The synthesis and biological evaluation of 7.Beta.- (2- (2-aminooxazol-4-yl) -2-Z-methoximinoacetamido) cephalosporin antibiotics
Wheeler, W.J.; Finley, D.R.; Messenger, R.J.; Koehler, R.; Ott, J.T.
The Journal of Antibiotics 39(1): 121-127
1986
DOI: 10.7164/antibiotics.39.121
Accession: 068516204
7 beta-[2-(2-Aminooxazol-4-yl)-2-Z-methoximinoacetamido]-3-cep hem -4-carboxylic acids 12 and 13 were synthesized. The microbiological activity of 12 and 13 as well as the beta-lactamase stability of 12 were discussed. Both 12 and 13 were quite active against a wide variety of microorganisms although usually less active than cefotaxime.
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