Studies on semi-synthetic 7.Alpha.-formamidocephalosporins. Iii. Synthesis and antibacterial activity of some 7.Beta.- (D-2- (aryl) -2- ( (4-ethyl-2,3-dioxopiperazin-1-yl) -carbonylamino) acetamido) -7.Alpha.-formamido-ceph-3-em-4-carboxylate derivatives
Branch, C.L.; Basker, M.J.; Finch, S.C.; Guest, A.W.; Harrngton, F.P.; Kaura, A.C.; Knott, S.J.; Milner, P.H.; Pearson, M.J.
The Journal of Antibiotics 40(5): 646-651
1987
DOI: 10.7164/antibiotics.40.646
Accession: 068516260
The synthesis and antibacterial activity of 7 beta-[D-2-(aryl)-2-[(4-ethyl-2,3-dioxopiperazin-1-yl) carbonylamino] acetamido]-7 alpha-formamidocephalosporins with various substituents at the C-3 position of the cephalosporin nucleus is described. Inhibition of Gram-positive and Gram-negative bacteria including beta-lactamase producing strains was observed with phenyl as the aryl residue. The 3,4-dihydroxyphenyl group further enhanced the activity against Gram-negative organisms; in this series, the 3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl] and 3-[(1-carboxymethyl-1H-tetrazol-5-yl)thiomethyl] analogues (2 and 12b) exhibited exceptional activity against Gram-negative bacteria, including Pseudomonas aeruginosa.