Section 69
Chapter 68,517

Semisynthetic .Beta.-lactam antibiotics. Iii Synthesis and antibacterial activity of 7.Beta.- (2- (2-aminothiazol-4-yl) -2- (substituted carbamoylmethoxyimino) acetamido) cephalosporins

Arimoto, M.; Hayano, T.; Soga, T.; Yoshioka, T.; Tagawa, H.; Furukawa, M.

The Journal of Antibiotics 39(9): 1243-1256


DOI: 10.7164/antibiotics.39.1243
Accession: 068516207

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Syntheses of cephalosporins modified with a 7 beta-[2-(2-aminothiazol-4-yl)-2-(substituted carbamoylmethoxyimino)acetamido] group at the C-7 position and with various hetero aromatics at the C-3 position are described. The effects of substituents on the carbamoyl group in the 7-side chain were investigated in order to improve antibacterial activity. Some of these compounds exhibited high antibacterial activity against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa, as well as good resistance to beta-lactamase.

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