Dihydromonacolin L and monacolin X. new metabolites those inhibit cholesterol biosynthesis

Endo, A.; Hasumi, K.; Nakamura, T.; Kunishima, M.; Masuda, M.

The Journal of Antibiotics 38(3): 321-327

1985


DOI: 10.7164/antibiotics.38.321
Accession: 068516184

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Abstract
Dihydromonacolin L and monacolin X those are structurally related to monacolin K, a potent inhibitor of cholesterol biosynthesis, were isolated from cultures of a mutant of Monascus ruber. The structures of these two metabolites were determined by a combination of physical techniques. Data for dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are also given.