Darlucins A and B, New Isocyanide Antibiotics from Sphaerellopsis filum (Darluca filum)

Zapf, S.; Hoßfeld, M.; Anke, H.; Velten, R.; Steglich, W.

The Journal of Antibiotics 48(1): 36-41

1995


DOI: 10.7164/antibiotics.48.36
Accession: 068516598

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Abstract
Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1,2-diisocyanoalkene moiety. Both compounds exhibited antibacterial, antifungal and weak cytotoxic activities.