New Diketopiperazines from the Entomopathogenic Fungus Verticillium hemipterigenum Bcc 1449

Nilanonta, C.; Isaka, M.; Kittakoop, P.; Saenboonrueng, J.; Rukachaisirikul, V.; Kongsaeree, P.; Thebtaranonth, Y.

The Journal of Antibiotics 56(7): 647-651


DOI: 10.7164/antibiotics.56.647
Accession: 068517041

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Two new diketopiperazines, bisdethiodi(methylthio)-1-demethylhyalodendrin and 1-demethylhyalodendrin tetrasulfide, together with two known cyclodepsipeptides, enniatins B and B4, and two known pyrones, pyrenocines A and B, were isolated from a culture broth of the entomopathogenic fungus Verticillium hemipterigenum BCC 1449. These structures were elucidated using spectroscopic methods and X-ray crystallography. Antimalarial and cytotoxic activities of these compounds were evaluated.