Thiotetromycin,a new antibiotic. Taxonomy,production,isolation,and physicochemical and biological properties

Omura, S.; Iwai, Y.; Nakagawa, A.; Iwata, R.; Takahashi, Y.; Shimizu, H.; Tanaka, H.

The Journal of Antibiotics 36(2): 109-114


DOI: 10.7164/antibiotics.36.109
Accession: 068516027

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A new antibiotic, thiotetromycin, has been isolated from the culture filtrate of Streptomyces sp. OM-674 by solvent extraction and silica gel chromatography. The molecular formula of the antibiotic has been determined as C13H18O2S on the basis of elemental analysis and its high resolution mass spectrometry. The antibiotic contains a thiotetronic acid in the molecule and possesses a selective activity against Bacteroides fragilis.