Semisynthetic .Beta.-lactam antibiotics. Ii Synthesis and antibacterial activity of 7.Beta.- (2- (acylamino) -2- (2-aminothiazol-4-yl) acetamido) cephalosporins
Arimoto, M.; Ejima, A.; Watanabe, T.; Tagawa, H.; Furukawa, M.
The Journal of Antibiotics 39(9): 1236-1242
1986
DOI: 10.7164/antibiotics.39.1236
Accession: 068516206
Cephalosporin derivatives (I) substituted with a neutral, acidic or basic amino acid group as the terminal group attached to the 2-amino-2-(2-aminothiazol-4-yl)acetamido side chain at the C-7 position were synthesized, and the effect of each group on antibacterial activity was examined. The derivatives bearing an amidino or guanidino group showed broad spectra of antibacterial activity similar to those of cefotaxime, but they were relatively sensitive to beta-lactamases.
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