Ferroverdins, Inhibitors of Cholesteryl Ester Transfer Protein Produccd by Streptomyces sp. Wk-5344. I. Production, Isolation and Biological Properties

Tomoda, H.; Tabata, N.; Shinose, M.; Takahashi, Y.; Woodruff, H.B.; Omura, S.

The Journal of Antibiotics 52(12): 1101-1107


DOI: 10.7164/antibiotics.52.1101
Accession: 068516802

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Streptomyces sp. WK-5344, a soil isolate, was found to produce structurally related inhibitors of cholesteryl ester transfer protein (CETP). New active compounds, designated ferroverdins B and C, were isolated along with known ferroverdin A from the fermentation broth by solvent extraction, ODS column chromatography and silica gel column chromatography. All ferroverdins showed a dose-dependent inhibitory activity against human CETP. The IC50 values were 21, 0.62 and 2.2 microM for ferroverdins A, B and C, respectively, indicating that ferroverdin B is one of the most potent CETP inhibitors of microbial origin.