Novel Antifungal Diketopiperazine from Marine Fungus

Byun, H.-G.; Zhang, H.; Mochizuki, M.; Adachi, K.; Shizuri, Y.; Lee, W.-J.; Kim, S.-K.

The Journal of Antibiotics 56(2): 102-106


DOI: 10.7164/antibiotics.56.102
Accession: 068517004

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Marine fungi producing antifungal compounds were screened against Pyricularia oryzae (P. oryzae), and a metabolite of marine fungus M-3 isolated from laver (Porphyra yezoensis) showed potent activity. Novel diketopiperazine (1) was isolated from the culture extracts, and its structure was elucidated by spectroscopic methods. The MIC of 1 against P. oryzae was 0.36 microM.