora lutea. The Journal of Antibiotics 53(11): 1296-1300

Kohno, J.; Nishio, M.; Kishi, N.; Okuda, T.; Komatsubara, S. 2000: Biosynthesis of the Fungal Polyketide Antibiotics Tmc-151s. Origin of the Carbon Skeleton. The Journal of Antibiotics 53(11): 1301-1304

Takatsu, T.; Ohtsuki, M.; Muramatsu, A.; Enokita, R.; Kurakata, S.-I. 2000: Reblastatin, a Novel Benzenoid Ansamycin-type Cell Cycle Inhibitor. The Journal of Antibiotics 53(11): 1310-1312

Berg, A.; Reiber, K.; Dorfelt, H.; Walther, G.; Schlegel, B.; Gräfe, U. 2000: Laccaridiones A and B, New Protease Inhibitors from Laccana amethystea. The Journal of Antibiotics 53(11): 1313-1316

Imamura, N.; Motoike, I.; Noda, M.; Adachi, K.; Konno, A.; Fukami, H. 2000: Argimicin A, a Novel Anti-cyanobacterial Compound Produced by an Algae-lysing Bacterium. The Journal of Antibiotics 53(11): 1317-1319

Nishihara, Y.; Tsujii, E.; Takase, S.; Tsurumi, Y.; Kino, T.; Hino, M.; Yamashita, M.; Hashimoto, S. 2000: Fr191512, a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation. The Journal of Antibiotics 53(12): 1333-1340

Nishihara, Y.; Tsujii, E.; Yamagishi, Y.; Kino, T.; Hino, M.; Yamashita, M.; Hashimoto, S. 2000: Fr191512, a Novel Anti-influenza Agent Isolated from a Fungus Strain No.17415. Ii. Biological Properties. The Journal of Antibiotics 53(12): 1341-1345

Stefanska, A.L.; Fulston, M.; Houge-Frydrych, C.S.V.; Jones, J.J.; Warr, S.R. 2000: A Potent Seryl tRna Synthetase Inhibitor Sb-217452 Isolated from a Streptomyces species. The Journal of Antibiotics 53(12): 1346-1353

Jonsbu, E.; Ellingsenc, T.E.; Nielsen, J. 2000: Effects of Nitrogen Sources on Cell Growth and Production of Nystatin by Streptomyces noursei. The Journal of Antibiotics 53(12): 1354-1362

Shimotohno, K.W.; Hiraishi, Y.; Miura, Y.; Endo, T. 2000: Molecular Cloning and Sequencing of the Edeine B1 Amidinohydrolase Gene of Bacillus brevis Tt02-8 and Its Expression in Escherichia coli. The Journal of Antibiotics 53(12): 1363-1372

Gerth, K.; Steinmetz, H.; Höfle, G.; Reichenbach, H. 2000: Studies on the Biosynthesis of Epothilones: The Biosynthetic Origin of the Carbon Skeleton. The Journal of Antibiotics 53(12): 1373-1377

Sakuda, S.; Ikeda, H.; Nakamura, T.; Kawachi, R.; Kondo, T.; Ono, M.; Sakurada, M.; Inagaki, H.; Ito, R.; Nagasawa, H. 2000: Blasticidin A Derivatives with Highly Specific Inhibitory Activity toward Aflatoxin Production in Aspergillus parasiticus. The Journal of Antibiotics 53(12): 1378-1384

Yanai, M.; Suzuki, M.; Kawamura, K.; Oshida, N.; Hiramoto, S.; Yasuda, O.; Shingai, A.; Suguro, T. 2000: Synthesis of N-4909 Analogs. Part I. A Stimulant of Apolipoprotein E Secretion in Human Hepatoma G2 Cells. The Journal of Antibiotics 53(12): 1385-1396

Otani, T.; Yoshida, K.-I.; Kubota, H.; Kawai, S.; Ito, S.; Hori, H.; Ishiyama, T.; Oki, T. 2000: Novel Triene-.Beta.-lactone Antibiotics, Oxazolomycin Derivative and Its Isomer, Produced by Streptomyces sp. Ksm-2690. The Journal of Antibiotics 53(12): 1397-1400

Erkel, G.; Rether, J.; Anke, T.; Sterner, O. 2000: Trichodion, a New Bioactive Pyrone from a Trichosporiella species. The Journal of Antibiotics 53(12): 1401-1404

Fronko, R.M.; Lee, J.C.; Galazzo, J.G.; Chamberland, S.; Malouin, F.; Lee, M.D. 2000: New Pacidamycins Produced by Streptomyces coeruleorubidus, Nrrl 18370. The Journal of Antibiotics 53(12): 1405-1410

Iijima, M.; Someno, T.; Amemiya, M.; Ishizuka, M.; Naganawa, H.; Takeuchi, T. 2000: Biosynthesis of Ic202C, a New Siderophore with Immunosuppressive Activity. The Journal of Antibiotics 53(12): 1411-1415

Sunada, A.; Ikeda, Y.; Kondo, S.; Hotta, K. 2000: Acetylation of Aminoglycoside Antibiotics with 6'-Methylamino Group, Istamycin B and Micronomicin, by a Novel Aminoglycoside 6'-Acetyltransferase of Actinomycete Origin. The Journal of Antibiotics 53(12): 1416-1419

Habib, E.-S.E.; Yokomizo, K.; Murata, K.; Uyeda, M. 2000: Structures of Fattiviracin Family, Antiviral Antibiotics. The Journal of Antibiotics 53(12): 1420-1423

Otani, T.; Sugimoto, Y.; Aoyagi, Y.; Igarashi, Y.; Furumai, T.; Saito, N.; Yamada, Y.; Asao, T.; Oki, T. 2000: New Cdc25B Tyrrosine Phosphatase Inhibitors, Nocardiones A and B, Produced by Nocardia sp. Tp-A0248. Taxonomy, Fermentation, Isolation, Structural Elucidation and Biological Prbperties. The Journal of Antibiotics 53(4): 337-344

Houge-Frydrych, C.S.V.; Gilpin, M.L.; Skett, P.W.; Tyler, J.W. 2000: Sb-203207 and Sb-203208, Too Novel Isoleucyl tRna Synthetase Inhibitors from a Streptomyces sp. Ii. Structure Determination. The Journal of Antibiotics 53(4): 364-372

Ikeno, S.; Yamane, Y.; Ohishi, Y.; Kinoshita, N.; Hamada, M.; Tsuchiya, K.S.; Hori, M. 2000: Abc Taansporter Genes, kasKlm, Responsible for Self-resistance of a Kasugamycin Producer Strain. The Journal of Antibiotics 53(4): 373-384

Tatsuta, K.; Mukai, H.; Takahashi, M. 2000: Novel Synthesis of Natural Pseudo-aminosugars, (+)-Valienamine and (+)-Valienamine. The Journal of Antibiotics 53(4): 430-435

Yamazaki, H.; Tsuchida, Y.; Satoh, H.; Kawashima, S.; Hanaki, H.; Hiramaisu, K. 2000: Novel Cephalosporins 1. Synthesis of 3-Benzothiopyranylthiovinyl Cephalosporins and Antibacterial Activity against Methicillin-resistant Staphylococcus aureus and Vancomy cm-resistant Enterococcus faecalis. The Journal of Antibiotics 53(5): 546-550

Toyoda, E.; Hiratsuka, M.; Nemoto, K.; Yoneda, M.; Odaka, C. 2000: Immunosuppressant Deoxyspergualin Affests Mitochondrial Respiratory Function in Growing Cells. The Journal of Antibiotics 53(6): 633-636

Dörfelt, H.; Schlegel, B.; Gräfe, U. 2000: Dictyopanines A, B and C, New Bicyclic Sesquiterpene Esters from Dicotyopanus sp. Hki 0181. The Journal of Antibiotics 53(8): 839-843

Fujie, A.; Iwamoto, T.; Muramatsu, H.; Okudaira, T.; Nitta, K.; Nakanishi, T.; Sakamoto, K.; Hori, Y.; Hino, M.; Hashimoto, S.; Okuhara, M. 2000: Fr901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No. 11243. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Properties. The Journal of Antibiotics 53(9): 912-919

Fujie, A.; Iwamoto, T.; Muramatsu, H.; Okudaira, T.; Sato, I.; Furuta, T.; Tsurumi, Y.; Hori, Y.; Hino, M.; Hashimoto, S.; Okuhara, M. 2000: Fr901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No. 11243. Ii. In Vitro and In Vivo Activities. The Journal of Antibiotics 53(9): 920-927

Kobayashi, H.; Shin-Ya, K.; Nagai, K.; Suzuki, K.-I.; Hayakawa, Y.; Seto, H.; Yun, B.-S.; Ryoo, I.-J.; Kim, J.-S.; Kim, C.-J.; Yoo, I.-D. 2001: Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neuronal Cells from Excitotoxicity. I. Fermentation, Isolation, Physico-chemical Properties and Biological Activity. The Journal of Antibiotics 54(12): 1013-1018

Kobayashi, H.; Shin-Ya, K.; Furihata, K.; Nagai, K.; Suzuki, K.-I.; Hayakawa, Y.; Seto, H.; Yun, B.-S.; Ryoo, I.-J.; Kim, J.-S.; Kim, C.-J.; Yoo, I.-D. 2001: Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neurons from Excitotoxicity. Ii. Structure Determination. The Journal of Antibiotics 54(12): 1019-1024

Watanabe, S.; Hirai, H.; Kambara, T.; Kojima, Y.; Nlshida, H.; Sugiura, A.; Yamauchi, Y.; Yoshikawa, N.; Harwood, H.J.; Huang, L.H.; Kojima, N. 2001: Cj-13,981 and Cj-13,982, New Squalene Synthase Inhibitors. The Journal of Antibiotics 54(12): 1025-1030

Watanabe, S.; Hirai, H.; Kato, Y.; Nishida, H.; Saito, T.; Yoshikawa, N.; Parkinson, T.; Kojima, Y. 2001: Cj-19,784, a New Antifungal Agent from a Fungus, Acanthostigmella sp. The Journal of Antibiotics 54(12): 1031-1035

Onaka, H.; Tabata, H.; Igarashi, Y.; Sato, Y.; Furumai, T. 2001: Goadsporin, a Chemical Substance which Promotes Secondary Metabolism and Morphogenesis in Streptomycetes. I. Purification and Characterization. The Journal of Antibiotics 54(12): 1036-1044

Igarashi, Y.; Kan, Y.; Fujii, K.; Fujita, T.; Harada, K.-I.; Naoki, H.; Tabata, H.; Onaka, H.; Furumai, T. 2001: Goadsporin, a Chemical Substance which Promotes Secondary Metabolism and Morphogenesis in Streptomycetes. Ii. Structure Determination. The Journal of Antibiotics 54(12): 1045-1053

Hashizume, H.; Igarashi, M.; Hattori, S.; Hori, M.; Hamada, M.; Takeuchi, T. 2001: Tripropeptins, Novel Antimicrobial Agents Produced by Lysobacter sp. I. Taxonomy, Isolation and Biological Activities. The Journal of Antibiotics 54(12): 1054-1059

Sugie, Y.; Dekker, K.A.; Hirai, H.; Ichiba, T.; Ishiguro, M.; Shioni, Y.; Sugiura, A.; Brennan, L.; Duignan, J.; Huang, L.H.; Sutcliffe, J.; Kojima, Y. 2001: Cj-15,801, a Novel Antibiotic from a Fungus, Seimatosporium sp. The Journal of Antibiotics 54(12): 1060-1065

Pietro, M.T.D.; Marazzi, A.; Sosio, M.; Donadio, S.; Lancini, G. 2001: Biosynthesis of the Thiazolylpeptide Antibiotic Ge2270. The Journal of Antibiotics 54(12): 1066-1071

Igarashi, M.; Kawada, M.; Hamada, M.; Iinuma, H.; Hayashi, H.; Tsuchiya, K.; Hori, M. 2001: Some Biological and Biochemical Activities of Resormycin, a Novel Herbicidal Antibiotic. The Journal of Antibiotics 54(12): 1072-1079

Kawamoto, I.; Shimoji, Y.; Kanno, O.; Endo, R.; Miyauchi, M.; Kojima, K.; Ishikawa, K.; Morimoto, M.; Ohya, S. 2001: Synthesis and Antibacterial Activity of Novel 1.Beta.-Methyl Carbapenems with Cycloalkylamine Moiety at the C-2 Position. The Journal of Antibiotics 54(12): 1080-1092

Ueki, M.; Teruya, T.; Nie, L.; Usami, R.; Yoshida, M.; Osada, H. 2001: A New Trichostatin Derivative, Trichostatin Rk, from Streptomyces sp. Rk98-A74. The Journal of Antibiotics 54(12): 1093-1095

Chu, M.; Mierzwa, R.; He, L.; Xu, L.; Patel, M.; Patel, D.; Chan, T.-M. 2001: Structure of Sch 528647: A New Antitumor Antibiotic Related to Fumagillin. The Journal of Antibiotics 54(12): 1096-1099

Qureshi, A.; Mauger, J.B.; Cano, R.J.; Galazzo, J.L.; Lee, M.D. 2001: Mf-Ea-705.Alpha. & Mf-Ea-705.Beta., New Metabolites from Microbial Fermentation of a Streptomyces sp. The Journal of Antibiotics 54(12): 1100-1103

Takemoto, Y.; Nakae, K.; Kawatani, M.; Takahashi, Y.; Naganawa, H.; Imoto, M. 2001: Migrastatin, a Novel 14-Membered Ring Macrolide, Inhibits Anchorage-independent Growth of Human Small Cell Lung Carcinoma Ms-1 Cells. The Journal of Antibiotics 54(12): 1104-1107

Qian, X.; Li, Z.; Liu, Z.; Song, G.; Li, Z. 2001: Syntheses of 2-Aryliminooxazolidine Derivatives as Trehalase Inhibitors. The Journal of Antibiotics 54(12): 1108-1110

Takayasu, Y.; Tsuchiya, K.; Aoyama, T.; Sukenaga, Y. 2001: Nk30424A and B, Novel Inhibitors of Lipopolysaccharide-induced Tumour Necrosis Factor Alpha Production, Produced by Streptomyces sp. Na30424. The Journal of Antibiotics 54(12): 1111-1115

Hegde, V.R.; Puar, M.S.; Dai, P.; Pu, H.; Patel, M.; Anthes, J.C.; Richard, C.; Terracciano, J.; Das, P.R.; Gullo, V. 2001: A Family of Depsi-peptide Fungal Metabolites, as Selective and Competitive Human Tachykinin Receptor (Nk2) Antagonists. Fermentation, Isolation, PhysicQ-chemical Properties, and Biological Activity. The Journal of Antibiotics 54(2): 125-135

Kwon, O.S.; Park, S.H.; Yun, B.-S.; Pyun, Y.R.; Kim, C.-J. 2001: Cyclo (D-Pro-L-Val), a Specific .Beta.-Glucosidase Inhibitor Produced by Aspergillus sp. F70609. The Journal of Antibiotics 54(2): 179-181

Kara, M.; Soga, S.; Shono, K.; Eishima, J.; Mizukami, T. 2001: Ucf76 Compounds, New Inhibitors of Farnesyltransferase Produced by Steptomyces. The Journal of Antibiotics 54(2): 182-186

Fernekorn, U.; Heinze, T.; Schlegel, B.; Dahse, H.-M.; Gräfe, U. 2001: Synthesis of a New Polycyclic Quinone by Reduction of a Dihydrobenzo[a]naphthacenequinone. The Journal of Antibiotics 54(2): 191-192

Tanaka, A.; Barrett, D.; Fujie, A.; Shigematsu, N.; Hashimoto, M.; Hashimoto, S.; Ikeda, F. 2001: Site-specific Structural Transformation of the Novel Antifungal Cycle Depsipeptide Fr901469. Synthesis and Biological Activity of Fr203903. The Journal of Antibiotics 54(2): 193-197

Suzuki, Y.; Ojika, M.; Sakagami, Y.; Kaida, K.; Fudou, R.; Kameyama, T. 2001: New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica. The Journal of Antibiotics 54(1): 22-28

Ishikawa, T.; Kamiyama, K.; Nakayama, Y.; Iizawa, Y.; Okonogi, K.; Miyake, A. 2001: Studies on Anti-Mrsa Parenteral Cephalosporins. Iii. Synthesis and Antibacterial Activity of 7.Beta.-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-[(E)-2-(1-alkylimidazo[1,2-b]pyridazinium-6-yl)thiovinyl]-3-cephem-4-carboxylates and Related Compounds. The Journal of Antibiotics 54(3): 257-277

Hirano, N.; Kohno, J.; Tsunoda, S.; Nishio, M.; Kishi, N.; Okuda, T.; Kawano, K.; Komatsubara, S.; Nakanishi, N. 2001: Tmc-69, a New Antitumor Antibiotic with Cdc25A Inhibitory Activity, Produced by Chrysosporium sp. Tc1068. The Journal of Antibiotics 54(5): 421-427

Gebhardt, K.; Pukall, R.; Fiedler, H.-P. 2001: Streptocidins A-D, Novel Cyclic Decapeptide Antibiotics Produced by Streptomyces sp. Tue 6071. I. Taxonomy, Fermentation, Isolation and Biological Activities. The Journal of Antibiotics 54(5): 428-433

Höltzel, A.; Jack, R.W.; Nicholson, G.J.; Jung, G.; Gebhardt, K.; Fiedler, H.-P.; Süssmuth, R.D. 2001: Streptocidins A-D, Novel Cyclic Decapeptide Antibiotics Produced by Streptomyces sp. Tue 6071. Ii. Structure Elucidation. The Journal of Antibiotics 54(5): 434-440

Wrigley, S.K.; Ainsworth, A.M.; Kau, D.A.; Martin, S.M.; Bahl, S.; Tang, J.S.; Hardick, D.J.; Rawlins, P.; Sadheghi, R.; Moore, M. 2001: Novel Reduced Benzo[j]fluoranthen-3-ones from Cladosporium cf. cladosporioides with Cytokine Production and Tyrosine Kinase Inhibitory Properties. The Journal of Antibiotics 54(6): 479-488

Kleinwächter, P.; Schlegel, B.; Dörfelt, H.; Gräfe, U. 2001: Spirobenzofuran, a New Bioactive Metabolite from Acremonium sp. Hki 0230. The Journal of Antibiotics 54(6): 526-527

Seephonkai, P.; Isaka, M.; Kittakoop, P.; Trakulnaleamsai, S.; Rattanajak, R.; Tanticharoen, M.; Thebtaranonth, Y. 2001: A New Tropolone fromn the Insect Pathogenic Fungus Cordyceps sp. Bcc 1681. The Journal of Antibiotics 54(9): 751-752

Ino, A.; Kobayashi, S.; Ueda, K.; Hidaka, S.; Hayase, Y. 2001: Structure-activity Relationship of the Antimycoplasma Anitibiotic Micacocidin. A Preliminary Study. The Journal of Antibiotics 54(9): 753-756

Vértesy, L.; Kogler, H.; Markus, A.; Schiell, M.; Vogel, M.; Wink, J. 2001: Memnopeptide A, a Novel Terpene Peptide from Memnoniella with an Activating Effect on Serca2. The Journal of Antibiotics 54(10): 771-782

Nie, L.; Ueki, M.; Kakeya, H.; Osada, H. 2001: A Facile and Effective Screening Method for p21Waf1 Promoter Activators from Microbial Metabolites. The Journal of Antibiotics 54(10): 783-788

Endo, K.; Kamo, K.; Hosono, K.; Beppu, T.; Ueda, K. 2001: Characterization of Mutants Defective in Melanogenesis and a Gene for Tyrosinase of Streptomyces griseus. The Journal of Antibiotics 54(10): 789-796

Krause, M.; Lindemann, A.; Gnnski, M.; Hornbogen, T.; Bonse, G.; Jeschke, P.; Tmelking, G.; Gau, W.; Kleinkauf, H.; Zocher, R. 2001: Directed Biosynthesis of New Enniatins. The Journal of Antibiotics 54(10): 797-804

Fang, K.; Schlingmann, G.; Enos, A.; Carter, G.T. 2001: New Biotransformation Products of Nemadectins. The Journal of Antibiotics 54(10): 805-809

Chiba, H.; Asanuma, S.; Okamoto, M.; Inokoshi, J.; Tanaka, H.; Fujita, K.; Omura, S. 2001: A Simple Screening System for Anti-Hiv Drugs: Syncytium Formation Assay Using T-Cell Line Tropic and Macrophage Tropic Hiv env Expressing Cell Lines. Establishment and Validation. The Journal of Antibiotics 54(10): 818-826

Kim, W.-G.; Song, N.-K.; Yoo, I.-D. 2001: Quinolactacins A1 and A2, New Acetylcholinesterase Inhibitors from Penicillium citrinum. The Journal of Antibiotics 54(10): 831-835

Nakai, R.; Kakita, S.; Asai, A.; Cniba, S.; Akinaga, S.; Mizukami, T.; Yamashita, Y. 2001: Chrolactomycin, a Novel Antitumor Antibiotic Produced by Streptomyces sp. The Journal of Antibiotics 54(10): 836-839

Hanr, S.B.; Lee, H.J.; Kho, Y.H.; Jeon, Y.J.; Lee, S.H.; Kim, H.C.; Kim, H.M. 2001: New Immunosuppressive Activity of Dykellic Acid. The Journal of Antibiotics 54(10): 840-843

Barrett, D.; Tanaka, A.; Watabe, E.; Maki, K.; Ikeda, F. 2001: Novel Amidine Conjugates of the Ornithine Moiety of the Macrocyclic Antifungal Lipopeptidolactone Fr901469. The Journal of Antibiotics 54(10): 844-847

Rao, K.C.S.; Divakar, S.; Karanth, N.G.; Sattur, A.P. 2001: 14-(2', 3', 5'-Trihy droxyphenyl)tetradecan-2-ol, a Novel Acetylcholinesterase Inhibitor from Chrysosporium sp. The Journal of Antibiotics 54(10): 848-849

Kakeya, H.; Kageyama, S.-I.; Nie, L.; Onose, R.; Okada, G.; Beppu, T.; Norbury, C.J.; Osada, H. 2001: Lucilactaene, a New Cell Cycle Inhibitor in p53-Transfected Cancer Cells, Produced by a Fusarium sp. The Journal of Antibiotics 54(10): 850-854

Takahashi, K.; Tsuda, E.; Kurosawa, K. 2001: Sw-163A and B, Novel Immunosuppressants Produced by Streptomyces sp. The Journal of Antibiotics 54(11): 867-873

Sekizawa, R.; Momose, I.; Kinoshita, N.; Naganawa, H.; Hamada, M.; Muraoka, Y.; Iinuma, H.; Takeuchi, T. 2001: Isolation and Structural Determination of Phepropeptins A, B, C, and D, New Proteasome Inhibitors, Produced by Streptomyces sp. The Journal of Antibiotics 54(11): 874-881

Uchida, R.; Tomoda, H.; Arai, M.; Omura, S. 2001: Chlorogentisylquinone, a New Neutral Sphingomyelinase Inhibitor, Produced by a Marine Fungus. The Journal of Antibiotics 54(11): 882-889

Minagawa, K.; Kouzuki, S.; Nomura, K.; Yamaguchi, T.; Kawamura, Y.; Matsushima, K.; Tani, H.; Ishii, K.; Tanimoto, T.; Kamigauchi, T. 2001: Bisabosquals, Novel Squalene Synthase Inhibitors. I. Taxonomy, Fermentation, Isolation and Biological Activities. The Journal of Antibiotics 54(11): 890-895

Minagawa, K.; Kouzuki, S.; Nomura, K.; Kawamura, Y.; Tani, H.; Terui, Y.; Nakai, H.; Kamigauchi, T. 2001: Bisabosquals, Novel Squalene Synthase Inhibitors. Ii. Physico-chemical Properties and Structure Elucidation. The Journal of Antibiotics 54(11): 896-903

Watanabe, S.; Hirai, H.; Ishiguro, M.; Kambara, T.; Kojima, Y.; Matsunaga, T.; Nishida, H.; Suzuki, Y.; Sugiura, A.; Harwood, H.J.; Huang, L.H.; Kojima, N. 2001: Cj-15,183, a New Inhibitor of Squalene Synthase Produced by a Fungus, Aspergillus aculeatus. The Journal of Antibiotics 54(11): 904-910

Sugie, Y.; Hirai, H.; Inagaki, T.; Ishiguro, M.; Kim, Y.-J.; Kojima, Y.; Sakakibara, T.; Sakemi, S.; Sugiura, A.; Suzuki, Y.; Brennan, L.; Duignan, J.; Huang, L.H.; Sutcliffe, J.; Kojima, N. 2001: A New Antibiotic Cj-17,665 from Aspergillus ochraceus. The Journal of Antibiotics 54(11): 911-916

Sugie, Y.; Hirai, H.; Kachi-Tonai, H.; Kim, Y.-J.; Kojima, Y.; Shiomi, Y.; Sugiura, A.; Sugiura, A.; Suzuki, Y.; Yqshikawa, N.; Brennan, L.; Duignan, J.; Huang, L.H.; Sutcliffe, J.; Kojima, N. 2001: New Pyrrolizidinone Antibiotics Cj-16,264 and Cj-16,367. The Journal of Antibiotics 54(11): 917-925

Nakao, M.; Miyagawa, K.-I.; Nakano, Y.; Sakane, T.; Tada, M.; Nishimura, O.; Fujino, M. 2001: Pyloricidins, Novel Anti-Helicobacter pylori Antibiotics Produced by Bacillus sp. I. Taxonomy, Fermentation and Biological Activity. The Journal of Antibiotics 54(11): 926-933

Nagano, Y.; Ikedo, K.; Fujishima, A.; Izawa, M.; Tsubotani, S.; Nishimura, O.; Fujino, M. 2001: Pyloricidins, Novel Anti-Helicobacter pylori Antibiotics Produced by Bacillus sp. Ii. Isolation and Structure Elucidation. The Journal of Antibiotics 54(11): 934-947

Hall, R.M.; Dawson, M.J.; Jones, C.A.; Roberts, A.D.; Sidebottom, P.J.; Stead, P.; Taylor, N.L. 2001: The Production of Novel Sordarin Analogues by Biotransformation. The Journal of Antibiotics 54(11): 948-957

Gao, Q.; Demain, A.L. 2001: Effect of Solvents on Bioconversion of Penicillin G to Deacetoxycephalosporin G. The Journal of Antibiotics 54(11): 958-961

Hu, W.; Narasaki, R.; Ohyama, S.; Hasumi, K. 2001: Selective Production of Staplabin and Smtps in Cultures of Stachybotrys microspora Fed with Precursor Amines. The Journal of Antibiotics 54(11): 962-966

Cheng, Y.R.; Huang, J.; Qiang, H.; Lin, W.L.; Demain, A.L. 2001: Mutagenesis of the Rapamycin Producer Streptomyces hygroscopicus Fc904. The Journal of Antibiotics 54(11): 967-972

Vijayakumar, E.K.S.; Roy, K.; Hiremath, C.P.; Deshmukh, S.K.; Mukhopadhyay, T.; Kogler, H. 2001: L 970843 and L 970844, Two New Antifungal Metabolites from an Unidentified Fungal Species Hil Y-903146. The Journal of Antibiotics 54(11): 973-976

Ichikawa, K.; Inagaki, T.; Kojima, Y.; Nakamura, T.-A.; Nishida, H.; Ueno, Y.; Kojima, N. 2001: Regulation of Tumor Necrosis Factor-.Alpha. Production by a Fungal Metabolite, Pr 1388. The Journal of Antibiotics 54(11): 977-979

Murakami, Y.; Okuda, T.; Shindo, K. 2001: Roridin L, M and Verrucarin M, New Macrocyclic Trichothecene Group Antitumor Antibiotics, from Myrothecium verrucaria. The Journal of Antibiotics 54(11): 980-983

Kwon, O.E.; Rho, M.-C.; Song, H.Y.; Lee, S.W.; Chung, M.Y.; Lee, J.H.; Kim, Y.H.; Lee, H.S.; Kim, Y.-K. 2002: Phenylpyropene A and B, New Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium griseofulvum F1959. The Journal of Antibiotics 55(11): 1004-1008

Sasaki, T.; Igarashi, Y.; Ogawa, M.; Furumai, T. 2002: Identification of 6-Prenylindole as an Antifungal Metabolite of Streptomyces sp. Tp-A0595 and Synthesis and Bioactivity of 6-Substituted Indoles. The Journal of Antibiotics 55(11): 1009-1012

Ahn, S.C.; Kim, B.Y.; Oh, W.K.; Kang, D.O.; Heo, G.Y.; Kim, M.S.; Lee, M.S.; Ahn, J.S. 2002: Screening of Interleukin-2 Production Inhibitor with Mouse Thymoma El4 Cells. The Journal of Antibiotics 55(11): 1013-1015

Maskey, R.P.; Helmke, E.; Fiebig, H.-H.; Laatsch, H. 2002: Parimycin: Isolation and Structure Elucidation of a Novel Cytotoxic 2,3-Dihydroquinizarin Analogue of .Gamma.-Indomycinone from a Marine Streptomycete Isolate. The Journal of Antibiotics 55(12): 1031-1035

Kanzaki, H.; Yanagisawa, S.; Kanoh, K.; Nitoda, T. 2002: A Novel Potent Cell Cycle Inhibitor Dehydrophenylahistin. Enzymatic Synthesis and Inhibitory Activity toward Sea Urchin Embryo. The Journal of Antibiotics 55(12): 1042-1047

Namatame, I.; Matsuda, D.; Tomoda, H.; Yamaguchi, Y.; Masuma, R.; Kobayashi, S.; Omura, S. 2002: Selective Production of Fungal Beauveriolide I or Iii by Fermentation in Amino Acid-supplemented Media. The Journal of Antibiotics 55(12): 1048-1052

Onaka, H.; Tanifguchi, S.-I.; Igarashi, Y.; Furumai, T. 2002: Cloning of the Staurosporine Biosynthetic Gene Cluster from Streptomyces sp. Tp-A0274 and Its Heterologous Expression in Streptomyces lividans. The Journal of Antibiotics 55(12): 1063-1071

He, H.; Yang, H.Y.; Luckman, S.W.; Roll, D.M.; Carter, G.T. 2002: Chloroquinocin, a Novel Chlorinated Naphthoquinone Antibiotic from Streptomyces sp., Ll-A9227. The Journal of Antibiotics 55(12): 1072-1075

Tatsuta, K.; Inukai, T.; Itoh, S.; Kawarasaki, M.; Nakano, Y. 2002: Total Synthesis of a Tetracyclic Anti-tumor, Uce6. The Journal of Antibiotics 55(12): 1076-1080

Arai, M.; Tomoda, H.; Okuda, T.; Wang, H.; Tabata, N.; Masuma, R.; Yamaguchi, Y.; Omura, S. 2002: Funicone-related Compounds, Potentiators of Antifungal Miconazole Activity, Produced by Talaromyces flavus Fki-0076. The Journal of Antibiotics 55(2): 172-180

Minagawa, K.; Kouzuki, S.; Tani, H.; Ishii, K.; Tanimoto, T.; Terui, Y.; Kamigauchi, T. 2002: Novel Stachyflin Derivatives from Stachybotrys sp. Rf-7260. The Journal of Antibiotics 55(3): 239-248

Roll, D.M.; Tischler, M.; Williamson, R.T.; Carter, G.T. 2002: The Structure of V214w From an Unidentified Fungus. The Journal of Antibiotics 55(5): 520-523

Naganawa, H.; Hashizume, H.; Kubota, Y.; Sawa, R.; Takahashi, Y.; Arakawa, K.; Bowers, S.G.; Mahmud, T. 2002: Biosynthesis of the Cyclitol Moiety of Pyralomicin la in Nonomuraea spiralis Mi178-34F18. The Journal of Antibiotics 55(6): 578-584

Usuki, Y.; Goto, K.; Kiso, T.; Tani, K.; Ping, X.; Fujita, K.-I.; Iio, H.; Taniguchi, M. 2002: Uk-2A, B, C and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02 Vi(2). Structure-activity Relationships of Uk-2A. The Journal of Antibiotics 55(6): 607-610

Kim, H.S.; Park, I.Y.; Park, Y.J.; Lee, J.H.; Hong, Y.S.; Lee, J.J. 2002: A Novel Dihydroxanthenone, Agi-B4 with Inhibition of Begf-induced Endothelial Cell Growth. The Journal of Antibiotics 55(7): 669-672

Sunagawa, M.; Itoh, M.; Kubota, K.; Sasaki, A.; Ueda, Y.; Angehrn, P.; Bourson, A.; Goetschi, E.; Hebeisen, P.; Then, R.L. 2002: New Anti-Mrsa and Anti-Vre Carbapenems; Synthesis and Structure-activity Relationships of 1.Beta.-Metyl-2-(thiazol-2-ylthio)carbapenems. The Journal of Antibiotics 55(8): 722-757

Ohyama, T.; Iwadate-Kurihara, Y.; Hosoya, T.; Ishikawa, T.; Miyakoshi, S.; Hamano, K.; Inukai, M. 2002: F-10748 A1,A2,B1,B2,C1,C2,D1 and D2, Novel Papulacandins. The Journal of Antibiotics 55(8): 758-763

Gebhardt, K.; Schimana, J.; Krastel, P.; Dettner, K.; Rheinheimer, J.; Zeeck, A.; Fiedler, H.-P. 2002: Biosynthetic Capacities of Actinomysetes. No.26. Endophenazines A-D, New Phenazine Antibiotics from the Arthropod Associated Endosymbiont Streptomyces anulatus. I. Taxonomy, Fermentation, Isolation and Biological Activities. The Journal of Antibiotics 55(9): 794-800

Krastel, P.; Zeeck, A.; Gebhardt, K.; Fiedler, H.-P.; Rheinheimer, J. 2002: Biosynthetic Capacities of Actinomysetes. No.27. Endophenazines A-D, New Phenazine Antibiotics from the Athropod Associated Endosymbiont Streptomyces anulatus. Ii. Structure Elucidation. The Journal of Antibiotics 55(9): 801-806

Schlegel, B.; Härtl, A.; Dahse, H.-M.; Gollmick, F.A.; Gräfe, U.; Dörfelt, H.; Kappes, B. 2002: Hexacylinol, a New Antiproliferative Metabolite of Panus rudis Hki 0254. The Journal of Antibiotics 55(9): 814-817

Berg, A.; Dörfelt, H.; Kiet, T.T.; Schlegel, B.; Gräfe, U. 2002: Agrocybolacton, a New Bioactvi Metabolite from Agrocybe sp. Hki0259. The Journal of Antibiotics 55(9): 818-820

Saito, T.; Hirai, H.; Kim, Y.-J.; Kojima, Y.; Matsunaga, Y.; Nishida, H.; Sakakibara, T.; Suga, O.; Sujaku, T.; Kojima, N. 2002: Cj-15,208, a Novel Kappa Opioid Receptor Antagonist from a Fungus, Ctenomyces serratus Atcc15502. The Journal of Antibiotics 55(10): 847-854

Sakai, Y.; Yoshida, T.; Ochiai, K.; Uosaki, Y.; Saitoh, Y.; Tanaka, F.; Akiyama, T.; Akinaga, S.; Mizukami, T. 2002: Gex1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. I. Taxonomy, Production, Isolation, Physicochemical Properties and Biological Activities. The Journal of Antibiotics 55(10): 855-862

Sakai, Y.; Tsujita, T.; Akiyama, T.; Yoshida, T.; Mizukami, T.; Akinaga, S.; Horinouchi, S.; Yoshida, M.; Yoshida, T. 2002: Gex1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. Ii. The Effects on Cell Cycle Progression and Gene Expression. The Journal of Antibiotics 55(10): 863-872

Furumai, T.; Eto, K.; Sasaki, T.; Higuchi, H.; Onaka, H.; Saito, N.; Fujita, T.; Naoki, H.; Igarashi, Y. 2002: Tpu-0037-A, B, C and D, Novel Lydicamycin Congeners with Anti-Mrsa Activity from Streptomyces platensis Tp-A0598. The Journal of Antibiotics 55(10): 873-880

Hellwig, V.; Grothe, T.; Mayer-Bartschmid, A.; Endermann, R.; Geschke, F.-U.; Henkel, T.; Stadler, M. 2002: Altersetin, a New Antibiotic from Cultures of Endophytic Alternaria spp. Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activities. The Journal of Antibiotics 55(10): 881-892

Asolkar, R.N.; Maskey, R.P.; Helmke, E.; Laatsch, H. 2002: Chalcomycin B, a New Macrolide Antibiotic from the Marine Isolate Streptomyces sp. B7064. The Journal of Antibiotics 55(10): 893-898

Ditullio, D.; Rocheleau, N.; Talbot, M.K.E.L.L.Y.; Millett, W.; McALPINE, J.; Robakiewicz, P. 2002: Strain Diversity within a Microbial Collection. The Journal of Antibiotics 55(10): 899-903

Tanaka, Y.; Ishikawa, F.; Osada, H.; Imajoh-Ohmi, S.; Uchida, T.; Kakiuchi, T. 2002: Reveromycin A Inhibits Antigen Receptor-mediated Antigen Presentation by B Lymphoma Cells via Its Effect on Intracellular Trafficking of the Antigen. The Journal of Antibiotics 55(10): 904-913

Ivanova, V.B.; Hoshino, Y.; Yazawa, K.; Ando, A.; Mikami, Y.; Zaki, S.M.; Gräfe, U. 2002: Isolation and Structure Elucidation of Two New Antibacterial Compounds Produced by Chrysosporium queenslandicum. The Journal of Antibiotics 55(10): 914-918

Kuzuyama, T.; Takahashi, S.; Dairi, T.; Seto, H. 2002: Detection of the Mevalonate Pathway in Streptomyces Species Using the 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene. The Journal of Antibiotics 55(10): 919-923

Kaneda, M. 2002: Studies on Bottromycins. Ii. Structure Elucidation of Bottromycins B2 and C2. The Journal of Antibiotics 55(10): 924-928

Shiomi, K.; Hatae, K.; Yamaguchi, Y.; Masuma, R.; Tomoda, H.; Kobayashi, S.; Omura, S. 2002: New Antibiotics Miyakamides Produced by a Fungus. The Journal of Antibiotics 55(11): 952-961

Nose, H.; Miyara, T.; Kushida, N.; Hoshiko, S. 2002: Isolation of Temperature-sensitive Saccharomyces cerevisiae with a Mutation in erg25 for C-4 Sterol Methyl Oxidase. The Journal of Antibiotics 55(11): 962-968

Nose, H.; Fushimi, H.; Seki, A.; Sasaki, T.; Watabe, H.; Hoshiko, S. 2002: Pf1163A, a Novel Antifungal Agent, Inhibit Ergosterol Biosynthesis at C-4 Sterol Methyl Oxidase. The Journal of Antibiotics 55(11): 969-974

Tsukiyama, T.; Kajino, H.; Kajino, F.; Furuta, S.; Tsukamoto, Y.; Sato, K.; Kinoshita, A.; Ichinose, R.; Tanaka, K. 2002: Synthesis of Milbemycins .Alpha.9, .Alpha.10, .Alpha.11, .Alpha.12, .Alpha.14, .Alpha.15, .Alpha.20, .Alpha.21, .Alpha.22, .Alpha.23, .Alpha.26, .Alpha.27, .Delta.2,3,.Delta.4,26-Milbemycins A3, A4 from Milbemycins A3, A4, and Their Acaricidal Activities. The Journal of Antibiotics 55(11): 993-1003